StartupBlink

1426 Top startups in San Diego for July 2026

We rank Cloudbeds, StockTwits and SOCi in San Diego along with 1423 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. San Diego startup ecosystem ranks #23 globally and #10 in United States.

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Startups

Unicorns

Exits

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Accelerators

Top Unicorn Startups in San Diego for 2026

Six startups have achieved unicorn status by exceeding USD 1 billion in valuation. Collectively, the top three unicorns in San Diego have raised more than USD 9.8B.
1st
ClickUp logo
ClickUpSB Score: 761

ClickUp combines tasks, docs, spreadsheets, goal tracking, resources, and an inbox in one app for seamless organization. Streamline your workflow and stay productive with all your essential tools in one place.

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Website
www.clickup.com
Employee range
501 – 1,000
Web Traffic (Monthly)
Funding amount
$537.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Seismic logo
SeismicSB Score: 644

Seismic provides software solutions for global sales and marketing teams, enabling them to streamline processes and drive revenue.

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Website
seismic.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$446.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Shield AI logo
Shield AISB Score: 589

Shield AI utilizes advanced artificial intelligence to safeguard both service members and civilians. Their mission is to provide protection through intelligent systems, ensuring safety and security in high-risk situations.

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Website
www.shield.ai
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$1B
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:6

Best Startups in San Diego for 2026

1st
Cloudbeds logo
CloudbedsSB Score: 666

Cloudbeds’ mission is to power every property globally with our integrated, cloud-based hospitality management platform. We empower independent hoteliers and hosts with the technology they need to grow their revenue, streamline operations, and deliver memorable guest experiences with confidence and ease via better technology. Cloudbeds was founded in 2012 and is headquartered in San Diego, California.

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Website
www.cloudbeds.com
Employee range
501 – 1,000
Web Traffic (Monthly)
Funding amount
$248.4M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
StockTwits logo
StockTwitsSB Score: 622

Stocktwits is a real-time financial communications platform for the financial and investing community. Stocktwits created the $TICKER tag to enable and organize “streams” of information around stocks and markets across the web and social media. These streams provide new forms of insight, ideas, and information that are used by investors, analysts, media, and others as they research stocks and manage their investments. The company was founded in 2008 by long-time investor Howard Lindzon. Today, more than 300,000 investors, market professionals, and public companies share information and ideas about the market and individual stocks using Stocktwits, producing streams that are viewed by an audience of over 40 million across the financial web and social media platforms.

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Website
stocktwits.com
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
$43.2M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
SOCi logo
SOCiSB Score: 579

SOCi is the leader in AI-powered marketing solutions for multi-location businesses. With its proprietary Genius AI™ and suite of Genius Agents™, SOCi provides a first-of-its-kind, AI-powered digital workforce capable of handling the workload of 1,000 local marketers™, empowering brands to achieve unmatched digital visibility, strengthen customer engagement, and scale faster than ever before. SOCi is recognized by Fast Company as one of the World's Most Innovative Companies, and is trusted by nearly 1,000 top brands—including Ford, Ace Hardware, Kumon, Liberty Tax, and more—to automate and optimize local marketing tasks across all locations. Founded in 2012 and backed by leading strategic investors, SOCi is transforming how multi-location brands manage and scale their marketing efforts.

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Website
www.meetsoci.com
Employee range
501 – 1,000
Web Traffic (Monthly)
Funding amount
$237.8M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
4th
GovX logo
GovXSB Score: 577

GovX is an eCommerce site dedicated to the military (Active, Reserve, and Veteran U.S. Military) and Federal, State, and Local government employees with an emphasis on first-responder communities. GovX is the largest privately operated e-commerce sales channel serving verified U.S. Military and Government employees. The company also operates the largest online event ticketing platform for verified U.S. Military and government employees working with MLB, NFL, NBA, NHL, MLS, major college sports as well as Ticketmaster, Tickets.com, and other strategic partners. GovX was founded in 2011 and headquartered in La Jolla, California.

