29 Top startups in Littleton for April 2025

We rank Luxonis, Gallus Medical Detox Centers - Phoenix and JETCOOL Technologies in Littleton along with 26 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Littleton is part of Denver startup ecosystem which ranks #31 globally and #14 in North America.

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Best Startups in Littleton for 2025

SB Score:394

Luxonis is a leader in spatial AI and computer vision, focusing on embedded machine learning technology. By offering open-source, MIT-licensed hardware and software, the company empowers developers with innovative tools for training and applying AI, advancing human-level perception in embedded systems.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:378

JETCOOL Technologies develops microjet cooling modules for advanced electronics, publishing the results in several papers. The technology behind JETCOOL was developed at MIT Lincoln Laboratory, by a team led by Bernie Malouin. It was founded in 2019 and is based in Littleton, Massachusetts.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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Infinite Power Solutions, Inc. (IPS), a U.S. based clean-technology company, is the global leader in developing, marketing and manufacturing solid-state, rechargeable thin-film micro-energy storage devices for a variety of micro-electronic applications. Founded in 2001, IPS is privately held with corporate headquarters and manufacturing facilities in the western suburbs of [Denver, CO](http://www.crunchbase.com/maps/search?range=10&geo=denver,+co). The company has completed the build-out of the world's first volume manufacturing facility dedicated to the production of its revolutionary thin-film micro-energy cell (MEC(TM)) products (often referred to as thin-film batteries). IPS has recently commenced pre-production activities at this state-of-the-art facility to address growing demand among customers in the wireless sensor, active RFID, powered smart card, medical device, consumer electronics, automotive and civil/military/aerospace markets

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

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SB Score:317

Nexo Therapeutics is a pioneering oncology company focused on discovering and developing innovative small molecule therapies for cancer patients who have limited treatment options. By harnessing cutting-edge science, Nexo aims to provide hope and improve outcomes for those in need of effective cancer care.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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SB Score:303

CyGlass offers cutting-edge threat detection solutions for mid-market customers, enabling them to identify and respond to advanced cyber threats that bypass traditional security measures.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

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SB Score:299

CereScan offers cutting-edge functional brain imaging using a unique process. Their biotech services help clients visualize brain activity with precision and accuracy.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:283

ExoTerra aims to expand space exploration by offering affordable access to a wider audience.

Industry:
Transportation
Subindustry:
Aerospace

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SB Score:258

Storion Energy, a U.S.-based technology company spun off from ITN Energy Systems, specializes in innovative energy solutions. By leveraging advanced research and development, Storion Energy empowers businesses and consumers with cutting-edge technologies designed to enhance efficiency and sustainability in energy management.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

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10th

dBMEDx
SB Score:252

DBMEDx creates non-invasive patient monitoring devices using advanced scanning technology. Their devices offer accurate health data in real-time, revolutionizing the way healthcare is delivered.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:243

AJNA BioSciences is a pioneering botanical drug development company specializing in psilocybin and other naturally derived psychedelics. It focuses on creating innovative therapies for conditions such as depression, addiction, PTSD, Alzheimer's, and Parkinson's disease, aiming to transform mental health and neurological treatment through natural solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Total amount:29

Top 7 Software & Data Startups in Littleton for 2025

The top three Software & Data startups in Littleton have raised more than USD 6.25M. Littleton is part of Denver startup ecosystem which ranks #18 globally for the Software & Data industry.
SB Score:394

Luxonis is a leader in spatial AI and computer vision, focusing on embedded machine learning technology. By offering open-source, MIT-licensed hardware and software, the company empowers developers with innovative tools for training and applying AI, advancing human-level perception in embedded systems.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:196

Introducing a global timing service revolutionizing precision timing without relying on GPS. Offering accurate timing solutions worldwide, this service ensures reliable timekeeping for various applications.

Industry:
Software & Data
Subindustry:
Comtech

National Rank (United States)

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:7

Top 5 Healthtech Startups in Littleton for 2025

The top three Healthtech startups in Littleton have raised more than USD 81.9M. Littleton is part of Denver startup ecosystem which ranks #13 globally for the Healthtech industry.
SB Score:317

Nexo Therapeutics is a pioneering oncology company focused on discovering and developing innovative small molecule therapies for cancer patients who have limited treatment options. By harnessing cutting-edge science, Nexo aims to provide hope and improve outcomes for those in need of effective cancer care.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:299

CereScan offers cutting-edge functional brain imaging using a unique process. Their biotech services help clients visualize brain activity with precision and accuracy.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:5

Top 1 Social & Leisure Startups in Littleton for 2025

Littleton is part of Denver startup ecosystem which ranks #17 globally for the Social & Leisure industry.

Total amount:1

Most Funded Startups in Littleton for 2025

The top three most funded startups in Littleton have raised total funding of more than USD 297M. Infinite Power Solutions has 0.33% more funding than JETCOOL Technologies.

Infinite Power Solutions, Inc. (IPS), a U.S. based clean-technology company, is the global leader in developing, marketing and manufacturing solid-state, rechargeable thin-film micro-energy storage devices for a variety of micro-electronic applications. Founded in 2001, IPS is privately held with corporate headquarters and manufacturing facilities in the western suburbs of [Denver, CO](http://www.crunchbase.com/maps/search?range=10&geo=denver,+co). The company has completed the build-out of the world's first volume manufacturing facility dedicated to the production of its revolutionary thin-film micro-energy cell (MEC(TM)) products (often referred to as thin-film batteries). IPS has recently commenced pre-production activities at this state-of-the-art facility to address growing demand among customers in the wireless sensor, active RFID, powered smart card, medical device, consumer electronics, automotive and civil/military/aerospace markets

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:378

JETCOOL Technologies develops microjet cooling modules for advanced electronics, publishing the results in several papers. The technology behind JETCOOL was developed at MIT Lincoln Laboratory, by a team led by Bernie Malouin. It was founded in 2019 and is based in Littleton, Massachusetts.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:317

Nexo Therapeutics is a pioneering oncology company focused on discovering and developing innovative small molecule therapies for cancer patients who have limited treatment options. By harnessing cutting-edge science, Nexo aims to provide hope and improve outcomes for those in need of effective cancer care.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:29

Top Hiring Startups in Littleton by Employee Number

The top three hiring startups in Littleton have an median employee size that is between [51-100]
SB Score:394

Luxonis is a leader in spatial AI and computer vision, focusing on embedded machine learning technology. By offering open-source, MIT-licensed hardware and software, the company empowers developers with innovative tools for training and applying AI, advancing human-level perception in embedded systems.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:234

Emporia, based in Littleton, Colorado, is an electrical company specializing in smart home technology systems like energy monitors, smart plugs, and batteries. Founded in 2018, Emporia offers innovative solutions for creating energy-efficient homes.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

Browse
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SB Score:378

JETCOOL Technologies develops microjet cooling modules for advanced electronics, publishing the results in several papers. The technology behind JETCOOL was developed at MIT Lincoln Laboratory, by a team led by Bernie Malouin. It was founded in 2019 and is based in Littleton, Massachusetts.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:29

Explore the Startup Ecosystem of Littleton

National Rank

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Regional Rank

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14th

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Global Rank

(WorldWide)

31st

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
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1
37.971
00.00
00.00
00.00
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0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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