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332 Top startups in St. Louis for July 2026

We rank Lumeris, Capacity and Clever Real Estate in St. Louis along with 329 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. St. Louis startup ecosystem ranks #119 globally and #39 in United States.

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Best Startups in St. Louis for 2026

1st
Lumeris logo
LumerisSB Score: 493

Lumeris is an accountable care delivery innovation company offering health systems, payers, and providers operational support, technology, and consulting services. Its innovative solutions help healthcare organizations design, build, operate, measure, and optimize any accountable care model to accomplish the Triple Aim Plus One: improved quality, cost, and patient and physician satisfaction.

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Website
lumeris.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$275.3M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Capacity logo
CapacitySB Score: 492

Capacity is a platform that offers AI support automation for customer and internal teams. It provides various tools, including intelligent virtual agents, agent assist, and conversational AI, to automate responses across multiple channels. The company also offers a unified knowledge base and integration with over 250 business systems and platforms.

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Website
capacity.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$153.8M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Clever Real Estate logo
Clever Real EstateSB Score: 471

Clever Real Estate is a company that specializes in the fields of commercial real estate and online marketplaces. It offers a software platform that guides its users through the process of interviewing real estate agents to find the right one for them. The company was founded in 2017 and is headquartered in St Louis, Missouri.

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Website
www.listwithclever.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$15.2M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
4th
SureCam logo
SureCamSB Score: 446

SureCam specializes in video telematics and GPS tracking solutions designed for fleet management. Their products include various dash cam options that capture critical footage and data to enhance safety and efficiency. With cloud storage and real-time monitoring, SureCam helps businesses reduce claims costs and improve driver accountability.

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Website
surecam.com
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
$16.1M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
5th
Summersalt logo
SummersaltSB Score: 439

Summersalt is a generation-defining apparel brand, providing wardrobe essentials for women who are going places. Summersalt launched in 2017 with swimwear made from recycled materials at a $95 price point — designer quality swimwear without the designer price tag. Since then, we’ve launched additional categories including loungewear, knitwear, sleepwear and activewear. Summersalt pieces are modern, sophisticated and fun, with an impeccable data-backed fit based on millions of measurements from over 10,000 women. In the few short years since our founding, Summersalt has built a loyal following of customers, influencers and celebrities, while garnering praise from leading fashion media including ELLE, Vogue and People.

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Website
www.summersalt.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$26.7M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
6th
Native Pet logo
Native PetSB Score: 437

Native Pet is a pet food and nutrition company that makes organic, highly effective, and limited-ingredient pet supplements for dogs and cats. The company develops proprietary formulas and formats, offering only the best, most innovative nutrition to directly benefit the health of pets.

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Website
nativepet.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$17.9M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
7th
PierianDx logo
PierianDxSB Score: 429

PierianDx is catalyzing global adoption of genomic sequencing in healthcare by empowering physicians in the laboratory and clinic to more effectively diagnose and treat patients with cancer and other complex diseases. PierianDx’s industry-leading genomic SaaS solutions, CAP and CLIA accredited laboratory, and shared knowledgebase are used by health systems, cancer centers and commercial laboratories worldwide driving the most integrated approach across the clinical care spectrum. From genomic sequencing and biomedical informatics in the laboratory to reporting and decision support at the patient’s bedside, PierianDx has rapidly become the trusted source of ‘wisdom’ in every advanced genomic report.

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Website
www.pieriandx.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$74M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
8th
Balto logo
BaltoSB Score: 426

Balto unites agents and supervisors with AI to power better agent performance. Agents and managers trust Balto's real-time guidance to prevent missed sales opportunities, costly compliance mistakes, and negative customer experiences. Empowering agents results in happier customers, increased revenue, and better retention. Today, Balto has guided over 150 million calls, provided over 185 million real-time recommendations, driven millions in increased revenue, and has a 4.8-star rating on G2. Balto is trusted by top contact centers, including National General Insurance, eHealth, American Homes for Rent, Spring Venture Group, and Cellular Sales. Want to learn more? Visit https://balto.ai.

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Website
balto.ai
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$57.6M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
9th
SteadyMD logo
SteadyMDSB Score: 425

SteadyMD is a B2B telehealth infrastructure provider that powers high-quality telehealth patient experiences for leaders and innovators in healthcare in all 50 states. The company was founded in 2016 as a first-of-its-kind concierge primary care service, direct-to-consumer, and completely online. Today, SteadyMD enables its partners to scale their telehealth offerings quickly and efficiently nationwide by offering a 50-state licensed clinician workforce, clinical operations, legal and regulatory guidance, and world-class product and technology. SteadyMD’s carefully curated community of thousands of board-certified clinicians are passionate about improving access to high-quality care by utilizing state-of-the-art delivery modalities and serving patients across the entire care spectrum.

