StartupBlink

31 Top startups in Santa Clarita for June 2026

We rank Scorpion, PayForward and SetPoint Medical in Santa Clarita along with 28 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Santa Clarita is part of Los Angeles Area startup ecosystem which ranks #4 globally and #3 in North America.

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Best Startups in Santa Clarita for 2026

SB Score:566

Scorpion provides technologies and services to help businesses. Their service-oriented businesses provide web design, search engine optimization, social media management, paid search advertising, content creation, video production, tracking, and analytics.

Industry:
Marketing & Sales
Subindustry:
Adtech

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SB Score:431

PayForward is a financial technology company that provides reward incentives, fast money transfers, and customized engagement solutions. The company's platform enables members to earn instant cash by shopping at participating merchant partners such as restaurants, retail stores, grocers, and more by using prepaid debit cards and receiving instant rebates, points that can be used to donate to any charitable organization or to shop further.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:426

SetPoint Medical is a company that developed a device-based therapeutic approach for treating rheumatoid arthritis. The company's product, the SetPoint System, is a small, wireless implantable device that stimulates the vagus nerve to reduce inflammation. The therapy is an approach for adults with active rheumatoid arthritis who have not responded to other treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:389

Valencia Technologies develops neuromodulation devices to treat urinary incontinence. The company manufactures and markets the eCoin system, an FDA-approved subcutaneous implantable tibial nerve stimulator for Urge Urinary Incontinence (UUI). The eCoin device, a small neurostimulator implanted under the skin near the ankle, delivers automatic tibial nerve stimulation through a dome-shaped field. The procedure is minimally invasive, requiring only local anesthesia. The device is designed to function without external remotes, lead wires, recharge requirements, or the need for general anesthesia during placement.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:375

Kadenze operates in the technology industry. It was founded in 2013 and is based in Valencia, California.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:371

H2scan Corporation is headquartered in Valencia, California, and was formed September 18, 2002 through an MBO with capital assistance from Vancouver-based Chrysalix Energy Limited Partnership and Ravinia Venture Fund. The company was created upon the purchase of all sensor assets of DCH Sensor Corporation. Ballard Power Systems Inc., Shell Hydrogen, and Duke Energy formed Chrysalix (www.chrysalix.com) in July 2001. This Partnership has since been joined by The BOC Group, BASF Venture Capital, The Mitsubishi Corporation. The fundamental technology of H2scan sensor systems was developed by the U.S. National Laboratory at Sandia. H2scan has significantly improved upon this technology through US patents and manufacturing trade secrets.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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SB Score:369

Tombot specializes in creating robotic animals and digital health solutions. The company targets a market of over 200 million individuals living with dementia or pre-dementia mild cognitive impairment. Research has demonstrated that robotic animals can effectively alleviate behavioral and psychological symptoms associated with dementia, including loneliness, anxiety, depression, hallucinations, and violent anger, while also reducing the dependence on harmful psychotropic medications. Tombot’s mission is encapsulated in its tagline, "A dog for people who can’t have dogs.

Industry:
Healthtech
Subindustry:
Assisted Living

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SB Score:333

CELITECH is an award-winning premium connectivity platform for global travel companies and their customers & employees. Our highly secure US-hosted & US-made eSIM solution delivers affordable, best-in-class cellular data service in 160+ countries. We power travel-related companies to generate new revenues and mobile engagement while helping their travelers save 80% on data roaming. Reach out to learn how we rock your world.

Industry:
Software & Data
Subindustry:
Cloud

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SB Score:322

Tatum Games is helping indie game developers and small game studios reclaim billions of dollars (worldwide) lost due to their lack of comparable industry data and difficulty to identify their most valuable users. They combine cutting-edge technology solutions and community engagement, upskilling and employment opportunities for marginalized and underserved individuals. Their flagship product, MIKROS, is a specialized data analytics platform that reduces risks and product failure by focusing on improving user acquisition, retention, and revenue. Beyond their technology, they are committed to social impact. At their hosted events in South LA they have donated over 100+ computers for free to kids, teens, and young adults to cultivate their learning. They engage attendees in hands-on technology skill development workshops alongside other industry professionals from major game studios such as Riot Games, Bethesda, Microsoft and more.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:264

Help Worldwide generates continuous charitable donations with everyday shopping. HELP stands for the “Humanitarian Empowerment Loyalty Platform” and its goal is to help support humanity. It uses a universal loyalty card that connects shoppers, businesses, and their favorite charities in a single network that rewards everyone. The result is more rebates, a growing list of stores to shop with, and increased donations to more charities. It was founded in 2000 and is headquartered in Santa Clarita, California.

Industry:
Social & Leisure
Subindustry:
Communities

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SB Score:248

Hart & Main offers an event venue with indoor and outdoor options to fit any occasion. Its space is well equipped with a full commercial kitchen and bar, a beautiful rooftop deck, bridal and groom suites and will feature a Mid-century vibe. The company is owned by Rob and Lisa Younkin and is based in Newhall, California.

Industry:
Social & Leisure
Subindustry:
Entertainment

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Total amount:31

SB Score:566

Scorpion provides technologies and services to help businesses. Their service-oriented businesses provide web design, search engine optimization, social media management, paid search advertising, content creation, video production, tracking, and analytics.

Industry:
Marketing & Sales
Subindustry:
Adtech

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SB Score:431

PayForward is a financial technology company that provides reward incentives, fast money transfers, and customized engagement solutions. The company's platform enables members to earn instant cash by shopping at participating merchant partners such as restaurants, retail stores, grocers, and more by using prepaid debit cards and receiving instant rebates, points that can be used to donate to any charitable organization or to shop further.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:426

SetPoint Medical is a company that developed a device-based therapeutic approach for treating rheumatoid arthritis. The company's product, the SetPoint System, is a small, wireless implantable device that stimulates the vagus nerve to reduce inflammation. The therapy is an approach for adults with active rheumatoid arthritis who have not responded to other treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Santa Clarita)

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Regional Rank (North America)

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Total amount:31

SB Score:566

Scorpion provides technologies and services to help businesses. Their service-oriented businesses provide web design, search engine optimization, social media management, paid search advertising, content creation, video production, tracking, and analytics.

