Top Unicorn Startups in San Diego for 2025

In San Diego, we rank 6 unicorn startups based on an algorithm that considers factors such as total investment, quarterly employee count, and website traffic. Unicorns in San Diego are falling behind the performance of their global counterparts.

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Top Unicorn Startups in San Diego for 2025

SB Score:760

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Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:641

Seismic provides software solutions for global sales and marketing teams, enabling them to streamline processes and drive revenue.

Industry:
Software & Data
Subindustry:
Software

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SB Score:552

Drata is an advanced security and compliance automation platform with the mission to help companies earn and keep the trust of their users, customers, partners, and prospects. Drata helps thousands of companies streamline their security compliance (SOC 2, ISO 27001, HIPAA, PCI DSS, GDPR, CCPA, CMMC, NIST CSF, etc.) through continuous, automated control monitoring and evidence collection, resulting in lower costs and time spent preparing for annual audits. Drata was founded in 2020 by Adam Markowitz, Daniel Marashlian, and Troy Markowitz and is based in San Diego, California, United States.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:6

Best Healthtech Startups in San Diego for 2025

San Diego startups in the Healthtech industry are overperforming their global industry peers. The top three Healthtech unicorns in San Diego have raised more than USD 2.68B, an amount that is higher than the global industry average.
SB Score:398

Biosplice Therapeutics specializes in developing advanced treatments for tissue regeneration at the cellular level. Our cutting-edge research focuses on restoring damaged tissues to improve overall health and well-being.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:1

Most Valuable Unicorns in San Diego for 2025

The top three most valuable unicorns in San Diego have raised total funding of more than USD 198M. Among the top three funded unicorns, the most popular industry, based on total funding, is Software & Data.
SB Score:760

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Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:641

Seismic provides software solutions for global sales and marketing teams, enabling them to streamline processes and drive revenue.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:540

Shield AI utilizes advanced artificial intelligence to safeguard both service members and civilians. Their mission is to provide protection through intelligent systems, ensuring safety and security in high-risk situations.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:552

Drata is an advanced security and compliance automation platform with the mission to help companies earn and keep the trust of their users, customers, partners, and prospects. Drata helps thousands of companies streamline their security compliance (SOC 2, ISO 27001, HIPAA, PCI DSS, GDPR, CCPA, CMMC, NIST CSF, etc.) through continuous, automated control monitoring and evidence collection, resulting in lower costs and time spent preparing for annual audits. Drata was founded in 2020 by Adam Markowitz, Daniel Marashlian, and Troy Markowitz and is based in San Diego, California, United States.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:398

Biosplice Therapeutics specializes in developing advanced treatments for tissue regeneration at the cellular level. Our cutting-edge research focuses on restoring damaged tissues to improve overall health and well-being.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:521

Tealium is a provider of customer data orchestration tools aimed to address challenges in online search, analytics, marketing, and segment targeting. It helps clients solve their customer data integration challenges at the source The company connects customer data – spanning web, mobile, offline, and IoT devices, enabling brands to connect with their customers. Tealium's turnkey integration ecosystem supports over 1,300 client-side and server-side vendors and technologies, empowering brands to create a unified, real-time customer data infrastructure. The Tealium Customer Data Hub encompasses tag management, an API hub, a customer data platform with machine learning, and data management solutions that make customer data more valuable, actionable, and secure. More than 1,000 businesses worldwide trust Tealium to power their customer data strategies. Tealium is funded by Battery Ventures, Tenaya Capital, Presidio Ventures, Georgian, and Silver Lake Waterman. It was named to Forbes’ list of “America’s Most Promising Companies,” and is also a recent winner of the 2013 Red Herring Global 100 Award. Former WebSideStory colleagues Ali Behnam and Mike Anderson co-founded the San Diego, California-based Tealium in 2008.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:6

Top Hiring Unicorns in San Diego by Employee Number

The top three hiring unicorns in San Diego have an average employee size that is smaller than to the global average. Among these, the Software & Data industry features the unicorn with the largest workforce.
SB Score:641

Seismic provides software solutions for global sales and marketing teams, enabling them to streamline processes and drive revenue.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

0

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SB Score:760

ClickUp combines tasks, docs, spreadsheets, goal tracking, resources, and an inbox in one app for seamless organization. Streamline your workflow and stay productive with all your essential tools in one place.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

Browse
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SB Score:552

Drata is an advanced security and compliance automation platform with the mission to help companies earn and keep the trust of their users, customers, partners, and prospects. Drata helps thousands of companies streamline their security compliance (SOC 2, ISO 27001, HIPAA, PCI DSS, GDPR, CCPA, CMMC, NIST CSF, etc.) through continuous, automated control monitoring and evidence collection, resulting in lower costs and time spent preparing for annual audits. Drata was founded in 2020 by Adam Markowitz, Daniel Marashlian, and Troy Markowitz and is based in San Diego, California, United States.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:540

Shield AI utilizes advanced artificial intelligence to safeguard both service members and civilians. Their mission is to provide protection through intelligent systems, ensuring safety and security in high-risk situations.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:6

Explore the Startup Ecosystem of San Diego

National Rank

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Regional Rank

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10th

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Global Rank

(WorldWide)

24th

2

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal RankTotal Score

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Quantity Score
Quality ScoreBusiness Score
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1st
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710.966
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2nd
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2nd
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251.377
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3rd
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4th
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121.937
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00.00
4th
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5th
0
109.679
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00.00
00.00
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