34 Top startups in Winston-Salem for April 2025

We rank Javara Research, F5 Sports and Triad Semiconductor in Winston-Salem along with 31 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Winston-Salem startup ecosystem ranks #387 globally and #113 in United States.

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Best Startups in Winston-Salem for 2025

SB Score:398

Javara is an innovative Integrated Research Organization (IRO) revolutionizing the clinical research process. They aim to enhance the experience for all involved by providing comprehensive services and solutions.

Industry:
Healthtech
Subindustry:
Health-Other

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SB Score:368

F5 Sports utilizes body movement data to enhance player performance through real-time insights. Their pitchLogic ball and mobile apps aid players in training efficiently and achieving success in games of all levels.

Industry:
Social & Leisure
Subindustry:
Sports

National Rank (United States)

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SB Score:353

Triad Semiconductor specializes in developing customizable analog and digital technology for mixed-signal ASICs. They create prototypes for various applications in the market, offering innovative solutions to meet unique design needs.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

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SB Score:329

Fluree leverages decentralized apps and a blockchain database for streamlined, secure data management. Their innovative platform offers a seamless user experience, empowering businesses to harness the power of blockchain technology for improved efficiency and transparency.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

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Regional Rank (North America)

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SB Score:307

Introducing a revolutionary closed-loop fashion economy solution. This startup enables users to easily recycle and upcycle clothing items, promoting sustainable practices in the fashion industry. Join the movement towards a more environmentally friendly future.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:300

Titan's Next Generation Mining Pool offers a powerful North American alternative and a way for the continent’s Bitcoin miners to achieve the efficiency and scale enjoyed by miners in other regions. We offer a highly efficient public (permissioned) and private Bitcoin Mining Pool Services. For more information please visit titan.io. Built by miners for miners, Titan makes mining easy, profitable, and scalable. Titan was formed and founded within Bloq in 2018, by Ryan Condron, Jeff Garzik and Matthew Roszak. Most mining management software options are either incomplete or difficult to scale.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

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SB Score:290

Precise Bio is a regenerative medicine company based in Winston-Salem, North Carolina, specializing in the development and commercialization of 4D bio-fabricated functional tissues and organs, aiming to revolutionize healthcare by providing innovative solutions for tissue and organ replacement.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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SB Score:289

Wellnecity revolutionizes healthcare interactions for employers and employees through innovative technology solutions. Their platform streamlines access to healthcare services, creating a seamless experience for all users.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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SB Score:287

SWIPEBY empowers suburban restaurants with automated curbside service to boost sales and loyalty.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:272

MOMI Brands, based in Winston-Salem, NC, creates innovative products that mimic the natural nursing experience. Founded in 2019, the startup is dedicated to developing and bringing to market solutions that support breastfeeding and maternal health.

Industry:
Social & Leisure
Subindustry:
Social & Leisure-Other

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SB Score:261

Piedmont Stone Center offers non-surgical treatment for kidney stones using Extracorporal Shock Wave Lithotripsy (ESWL). Patients can experience relief from kidney stones without undergoing surgery, thanks to this innovative technology.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Total amount:34

Top 14 Healthtech Startups in Winston-Salem for 2025

The top three Healthtech startups in Winston-Salem have raised more than USD 87.2M. Winston-Salem startup ecosystem ranks #184 globally for the Healthtech industry.
SB Score:398

Javara is an innovative Integrated Research Organization (IRO) revolutionizing the clinical research process. They aim to enhance the experience for all involved by providing comprehensive services and solutions.

