48 Top startups in Knoxville for April 2025

We rank Vendor Registry, HES Facilities and Lirio in Knoxville along with 45 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Knoxville startup ecosystem ranks #334 globally and #94 in United States.

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Best Startups in Knoxville for 2025

SB Score:454

Vendor Registry streamlines public procurement by connecting local governments with vendors. With an online registration and bid notification system, businesses can easily register and receive notices when governments are buying their products. This innovative platform increases vendor participation, reduces costs, and improves the quality of goods and services purchased by local governments.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:424

HES Facilities is a comprehensive facilities management company specializing in custodial, maintenance, grounds, and landscaping services for educational institutions. Committed to enhancing the learning environment, HES Facilities ensures that schools operate smoothly and efficiently, allowing educators and students to focus on education rather than facility concerns.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:375

Lirio combines behavioral science and AI to guide individuals towards better health through personalized communication, making behavior change more effective and engaging.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:358

This startup creates innovative healthcare solutions to enhance patient care and clinical results. Their focus is on improving outcomes and delivering high-quality, patient-centered care.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:309

HOA boards manage properties. Streamline operations with our platform. Simplify communication, document storage, and financial tracking. Increase efficiency and transparency. Join us today.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

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SB Score:299

SmartRIA aims to excel as a top SaaS company by streamlining compliance for financial services.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:295

Sparkz develops innovative battery technology that addresses the challenges faced by advanced lithium batteries. By enhancing performance and efficiency, Sparkz aims to revolutionize energy storage solutions, empowering users with longer-lasting, more reliable power sources for various applications.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:279

This startup provides instant, scalable, and explainable solutions for correlating and contextualizing alerts, events, and logs. By streamlining these processes, it empowers organizations to enhance their security and operational efficiency, enabling them to make informed decisions quickly and effectively.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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10th

TCPoly
SB Score:256

TCPoly specializes in advanced thermally conductive plastics for additive manufacturing. Leveraging deep expertise in materials science and heat transfer, TCPoly has developed Ice9TM Flex, a cutting-edge 3D printing filament that enhances thermal conductivity, making it ideal for innovative applications in the industry.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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Total amount:48

Top 12 Ecommerce & Retail Startups in Knoxville for 2025

The top three Ecommerce & Retail startups in Knoxville have raised more than USD 40.5M. Knoxville startup ecosystem ranks #197 globally for the Ecommerce & Retail industry.
SB Score:309

HOA boards manage properties. Streamline operations with our platform. Simplify communication, document storage, and financial tracking. Increase efficiency and transparency. Join us today.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

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SB Score:195

Survature revolutionizes online surveys with a patent pending approach that makes the process fun, informative, and quick. By analyzing survey data using scientific methods, Survature helps businesses uncover key insights. Winner of #thetenn, Survature is a game-changer in the survey industry.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

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Total amount:12

Top 8 Software & Data Startups in Knoxville for 2025

The top three Software & Data startups in Knoxville have raised more than USD 159M. Knoxville startup ecosystem ranks #428 globally for the Software & Data industry.
SB Score:454

Vendor Registry streamlines public procurement by connecting local governments with vendors. With an online registration and bid notification system, businesses can easily register and receive notices when governments are buying their products. This innovative platform increases vendor participation, reduces costs, and improves the quality of goods and services purchased by local governments.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:424

HES Facilities is a comprehensive facilities management company specializing in custodial, maintenance, grounds, and landscaping services for educational institutions. Committed to enhancing the learning environment, HES Facilities ensures that schools operate smoothly and efficiently, allowing educators and students to focus on education rather than facility concerns.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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SB Score:375

Lirio combines behavioral science and AI to guide individuals towards better health through personalized communication, making behavior change more effective and engaging.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

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Regional Rank (North America)

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Total amount:8

Top 4 Edtech Startups in Knoxville for 2025

Knoxville startup ecosystem ranks #176 globally for the Edtech industry.
SB Score:143

Vehlo offers innovative software and financial solutions tailored for the automotive repair industry. Their comprehensive tools enhance shop management and facilitate digital vehicle inspections for aftermarket service centers, while also providing efficient solutions for dealer service lanes, streamlining operations and improving customer experiences.

Industry:
Edtech
Subindustry:
Edutainment

National Rank (United States)

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2nd

Loop
SB Score:77

Loop integrates with existing school technology to monitor activity and data generation, providing automatic real-time updates to students and parents. It delivers actionable insights to school decision-makers, enhancing communication and decision-making processes within educational institutions.

Industry:
Edtech
Subindustry:
Education-Other

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SB Score:53

Rustik specializes in product strategy services, offering expertise in R&D, technology innovation, product management, and ideation. Their comprehensive offerings include UX/UI design, logo creation, and branding services, empowering businesses to enhance their product design and establish a compelling brand identity.

Industry:
Edtech
Subindustry:
Education-Other

National Rank (United States)

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Total amount:4

Most Funded Startups in Knoxville for 2025

The top three most funded startups in Knoxville have raised total funding of more than USD 183M. HES Facilities has 0.39% more funding than Lirio.
SB Score:424

HES Facilities is a comprehensive facilities management company specializing in custodial, maintenance, grounds, and landscaping services for educational institutions. Committed to enhancing the learning environment, HES Facilities ensures that schools operate smoothly and efficiently, allowing educators and students to focus on education rather than facility concerns.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:375

Lirio combines behavioral science and AI to guide individuals towards better health through personalized communication, making behavior change more effective and engaging.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:48

Top Hiring Startups in Knoxville by Employee Number

The top three hiring startups in Knoxville have an median employee size that is between [501-1000]
SB Score:424

HES Facilities is a comprehensive facilities management company specializing in custodial, maintenance, grounds, and landscaping services for educational institutions. Committed to enhancing the learning environment, HES Facilities ensures that schools operate smoothly and efficiently, allowing educators and students to focus on education rather than facility concerns.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:143

Vehlo offers innovative software and financial solutions tailored for the automotive repair industry. Their comprehensive tools enhance shop management and facilitate digital vehicle inspections for aftermarket service centers, while also providing efficient solutions for dealer service lanes, streamlining operations and improving customer experiences.

Industry:
Edtech
Subindustry:
Edutainment

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:358

This startup creates innovative healthcare solutions to enhance patient care and clinical results. Their focus is on improving outcomes and delivering high-quality, patient-centered care.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:375

Lirio combines behavioral science and AI to guide individuals towards better health through personalized communication, making behavior change more effective and engaging.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:48

Explore the Startup Ecosystem of Knoxville

National Rank

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Regional Rank

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108th

1

Global Rank

(WorldWide)

334th

8

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
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1
37.971
00.00
00.00
00.00
9th
0
24th
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2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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