Industry:
Marketing & Sales
Subindustry:
Adtech

City Rank (Santa Clarita)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:431

PayForward is a financial technology company that provides reward incentives, fast money transfers, and customized engagement solutions. The company's platform enables members to earn instant cash by shopping at participating merchant partners such as restaurants, retail stores, grocers, and more by using prepaid debit cards and receiving instant rebates, points that can be used to donate to any charitable organization or to shop further.

Industry:
Fintech
Subindustry:
Financial Services

City Rank (Santa Clarita)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:426

SetPoint Medical is a company that developed a device-based therapeutic approach for treating rheumatoid arthritis. The company's product, the SetPoint System, is a small, wireless implantable device that stimulates the vagus nerve to reduce inflammation. The therapy is an approach for adults with active rheumatoid arthritis who have not responded to other treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Santa Clarita)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:31

SB Score:566

Scorpion provides technologies and services to help businesses. Their service-oriented businesses provide web design, search engine optimization, social media management, paid search advertising, content creation, video production, tracking, and analytics.

Industry:
Marketing & Sales
Subindustry:
Adtech

City Rank (Santa Clarita)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:431

PayForward is a financial technology company that provides reward incentives, fast money transfers, and customized engagement solutions. The company's platform enables members to earn instant cash by shopping at participating merchant partners such as restaurants, retail stores, grocers, and more by using prepaid debit cards and receiving instant rebates, points that can be used to donate to any charitable organization or to shop further.

Industry:
Fintech
Subindustry:
Financial Services

City Rank (Santa Clarita)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:426

SetPoint Medical is a company that developed a device-based therapeutic approach for treating rheumatoid arthritis. The company's product, the SetPoint System, is a small, wireless implantable device that stimulates the vagus nerve to reduce inflammation. The therapy is an approach for adults with active rheumatoid arthritis who have not responded to other treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Santa Clarita)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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Total amount:31

Most Funded Startups in Santa Clarita for 2026

The top three most funded startups in Santa Clarita have raised total funding of more than USD 535M. SetPoint Medical has 2.89% more funding than Scorpion.
SB Score:426

SetPoint Medical is a company that developed a device-based therapeutic approach for treating rheumatoid arthritis. The company's product, the SetPoint System, is a small, wireless implantable device that stimulates the vagus nerve to reduce inflammation. The therapy is an approach for adults with active rheumatoid arthritis who have not responded to other treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Santa Clarita)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:566

Scorpion provides technologies and services to help businesses. Their service-oriented businesses provide web design, search engine optimization, social media management, paid search advertising, content creation, video production, tracking, and analytics.

Industry:
Marketing & Sales
Subindustry:
Adtech

City Rank (Santa Clarita)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:389

Valencia Technologies develops neuromodulation devices to treat urinary incontinence. The company manufactures and markets the eCoin system, an FDA-approved subcutaneous implantable tibial nerve stimulator for Urge Urinary Incontinence (UUI). The eCoin device, a small neurostimulator implanted under the skin near the ankle, delivers automatic tibial nerve stimulation through a dome-shaped field. The procedure is minimally invasive, requiring only local anesthesia. The device is designed to function without external remotes, lead wires, recharge requirements, or the need for general anesthesia during placement.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Santa Clarita)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:31

Top Hiring Startups in Santa Clarita by Employee Number

The top three hiring startups in Santa Clarita have an median employee size that is between [101-250]
SB Score:566

Scorpion provides technologies and services to help businesses. Their service-oriented businesses provide web design, search engine optimization, social media management, paid search advertising, content creation, video production, tracking, and analytics.

Industry:
Marketing & Sales
Subindustry:
Adtech

City Rank (Santa Clarita)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

Browse
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SB Score:389

Valencia Technologies develops neuromodulation devices to treat urinary incontinence. The company manufactures and markets the eCoin system, an FDA-approved subcutaneous implantable tibial nerve stimulator for Urge Urinary Incontinence (UUI). The eCoin device, a small neurostimulator implanted under the skin near the ankle, delivers automatic tibial nerve stimulation through a dome-shaped field. The procedure is minimally invasive, requiring only local anesthesia. The device is designed to function without external remotes, lead wires, recharge requirements, or the need for general anesthesia during placement.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Santa Clarita)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:431

PayForward is a financial technology company that provides reward incentives, fast money transfers, and customized engagement solutions. The company's platform enables members to earn instant cash by shopping at participating merchant partners such as restaurants, retail stores, grocers, and more by using prepaid debit cards and receiving instant rebates, points that can be used to donate to any charitable organization or to shop further.

Industry:
Fintech
Subindustry:
Financial Services

City Rank (Santa Clarita)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

Browse
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SB Score:426

SetPoint Medical is a company that developed a device-based therapeutic approach for treating rheumatoid arthritis. The company's product, the SetPoint System, is a small, wireless implantable device that stimulates the vagus nerve to reduce inflammation. The therapy is an approach for adults with active rheumatoid arthritis who have not responded to other treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Santa Clarita)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:31

Explore the Startup Ecosystem of Santa Clarita

National Rank

(United States)

new

Regional Rank

(North America)

3rd

0

Global Rank

(WorldWide)

4th

0

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal ScoreAnnual Growth

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Quality ScoreBusiness Score
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152.371
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127.119
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