StartupBlink

26 Top startups in Sioux Falls for October 2026

We rank Prismatic, C-Suite Network and RENEW Energy in Sioux Falls along with 23 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Sioux Falls startup ecosystem ranks #505 globally and #138 in United States.

Powered by

Category

Startups

Unicorns

Exits

Coworking Spaces

Accelerators

Best Startups in Sioux Falls for 2026

1st
Prismatic logo
PrismaticSB Score: 414

Prismatic is the leading embedded iPaaS, enabling B2B SaaS teams to ship product integrations faster and with less dev time. The only embedded iPaaS that empowers both developers and non-developers with tools for the complete integration lifecycle, Prismatic includes low-code and full-code building options, deployment and management tooling, and self-serve customer tools. Prismatic's unparalleled versatility lets teams deliver any integration from simple to complex in one powerful platform. SaaS companies worldwide, from startups to Fortune 500s, trust Prismatic to help connect their products to the other products their customers use.

View Full Page
Website
prismatic.io
Employee range
51 – 100
Web Traffic (Monthly)
—
Funding amount
$39.3M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
3rd
Custom One - Custom T-Shirt & Screen Printing logo

Jetpack.AI builds analytics-driven applications that improve the performance of business operations across all industries. We use the best-in-class technologies, including cloud infrastructure, big data technologies, ML/AI toolboxes and add a great deal of creative data-visualisations to democratise access and use of analytics across organisations.

View Full Page
Website
customoneonline.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
—
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
5th
ANI Pharmaceuticals logo
ANI PharmaceuticalsSB Score: 193

ANI Pharmaceuticals is a specialty pharmaceuticals industry that develops, manufactures and markets top-quality prescription pharmaceuticals, made in the U.S.A. ANI manufactures oral solid dose products, as well as liquids and topicals, including narcotics and those that must be manufactured in a fully contained environment due to their potency and/or toxicity. ANI also performs contract manufacturing for other pharmaceutical companies.

View Full Page
Website
www.anipharmaceuticals.com
Employee range
501 – 1,000
Web Traffic (Monthly)
—
Funding amount
—
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
6th
BlueDop Medical logo
BlueDop MedicalSB Score: 174

BlueDop Medical is a proprietary vascular expert software that gives healthcare providers useful and actionable information. The company is headquartered in Sioux Falls, South Dakota, United States.

View Full Page
Website
www.bluedop.com
Employee range
1 – 10
Web Traffic (Monthly)
—
Funding amount
$250K
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
7th
Lemonly logo
LemonlySB Score: 147

Lemonly is a visual marketing firm that specializes in infographics, interactive graphics, and UI/UX design. The company was founded by John Meyer and Amy Colgan in 2011. The company is based in Sioux Falls, South Dakota.

View Full Page
Website
lemonly.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
—
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
8th
Four Percent logo
Four PercentSB Score: 144

Four Percent is one of the fastest-growing communities for digital, modern-day entrepreneurs. We deliver world-class education, tools, resources, collaborations, and a community that helps entrepreneurs become great at what they do.

View Full Page
Website
fourpercent.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
—
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
9th
CoinLion logo
CoinLionSB Score: 133

CoinLion is a digital currency exchange and portfolio management platform that empowers users to navigate the complexities of digital assets. By incentivizing information sharing, it simplifies asset management and rewards participation, creating an engaging community focused on enhancing the digital investment experience.

View Full Page
Website
coinlion.com
Employee range
101 – 250
Web Traffic (Monthly)
—
Funding amount
—
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
10th
Spread Great Ideas logo
Spread Great IdeasSB Score: 112
EdtechEducation-Other

Spread Great Ideas is an amalgamation of sorts: Part podcasts and part writings, at first glance it’s likely seen as one of those Frankenstein endeavors potentially beloved only by its creator. Look closer, and you’ll see that there’s a unifying ethos to the brand: “To explore ideas in order to understand their genesis and their ramifications.” This is a fancy way of saying ideas have consequences, both intentional and unintentional.

View Full Page
Website
spreadgreatideas.org
Employee range
1 – 10
Web Traffic (Monthly)
—
Funding amount
—
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
11th
Dromo logo
DromoSB Score: 112

Dromo provides an end-to-end spreadsheet import flow that uses artificial intelligence to automatically match excel columns and decrease onboarding friction, giving users flexibility for data cleaning and validation.