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Website
www.steadymd.com
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
$35M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
10th
Battle Financial logo
Battle FinancialSB Score: 418

Battle Financial offers exceptional banking values and other financial services. Battle Bank is not open or approved at this time. The company was founded in 2021 and is based in Vail, Colorado, United States.

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Website
battlebank.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$98.7M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
11th
Engagedly logo
EngagedlySB Score: 417

With the Engagedly Platform, organisations can align and motivate their workforce. Features include Manager Feedback, Peer Praise, Idea Generation, Knowledge Sharing/eLearning, rewards, objectives alignment (OKR) & social performance. Engagedly is the most comprehensive tool available to drive Employee Engagement.

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Website
www.engagedly.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$1.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:190

Most Funded Startups in St. Louis for 2026

The top three most funded startups in St. Louis have raised total funding of more than USD 1.14B. Surround Care has 1.00% more funding than Wugen.
1st
Wugen logo
WugenSB Score: 387

Wugen is developing off-the-shelf cellular therapies for cancer. Our NK cell therapy products originate from healthy donors and are further manipulated in order to enhance their function to eliminate cancer cells. Our NK cell and CAR-T immuno-oncology therapies address the needs of patients with solid tumors, acute myeloid leukemia (AML) and T-cell malignancies.

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Website
www.wugen.com
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
$287M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Lumeris logo
LumerisSB Score: 493

Lumeris is an accountable care delivery innovation company offering health systems, payers, and providers operational support, technology, and consulting services. Its innovative solutions help healthcare organizations design, build, operate, measure, and optimize any accountable care model to accomplish the Triple Aim Plus One: improved quality, cost, and patient and physician satisfaction.

View Full Page
Website
lumeris.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$275.3M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Geneoscopy logo
GeneoscopySB Score: 385

Geneoscopy is a non-invasive colorectal cancer diagnostic powered by advanced research in computational biology. The company is determined to replace every patient’s least favorite screen: the colonoscopy. Currently, there is no test with high enough specificity and sensitivity to allow patients an alternative to the unpleasant, invasive colonoscopy. Geneoscopy is changing that. It has developed a novel methodology to reliably and consistently extract human RNA transcripts from stool samples and detect changes in gene expression. This provides Geneoscopy a platform to harness the power of RNA to detect, prevent, and guide treatment for gastrointestinal disease. Geneoscopy is currently developing a diagnostic test for the prevention of colorectal cancer and is conducting research on other applications of its technology for tangential indications.

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Website
www.geneoscopy.com
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
$217.9M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:190

Top Hiring Startups in St. Louis by Employee Number

The top three hiring startups in St. Louis have an median employee size that is between [1001-5000]
1st
Lumeris logo
LumerisSB Score: 493

Lumeris is an accountable care delivery innovation company offering health systems, payers, and providers operational support, technology, and consulting services. Its innovative solutions help healthcare organizations design, build, operate, measure, and optimize any accountable care model to accomplish the Triple Aim Plus One: improved quality, cost, and patient and physician satisfaction.

View Full Page
Website
lumeris.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$275.3M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Surround Care logo
Surround CareSB Score: 434

Surround Care focuses on fixing healthcare affordability, quality, access, and experience for all. Its mission is to fundamentally change how care is delivered by transforming care delivery and delivering transformative care

View Full Page
Website
surround-care.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$573.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
EmpowerMe Wellness logo
EmpowerMe WellnessSB Score: 394

EmpowerMe provides senior living communities with outstanding, integrated on-site therapy, diagnostics, and primary care services.

View Full Page
Website
www.empowerme.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$200K
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
4th
Hicuity Health logo
Hicuity HealthSB Score: 415

Hicuity Health is the nation’s leading provider of high acuity telehealth services, contracted to provide care to more than 115 hospitals in 30 states on a 24 x 7 x 365 basis. Hicuity Health is a technology-enabled clinical services provider that employs cutting edge tele-technology, U.S. board-certified intensivists, multiple dedicated tele-care delivery centers, and a proven implementation and client service approach to the benefit of patients, families, providers and hospitals.

View Full Page
Website
www.HicuityHealth.com
Employee range
501 – 1,000
Web Traffic (Monthly)
Funding amount
$26.7M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:332

Explore More Top Startups

Explore the Startup Ecosystem of St. Louis

National Rank

(United States)

39th

new

Regional Rank

(North America)

46th

3

Global Rank

(WorldWide)

119th

1

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal Score & National ShareAnnual Growth

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