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Website
www.govx.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$23.1M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
5th
Classy logo
ClassySB Score: 573

Classy is a social enterprise that helps nonprofits maximize their impact through a suite of world-class online fundraising tools. The company also hosts the Collaborative and Classy Awards to recognize excellence in social innovation. Since 2011, they've powered tens of millions of donations from over 190 countries and raised over $2 billion for social good.

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Website
www.classy.org
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$166M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
6th
NetraDyne logo
NetraDyneSB Score: 571

Netradyne engages in improving fleet safety through computer vision and in-depth data analysis. Through processing visual and sensory inputs, the company targets industries where the timeliness of actionable data is a key differentiator of performance. There is a continuing technology movement that is driving rapid improvements in camera technology together with reductions in the cost of sensors, processing, and connectivity. These improvements, along with advancements in deep learning technology, have created a perfect opportunity to deliver vision-based solutions across multiple industries.

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Website
www.netradyne.com
Employee range
501 – 1,000
Web Traffic (Monthly)
Funding amount
$287.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
7th
Cortica logo
CorticaSB Score: 566

Cortica provides diagnoses for autism, ADHD, developmental delays, and developmental differences. They offer in-home, in-clinic, and telehealth services. Their services include gene sequencing, metabolic testing, electroencephalography, nutrition evaluation, medication management, ABA therapy, parent coaching, speech-language therapy, occupational therapy, physical therapy, music therapy, and more.

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Website
www.corticacare.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$255M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
8th
Workiz logo
WorkizSB Score: 554

Founded in 2015, Workiz is a SaaS CRM platform for small to medium-sized on-demand field service businesses, such as HVAC, Plumbing and Electrician businesses. With Workiz, field service pros can grow their business by ditching antiquated business management methods such as pen and paper, Excel spreadsheets and Google Calendar. Workiz provides an all-in0one platform which allows them to manage and streamline their operation and continuously grow. Clients report a 22% increase in revenue since starting to use the Workiz platform. Headquartered in San Diego, California, Workiz serves the North America field service markets, and was selected as both a ‘Facebook Playground’ partner and a ‘Google for Startup Accelerator’ partner.

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Website
workiz.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$60.3M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
9th
Cars & Bids logo
Cars & BidsSB Score: 553

Experience Cars & Bids, an online auction marketplace for modern enthusiast cars with daily auctions from the 1980s to the 2020s. Buy and sell your dream car with ease on this platform designed for car enthusiasts.

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Website
carsandbids.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$37M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
10th
Lytx logo
LytxSB Score: 552

Lytx, Inc. develops video-based driver safety and fleet management solutions. The company offers DriveCam that identifies, prioritizes, and corrects the causes of poor driving to set standards for driver safety needs, RAIR web-based suite of compliance services that helps carriers manage CSA, hours-of-service, driver vehicle inspection report, and driver qualification aspects, a fleet tracking solution, and a fuel management solution. The company provides its solutions to trucking and transportation organizations, and their drivers, and the construction, distribution, government, transit, utility, waste and environmental, and commercial markets. It serves customers in the United States and internationally. The company was formerly known as DriveCam, Inc. and changed its name to Lytx, Inc. in November 2013. It was founded in 1998 and is based in San Diego, California.

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Website
www.lytx.com
Employee range
501 – 1,000
Web Traffic (Monthly)
Funding amount
$69M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
11th
Equip Health logo
Equip HealthSB Score: 547

Equip is a virtual program helping families recover from eating disorders at home with comprehensive, gold-standard care created by experts in the field and people in recovery. Equip’s five-person care teams include dieticians, physicians, therapists, and mentors who deliver wrap-around support to provide families progress and lasting recovery. Kristina Saffran and Erin Parks co-founded the company in San Diego, California in 2019.

