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332 Top startups in St. Louis for June 2026

We rank Lumeris, Capacity and Clever Real Estate in St. Louis along with 329 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. St. Louis startup ecosystem ranks #119 globally and #39 in United States.

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Best Startups in St. Louis for 2026

SB Score:493

Lumeris is an accountable care delivery innovation company offering health systems, payers, and providers operational support, technology, and consulting services. Its innovative solutions help healthcare organizations design, build, operate, measure, and optimize any accountable care model to accomplish the Triple Aim Plus One: improved quality, cost, and patient and physician satisfaction.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:492

Capacity is a platform that offers AI support automation for customer and internal teams. It provides various tools, including intelligent virtual agents, agent assist, and conversational AI, to automate responses across multiple channels. The company also offers a unified knowledge base and integration with over 250 business systems and platforms.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:471

Clever Real Estate is a company that specializes in the fields of commercial real estate and online marketplaces. It offers a software platform that guides its users through the process of interviewing real estate agents to find the right one for them. The company was founded in 2017 and is headquartered in St Louis, Missouri.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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SB Score:446

SureCam specializes in video telematics and GPS tracking solutions designed for fleet management. Their products include various dash cam options that capture critical footage and data to enhance safety and efficiency. With cloud storage and real-time monitoring, SureCam helps businesses reduce claims costs and improve driver accountability.

Industry:
Transportation
Subindustry:
Logistics

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SB Score:439

Summersalt is a generation-defining apparel brand, providing wardrobe essentials for women who are going places. Summersalt launched in 2017 with swimwear made from recycled materials at a $95 price point — designer quality swimwear without the designer price tag. Since then, we’ve launched additional categories including loungewear, knitwear, sleepwear and activewear. Summersalt pieces are modern, sophisticated and fun, with an impeccable data-backed fit based on millions of measurements from over 10,000 women. In the few short years since our founding, Summersalt has built a loyal following of customers, influencers and celebrities, while garnering praise from leading fashion media including ELLE, Vogue and People.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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SB Score:437

Native Pet is a pet food and nutrition company that makes organic, highly effective, and limited-ingredient pet supplements for dogs and cats. The company develops proprietary formulas and formats, offering only the best, most innovative nutrition to directly benefit the health of pets.

Industry:
Foodtech
Subindustry:
Food and Beverage

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SB Score:434

Surround Care focuses on fixing healthcare affordability, quality, access, and experience for all. Its mission is to fundamentally change how care is delivered by transforming care delivery and delivering transformative care

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:429

PierianDx is catalyzing global adoption of genomic sequencing in healthcare by empowering physicians in the laboratory and clinic to more effectively diagnose and treat patients with cancer and other complex diseases. PierianDx’s industry-leading genomic SaaS solutions, CAP and CLIA accredited laboratory, and shared knowledgebase are used by health systems, cancer centers and commercial laboratories worldwide driving the most integrated approach across the clinical care spectrum. From genomic sequencing and biomedical informatics in the laboratory to reporting and decision support at the patient’s bedside, PierianDx has rapidly become the trusted source of ‘wisdom’ in every advanced genomic report.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:426

Balto unites agents and supervisors with AI to power better agent performance. Agents and managers trust Balto's real-time guidance to prevent missed sales opportunities, costly compliance mistakes, and negative customer experiences. Empowering agents results in happier customers, increased revenue, and better retention. Today, Balto has guided over 150 million calls, provided over 185 million real-time recommendations, driven millions in increased revenue, and has a 4.8-star rating on G2. Balto is trusted by top contact centers, including National General Insurance, eHealth, American Homes for Rent, Spring Venture Group, and Cellular Sales. Want to learn more? Visit https://balto.ai.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:425

SteadyMD is a B2B telehealth infrastructure provider that powers high-quality telehealth patient experiences for leaders and innovators in healthcare in all 50 states. The company was founded in 2016 as a first-of-its-kind concierge primary care service, direct-to-consumer, and completely online. Today, SteadyMD enables its partners to scale their telehealth offerings quickly and efficiently nationwide by offering a 50-state licensed clinician workforce, clinical operations, legal and regulatory guidance, and world-class product and technology. SteadyMD’s carefully curated community of thousands of board-certified clinicians are passionate about improving access to high-quality care by utilizing state-of-the-art delivery modalities and serving patients across the entire care spectrum.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:418

Battle Financial offers exceptional banking values and other financial services. Battle Bank is not open or approved at this time. The company was founded in 2021 and is based in Vail, Colorado, United States.

Industry:
Fintech
Subindustry:
Financial Services

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Total amount:332

Top 51 Healthtech Startups in St. Louis for 2026

The top three Healthtech startups in St. Louis have raised more than USD 1.14B. St. Louis startup ecosystem ranks #94 globally for the Healthtech industry.
SB Score:493

Lumeris is an accountable care delivery innovation company offering health systems, payers, and providers operational support, technology, and consulting services. Its innovative solutions help healthcare organizations design, build, operate, measure, and optimize any accountable care model to accomplish the Triple Aim Plus One: improved quality, cost, and patient and physician satisfaction.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (St. Louis)

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SB Score:434

Surround Care focuses on fixing healthcare affordability, quality, access, and experience for all. Its mission is to fundamentally change how care is delivered by transforming care delivery and delivering transformative care

Industry:
Healthtech
Subindustry:
Health Care

City Rank (St. Louis)

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SB Score:429

PierianDx is catalyzing global adoption of genomic sequencing in healthcare by empowering physicians in the laboratory and clinic to more effectively diagnose and treat patients with cancer and other complex diseases. PierianDx’s industry-leading genomic SaaS solutions, CAP and CLIA accredited laboratory, and shared knowledgebase are used by health systems, cancer centers and commercial laboratories worldwide driving the most integrated approach across the clinical care spectrum. From genomic sequencing and biomedical informatics in the laboratory to reporting and decision support at the patient’s bedside, PierianDx has rapidly become the trusted source of ‘wisdom’ in every advanced genomic report.