View Full Page
Website
dromo.io
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
—
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—

Total amount:16

Most Funded Startups in Sioux Falls for 2026

The top three most funded startups in Sioux Falls have raised total funding of more than USD 50.5M. Prismatic has 2.93% more funding than Bridge Medicines.
1st
Prismatic logo
PrismaticSB Score: 414

Prismatic is the leading embedded iPaaS, enabling B2B SaaS teams to ship product integrations faster and with less dev time. The only embedded iPaaS that empowers both developers and non-developers with tools for the complete integration lifecycle, Prismatic includes low-code and full-code building options, deployment and management tooling, and self-serve customer tools. Prismatic's unparalleled versatility lets teams deliver any integration from simple to complex in one powerful platform. SaaS companies worldwide, from startups to Fortune 500s, trust Prismatic to help connect their products to the other products their customers use.

View Full Page
Website
prismatic.io
Employee range
51 – 100
Web Traffic (Monthly)
—
Funding amount
$39.3M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
3rd
BlueDop Medical logo
BlueDop MedicalSB Score: 174

BlueDop Medical is a proprietary vascular expert software that gives healthcare providers useful and actionable information. The company is headquartered in Sioux Falls, South Dakota, United States.

View Full Page
Website
www.bluedop.com
Employee range
1 – 10
Web Traffic (Monthly)
—
Funding amount
$250K
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—

Total amount:16

Top Hiring Startups in Sioux Falls by Employee Number

The top three hiring startups in Sioux Falls have an median employee size that is between [251-500]
1st
ANI Pharmaceuticals logo
ANI PharmaceuticalsSB Score: 193

ANI Pharmaceuticals is a specialty pharmaceuticals industry that develops, manufactures and markets top-quality prescription pharmaceuticals, made in the U.S.A. ANI manufactures oral solid dose products, as well as liquids and topicals, including narcotics and those that must be manufactured in a fully contained environment due to their potency and/or toxicity. ANI also performs contract manufacturing for other pharmaceutical companies.

View Full Page
Website
www.anipharmaceuticals.com
Employee range
501 – 1,000
Web Traffic (Monthly)
—
Funding amount
—
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
2nd
RENEW Energy logo
RENEW EnergySB Score: 274

RENEW Energy is a renewables & environment company that provides wind and solar power maintenance services. RENEW Energy has extensive experience with all major wind turbine makes and models. From construction, maintenance, and testing to handling highly complex and technical jobs. RENEW Energy is in charge of construction as well as preventive and corrective maintenance.

View Full Page
Website
renewenergy.com
Employee range
251 – 500
Web Traffic (Monthly)
—
Funding amount
$1.2M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
3rd
CoinLion logo
CoinLionSB Score: 133

CoinLion is a digital currency exchange and portfolio management platform that empowers users to navigate the complexities of digital assets. By incentivizing information sharing, it simplifies asset management and rewards participation, creating an engaging community focused on enhancing the digital investment experience.

View Full Page
Website
coinlion.com
Employee range
101 – 250
Web Traffic (Monthly)
—
Funding amount
—
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
4th
Prismatic logo
PrismaticSB Score: 414

Prismatic is the leading embedded iPaaS, enabling B2B SaaS teams to ship product integrations faster and with less dev time. The only embedded iPaaS that empowers both developers and non-developers with tools for the complete integration lifecycle, Prismatic includes low-code and full-code building options, deployment and management tooling, and self-serve customer tools. Prismatic's unparalleled versatility lets teams deliver any integration from simple to complex in one powerful platform. SaaS companies worldwide, from startups to Fortune 500s, trust Prismatic to help connect their products to the other products their customers use.

View Full Page
Website
prismatic.io
Employee range
51 – 100
Web Traffic (Monthly)
—
Funding amount
$39.3M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—

Total amount:26

Explore More Top Startups

Explore the Startup Ecosystem of Sioux Falls

National Rank

(United States)

138th

new

Regional Rank

(North America)

166th

2

Global Rank

(WorldWide)

505th

3

Visit

Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal Score & National ShareAnnual Growth

Access subscores for 1000 cities and 100 countries

Quantity Score
Quality ScoreBusiness Score
1st
0
1st
0
935.32535.2%
0.0%
00.00
00.00
00.00
2nd
0
2nd
0
352.15913.3%
0.0%
00.00
00.00
00.00
3rd
0
4th
0
152.3715.7%
0.0%
00.00
00.00
00.00
4th
0
5th
+
1
127.1194.8%
0.0%
00.00
00.00
00.00
Microsoft Excel icon
Download CSV file