30 Top startups in Worcester for April 2025

We rank Vella Bioscience, Leal Therapeutics and Helixbind in Worcester along with 27 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Worcester startup ecosystem ranks #454 globally and #134 in United States.

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Best Startups in Worcester for 2025

SB Score:377

Vella Bioscience is a health-tech company focused on empowering women through sexual wellness. By providing innovative solutions and resources, it enhances women's understanding and experiences, fostering confidence and autonomy in their sexual health journey.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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SB Score:341

Leal Therapeutics pioneers innovative treatments for patients, focusing on developing groundbreaking therapeutics that address unmet medical needs. Their mission is to enhance patient outcomes through cutting-edge research and a commitment to improving health and well-being.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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SB Score:306

HelixBind, a biotech company in Massachusetts, specializes in innovative technologies. They create cutting-edge solutions for the healthcare industry, focusing on improving diagnostics and treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:291

Blustream connects companies with customers by using product usage data for better post-sale engagement.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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SB Score:289

OpenCity is a dynamic Live Chat Platform designed for restaurants and nightclubs. Engage with customers in real-time, boost customer service, and streamline communication. Join OpenCity to revolutionize your venue's online presence.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

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Regional Rank (North America)

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SB Score:281

ComputerVault, accessible at www.ComputerVault.com, partners with TD SYNNEX and Arrow Electronics to provide cutting-edge software solutions. Positioned as the exclusive alternative to VMware and Citrix, ComputerVault offers a robust on-premises private cloud that enhances efficiency and performance for businesses seeking reliable virtualization options.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

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SB Score:267

Multiscale Systems is an innovative company that manufactures advanced materials. They specialize in creating cutting-edge products using state-of-the-art technology.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

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SB Score:247

Revolutionize trucking management with our AI-powered web platform. Simplify on-the-go operations and optimize efficiency with cutting-edge technology. Experience the future of trucking business management at your fingertips.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

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SB Score:237

EnerConnex, led by experts with 20+ years in deregulated energy markets, simplifies access to electricity and natural gas options.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

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SB Score:220

At Nutrimedy they are defining telenutrition through their novel online wellness platform based on the integration of leading edge science, technology and behavioral health. To improve health and reduce the epidemic burden of chronic disease by improving access to convenient, expert, personalized and affordable nutritional counseling around the globe.

Industry:
Foodtech
Subindustry:
Food and Beverage

National Rank (United States)

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Regional Rank (North America)

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Total amount:30

Top 9 Software & Data Startups in Worcester for 2025

The top three Software & Data startups in Worcester have raised more than USD 26.3M. Worcester startup ecosystem ranks #365 globally for the Software & Data industry.
SB Score:291

Blustream connects companies with customers by using product usage data for better post-sale engagement.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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Regional Rank (North America)

0

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SB Score:281

ComputerVault, accessible at www.ComputerVault.com, partners with TD SYNNEX and Arrow Electronics to provide cutting-edge software solutions. Positioned as the exclusive alternative to VMware and Citrix, ComputerVault offers a robust on-premises private cloud that enhances efficiency and performance for businesses seeking reliable virtualization options.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:247

Revolutionize trucking management with our AI-powered web platform. Simplify on-the-go operations and optimize efficiency with cutting-edge technology. Experience the future of trucking business management at your fingertips.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:9

Top 11 Healthtech Startups in Worcester for 2025

The top three Healthtech startups in Worcester have raised more than USD 79.8M. Worcester startup ecosystem ranks #251 globally for the Healthtech industry.
SB Score:377

Vella Bioscience is a health-tech company focused on empowering women through sexual wellness. By providing innovative solutions and resources, it enhances women's understanding and experiences, fostering confidence and autonomy in their sexual health journey.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:341

Leal Therapeutics pioneers innovative treatments for patients, focusing on developing groundbreaking therapeutics that address unmet medical needs. Their mission is to enhance patient outcomes through cutting-edge research and a commitment to improving health and well-being.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:306

HelixBind, a biotech company in Massachusetts, specializes in innovative technologies. They create cutting-edge solutions for the healthcare industry, focusing on improving diagnostics and treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:11

Top 3 Social & Leisure Startups in Worcester for 2025

The top three Social & Leisure startups in Worcester have raised more than USD 22.6M. Worcester startup ecosystem ranks among the top 10 locations in the world for startups in Social & Leisure, holding the falseth position.
SB Score:289

OpenCity is a dynamic Live Chat Platform designed for restaurants and nightclubs. Engage with customers in real-time, boost customer service, and streamline communication. Join OpenCity to revolutionize your venue's online presence.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:209

Creative Hub Worcester provides inclusive and affordable artistic programs for all. It offers a welcoming space for creative expression, ensuring everyone has the opportunity to participate and showcase their talents.

Industry:
Social & Leisure
Subindustry:
Arts

National Rank (United States)

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Regional Rank (North America)

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SB Score:26

Zephyr Workshop creates and publishes tabletop games with a focus on compact size and immersive storytelling. Their games are designed to bring joy through innovative mechanics and premium components, inviting players to explore new worlds and experience unforgettable adventures.

Industry:
Social & Leisure
Subindustry:
Gaming

National Rank (United States)

0

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Regional Rank (North America)

0

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Total amount:3

Most Funded Startups in Worcester for 2025

The top three most funded startups in Worcester have raised total funding of more than USD 90.2M. Leal Therapeutics has 0.98% more funding than Helixbind.
SB Score:341

Leal Therapeutics pioneers innovative treatments for patients, focusing on developing groundbreaking therapeutics that address unmet medical needs. Their mission is to enhance patient outcomes through cutting-edge research and a commitment to improving health and well-being.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:306

HelixBind, a biotech company in Massachusetts, specializes in innovative technologies. They create cutting-edge solutions for the healthcare industry, focusing on improving diagnostics and treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:289

OpenCity is a dynamic Live Chat Platform designed for restaurants and nightclubs. Engage with customers in real-time, boost customer service, and streamline communication. Join OpenCity to revolutionize your venue's online presence.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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Total amount:30

Top Hiring Startups in Worcester by Employee Number

The top three hiring startups in Worcester have an median employee size that is between [11-50]
SB Score:281

ComputerVault, accessible at www.ComputerVault.com, partners with TD SYNNEX and Arrow Electronics to provide cutting-edge software solutions. Positioned as the exclusive alternative to VMware and Citrix, ComputerVault offers a robust on-premises private cloud that enhances efficiency and performance for businesses seeking reliable virtualization options.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:341

Leal Therapeutics pioneers innovative treatments for patients, focusing on developing groundbreaking therapeutics that address unmet medical needs. Their mission is to enhance patient outcomes through cutting-edge research and a commitment to improving health and well-being.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:306

HelixBind, a biotech company in Massachusetts, specializes in innovative technologies. They create cutting-edge solutions for the healthcare industry, focusing on improving diagnostics and treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:291

Blustream connects companies with customers by using product usage data for better post-sale engagement.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:30

Explore the Startup Ecosystem of Worcester

National Rank

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Regional Rank

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152nd

26

Global Rank

(WorldWide)

454th

77

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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Quality Score
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Business Score
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1st
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710.966
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251.377
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4th
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121.937
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5th
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109.679
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