StartupBlink

40 Top startups in Worcester for June 2026

We rank Vella Bioscience, Leal Therapeutics and Blustream in Worcester along with 37 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Worcester startup ecosystem ranks #394 globally and #106 in United States.

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Best Startups in Worcester for 2026

SB Score:397

Vella Bioscience is a health-tech company dedicated to sexually empowering every woman. Vella, the company's flagship product, is a nano-encapsulated topical lotion specially designed and formulated for women who seek easier, more intense, and more frequent orgasms, regardless of their hormonal status. Vella is the first and only lotion that relaxes vaginal smooth muscle, a prerequisite for sexual response, and is the only cannabidiol (CBD) sexual enhancement formulation to have been clinically demonstrated in a study of women aged 23 to 61.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:332

Blustream is a SaaS-based customer engagement company that helps physical goods companies build after-sale connections between their products and end-users. By integrating with IoT sensors on tangible products, Blustream’s platform collects aggregate usage, environment and performance analytics for brands and delivers automated education, alerts and purchase recommendations to end-users. Today, CEOs, CMOs, and executives in charge of digital transformation use Blustream’s Platform to create a direct channel with their customers that increases revenue, profit, and delivers better customer satisfaction. Michael Audi, Michael Gordon, and Robert Bean established the company in Worcester, Massachusetts in 2015.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:302

Multiscale Systems produces industrial innovations through technical engineering services and a robust in-house R&D program. The company specializes in metamaterial composites and focuses on advanced manufacturing.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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Planet Found Energy Development specializes in creating innovative manure management solutions. They use a unique combination of anaerobic digestion, solids separation, and filtration technologies to develop their patent-pending Combined Anaerobic Digestion and Nutrient Capture Systems.

Industry:
Foodtech
Subindustry:
Agtech

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SB Score:292

HelixBind is a Massachusetts-based company that operates in the biotechnology sector. The company was founded in 2012 and is based in Worcester, Massachusetts.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:279

ComputerVault On-Premises Private Cloud ComputerVault, (www.ComputerVault.com) has software distribution and resale agreements with TD SYNNEX, and Arrow Electronics. They have positioned ComputerVault to be the sole replacement product for VMware and Citrix. VMware and Citrix are attempting to migrate on-prem customers to their public clouds. Our partners anticipate massive customer defections from VMware and Citrix, and ComputerVault is now their on-premises IT infrastructure solution of choice. ComputerVault is a fixed-price, subscription based On-Premises Private Cloud wrapping a Virtualization and Security Platform with: Virtual Desktops that are faster than PCs, Cybersecurity that stops malware, ransomware and phishing attacks, and the Highest ROI/Lowest TCO of any cloud or virtualization platform. ComputerVault is a better cloud.

Industry:
Software & Data
Subindustry:
Software

City Rank (Worcester)

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SB Score:277

OpenCity is a conversational AI platform that allows restaurants to automate taking orders at the drive-thru window.

Industry:
Social & Leisure
Subindustry:
Entertainment

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SB Score:272

Stability Health is a virtual health-enabled care company which improves outcomes and lowers healthcare costs for patients with complex diabetes. Our clients are those healthcare organizations and clinicians who serve these patients. We bring deep diabetes/endocrine clinical expertise and marry that expertise with both technology and human elements to extend and enhance a patient’s care team.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Worcester)

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SB Score:263

Xceedance is a global provider of consulting and managed services, technology, analytics and data sciences to re/insurance organisations.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:256

Juniper Biomedical is a medical device company that specializes in implantable neuromodulation technology. The company develops a micro-implant that delivers precision treatment for a spectrum of conditions in pelvic health.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Worcester)

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Total amount:40

Top 10 Healthtech Startups in Worcester for 2026

The top three Healthtech startups in Worcester have raised more than USD 110M. Worcester startup ecosystem ranks #291 globally for the Healthtech industry.
SB Score:397

Vella Bioscience is a health-tech company dedicated to sexually empowering every woman. Vella, the company's flagship product, is a nano-encapsulated topical lotion specially designed and formulated for women who seek easier, more intense, and more frequent orgasms, regardless of their hormonal status. Vella is the first and only lotion that relaxes vaginal smooth muscle, a prerequisite for sexual response, and is the only cannabidiol (CBD) sexual enhancement formulation to have been clinically demonstrated in a study of women aged 23 to 61.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Worcester)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:292

HelixBind is a Massachusetts-based company that operates in the biotechnology sector. The company was founded in 2012 and is based in Worcester, Massachusetts.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Worcester)

0

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Regional Rank (North America)

0

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Total amount:10

Top 6 Marketing & Sales Startups in Worcester for 2026

Worcester startup ecosystem ranks #307 globally for the Marketing & Sales industry.

1st

Munq
SB Score:58

Munq is a creative agency that focuses on storytelling to help organizations with their branding challenges. The company offers services such as brand strategy, website development, and videography. Munq collaborates with clients to create compelling brand stories that resonate with their target audience. The agency aims to connect brands with their customers through innovative and story-centric communications.

Industry:
Marketing & Sales
Subindustry:
Marketing & Sales-Other

City Rank (Worcester)

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Results-focused digital marketing program fulfillment & white-label services. We help agencies, brands, & consultants achieve real roi With search engine optimization, website development, and more.

