StartupBlink

82 Top startups in Knoxville for June 2026

We rank HES Facilities, Vendor Registry and Provision Healthcare in Knoxville along with 79 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Knoxville startup ecosystem ranks #342 globally and #90 in United States.

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Best Startups in Knoxville for 2026

SB Score:422

HES Facilities is a full-service facilities management company, dedicated to providing educational facilities with custodial, maintenance, grounds, and landscaping services. The company partners with K-12 schools and higher education institutions to provide best-in-class facilities management programs.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:394

They are a small company, but big on passion and drive. They founded Vendor Registry with the simple purpose of making it easier to do business with your state and local governments and institutions. Too much time is spent filling out repetitive paperwork and too little time is spent taking advantage of new revenue opportunities. Businesses, especially local small businesses, need to generate more sales. Governments are forced to do more with less, which means they need more competitive bids. The vendors' and governments' problems are like a hand in glove. By just eliminating repetition (and automating the rest) and replacing paper with a single web-based tool used by both buyers and suppliers, they've created a win win solution. Vendor Registry is focused on creating this win win solution that generates new revenues for vendors and suppliers, saves time for everyone, and decreases costs for government and institutional purchasing departments. After all, they are spending their taxpayer dollars.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:345

Provision Healthcare develops healthcare solutions focusing on improving patient care, clinical outcomes, and a commitment to driving research, education, and charitable causes. Cancers they treat include prostate, breast, head, neck, oral, lung, brain, spine, gynecologic, and more.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:339

General Graphene is a pure-play CVD graphene foundry focusing on industrial-scale CVD graphene production. It provides expertise in applying CVD graphene across industries and applications.

Industry:
Ecommerce & Retail
Subindustry:
Retail

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SB Score:317

Sparkz is a creator of a creative battery technology designed to overcome the problems that the most advanced lithium batteries now face. Due to the company's cobalt-free battery technology, challenges with the supply chain, insufficient run-time, slow charging, rapid deterioration, and environmental and safety concerns can be resolved, allowing the electric mobility sector to scale up electrochemical energy storage innovation.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:317

Mosey helps businesses stay compliant with employment and tax requirements in all 50 states and 100+ cities for a fraction of the cost of professional services or hiring.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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SB Score:298

SmartRIA makes software that simplifies compliance for the financial services industry. We excel at making the complex and often frustrating world of regulatory compliance simple to manage and easy to understand. Our unique roles for compliance consultants and distributed management of large corporations make our solution able to handle any compliance problem for any sized company. Since our launch in 2016, we have built the most complete, easiest-to-use compliance software platform for the Registered Investment Advisor industry. We have since moved on to compliance in other financial services verticals in the US, and have expanded to wealth management compliance in the UK.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:289

HOA boards manage properties. Streamline operations with our platform. Simplify communication, document storage, and financial tracking. Increase efficiency and transparency. Join us today.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

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SB Score:276

Alerts, events, and logs, RULE-LESS correlation & contextualization made instant, scalable, & explainable, right in your SIEM/SOAR.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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10th

TCPoly
SB Score:251

TCPoly makes thermally conductive and next-generation plastics for additive manufacturing. TCPoly uses its extensive knowledge of materials science and heat transfer to create the Ice9TM Flex filament, a thermally conductive 3D printing filament. Their product is actively used in the heat exchanger, mold tooling, and electronics thermal management industries, and it has been sold in over 20 countries.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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Prisma Renewable Composites is a biotechnology company specializing in efficiently separating highly renewable energy crops into pure fractions of lignin, cellulose, hemicellulose, and other extractives for use in a multitude of applications including pulp, biopolymers, specialty chemicals and advanced composite materials.

Industry:
Energy & Environment
Subindustry:
Energy

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Total amount:82

Top 7 Energy & Environment Startups in Knoxville for 2026

The top three Energy & Environment startups in Knoxville have raised more than USD 17.2M. Knoxville startup ecosystem ranks #201 globally for the Energy & Environment industry.
SB Score:317

Sparkz is a creator of a creative battery technology designed to overcome the problems that the most advanced lithium batteries now face. Due to the company's cobalt-free battery technology, challenges with the supply chain, insufficient run-time, slow charging, rapid deterioration, and environmental and safety concerns can be resolved, allowing the electric mobility sector to scale up electrochemical energy storage innovation.

Industry:
Energy & Environment
Subindustry:
Energy

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Prisma Renewable Composites is a biotechnology company specializing in efficiently separating highly renewable energy crops into pure fractions of lignin, cellulose, hemicellulose, and other extractives for use in a multitude of applications including pulp, biopolymers, specialty chemicals and advanced composite materials.

Industry:
Energy & Environment
Subindustry:
Energy

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Total amount:7

Top 14 Ecommerce & Retail Startups in Knoxville for 2026

The top three Ecommerce & Retail startups in Knoxville have raised more than USD 40M. Knoxville startup ecosystem ranks #269 globally for the Ecommerce & Retail industry.
SB Score:339

General Graphene is a pure-play CVD graphene foundry focusing on industrial-scale CVD graphene production. It provides expertise in applying CVD graphene across industries and applications.

