18 Top startups in Roanoke for April 2025

We rank Slync.io, Floafers and PogoTec in Roanoke along with 15 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Roanoke startup ecosystem ranks #605 globally and #165 in United States.

Powered by:

Category

Startups

Unicorns

Exits

Coworking Spaces

Accelerators

Best Startups in Roanoke for 2025

SB Score:473

Slync.io offers process automation for enterprise supply chains and the global logistics industry, streamlining operations and increasing efficiency.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:345

Floafers crafts stylish EVA foam shoes for men and women. Lightweight and comfortable, their footwear is ideal for everyday wear. Join the Floafers movement for fashionable, durable shoes that are perfect for any occasion.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:305

PogoTec specializes in developing the world's smallest and lightest camera that seamlessly attaches to nearly all types of glasses. This innovative device empowers users to capture high-quality photos and videos effortlessly, enhancing their daily experiences without compromising style or comfort.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:295

KlariVis is a cutting-edge data analytics platform that provides powerful insights. With its proprietary software, users can easily analyze data to make informed decisions.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:275

Generated Photos uses advanced technology to create lifelike human faces and bodies that are completely virtual. Their generative adversarial networks (GANs) generate unique and realistic images of people that do not actually exist, providing a valuable resource for a variety of industries.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:201

Coeurative pioneers biotechnology solutions for diseases caused by cellular hypoxia, delivering innovative curative treatments. Their focus is on developing strategies to combat the effects of low oxygen levels in the body.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:180

Art Money offers innovative financial services that empower art enthusiasts to purchase artwork while supporting artists and galleries. With seamless online payment solutions and secure transaction verification, Art Money enhances the art-buying experience across galleries, auction houses, and digital platforms, fostering growth in the creative economy.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:176

Acomhal Research, a biotech startup founded in 2017, develops innovative cancer treatments. Co-founded by Dr. Samy Lamouille and Dr. Robert Gourdie at Virginia Tech Carilion, the company focuses on targeting cancer cells with novel therapies.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:176

Nursesbnb is an innovative mid-term rental platform that utilizes proprietary technology to address the housing shortage for traveling healthcare professionals. By connecting them to safe and budget-friendly accommodations, it offers peace of mind and supports the essential workforce in the healthcare industry.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:176

Chorda Pharma, established by Rick Carliss in 2018 in Roanoke, Virginia, focuses on delivering long-term pain relief solutions for conditions such as arthritis, diabetic neuropathy, and sports injuries. Their innovative treatments aim to enhance the quality of life for those suffering from chronic pain.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

GEM Equipment & Manufacturing offers a wide range of manufacturing services including laser cutting, metal forming, machining, welding, assembly, and shipping. They specialize in creating carts, returnable packaging, platforms, and contract manufacturing solutions for businesses.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:18

Top 9 Software & Data Startups in Roanoke for 2025

The top three Software & Data startups in Roanoke have raised more than USD 117M. Roanoke startup ecosystem ranks #379 globally for the Software & Data industry.
SB Score:473

Slync.io offers process automation for enterprise supply chains and the global logistics industry, streamlining operations and increasing efficiency.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:295

KlariVis is a cutting-edge data analytics platform that provides powerful insights. With its proprietary software, users can easily analyze data to make informed decisions.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:275

Generated Photos uses advanced technology to create lifelike human faces and bodies that are completely virtual. Their generative adversarial networks (GANs) generate unique and realistic images of people that do not actually exist, providing a valuable resource for a variety of industries.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:9

Top 3 Healthtech Startups in Roanoke for 2025

The top three Healthtech startups in Roanoke have raised more than USD 1.72M. Roanoke startup ecosystem ranks among the top 10 locations in the world for startups in Healthtech, holding the falseth position.
SB Score:201

Coeurative pioneers biotechnology solutions for diseases caused by cellular hypoxia, delivering innovative curative treatments. Their focus is on developing strategies to combat the effects of low oxygen levels in the body.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:176

Acomhal Research, a biotech startup founded in 2017, develops innovative cancer treatments. Co-founded by Dr. Samy Lamouille and Dr. Robert Gourdie at Virginia Tech Carilion, the company focuses on targeting cancer cells with novel therapies.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:176

Chorda Pharma, established by Rick Carliss in 2018 in Roanoke, Virginia, focuses on delivering long-term pain relief solutions for conditions such as arthritis, diabetic neuropathy, and sports injuries. Their innovative treatments aim to enhance the quality of life for those suffering from chronic pain.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:3

Top 2 Ecommerce & Retail Startups in Roanoke for 2025

The top three Ecommerce & Retail startups in Roanoke have raised more than USD 3.09M. Roanoke startup ecosystem ranks among the top 10 locations in the world for startups in Ecommerce & Retail, holding the falseth position.
SB Score:345

Floafers crafts stylish EVA foam shoes for men and women. Lightweight and comfortable, their footwear is ideal for everyday wear. Join the Floafers movement for fashionable, durable shoes that are perfect for any occasion.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:13

Wheeler Digital specializes in crafting unique online brands through tailored and effective digital marketing strategies. By combining creativity with proven techniques, they empower businesses to enhance their online presence and engage their target audiences more effectively.

Industry:
Ecommerce & Retail
Subindustry:
Social Commerce

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:2

Most Funded Startups in Roanoke for 2025

The top three most funded startups in Roanoke have raised total funding of more than USD 123M. Slync.io has 5.28% more funding than KlariVis.
SB Score:473

Slync.io offers process automation for enterprise supply chains and the global logistics industry, streamlining operations and increasing efficiency.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:295

KlariVis is a cutting-edge data analytics platform that provides powerful insights. With its proprietary software, users can easily analyze data to make informed decisions.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:305

PogoTec specializes in developing the world's smallest and lightest camera that seamlessly attaches to nearly all types of glasses. This innovative device empowers users to capture high-quality photos and videos effortlessly, enhancing their daily experiences without compromising style or comfort.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:18

Top Hiring Startups in Roanoke by Employee Number

The top three hiring startups in Roanoke have an median employee size that is between [11-50]
SB Score:473

Slync.io offers process automation for enterprise supply chains and the global logistics industry, streamlining operations and increasing efficiency.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:345

Floafers crafts stylish EVA foam shoes for men and women. Lightweight and comfortable, their footwear is ideal for everyday wear. Join the Floafers movement for fashionable, durable shoes that are perfect for any occasion.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:305

PogoTec specializes in developing the world's smallest and lightest camera that seamlessly attaches to nearly all types of glasses. This innovative device empowers users to capture high-quality photos and videos effortlessly, enhancing their daily experiences without compromising style or comfort.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:295

KlariVis is a cutting-edge data analytics platform that provides powerful insights. With its proprietary software, users can easily analyze data to make informed decisions.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:18

Explore the Startup Ecosystem of Roanoke

National Rank

(undefined)

new

Regional Rank

(undefined)

189th

19

Global Rank

(WorldWide)

605th

84

Visit

Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
Pro
Pro
Pro
Pro
2024 National Rank CityGlobal Rank
informational icon
Total Score

Access subscores for 1000 cities and 100 countries

informational icon
Quantity Score
informational icon
Quality Score
informational icon
Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
Microsoft Excel icon
Download CSV file
Pro