13 Top startups in Exton for April 2025

We rank Energage, Castle Creek Biosciences and Morphotek in Exton along with 10 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Exton is part of Philadelphia startup ecosystem which ranks #35 globally and #16 in North America.

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Best Startups in Exton for 2025

SB Score:468

Energage empowers organizations to optimize their workforce's performance and unlock their full potential.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Castle Creek Biosciences specializes in creating personalized gene therapies for rare skin disorders. Their innovative approach aims to develop and bring to market unique treatments for these conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:330

Morphotek is one of the leading companies in the life science industry that develops novel classes of biological-based products to treat cancer, inflammation and infectious diseases. Since its founding in 2000, Morphotek has made extraordinary progress in discovering and developing monoclonal antibodies (mABs) to treat these diseases and continues to develop additional antibody products using its proprietary technologies. Post-graduate research executed by Morphotek’s President and CEO, Dr. Nicholas Nicolaides, during his studies at Johns Hopkins Medical School was the basis for the company’s inception. It was there that Dr. Nicolaides co-invented the company's legacy technology called morphogenics. Along with the honed applications for applying morphogenics for product development refined by the company’s other co-founders, Dr. Philip Sass and Dr. Luigi Grasso, morphogenics has taken Morphotek an incredible distance in the advancement of novel pharmaceutical products and targets.

Industry:
Healthtech
Subindustry:
Biotechnology

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Regional Rank (North America)

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SB Score:293

Melior Discovery provides a pharmacology platform that uncovers new uses for early-stage drug candidates. Their innovative approach helps identify potential indications for further development, making drug discovery more efficient and effective.

Industry:
Healthtech
Subindustry:
Biotechnology

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Regional Rank (North America)

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Agronomed Pharmaceuticals cultivates, processes, and supplies high-quality cannabis-based health products. Committed to enhancing wellness, the company leverages innovative techniques to deliver effective and reliable solutions for health-conscious consumers seeking natural alternatives.

Industry:
Social & Leisure
Subindustry:
Communities

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SB Score:229

KinderPharm is a dedicated pediatric contract research organization (CRO) specializing in pediatric drug development. By collaborating closely with partners, KinderPharm advances innovative pediatric products through every stage of the development process, ensuring the unique needs of children are met in healthcare advancements.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:227

Praeventix develops innovative therapies for bowel diseases, aiming to revolutionize treatment options. Their groundbreaking approach offers hope for patients and the potential for significant medical advancements in the field.

Industry:
Healthtech
Subindustry:
Biotechnology

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8th

uTu
SB Score:140

uTu connects brands with their target audiences through interactive channels. Their platform facilitates engaging conversations to drive brand awareness and customer loyalty.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

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Regional Rank (North America)

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Spherix Global Insights is a market research firm providing business intelligence services. Specializing in healthcare, they offer valuable insights to help companies make informed decisions.

Industry:
Software & Data
Subindustry:
Data Analytics

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Regional Rank (North America)

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SB Score:85

OneSky Systems creates cutting-edge platforms for managing drone traffic and enabling urban air transportation. Their technology revolutionizes airspace management and paves the way for safe and efficient drone operations in urban environments.

Industry:
Transportation
Subindustry:
Aerospace

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SB Score:71

COMSPOC offers a cutting-edge platform for space situational awareness by aggregating data from various commercial sensors to provide comprehensive and reliable information. Their services deliver unparalleled commercial SSA/STM solutions for enhanced space monitoring and management.

Industry:
Edtech
Subindustry:
Edutainment

National Rank (United States)

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Regional Rank (North America)

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Total amount:13

Top 3 Software & Data Startups in Exton for 2025

The top three Software & Data startups in Exton have raised more than USD 30M. Exton is part of Philadelphia startup ecosystem which ranks #40 globally for the Software & Data industry.
SB Score:468

Energage empowers organizations to optimize their workforce's performance and unlock their full potential.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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Spherix Global Insights is a market research firm providing business intelligence services. Specializing in healthcare, they offer valuable insights to help companies make informed decisions.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:53

ONExia Robotics, founded in 2015, offers user-friendly robots with EASYreach Software for American manufacturers to enhance competitiveness. Robots are programmed through touch screen and hand controller interfaces.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:3

Top 5 Healthtech Startups in Exton for 2025

The top three Healthtech startups in Exton have raised more than USD 454M. Exton is part of Philadelphia startup ecosystem which ranks #14 globally for the Healthtech industry.

