51 Top startups in Naples for June 2025

We rank Drink LMNT, AngeLink, Inc. and Golf Life Navigators in Naples along with 48 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Naples is part of Fort Myers startup ecosystem which ranks #275 globally and #89 in North America.

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Best Startups in Naples for 2025

SB Score:447

LMNT offers a delicious electrolyte drink mix to help individuals stay hydrated and healthy. Enjoy the benefits of essential electrolytes without any added sugars or artificial ingredients. Keep your body in top shape with LMNT.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

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SB Score:437

AngeLink is a pioneering crowdfunding platform, empowering women and promoting social impact through innovative technology. With a focus on closing the gender economic gap, AngeLink offers a safe and trusted community for all to support life-changing projects. Join us in creating a more inclusive world.

Industry:
Fintech
Subindustry:
Fintech-Other

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SB Score:354

Golf Life Navigators is a trusted advisor helping clients navigate the numerous options available in Sunbelt golf clubs. They assist annually in finding the perfect fit, making the process simple and stress-free.

Industry:
Social & Leisure
Subindustry:
Sports

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SB Score:346

With our event management Platform as a Service, users can effortlessly plan, organize, and execute events of any size. Streamline your event logistics, increase attendee engagement, and track performance metrics all in one convenient platform. Let us handle the details so you can focus on creating unforgettable experiences.

Industry:
Marketing & Sales
Subindustry:
Adtech

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SB Score:331

Enalare Therapeutics Inc. is a biopharmaceutical company focused on developing innovative treatments for acute respiratory and critical care conditions. Their goal is to provide solutions for respiratory depression from drug overdose, post-surgery recovery, and infections.

Industry:
Healthtech
Subindustry:
Biotechnology

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Fountain Health Insurance offers a cutting-edge platform for innovative health plans that prioritize wellness and cost-effectiveness. Their goal is to revolutionize the industry by providing proactive solutions for optimal health and financial savings.

Industry:
Fintech
Subindustry:
Insurance

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SB Score:310

Catalyst OrthoScience is a medical device startup launching the innovative Catalyst CSR total shoulder. This cutting-edge technology aims to revolutionize shoulder surgery, providing patients with improved outcomes.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:307

CAREier empowers healthcare providers and medical device manufacturers to enhance care quality and save lives by ensuring that no information is overlooked. Through its innovative solutions, CAREier streamlines data management, enabling better decision-making and improved patient outcomes in the medical field.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:305

This innovative platform empowers users to enhance their writing with the help of an AI companion. It enables them to publish their work on a stunning website or share it directly with readers, making the writing and publishing process seamless and engaging.

Industry:
General
Subindustry:
Select an Industry first...

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SB Score:295

Better Together is a nonprofit that helps parents find jobs, prevent their children from going into foster care, and address family challenges.

Industry:
Social & Leisure
Subindustry:
Social & Leisure-Other

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SB Score:286

Gravitas Infinitum offers specialized financial services focusing on proprietary processor assembly. They provide innovative solutions for assembling processors, streamlining operations for businesses.

Industry:
Fintech
Subindustry:
Financial Services

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Total amount:51

Top 11 Software & Data Startups in Naples for 2025

The top three Software & Data startups in Naples have raised more than USD 26.5M. Naples is part of Fort Myers startup ecosystem which ranks #313 globally for the Software & Data industry.
SB Score:307

CAREier empowers healthcare providers and medical device manufacturers to enhance care quality and save lives by ensuring that no information is overlooked. Through its innovative solutions, CAREier streamlines data management, enabling better decision-making and improved patient outcomes in the medical field.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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2nd

Evja
SB Score:281

Evja is an exciting and fast-evolving ecosystem, thriving with people with long run experience in fields ranging from electronic engineer, physics and agronomy all the way to precision farming, machine learning and international business development. Evja is revolutionizing agriculture by combining Artificial Intelligence, Internet of Things and Agronomic Models, helping farmers to optimize their crop cycle, obtaining a healthier produce and having less impact on the environment.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

City Rank (Naples)

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Regional Rank (Western Europe)

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SB Score:262

Inspector provides automated monitoring that detects bugs and bottlenecks in production infrastructure, ensuring smooth operations. This comprehensive solution enables businesses to maintain optimal performance and swiftly address issues, promoting seamless functionality throughout their systems.