Industry:
Healthtech
Subindustry:
Biotechnology

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Total amount:51

Top 25 Foodtech Startups in St. Louis for 2026

The top three Foodtech startups in St. Louis have raised more than USD 66.1M. St. Louis startup ecosystem ranks #108 globally for the Foodtech industry.
SB Score:437

Native Pet is a pet food and nutrition company that makes organic, highly effective, and limited-ingredient pet supplements for dogs and cats. The company develops proprietary formulas and formats, offering only the best, most innovative nutrition to directly benefit the health of pets.

Industry:
Foodtech
Subindustry:
Food and Beverage

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SB Score:321

Pluton Biosciences tests and discovers microbes for the production of a variety of products, primarily pesticides, and pharmaceuticals. The company's platform mines and clones microbes to create a variety of useful products centered on biopesticides, crop protection, human health, and bioremediation.

Industry:
Foodtech
Subindustry:
Agtech

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SB Score:307

Solis Agrosciences is the trusted partner for high-quality AgTech research services. We generate gene-edited and transgenic crops, plant phenotype and efficacy data, and individually tailored research solutions for our startup and corporate customers. Solis’ highly trained and industry experienced scientists operate in state-of-the-art facilities in the 39 North Ag Biotech district of St. Louis, Missouri.

Industry:
Foodtech
Subindustry:
Agtech

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Total amount:25

Top 12 Transportation Startups in St. Louis for 2026

The top three Transportation startups in St. Louis have raised more than USD 39.9M. St. Louis startup ecosystem ranks #117 globally for the Transportation industry.
SB Score:446

SureCam specializes in video telematics and GPS tracking solutions designed for fleet management. Their products include various dash cam options that capture critical footage and data to enhance safety and efficiency. With cloud storage and real-time monitoring, SureCam helps businesses reduce claims costs and improve driver accountability.

Industry:
Transportation
Subindustry:
Logistics

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SB Score:347

Intramotev Autonomous Rail manufactures autonomous zero-emissions rail vehicles to advance the future of freight movement. Intramotev's vehicles provide efficient and cost-effective movement of materials across specialized private railroads for mines, manufacturing facilities, ports, and more that is autonomous and fully battery-electric, enabling rail and mining industries to get lower emissions than diesel-electric locomotives and diesel trucks, shorter stopping distance, and steeper grade capability than existing trains.

Industry:
Transportation
Subindustry:
Logistics

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SB Score:289

Whipz is a new online Used Car Dealership.Whipz specializes in getting people with all credit situations into cars, trucks, and SUV’s. We strive to give you the best experience.

Industry:
Transportation
Subindustry:
Automotive

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Total amount:12

Most Funded Startups in St. Louis for 2026

The top three most funded startups in St. Louis have raised total funding of more than USD 1.14B. Surround Care has 1.00% more funding than Wugen.
SB Score:434

Surround Care focuses on fixing healthcare affordability, quality, access, and experience for all. Its mission is to fundamentally change how care is delivered by transforming care delivery and delivering transformative care

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:387

Wugen is developing off-the-shelf cellular therapies for cancer. Our NK cell therapy products originate from healthy donors and are further manipulated in order to enhance their function to eliminate cancer cells. Our NK cell and CAR-T immuno-oncology therapies address the needs of patients with solid tumors, acute myeloid leukemia (AML) and T-cell malignancies.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:493

Lumeris is an accountable care delivery innovation company offering health systems, payers, and providers operational support, technology, and consulting services. Its innovative solutions help healthcare organizations design, build, operate, measure, and optimize any accountable care model to accomplish the Triple Aim Plus One: improved quality, cost, and patient and physician satisfaction.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (St. Louis)

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Total amount:332

Top Hiring Startups in St. Louis by Employee Number

The top three hiring startups in St. Louis have an median employee size that is between [1001-5000]
SB Score:493

Lumeris is an accountable care delivery innovation company offering health systems, payers, and providers operational support, technology, and consulting services. Its innovative solutions help healthcare organizations design, build, operate, measure, and optimize any accountable care model to accomplish the Triple Aim Plus One: improved quality, cost, and patient and physician satisfaction.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (St. Louis)

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SB Score:434

Surround Care focuses on fixing healthcare affordability, quality, access, and experience for all. Its mission is to fundamentally change how care is delivered by transforming care delivery and delivering transformative care

Industry:
Healthtech
Subindustry:
Health Care

City Rank (St. Louis)

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SB Score:415

Hicuity Health is the nation’s leading provider of high acuity telehealth services, contracted to provide care to more than 115 hospitals in 30 states on a 24 x 7 x 365 basis. Hicuity Health is a technology-enabled clinical services provider that employs cutting edge tele-technology, U.S. board-certified intensivists, multiple dedicated tele-care delivery centers, and a proven implementation and client service approach to the benefit of patients, families, providers and hospitals.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:332

Explore the Startup Ecosystem of St. Louis

National Rank

(United States)

39th

new

Regional Rank

(North America)

46th

3

Global Rank

(WorldWide)

119th

1

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal ScoreAnnual Growth

Access subscores for 1000 cities and 100 countries

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