Industry:
Marketing & Sales
Subindustry:
Digital Marketing

City Rank (Worcester)

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SB Score:38

Worcester Interactive provides a digital marketing agency specializing in responsive web design, social media marketing, search engine optimization (SEO), and digital advertising. They build websites and create online marketing campaigns for businesses looking to grow their online presence. They provide customized solutions to the customer and company needs. The customer contact through phone number, email, and application form.

Industry:
Marketing & Sales
Subindustry:
Digital Marketing

City Rank (Worcester)

0

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Total amount:6

Top 14 Software & Data Startups in Worcester for 2026

The top three Software & Data startups in Worcester have raised more than USD 16.4M. Worcester startup ecosystem ranks #378 globally for the Software & Data industry.
SB Score:332

Blustream is a SaaS-based customer engagement company that helps physical goods companies build after-sale connections between their products and end-users. By integrating with IoT sensors on tangible products, Blustream’s platform collects aggregate usage, environment and performance analytics for brands and delivers automated education, alerts and purchase recommendations to end-users. Today, CEOs, CMOs, and executives in charge of digital transformation use Blustream’s Platform to create a direct channel with their customers that increases revenue, profit, and delivers better customer satisfaction. Michael Audi, Michael Gordon, and Robert Bean established the company in Worcester, Massachusetts in 2015.

Industry:
Software & Data
Subindustry:
Data Analytics

City Rank (Worcester)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:279

ComputerVault On-Premises Private Cloud ComputerVault, (www.ComputerVault.com) has software distribution and resale agreements with TD SYNNEX, and Arrow Electronics. They have positioned ComputerVault to be the sole replacement product for VMware and Citrix. VMware and Citrix are attempting to migrate on-prem customers to their public clouds. Our partners anticipate massive customer defections from VMware and Citrix, and ComputerVault is now their on-premises IT infrastructure solution of choice. ComputerVault is a fixed-price, subscription based On-Premises Private Cloud wrapping a Virtualization and Security Platform with: Virtual Desktops that are faster than PCs, Cybersecurity that stops malware, ransomware and phishing attacks, and the Highest ROI/Lowest TCO of any cloud or virtualization platform. ComputerVault is a better cloud.

Industry:
Software & Data
Subindustry:
Software

City Rank (Worcester)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:263

Xceedance is a global provider of consulting and managed services, technology, analytics and data sciences to re/insurance organisations.

Industry:
Software & Data
Subindustry:
Data Analytics

City Rank (Worcester)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:14

Most Funded Startups in Worcester for 2026

The top three most funded startups in Worcester have raised total funding of more than USD 151M. Leal Therapeutics has 0.40% more funding than Planet Found Energy Development.

Planet Found Energy Development specializes in creating innovative manure management solutions. They use a unique combination of anaerobic digestion, solids separation, and filtration technologies to develop their patent-pending Combined Anaerobic Digestion and Nutrient Capture Systems.

Industry:
Foodtech
Subindustry:
Agtech

City Rank (Worcester)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:292

HelixBind is a Massachusetts-based company that operates in the biotechnology sector. The company was founded in 2012 and is based in Worcester, Massachusetts.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Worcester)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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Total amount:40

Top Hiring Startups in Worcester by Employee Number

The top three hiring startups in Worcester have an median employee size that is between [51-100]
SB Score:263

Xceedance is a global provider of consulting and managed services, technology, analytics and data sciences to re/insurance organisations.

Industry:
Software & Data
Subindustry:
Data Analytics

City Rank (Worcester)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:279

ComputerVault On-Premises Private Cloud ComputerVault, (www.ComputerVault.com) has software distribution and resale agreements with TD SYNNEX, and Arrow Electronics. They have positioned ComputerVault to be the sole replacement product for VMware and Citrix. VMware and Citrix are attempting to migrate on-prem customers to their public clouds. Our partners anticipate massive customer defections from VMware and Citrix, and ComputerVault is now their on-premises IT infrastructure solution of choice. ComputerVault is a fixed-price, subscription based On-Premises Private Cloud wrapping a Virtualization and Security Platform with: Virtual Desktops that are faster than PCs, Cybersecurity that stops malware, ransomware and phishing attacks, and the Highest ROI/Lowest TCO of any cloud or virtualization platform. ComputerVault is a better cloud.

Industry:
Software & Data
Subindustry:
Software

City Rank (Worcester)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:332

Blustream is a SaaS-based customer engagement company that helps physical goods companies build after-sale connections between their products and end-users. By integrating with IoT sensors on tangible products, Blustream’s platform collects aggregate usage, environment and performance analytics for brands and delivers automated education, alerts and purchase recommendations to end-users. Today, CEOs, CMOs, and executives in charge of digital transformation use Blustream’s Platform to create a direct channel with their customers that increases revenue, profit, and delivers better customer satisfaction. Michael Audi, Michael Gordon, and Robert Bean established the company in Worcester, Massachusetts in 2015.

Industry:
Software & Data
Subindustry:
Data Analytics

City Rank (Worcester)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:40

Explore the Startup Ecosystem of Worcester

National Rank

(United States)

106th

new

Regional Rank

(North America)

152nd

26

Global Rank

(WorldWide)

394th

137

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal ScoreAnnual Growth

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152.371
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127.119
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