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (Naples)

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Regional Rank (North America)

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Total amount:11

Top 6 Healthtech Startups in Naples for 2025

The top three Healthtech startups in Naples have raised more than USD 290M. Naples is part of Fort Myers startup ecosystem which ranks #198 globally for the Healthtech industry.
SB Score:331

Enalare Therapeutics Inc. is a biopharmaceutical company focused on developing innovative treatments for acute respiratory and critical care conditions. Their goal is to provide solutions for respiratory depression from drug overdose, post-surgery recovery, and infections.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Naples)

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Regional Rank (North America)

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SB Score:310

Catalyst OrthoScience is a medical device startup launching the innovative Catalyst CSR total shoulder. This cutting-edge technology aims to revolutionize shoulder surgery, providing patients with improved outcomes.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Naples)

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Regional Rank (North America)

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SB Score:249

Native Cardio, founded in 2018 and headquartered in Naples, Florida, is a pioneering cardiovascular device company dedicated to addressing postoperative atrial fibrillation. By developing innovative solutions, Native Cardio aims to enhance patient outcomes and improve recovery following cardiac procedures.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Naples)

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Total amount:6

Top 8 Fintech Startups in Naples for 2025

The top three Fintech startups in Naples have raised more than USD 47.3M. Naples is part of Fort Myers startup ecosystem which ranks #187 globally for the Fintech industry.
SB Score:437

AngeLink is a pioneering crowdfunding platform, empowering women and promoting social impact through innovative technology. With a focus on closing the gender economic gap, AngeLink offers a safe and trusted community for all to support life-changing projects. Join us in creating a more inclusive world.

Industry:
Fintech
Subindustry:
Fintech-Other

City Rank (Naples)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Fountain Health Insurance offers a cutting-edge platform for innovative health plans that prioritize wellness and cost-effectiveness. Their goal is to revolutionize the industry by providing proactive solutions for optimal health and financial savings.

Industry:
Fintech
Subindustry:
Insurance

City Rank (Naples)

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Regional Rank (North America)

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SB Score:286

Gravitas Infinitum offers specialized financial services focusing on proprietary processor assembly. They provide innovative solutions for assembling processors, streamlining operations for businesses.

Industry:
Fintech
Subindustry:
Financial Services

City Rank (Naples)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:8

Most Funded Startups in Naples for 2025

The top three most funded startups in Naples have raised total funding of more than USD 295M. Enalare Therapeutics has 2.09% more funding than Catalyst OrthoScience.
SB Score:331

Enalare Therapeutics Inc. is a biopharmaceutical company focused on developing innovative treatments for acute respiratory and critical care conditions. Their goal is to provide solutions for respiratory depression from drug overdose, post-surgery recovery, and infections.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Naples)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:310

Catalyst OrthoScience is a medical device startup launching the innovative Catalyst CSR total shoulder. This cutting-edge technology aims to revolutionize shoulder surgery, providing patients with improved outcomes.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Naples)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:286

Gravitas Infinitum offers specialized financial services focusing on proprietary processor assembly. They provide innovative solutions for assembling processors, streamlining operations for businesses.

Industry:
Fintech
Subindustry:
Financial Services

City Rank (Naples)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:51

Top Hiring Startups in Naples by Employee Number

The top three hiring startups in Naples have an median employee size that is between [251-500]

Fountain Health Insurance offers a cutting-edge platform for innovative health plans that prioritize wellness and cost-effectiveness. Their goal is to revolutionize the industry by providing proactive solutions for optimal health and financial savings.

Industry:
Fintech
Subindustry:
Insurance

City Rank (Naples)

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Regional Rank (North America)

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SB Score:128

Uxari, a Florida-based specialist in home automation and security, offers customers nationwide the latest DIY solutions at a reduced cost. With a focus on innovative technology, Uxari empowers homeowners to effortlessly enhance their security and automate their living spaces.

Industry:
Hardware & IoT
Subindustry:
Internet of Everything

City Rank (Naples)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:447

LMNT offers a delicious electrolyte drink mix to help individuals stay hydrated and healthy. Enjoy the benefits of essential electrolytes without any added sugars or artificial ingredients. Keep your body in top shape with LMNT.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

City Rank (Naples)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:437

AngeLink is a pioneering crowdfunding platform, empowering women and promoting social impact through innovative technology. With a focus on closing the gender economic gap, AngeLink offers a safe and trusted community for all to support life-changing projects. Join us in creating a more inclusive world.

Industry:
Fintech
Subindustry:
Fintech-Other

City Rank (Naples)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:51

Explore the Startup Ecosystem of Naples

National Rank

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Regional Rank

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92nd

7

Global Rank

(WorldWide)

274th

29

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2025 National Rank CityGlobal RankTotal Score

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Quantity Score
Quality ScoreBusiness Score
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1st
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852.643
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2nd
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315.515
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3rd
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4th
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139.115
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4th
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6th
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1
128.476
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