101 Top startups in Waltham for April 2025

We rank Fresenius Medical Care West Scranton, Digital Guardian and Alignable in Waltham along with 98 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Waltham is part of Boston Area startup ecosystem which ranks #5 globally and #4 in North America.

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Top Unicorn Startups in Waltham for 2025

Two startups have achieved unicorn status by exceeding USD 1 billion in valuation. Collectively, the top two unicorns in Waltham have raised more than USD 13.9B.
SB Score:677

Devoted Health provides personalized healthcare plans for seniors, offering dedicated guides and cutting-edge technology.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:412

BostonGene is a leading biomedical software company specializing in cutting-edge solutions for personalized cancer treatment. Their innovative technology enables healthcare providers to tailor therapies to individual patients, improving outcomes and transforming the future of cancer care.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:2

Best Startups in Waltham for 2025

SB Score:546

Digital Guardian provides the industry’s only data protection platform that is purpose-built to stop data theft from both insiders and external adversaries. The Digital Guardian Data Protection Platform performs across the corporate network, traditional endpoints, and cloud applications. It's buttressed by the DG Cloud, a big data security analytics backend that sees and blocks all threats to sensitive information. For more than 15 years, it has enabled data-rich organizations to protect their most valuable assets with a choice of on premises, SaaS or managed service deployment. Digital Guardian’s unique data awareness, combined with threat detection and response, enables organizations to protect data without slowing the pace of their business. It was founded in 2003 and is headquartered in Waltham, Massachusetts, United States.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:518

Alignable empowers local businesses to network, market, and support their communities. It provides a platform for businesses to grow together, shifting power back to the local level.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:493

Eleanor Health offers accessible mental health and substance use disorder treatment through clinics, virtual platforms, and in-home services. Receive comprehensive care from qualified professionals to support your journey to wellness.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:485

CallMiner offers AI-driven speech and customer interaction analysis. Enhance customer service and boost efficiency with their cutting-edge technology.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:479

LumiraDx empowers users to improve healthcare, social care, and financial outcomes at a reasonable cost. With LumiraDx, achieving better health and financial stability is more accessible and efficient.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:471

connectRN is a tech platform that enhances clinicians' lives by offering a supportive community, networking opportunities, and access to resources.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:465

PaymentWorks is a secure platform helping businesses prevent B2B payment fraud and stay compliant. Mitigate risk and ensure regulatory adherence with ease.

Industry:
Software & Data
Subindustry:
Cybersecurity

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SB Score:451

Vecna Robotics provides innovative solutions for automating material handling, optimizing workflows, and streamlining fulfillment processes. Their technologies seamlessly integrate into existing operations to increase efficiency and productivity.

Industry:
Transportation
Subindustry:
Logistics

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SB Score:444

Cogent Biosciences uses proprietary T-cell engineering technology in combination with tumor-targeting antibodies to activate the body’s own immune system to fight cancer. Unum’s lead program, based on its antibody-coupled T-cell receptor technology, is expected to enter Phase I clinical testing in the coming months to assess safety and efficacy.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:434

InterWell Health, a partnership between Fresenius Medical Care North America, is a physician-focused healthcare initiative. Offering nationwide services, it aims to enhance the healthcare experience through collaboration and innovation.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:101

Top 42 Healthtech Startups in Waltham for 2025

The top three Healthtech startups in Waltham have raised more than USD 1.11B. Waltham is part of Boston Area startup ecosystem which ranks #2 globally for the Healthtech industry.
SB Score:493

Eleanor Health offers accessible mental health and substance use disorder treatment through clinics, virtual platforms, and in-home services. Receive comprehensive care from qualified professionals to support your journey to wellness.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:479

LumiraDx empowers users to improve healthcare, social care, and financial outcomes at a reasonable cost. With LumiraDx, achieving better health and financial stability is more accessible and efficient.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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Total amount:42

Top 25 Software & Data Startups in Waltham for 2025

The top three Software & Data startups in Waltham have raised more than USD 646M. Waltham is part of Boston Area startup ecosystem which ranks #5 globally for the Software & Data industry.
SB Score:546