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Website
equip.health
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$163.8M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:831

Most Funded Startups in San Diego for 2026

The top three most funded startups in San Diego have raised total funding of more than USD 2.25B. Rakuten Medical has 0.15% more funding than Mirador Therapeutics.
1st
Rakuten Medical logo
Rakuten MedicalSB Score: 462

Rakuten Medical is a biotechnology company developing investigational cancer therapies based on its proprietary Alluminox™ platform. This platform integrates a drug, a device, and other components to deliver photoimmunotherapy, a treatment that combines a light-activated dye with a targeting agent to selectively destroy cancer cells. The company's lead asset, ASP-1929, is an antibody-dye conjugate currently approved in Japan for treating unresectable locally advanced or recurrent head and neck cancer. Rakuten Medical is conducting global clinical trials to evaluate the safety and efficacy of its therapies in combination with other treatments. The company also offers an Expanded Access Program to provide investigational products to patients with serious or life-threatening diseases who lack other treatment options. Rakuten Medical operates in multiple countries and focuses on developing new cancer treatments based on its Alluminox™ platform.

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Website
rakuten-med.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$837.6M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Mirador Therapeutics logo

Mirador Therapeutics envisions precision medicine for immune-mediated inflammatory and fibrotic diseases.

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Website
miradortx.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$730M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Element Biosciences logo
Element BiosciencesSB Score: 519

Element Biosciences is a life science company that focuses on developing innovative genetic analysis tools. The company is developing a modular and high-performing DNA sequencing platform that will deliver high-quality data, workflow flexibility, and make next-generation sequencing technology more accessible. The company's proprietary approach to improving the signal-to-noise ratio allows us to provide groundbreaking innovations in surface chemistry, instrumentation, and biochemistry to drastically decrease the run and capital costs while delivering high sequencing data quality.

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Website
www.elementbiosciences.com
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$678M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:831

Top Hiring Startups in San Diego by Employee Number

The top three hiring startups in San Diego have an median employee size that is between [10001+]
1st
Energizer logo
EnergizerSB Score: 169

Energizer is to provide consumers with solutions to their portable power and personal care needs better than anyone else, and in a manner that rewards all stakeholders: consumers, customers, colleagues and shareholders.

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Website
www.energizerpowerstation.com
Employee range
10,001+
Web Traffic (Monthly)
Funding amount
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Embassy of Things logo
Embassy of ThingsSB Score: 169

Headquartered in sunny San Diego, California, Embassy of Things was started by group of experienced, serial entrepreneurs with a track record of successful exits who are passionate about industrial automation, deep machine learning, big data analytics and internet of things. EOT is building an enterprise-class platform focused on enabling predictive analytics in industrial verticals, such as oil & gas, energy and manufacturing.

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Website
embassyofthings.com
Employee range
10,001+
Web Traffic (Monthly)
Funding amount
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Lumena Pharmaceuticals logo

Lumena Pharmaceuticals is developing oral therapeutics for rare liver diseases to improve liver function, relieve disease symptoms and dramatically impact patient health. The company’s clinical-stage product candidates carry a reduced risk of systemic toxicities by selectively targeting a transporter in the intestine and are designed to be minimally absorbed in the body. Lumena’s lead candidate, LUM001, has been extensively evaluated in other indications across 12 clinical studies in more than 1,400 subjects. Because of the extensive preclinical and clinical data package for a compound at this stage in development, LUM001 is positioned to rapidly progress through the clinic in pediatric and adult patients with several types of cholestatic liver disease. While Lumena’s primary focus is to develop novel treatments for patients with rare liver diseases, the company’s therapeutic approach also has promising potential in the treatment of metabolic diseases affecting the liver, a significant and growing health problem in children and adults.

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Website
lumenapharma.com
Employee range
5,001 – 10,000
Web Traffic (Monthly)
Funding amount
$68M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
4th
M-Form logo
M-FormSB Score: 163

M-Form specializes in manufacturing precast architectural panels and form liners for the construction industry. They provide innovative technology for creating high-quality building materials.

View Full Page
Website
m-form.com
Employee range
5,001 – 10,000
Web Traffic (Monthly)
Funding amount
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:1426

Explore More Top Startups

Explore the Startup Ecosystem of San Diego

National Rank

(United States)

10th

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Regional Rank

(North America)

10th

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Global Rank

(WorldWide)

23rd

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal Score & National ShareAnnual Growth

Access subscores for 1000 cities and 100 countries

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