33 Top startups in Gaithersburg for April 2025

We rank Robotic Research, Arcellx and GlycoMimetics in Gaithersburg along with 30 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Gaithersburg is part of Washington DC Area startup ecosystem which ranks #19 globally and #8 in North America.

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Best Startups in Gaithersburg for 2025

SB Score:488

Robotic Research enhances transportation safety and efficiency through advanced autonomous technology. Their innovations increase security and effectiveness, making travel safer for all.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:467

Arcellx is a clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. Arcellx believes that cell therapies are one of the forward pillars of medicine and Arcellx’s mission is to advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Arcellx’s lead product candidate, CART-ddBCMA, is being developed for the treatment of relapsed or refractory multiple myeloma (r/r MM) in an ongoing Phase 1 study. CART-ddBCMA has been granted Fast Track, Orphan Drug, and Regenerative Medicine Advanced Therapy designations by the U.S. Food and Drug Administration. Arcellx is also advancing its dosable and controllable CAR-T therapy, ARC-SparX, into the clinic through two programs: ACLX-001 in r/r MM and ACLX-002 in relapsed or refractory acute myeloid leukemia.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:388

GlycoMimetics, Inc., a biopharmaceutical company, engages in the design and development of small molecule therapeutics to mimic the functions of bioactive carbohydrates. Its products include GMI-1070, a synthetic glycomimetic molecule designed to inhibit selectin types, such as E, P, and L-selectin, and GMI-1051, a small molecular weight compound for the treatment or prevention of infections caused by pseudomonas aeruginosa. The company was founded in 2003 and is based in Gaithersburg, Maryland.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:372

NexImmune is an early stage biopharmaceutical company developing novel immuno-therapeutics based on the proprietary Artificial IMmune (AIMTM) technology. The AIM technology provides an important advance in the development of immunotherapies for a variety of cancers and other diseases. The AIM technology has been designed to orchestrate specific immune system responses in a highly controllable and reproducible way independent of the healthiness or abundance of the patient’s natural antigen presenting cell (APC) population. Natural APCs are major players in the body’s immune system as they direct the immune system cells in attacks on specifically targeted antigens and cells. However, under certain disease conditions, natural APCs can be damaged, absent or inactive.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:359

Roboteam creates advanced unmanned systems and controllers for defense applications. Their innovative platforms are designed to enhance military operations with cutting-edge technology.

Industry:
Software & Data
Subindustry:
Cybersecurity

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SB Score:358

SalubrisBio is a clinical-stage biotechnology company focused on the discovery and development of innovative antibody and protein-based therapeutics, aiming to advance healthcare by addressing unmet medical needs with cutting-edge treatment solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:354

Georgiamune develops innovative immunotherapy treatments for cancer and autoimmune diseases, enabling rapid patient recovery. Their advanced therapies harness the power of the immune system to combat illness effectively.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:350

Cardinality aims to revolutionize Health & Human Services by offering a user-friendly experience comparable to popular products like Apple and Gmail. Their mission is to provide stakeholders with modern, intuitive solutions for everyday tasks in the industry.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:342

RNAimmune specializes in developing mRNA-based therapeutics and vaccines. Their focus is on discovering innovative solutions for various medical conditions using cutting-edge technology.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:319

MiRecule is a biotech startup specializing in developing cutting-edge microRNA-based therapies. They aim to revolutionize medicine by harnessing the power of microRNAs for targeted treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:313

Revolutionizing cell therapy in oncology and beyond with safer, more powerful solutions. Join us in pioneering cutting-edge treatments that push the boundaries of what is possible in the medical field.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:33

Top 7 Software & Data Startups in Gaithersburg for 2025

The top three Software & Data startups in Gaithersburg have raised more than USD 618M. Gaithersburg is part of Washington DC Area startup ecosystem which ranks #11 globally for the Software & Data industry.
SB Score:488

Robotic Research enhances transportation safety and efficiency through advanced autonomous technology. Their innovations increase security and effectiveness, making travel safer for all.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:359

Roboteam creates advanced unmanned systems and controllers for defense applications. Their innovative platforms are designed to enhance military operations with cutting-edge technology.