Castle Creek Biosciences specializes in creating personalized gene therapies for rare skin disorders. Their innovative approach aims to develop and bring to market unique treatments for these conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:330

Morphotek is one of the leading companies in the life science industry that develops novel classes of biological-based products to treat cancer, inflammation and infectious diseases. Since its founding in 2000, Morphotek has made extraordinary progress in discovering and developing monoclonal antibodies (mABs) to treat these diseases and continues to develop additional antibody products using its proprietary technologies. Post-graduate research executed by Morphotek’s President and CEO, Dr. Nicholas Nicolaides, during his studies at Johns Hopkins Medical School was the basis for the company’s inception. It was there that Dr. Nicolaides co-invented the company's legacy technology called morphogenics. Along with the honed applications for applying morphogenics for product development refined by the company’s other co-founders, Dr. Philip Sass and Dr. Luigi Grasso, morphogenics has taken Morphotek an incredible distance in the advancement of novel pharmaceutical products and targets.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:293

Melior Discovery provides a pharmacology platform that uncovers new uses for early-stage drug candidates. Their innovative approach helps identify potential indications for further development, making drug discovery more efficient and effective.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:5

Most Funded Startups in Exton for 2025

The top three most funded startups in Exton have raised total funding of more than USD 473M. Castle Creek Biosciences has 3.64% more funding than Morphotek.

Castle Creek Biosciences specializes in creating personalized gene therapies for rare skin disorders. Their innovative approach aims to develop and bring to market unique treatments for these conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:330

Morphotek is one of the leading companies in the life science industry that develops novel classes of biological-based products to treat cancer, inflammation and infectious diseases. Since its founding in 2000, Morphotek has made extraordinary progress in discovering and developing monoclonal antibodies (mABs) to treat these diseases and continues to develop additional antibody products using its proprietary technologies. Post-graduate research executed by Morphotek’s President and CEO, Dr. Nicholas Nicolaides, during his studies at Johns Hopkins Medical School was the basis for the company’s inception. It was there that Dr. Nicolaides co-invented the company's legacy technology called morphogenics. Along with the honed applications for applying morphogenics for product development refined by the company’s other co-founders, Dr. Philip Sass and Dr. Luigi Grasso, morphogenics has taken Morphotek an incredible distance in the advancement of novel pharmaceutical products and targets.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:468

Energage empowers organizations to optimize their workforce's performance and unlock their full potential.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:13

Top Hiring Startups in Exton by Employee Number

The top three hiring startups in Exton have an median employee size that is between [51-100]
SB Score:468

Energage empowers organizations to optimize their workforce's performance and unlock their full potential.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:330

Morphotek is one of the leading companies in the life science industry that develops novel classes of biological-based products to treat cancer, inflammation and infectious diseases. Since its founding in 2000, Morphotek has made extraordinary progress in discovering and developing monoclonal antibodies (mABs) to treat these diseases and continues to develop additional antibody products using its proprietary technologies. Post-graduate research executed by Morphotek’s President and CEO, Dr. Nicholas Nicolaides, during his studies at Johns Hopkins Medical School was the basis for the company’s inception. It was there that Dr. Nicolaides co-invented the company's legacy technology called morphogenics. Along with the honed applications for applying morphogenics for product development refined by the company’s other co-founders, Dr. Philip Sass and Dr. Luigi Grasso, morphogenics has taken Morphotek an incredible distance in the advancement of novel pharmaceutical products and targets.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Castle Creek Biosciences specializes in creating personalized gene therapies for rare skin disorders. Their innovative approach aims to develop and bring to market unique treatments for these conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:293

Melior Discovery provides a pharmacology platform that uncovers new uses for early-stage drug candidates. Their innovative approach helps identify potential indications for further development, making drug discovery more efficient and effective.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:13

Explore the Startup Ecosystem of Exton

National Rank

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Regional Rank

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16th

1

Global Rank

(WorldWide)

35th

2

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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