StartupBlink

83 Top startups in Knoxville for August 2026

We rank HES Facilities, Vendor Registry and Provision Healthcare in Knoxville along with 80 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Knoxville startup ecosystem ranks #342 globally and #90 in United States.

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Best Startups in Knoxville for 2026

1st
Vendor Registry logo
Vendor RegistrySB Score: 399

They are a small company, but big on passion and drive. They founded Vendor Registry with the simple purpose of making it easier to do business with your state and local governments and institutions. Too much time is spent filling out repetitive paperwork and too little time is spent taking advantage of new revenue opportunities. Businesses, especially local small businesses, need to generate more sales. Governments are forced to do more with less, which means they need more competitive bids. The vendors' and governments' problems are like a hand in glove. By just eliminating repetition (and automating the rest) and replacing paper with a single web-based tool used by both buyers and suppliers, they've created a win win solution. Vendor Registry is focused on creating this win win solution that generates new revenues for vendors and suppliers, saves time for everyone, and decreases costs for government and institutional purchasing departments. After all, they are spending their taxpayer dollars.

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Website
www.vendorregistry.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$5.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Provision Healthcare logo

Provision Healthcare develops healthcare solutions focusing on improving patient care, clinical outcomes, and a commitment to driving research, education, and charitable causes. Cancers they treat include prostate, breast, head, neck, oral, lung, brain, spine, gynecologic, and more.

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Website
provisionhealthcare.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$30.4M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
General Graphene logo
General GrapheneSB Score: 341

General Graphene is a pure-play CVD graphene foundry focusing on industrial-scale CVD graphene production. It provides expertise in applying CVD graphene across industries and applications.

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Website
www.generalgraphenecorp.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$38M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
4th
Lirio logo
LirioSB Score: 329

Lirio combines behavioral science and AI to guide individuals towards better health through personalized communication, making behavior change more effective and engaging.

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Website
lirio.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
5th
Sparkz logo
SparkzSB Score: 319

Sparkz is a creator of a creative battery technology designed to overcome the problems that the most advanced lithium batteries now face. Due to the company's cobalt-free battery technology, challenges with the supply chain, insufficient run-time, slow charging, rapid deterioration, and environmental and safety concerns can be resolved, allowing the electric mobility sector to scale up electrochemical energy storage innovation.

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Website
sparkz.energy
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$9.8M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
6th
Eonix logo
EonixSB Score: 318

Mosey helps businesses stay compliant with employment and tax requirements in all 50 states and 100+ cities for a fraction of the cost of professional services or hiring.

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Website
www.eonixenergy.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$21M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
7th
SmartRIA logo
SmartRIASB Score: 301

SmartRIA makes software that simplifies compliance for the financial services industry. We excel at making the complex and often frustrating world of regulatory compliance simple to manage and easy to understand. Our unique roles for compliance consultants and distributed management of large corporations make our solution able to handle any compliance problem for any sized company. Since our launch in 2016, we have built the most complete, easiest-to-use compliance software platform for the Registered Investment Advisor industry. We have since moved on to compliance in other financial services verticals in the US, and have expanded to wealth management compliance in the UK.

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Website
www.smart-ria.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$1.7M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
8th
HOAworks logo
HOAworksSB Score: 298

HOA boards manage properties. Streamline operations with our platform. Simplify communication, document storage, and financial tracking. Increase efficiency and transparency. Join us today.

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Website
hoa.works
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$1.2M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
9th
Cypienta logo
CypientaSB Score: 277

Alerts, events, and logs, RULE-LESS correlation & contextualization made instant, scalable, & explainable, right in your SIEM/SOAR.

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Website
cypienta.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$6.8M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
10th
TCPoly logo
TCPolySB Score: 254

TCPoly makes thermally conductive and next-generation plastics for additive manufacturing. TCPoly uses its extensive knowledge of materials science and heat transfer to create the Ice9TM Flex filament, a thermally conductive 3D printing filament. Their product is actively used in the heat exchanger, mold tooling, and electronics thermal management industries, and it has been sold in over 20 countries.

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Website
tcpoly.com/#
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$1.2M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
11th
Prisma Renewable Composites logo

Prisma Renewable Composites is a biotechnology company specializing in efficiently separating highly renewable energy crops into pure fractions of lignin, cellulose, hemicellulose, and other extractives for use in a multitude of applications including pulp, biopolymers, specialty chemicals and advanced composite materials.

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Website
prismacomposites.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$2.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:44

Most Funded Startups in Knoxville for 2026

The top three most funded startups in Knoxville have raised total funding of more than USD 153M. HES Facilities has 1.22% more funding than General Graphene.
1st
General Graphene logo
General GrapheneSB Score: 341

General Graphene is a pure-play CVD graphene foundry focusing on industrial-scale CVD graphene production. It provides expertise in applying CVD graphene across industries and applications.

View Full Page
Website
www.generalgraphenecorp.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$38M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Provision Healthcare logo

Provision Healthcare develops healthcare solutions focusing on improving patient care, clinical outcomes, and a commitment to driving research, education, and charitable causes. Cancers they treat include prostate, breast, head, neck, oral, lung, brain, spine, gynecologic, and more.

View Full Page
Website
provisionhealthcare.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$30.4M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Eonix logo
EonixSB Score: 318

Mosey helps businesses stay compliant with employment and tax requirements in all 50 states and 100+ cities for a fraction of the cost of professional services or hiring.

View Full Page
Website
www.eonixenergy.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$21M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:44

Top Hiring Startups in Knoxville by Employee Number

The top three hiring startups in Knoxville have an median employee size that is between [1001-5000]
1st
HES Facilities logo
HES FacilitiesSB Score: 416

HES Facilities is a full-service facilities management company, dedicated to providing educational facilities with custodial, maintenance, grounds, and landscaping services. The company partners with K-12 schools and higher education institutions to provide best-in-class facilities management programs.

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Website
hesfacilitiesmanagement.com
Employee range
10,001+
Web Traffic (Monthly)
Funding amount
$84.3M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Inhabit IQ logo
Inhabit IQSB Score: 160

Inhabit IQ is a computer service company that specializes in providing software as a service platform for the real estate industry. It offers its strategic partnerships to deliver best-in-class software solutions and services while fostering innovation and collaboration with like-minded entrepreneurs and industry leaders.

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Website
inhabitiq.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Vehlo logo
VehloSB Score: 174
EdtechEdtech

Vehlo is a provider of software and financial solutions for the automotive repair industry. They provide shop management and digital vehicle inspection tools for aftermarket service centers, along with dealer service lane solutions. They also provide fintech solutions that power payments, small business loans, and repair financing. It provides business management software, digital vehicle inspections, automated communications, digital marketing, and integrated payment solutions.

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Website
vehlo.com
Employee range
501 – 1,000
Web Traffic (Monthly)
Funding amount
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
4th
Provision Healthcare logo

Provision Healthcare develops healthcare solutions focusing on improving patient care, clinical outcomes, and a commitment to driving research, education, and charitable causes. Cancers they treat include prostate, breast, head, neck, oral, lung, brain, spine, gynecologic, and more.

View Full Page
Website
provisionhealthcare.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$30.4M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:83

Explore More Top Startups

Explore the Startup Ecosystem of Knoxville

National Rank

(United States)

90th

new

Regional Rank

(North America)

108th

1

Global Rank

(WorldWide)

342nd

16

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal Score & National ShareAnnual Growth

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