Industry:
Software & Data
Subindustry:
Cybersecurity

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

0

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SB Score:350

Cardinality aims to revolutionize Health & Human Services by offering a user-friendly experience comparable to popular products like Apple and Gmail. Their mission is to provide stakeholders with modern, intuitive solutions for everyday tasks in the industry.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:7

Top 18 Healthtech Startups in Gaithersburg for 2025

The top three Healthtech startups in Gaithersburg have raised more than USD 604M. Gaithersburg is part of Washington DC Area startup ecosystem which ranks #10 globally for the Healthtech industry.
SB Score:467

Arcellx is a clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. Arcellx believes that cell therapies are one of the forward pillars of medicine and Arcellx’s mission is to advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Arcellx’s lead product candidate, CART-ddBCMA, is being developed for the treatment of relapsed or refractory multiple myeloma (r/r MM) in an ongoing Phase 1 study. CART-ddBCMA has been granted Fast Track, Orphan Drug, and Regenerative Medicine Advanced Therapy designations by the U.S. Food and Drug Administration. Arcellx is also advancing its dosable and controllable CAR-T therapy, ARC-SparX, into the clinic through two programs: ACLX-001 in r/r MM and ACLX-002 in relapsed or refractory acute myeloid leukemia.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:388

GlycoMimetics, Inc., a biopharmaceutical company, engages in the design and development of small molecule therapeutics to mimic the functions of bioactive carbohydrates. Its products include GMI-1070, a synthetic glycomimetic molecule designed to inhibit selectin types, such as E, P, and L-selectin, and GMI-1051, a small molecular weight compound for the treatment or prevention of infections caused by pseudomonas aeruginosa. The company was founded in 2003 and is based in Gaithersburg, Maryland.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:372

NexImmune is an early stage biopharmaceutical company developing novel immuno-therapeutics based on the proprietary Artificial IMmune (AIMTM) technology. The AIM technology provides an important advance in the development of immunotherapies for a variety of cancers and other diseases. The AIM technology has been designed to orchestrate specific immune system responses in a highly controllable and reproducible way independent of the healthiness or abundance of the patient’s natural antigen presenting cell (APC) population. Natural APCs are major players in the body’s immune system as they direct the immune system cells in attacks on specifically targeted antigens and cells. However, under certain disease conditions, natural APCs can be damaged, absent or inactive.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:18

Most Funded Startups in Gaithersburg for 2025

The top three most funded startups in Gaithersburg have raised total funding of more than USD 1.03B. Robotic Research has 0.33% more funding than Arcellx.
SB Score:488

Robotic Research enhances transportation safety and efficiency through advanced autonomous technology. Their innovations increase security and effectiveness, making travel safer for all.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:467

Arcellx is a clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. Arcellx believes that cell therapies are one of the forward pillars of medicine and Arcellx’s mission is to advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Arcellx’s lead product candidate, CART-ddBCMA, is being developed for the treatment of relapsed or refractory multiple myeloma (r/r MM) in an ongoing Phase 1 study. CART-ddBCMA has been granted Fast Track, Orphan Drug, and Regenerative Medicine Advanced Therapy designations by the U.S. Food and Drug Administration. Arcellx is also advancing its dosable and controllable CAR-T therapy, ARC-SparX, into the clinic through two programs: ACLX-001 in r/r MM and ACLX-002 in relapsed or refractory acute myeloid leukemia.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:358

SalubrisBio is a clinical-stage biotechnology company focused on the discovery and development of innovative antibody and protein-based therapeutics, aiming to advance healthcare by addressing unmet medical needs with cutting-edge treatment solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:33

Top Hiring Startups in Gaithersburg by Employee Number

The top three hiring startups in Gaithersburg have an median employee size that is between [251-500]
SB Score:488

Robotic Research enhances transportation safety and efficiency through advanced autonomous technology. Their innovations increase security and effectiveness, making travel safer for all.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:350

Cardinality aims to revolutionize Health & Human Services by offering a user-friendly experience comparable to popular products like Apple and Gmail. Their mission is to provide stakeholders with modern, intuitive solutions for everyday tasks in the industry.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:467

Arcellx is a clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. Arcellx believes that cell therapies are one of the forward pillars of medicine and Arcellx’s mission is to advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Arcellx’s lead product candidate, CART-ddBCMA, is being developed for the treatment of relapsed or refractory multiple myeloma (r/r MM) in an ongoing Phase 1 study. CART-ddBCMA has been granted Fast Track, Orphan Drug, and Regenerative Medicine Advanced Therapy designations by the U.S. Food and Drug Administration. Arcellx is also advancing its dosable and controllable CAR-T therapy, ARC-SparX, into the clinic through two programs: ACLX-001 in r/r MM and ACLX-002 in relapsed or refractory acute myeloid leukemia.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:388

GlycoMimetics, Inc., a biopharmaceutical company, engages in the design and development of small molecule therapeutics to mimic the functions of bioactive carbohydrates. Its products include GMI-1070, a synthetic glycomimetic molecule designed to inhibit selectin types, such as E, P, and L-selectin, and GMI-1051, a small molecular weight compound for the treatment or prevention of infections caused by pseudomonas aeruginosa. The company was founded in 2003 and is based in Gaithersburg, Maryland.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:33

Explore the Startup Ecosystem of Gaithersburg

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Regional Rank

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8th

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Global Rank

(WorldWide)

19th

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
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1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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