Digital Guardian provides the industry’s only data protection platform that is purpose-built to stop data theft from both insiders and external adversaries. The Digital Guardian Data Protection Platform performs across the corporate network, traditional endpoints, and cloud applications. It's buttressed by the DG Cloud, a big data security analytics backend that sees and blocks all threats to sensitive information. For more than 15 years, it has enabled data-rich organizations to protect their most valuable assets with a choice of on premises, SaaS or managed service deployment. Digital Guardian’s unique data awareness, combined with threat detection and response, enables organizations to protect data without slowing the pace of their business. It was founded in 2003 and is headquartered in Waltham, Massachusetts, United States.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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SB Score:518

Alignable empowers local businesses to network, market, and support their communities. It provides a platform for businesses to grow together, shifting power back to the local level.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

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Regional Rank (North America)

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SB Score:485

CallMiner offers AI-driven speech and customer interaction analysis. Enhance customer service and boost efficiency with their cutting-edge technology.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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Total amount:25

Top 4 Ecommerce & Retail Startups in Waltham for 2025

The top three Ecommerce & Retail startups in Waltham have raised more than USD 465M. Waltham is part of Boston Area startup ecosystem which ranks #11 globally for the Ecommerce & Retail industry.
SB Score:418

TakeOff empowers grocers with an automated software platform for e-Commerce success. Boost your online presence and streamline operations with our innovative solution.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

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SB Score:312

Peach provides women with high-quality, stylish athletic wear, essential basics, and intimate apparel. Offering a range of premium clothing, Peach aims to empower women to feel confident and comfortable in their everyday activities.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

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SB Score:294

SeQure DX offers secure data exchange services for non-commercial sites. Simplifying data sharing with advanced encryption technology, SeQure DX ensures confidentiality and integrity for all your digital information.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

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Total amount:4

Most Funded Startups in Waltham for 2025

The top three most funded startups in Waltham have raised total funding of more than USD 1.3B. CallMiner has 0.15% more funding than Upstream Bio.
SB Score:485

CallMiner offers AI-driven speech and customer interaction analysis. Enhance customer service and boost efficiency with their cutting-edge technology.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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Regional Rank (North America)

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SB Score:416

Upstream Bio focuses on developing an antibody therapy for the treatment of severe asthma. They are clinical-stage monoclonal antibodies that inhibit the TSLP receptor, a validated target located upstream of various signaling cascades that influence a range of immune cells that are important in common and unusual illnesses.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:418

TakeOff empowers grocers with an automated software platform for e-Commerce success. Boost your online presence and streamline operations with our innovative solution.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:101

Top Hiring Startups in Waltham by Employee Number

The top three hiring startups in Waltham have an median employee size that is between [1001-5000]
SB Score:546

Digital Guardian provides the industry’s only data protection platform that is purpose-built to stop data theft from both insiders and external adversaries. The Digital Guardian Data Protection Platform performs across the corporate network, traditional endpoints, and cloud applications. It's buttressed by the DG Cloud, a big data security analytics backend that sees and blocks all threats to sensitive information. For more than 15 years, it has enabled data-rich organizations to protect their most valuable assets with a choice of on premises, SaaS or managed service deployment. Digital Guardian’s unique data awareness, combined with threat detection and response, enables organizations to protect data without slowing the pace of their business. It was founded in 2003 and is headquartered in Waltham, Massachusetts, United States.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:479

LumiraDx empowers users to improve healthcare, social care, and financial outcomes at a reasonable cost. With LumiraDx, achieving better health and financial stability is more accessible and efficient.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:434

InterWell Health, a partnership between Fresenius Medical Care North America, is a physician-focused healthcare initiative. Offering nationwide services, it aims to enhance the healthcare experience through collaboration and innovation.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:101

Explore the Startup Ecosystem of Waltham

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

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Quantity Score
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Quality Score
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Business Score
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1st
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710.966
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251.377
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4th
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121.937
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4th
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5th
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109.679
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