24 Top startups in Lowell for April 2025

We rank American Mojo, Dassault Systèmes Enovia and ePropelled in Lowell along with 21 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Lowell is part of Boston Area startup ecosystem which ranks #5 globally and #4 in North America.

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Best Startups in Lowell for 2025

SB Score:459

American MoJo aimed to show social impact through a for-profit model by creating living wage apparel jobs in the US, offering free childcare to empower low-income single mothers to build sustainable careers. Providing education, financial management, and career counseling, the goal was to create long-term success for families.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

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Dassault Systèmes Enovia offers cutting-edge collaborative product lifecycle management solutions for businesses. Users can streamline processes, enhance communication, and increase efficiency with this innovative technology.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:367

ePropelled specializes in creating smart motors, controllers, generators, and power systems. Their cutting-edge technology revolutionizes how energy is managed and utilized, making them a leader in the industry.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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SB Score:362

RevBio is creating a groundbreaking bone adhesive for repairing fractures and securing metal implants.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:303

Virtual Iron Software, Inc. provides enterprise-class software solutions for server virtualization and virtual infrastructure management. The company’s platform is used for server consolidation, rapid provisioning, business continuity, workload management, and policy-based automations. Its virtual iron platform consists of virtualization manager that provides a central place to control and automate virtual resources, and virtualization services, which are deployed automatically on bare-metal and industry-standard servers without requiring software installation or management. The virtual iron platform also includes open source virtualization, which is based on an open source hypervisor derived from the open source community project. Its solutions are used for capacity management, virtual infrastructure management, and development and testing. Virtual Iron Software, Inc. was formerly known as Katana Technology, Inc. The company was founded in 2003 and is based in Lowell, Massachusetts.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:293

Phase Two Chemicals is an innovative clean chemistry company pioneering on-site hydrogen peroxide production technology, enabling businesses to generate this essential compound efficiently and sustainably. Their breakthrough approach not only enhances operational safety but also reduces environmental impact, making it a game-changer in the chemical industry.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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SB Score:291

This startup improves prostate disease management with innovative solutions. It offers a range of tools and resources to help individuals track symptoms, monitor progress, and access personalized treatment plans.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:272

ArthroMeda is an innovative navigation system using sensors for hip replacement surgery. It offers precise guidance and is protected by patents.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:247

Advanced Silicon Group provides cutting-edge silicon nanotechnology services. They specialize in offering innovative solutions for companies looking to enhance their products with the latest advancements in silicon technology.

Industry:
Energy & Environment
Subindustry:
Energy

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Total amount:24

Top 8 Healthtech Startups in Lowell for 2025

The top three Healthtech startups in Lowell have raised more than USD 112M. Lowell is part of Boston Area startup ecosystem which ranks #2 globally for the Healthtech industry.
SB Score:362

RevBio is creating a groundbreaking bone adhesive for repairing fractures and securing metal implants.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Total amount:8

Top 6 Software & Data Startups in Lowell for 2025

The top three Software & Data startups in Lowell have raised more than USD 48.5M. Lowell is part of Boston Area startup ecosystem which ranks #5 globally for the Software & Data industry.

Dassault Systèmes Enovia offers cutting-edge collaborative product lifecycle management solutions for businesses. Users can streamline processes, enhance communication, and increase efficiency with this innovative technology.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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SB Score:303

Virtual Iron Software, Inc. provides enterprise-class software solutions for server virtualization and virtual infrastructure management. The company’s platform is used for server consolidation, rapid provisioning, business continuity, workload management, and policy-based automations. Its virtual iron platform consists of virtualization manager that provides a central place to control and automate virtual resources, and virtualization services, which are deployed automatically on bare-metal and industry-standard servers without requiring software installation or management. The virtual iron platform also includes open source virtualization, which is based on an open source hypervisor derived from the open source community project. Its solutions are used for capacity management, virtual infrastructure management, and development and testing. Virtual Iron Software, Inc. was formerly known as Katana Technology, Inc. The company was founded in 2003 and is based in Lowell, Massachusetts.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:194

Weave offers the only open-source software for analyzing and visualizing vast datasets from multiple platforms. It empowers users to seamlessly integrate, process, and interpret complex information, driving informed decisions and innovative insights.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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Total amount:6

Top 2 Ecommerce & Retail Startups in Lowell for 2025

The top three Ecommerce & Retail startups in Lowell have raised more than USD 3.88M. Lowell is part of Boston Area startup ecosystem which ranks #11 globally for the Ecommerce & Retail industry.
SB Score:459

American MoJo aimed to show social impact through a for-profit model by creating living wage apparel jobs in the US, offering free childcare to empower low-income single mothers to build sustainable careers. Providing education, financial management, and career counseling, the goal was to create long-term success for families.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:23

Linger offers beautifully designed home textiles directly to consumers, partnering with global factories to ensure a transparent and sustainable supply chain. Their focus on inspirational designs and ethical practices makes it easy for customers to enhance their living spaces with quality products that reflect their values.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:2

Most Funded Startups in Lowell for 2025

The top three most funded startups in Lowell have raised total funding of more than USD 145M. RevBio has 0.41% more funding than Virtual Iron Software.
SB Score:362

RevBio is creating a groundbreaking bone adhesive for repairing fractures and securing metal implants.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:303

Virtual Iron Software, Inc. provides enterprise-class software solutions for server virtualization and virtual infrastructure management. The company’s platform is used for server consolidation, rapid provisioning, business continuity, workload management, and policy-based automations. Its virtual iron platform consists of virtualization manager that provides a central place to control and automate virtual resources, and virtualization services, which are deployed automatically on bare-metal and industry-standard servers without requiring software installation or management. The virtual iron platform also includes open source virtualization, which is based on an open source hypervisor derived from the open source community project. Its solutions are used for capacity management, virtual infrastructure management, and development and testing. Virtual Iron Software, Inc. was formerly known as Katana Technology, Inc. The company was founded in 2003 and is based in Lowell, Massachusetts.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:367

ePropelled specializes in creating smart motors, controllers, generators, and power systems. Their cutting-edge technology revolutionizes how energy is managed and utilized, making them a leader in the industry.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:24

Top Hiring Startups in Lowell by Employee Number

The top three hiring startups in Lowell have an median employee size that is between [1001-5000]

Dassault Systèmes Enovia offers cutting-edge collaborative product lifecycle management solutions for businesses. Users can streamline processes, enhance communication, and increase efficiency with this innovative technology.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:142

Titan.ium Platform offers essential network applications that enhance signaling, routing, subscriber data management, and security. By streamlining these core functions, it empowers businesses to optimize their network performance and safeguard user data effectively.

Industry:
Edtech
Subindustry:
Education-Other

National Rank (United States)

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Regional Rank (North America)

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SB Score:459

American MoJo aimed to show social impact through a for-profit model by creating living wage apparel jobs in the US, offering free childcare to empower low-income single mothers to build sustainable careers. Providing education, financial management, and career counseling, the goal was to create long-term success for families.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:367

ePropelled specializes in creating smart motors, controllers, generators, and power systems. Their cutting-edge technology revolutionizes how energy is managed and utilized, making them a leader in the industry.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:24

Explore the Startup Ecosystem of Lowell

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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