38 Top startups in Watertown for April 2025

We rank Athenahealth, Neumora Therapeutics and Mariana Oncology in Watertown along with 35 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Watertown is part of Boston Area startup ecosystem which ranks #5 globally and #4 in North America.

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Best Startups in Watertown for 2025

SB Score:764

Athenahealth offers cloud-based business and clinical services for physician practices, including practice management, electronic health record software, payer knowledge-base, and back-office operations. Their web-native solutions streamline healthcare workflows for more efficient and effective patient care.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:421

Lyndra Therapeutics revolutionizes medicine with a cutting-edge technology platform for a healthier future. Their innovative approach reinvents drug delivery, creating a more effective and convenient experience for patients.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:413

Tome Biosciences is a pioneering biotechnology company that specializes in programmable gene insertion technology. Utilizing advanced CRISPR techniques, it enables precise insertion of any genetic sequence, regardless of size or location, into any genome, unlocking new possibilities for genetic research and therapeutic applications.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:411

WiTricity is the trailblazer in wireless charging for electric vehicles, leading the development and implementation of magnetic resonance technology across passenger and commercial vehicles alike. The company’s technology is backed by an extensive patent portfolio and is the foundation for ratified global EV wireless charging standards including SAE, ISO, and GB. Automakers and Tier 1 suppliers turn to WiTricity to help accelerate the adoption of EVs by eliminating the hassle of plug-in charging, setting the stage for future autonomy.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:410

Seismic Therapeutics is a biotechnology company leveraging machine learning throughout the biologics discovery process to expedite the development of immunology drugs. By integrating advanced technology, it aims to enhance efficiency and innovation in creating effective therapeutic solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:394

Zus Health empowers healthcare innovators to develop technologies and services unhindered by traditional obstacles, fostering a new era of healthcare solutions.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:387

The ExSpiron device, cleared by FDA and CE Mark, measures minute ventilation non-invasively. It provides a clear understanding of breathing patterns, making it easier to monitor respiratory motion.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:384

Entact Bio is a biotech startup focused on developing medications to enhance protein function. With expertise in DUB biochemistry, chemical biology, and drug development, the team is advancing innovative therapies in the preclinical stage.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:384

Via Separations empowers industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing facilities, enabling them to produce more while minimizing their environmental impact.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

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Total amount:38

Top 27 Healthtech Startups in Watertown for 2025

The top three Healthtech startups in Watertown have raised more than USD 1.55B. Watertown is part of Boston Area startup ecosystem which ranks #2 globally for the Healthtech industry.
SB Score:764

Athenahealth offers cloud-based business and clinical services for physician practices, including practice management, electronic health record software, payer knowledge-base, and back-office operations. Their web-native solutions streamline healthcare workflows for more efficient and effective patient care.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:27

Top 5 Software & Data Startups in Watertown for 2025

The top three Software & Data startups in Watertown have raised more than USD 27.1M. Watertown is part of Boston Area startup ecosystem which ranks #5 globally for the Software & Data industry.
SB Score:262

Monotony.ai operates in Stealth mode, leveraging technology to revolutionize industries. Its innovative solutions are reshaping traditional processes behind the scenes.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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An AI-powered Pest Identification platform connects users with service providers quickly and efficiently, simplifying the process of addressing pest problems.

Industry:
Software & Data
Subindustry:
Software

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SB Score:39

Multitude Insights empowers law enforcement agencies to harness the power of unstructured data. Founded in 2021 and based in Watertown, Massachusetts, the company equips agencies with innovative tools to analyze and utilize valuable information, enhancing their operational capabilities and decision-making processes.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Total amount:5

Top 1 Ecommerce & Retail Startups in Watertown for 2025

Watertown is part of Boston Area startup ecosystem which ranks #11 globally for the Ecommerce & Retail industry.

Total amount:1

Most Funded Startups in Watertown for 2025

The top three most funded startups in Watertown have raised total funding of more than USD 1.55B. Neumora Therapeutics has 2.56% more funding than Lyndra Therapeutics.
SB Score:421

Lyndra Therapeutics revolutionizes medicine with a cutting-edge technology platform for a healthier future. Their innovative approach reinvents drug delivery, creating a more effective and convenient experience for patients.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:38

Top Hiring Startups in Watertown by Employee Number

The top three hiring startups in Watertown have an median employee size that is between [101-250]
SB Score:764

Athenahealth offers cloud-based business and clinical services for physician practices, including practice management, electronic health record software, payer knowledge-base, and back-office operations. Their web-native solutions streamline healthcare workflows for more efficient and effective patient care.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:413

Tome Biosciences is a pioneering biotechnology company that specializes in programmable gene insertion technology. Utilizing advanced CRISPR techniques, it enables precise insertion of any genetic sequence, regardless of size or location, into any genome, unlocking new possibilities for genetic research and therapeutic applications.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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SB Score:357

FORMA Therapeutics is a biopharmaceutical company integrating transformative biology and chemistry to unlock targets and pathways that have been validated through genomic medicine as root causes or major drivers of human cancers. FORMA’s approach to accessing such high value drug targets, many of which pose significant challenges to conventional discovery approaches, is rooted in the concerted integration of its innovative drug discovery technologies and oncology expertise, enabling screening, discovery and rational development of a generation of small molecule drug candidates with cellular mechanisms of action. FORMA is building a pipeline of therapeutics directed at Achilles heels in human cancers, such as key targets associated with cancer stem cells, tumor cell metabolism, programmed cell death or epigenetic disease mechanisms. FORMA builds on the vision of its academic founders: Stuart Schreiber, Todd Golub and Michael Foley, each of the Broad Institute of Harvard and MIT. FORMA leverages its innovative drug discovery platform to address challenging targets and develop a robust internal pipeline of breakthrough oncology drugs.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Total amount:38

Explore the Startup Ecosystem of Watertown

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
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1st
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710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
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00.00
00.00
3rd
0
4th
0
121.937
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00.00
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0
5th
0
109.679
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00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
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1
17th
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4
41.259
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00.00
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1
19th
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1
37.971
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00.00
00.00
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0
24th
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2
34.098
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00.00
00.00
10th
0
25th
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1
33.768
00.00
00.00
00.00
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