Industry:
Ecommerce & Retail
Subindustry:
Retail

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SB Score:289

HOA boards manage properties. Streamline operations with our platform. Simplify communication, document storage, and financial tracking. Increase efficiency and transparency. Join us today.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

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SB Score:190

Survature is a provider of an all-new survey platform that increases participation and reveals participant priorities. The company's proprietary survey tool, AnswerCloud, not only collects and analyzes survey responses but also examines how survey takers responded. By analyzing the order, timing, and placement of a response, Survature provides insightful reports regarding an answer's priority, importance, uncertainty, and reliability. Survature was founded in 2013 and is headquartered in Knoxville, Tennessee.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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Total amount:14

Top 6 Marketing & Sales Startups in Knoxville for 2026

Knoxville startup ecosystem ranks #289 globally for the Marketing & Sales industry.
SB Score:55

SH Data Centers was born in 2016, with the dream of building the best data center in the Knoxville area. They believe all data deserves a safe, protected home, but not all data centers are created equal. The Fort Data Center is coming to Knoxville soon. We're excited to create the only certified Tier III data center in East Tennessee.

Industry:
Marketing & Sales
Subindustry:
CRM

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SB Score:55

Be Known - Digital Marketing Agency specializes in the development and management of marketing automation systems designed to enhance the return on investment for digital marketing efforts. With a focus on generating significant financial growth for clients, Be Known employs strategies that have successfully added between $100,000 to over $1 million to the bottom lines of various companies. The agency's approach is rooted in the belief that effective marketing should directly contribute to increased revenue. Operating since 2018, Be Known offers a range of services aimed at optimizing digital marketing campaigns for small to mid-sized businesses, including but not limited to, designing marketing automation systems, digital strategy consultation, and performance analysis.

Industry:
Marketing & Sales
Subindustry:
Digital Marketing

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SB Score:47

Pursuit Digital specializes in advertising and marketing services, focusing on web design, social media management, and video production. The company aims to build brands through innovative digital strategies and creative content. With a team of 75 employees, Pursuit Digital offers comprehensive solutions to enhance online presence and engagement for businesses.

Industry:
Marketing & Sales
Subindustry:
Digital Marketing

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Total amount:6

Most Funded Startups in Knoxville for 2026

The top three most funded startups in Knoxville have raised total funding of more than USD 153M. HES Facilities has 1.22% more funding than General Graphene.
SB Score:422

HES Facilities is a full-service facilities management company, dedicated to providing educational facilities with custodial, maintenance, grounds, and landscaping services. The company partners with K-12 schools and higher education institutions to provide best-in-class facilities management programs.

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (Knoxville)

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SB Score:339

General Graphene is a pure-play CVD graphene foundry focusing on industrial-scale CVD graphene production. It provides expertise in applying CVD graphene across industries and applications.

Industry:
Ecommerce & Retail
Subindustry:
Retail

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SB Score:345

Provision Healthcare develops healthcare solutions focusing on improving patient care, clinical outcomes, and a commitment to driving research, education, and charitable causes. Cancers they treat include prostate, breast, head, neck, oral, lung, brain, spine, gynecologic, and more.

Industry:
Healthtech
Subindustry:
Biotechnology

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Total amount:82

Top Hiring Startups in Knoxville by Employee Number

The top three hiring startups in Knoxville have an median employee size that is between [1001-5000]
SB Score:422

HES Facilities is a full-service facilities management company, dedicated to providing educational facilities with custodial, maintenance, grounds, and landscaping services. The company partners with K-12 schools and higher education institutions to provide best-in-class facilities management programs.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:162

Inhabit IQ is a computer service company that specializes in providing software as a service platform for the real estate industry. It offers its strategic partnerships to deliver best-in-class software solutions and services while fostering innovation and collaboration with like-minded entrepreneurs and industry leaders.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

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SB Score:173

Vehlo is a provider of software and financial solutions for the automotive repair industry. They provide shop management and digital vehicle inspection tools for aftermarket service centers, along with dealer service lane solutions. They also provide fintech solutions that power payments, small business loans, and repair financing. It provides business management software, digital vehicle inspections, automated communications, digital marketing, and integrated payment solutions.

Industry:
Edtech
Subindustry:
Edtech

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SB Score:345

Provision Healthcare develops healthcare solutions focusing on improving patient care, clinical outcomes, and a commitment to driving research, education, and charitable causes. Cancers they treat include prostate, breast, head, neck, oral, lung, brain, spine, gynecologic, and more.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Knoxville)

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Total amount:82

Explore the Startup Ecosystem of Knoxville

National Rank

(United States)

90th

new

Regional Rank

(North America)

108th

1

Global Rank

(WorldWide)

342nd

16

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal ScoreAnnual Growth

Access subscores for 1000 cities and 100 countries

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