Industry:
Healthtech
Subindustry:
Health-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:290

Precise Bio is a regenerative medicine company based in Winston-Salem, North Carolina, specializing in the development and commercialization of 4D bio-fabricated functional tissues and organs, aiming to revolutionize healthcare by providing innovative solutions for tissue and organ replacement.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:289

Wellnecity revolutionizes healthcare interactions for employers and employees through innovative technology solutions. Their platform streamlines access to healthcare services, creating a seamless experience for all users.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:14

Top 9 Software & Data Startups in Winston-Salem for 2025

The top three Software & Data startups in Winston-Salem have raised more than USD 46.8M. Winston-Salem startup ecosystem ranks #447 globally for the Software & Data industry.
SB Score:329

Fluree leverages decentralized apps and a blockchain database for streamlined, secure data management. Their innovative platform offers a seamless user experience, empowering businesses to harness the power of blockchain technology for improved efficiency and transparency.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:300

Titan's Next Generation Mining Pool offers a powerful North American alternative and a way for the continent’s Bitcoin miners to achieve the efficiency and scale enjoyed by miners in other regions. We offer a highly efficient public (permissioned) and private Bitcoin Mining Pool Services. For more information please visit titan.io. Built by miners for miners, Titan makes mining easy, profitable, and scalable. Titan was formed and founded within Bloq in 2018, by Ryan Condron, Jeff Garzik and Matthew Roszak. Most mining management software options are either incomplete or difficult to scale.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:287

SWIPEBY empowers suburban restaurants with automated curbside service to boost sales and loyalty.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:9

Top 4 Ecommerce & Retail Startups in Winston-Salem for 2025

The top three Ecommerce & Retail startups in Winston-Salem have raised more than USD 2.51M. Winston-Salem startup ecosystem ranks #283 globally for the Ecommerce & Retail industry.
SB Score:307

Introducing a revolutionary closed-loop fashion economy solution. This startup enables users to easily recycle and upcycle clothing items, promoting sustainable practices in the fashion industry. Join the movement towards a more environmentally friendly future.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:111

Rent Assured is an award-winning company revolutionizing the rental industry with cutting-edge PropTech. Their innovative solution digitizes workflows, enhances transparency, and benefits all involved in the tenancy process.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

National Rank (United States)

0

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Regional Rank (North America)

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Village Juice & Kitchen, founded in 2015 and based in Winston-Salem, North Carolina, offers an array of fresh, in-house juices, including pressed, squeezed, ground, pureed, mixed, chopped, and crafted varieties. Their commitment to quality and creativity delivers vibrant flavors to juice enthusiasts.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:4

Most Funded Startups in Winston-Salem for 2025

The top three most funded startups in Winston-Salem have raised total funding of more than USD 131M. Javara Research has 0.77% more funding than Triad Semiconductor.
SB Score:398

Javara is an innovative Integrated Research Organization (IRO) revolutionizing the clinical research process. They aim to enhance the experience for all involved by providing comprehensive services and solutions.

Industry:
Healthtech
Subindustry:
Health-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:353

Triad Semiconductor specializes in developing customizable analog and digital technology for mixed-signal ASICs. They create prototypes for various applications in the market, offering innovative solutions to meet unique design needs.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:329

Fluree leverages decentralized apps and a blockchain database for streamlined, secure data management. Their innovative platform offers a seamless user experience, empowering businesses to harness the power of blockchain technology for improved efficiency and transparency.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:34

Top Hiring Startups in Winston-Salem by Employee Number

The top three hiring startups in Winston-Salem have an median employee size that is between [101-250]
SB Score:398

Javara is an innovative Integrated Research Organization (IRO) revolutionizing the clinical research process. They aim to enhance the experience for all involved by providing comprehensive services and solutions.

Industry:
Healthtech
Subindustry:
Health-Other

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:353

Triad Semiconductor specializes in developing customizable analog and digital technology for mixed-signal ASICs. They create prototypes for various applications in the market, offering innovative solutions to meet unique design needs.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:329

Fluree leverages decentralized apps and a blockchain database for streamlined, secure data management. Their innovative platform offers a seamless user experience, empowering businesses to harness the power of blockchain technology for improved efficiency and transparency.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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View full page
SB Score:287

SWIPEBY empowers suburban restaurants with automated curbside service to boost sales and loyalty.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:34

Explore the Startup Ecosystem of Winston-Salem

National Rank

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Regional Rank

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127th

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Global Rank

(WorldWide)

387th

20

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
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1
37.971
00.00
00.00
00.00
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0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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