40 Top startups in San Luis Obispo for April 2025

We rank Flume, Pashion Footwear and Postal in San Luis Obispo along with 37 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. San Luis Obispo startup ecosystem ranks #431 globally and #126 in United States.

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Best Startups in San Luis Obispo for 2025

SB Score:411

Flume is dedicated to conserving water and safeguarding homes by providing homeowners and communities with real-time water usage data. Founded in 2016 and based in San Luis Obispo, California, Flume empowers users to monitor their water consumption, helping to eliminate waste and promote sustainable practices.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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SB Score:380

Pashion has transformed footwear with its innovative convertible heel-to-flat technology, allowing wearers to effortlessly switch between heels and flats. This groundbreaking design combines style and comfort, providing the ultimate versatility for modern lifestyles. Users can now enjoy the best of both worlds in a single pair of shoes.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

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SB Score:377

Automated direct mail and gifting that integrates into sales and marketing workflows

Industry:
Software & Data
Subindustry:
Software

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SB Score:363

King Energy is an innovative energy company that brings solar power solutions to multi-tenant commercial properties. By leasing unused roof space from property owners, King Energy manages the financing, installation, and long-term maintenance of solar infrastructure, simplifying the transition to renewable energy for all stakeholders involved.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:315

StudentRoomStay (SRS) empowers international students and fellows by facilitating hosted accommodations and promoting cross-cultural connections worldwide, creating a supportive community that enhances their global experiences.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

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SB Score:312

FarmBot offers design and engineering hardware kits and software services. Their innovative products help users efficiently manage their farms with precision and ease.

Industry:
Foodtech
Subindustry:
Agtech

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SB Score:304

Welkio's mobile visitor platform streamlines office check-ins by collecting and storing visitor information with a user-friendly tablet interface. Easily capture names, emails, photos, and signatures for legal agreements.

Industry:
Software & Data
Subindustry:
Apps

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SB Score:296

Rx Redefined empowers physicians to provide specialized medical products to patients through a seamless logistics platform. Founded in 2018 by Brandon Boots and Erik Smith, the Oakland-based company offers innovative healthcare solutions.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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SB Score:293

Hello Work offers customizable template software for creating portfolio websites for top-tier photographers and architects. The user-friendly admin tool allows for precise design without needing to code. It's the industry's only front-facing application for website construction and design.

Industry:
Social & Leisure
Subindustry:
Arts

National Rank (United States)

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SB Score:288

Novocuff is a medical device company dedicated to enhancing pregnancy outcomes and minimizing preterm deliveries associated with preterm premature rupture of membranes (PPROM) and cervical shortening. Their innovative solutions aim to support expectant mothers and improve maternal and infant health.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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Total amount:40

Top 14 Software & Data Startups in San Luis Obispo for 2025

The top three Software & Data startups in San Luis Obispo have raised more than USD 49.4M. San Luis Obispo startup ecosystem ranks #364 globally for the Software & Data industry.
SB Score:377

Automated direct mail and gifting that integrates into sales and marketing workflows

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

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Regional Rank (North America)

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SB Score:304

Welkio's mobile visitor platform streamlines office check-ins by collecting and storing visitor information with a user-friendly tablet interface. Easily capture names, emails, photos, and signatures for legal agreements.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

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Regional Rank (North America)

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SB Score:285

Fundsquire empowers entrepreneurs to accelerate their growth by providing access to R&D tax credits months before they receive a low-interest business loan. They specialize in research and development tax credit loans, grant advance funding, and revenue-based financing, helping businesses secure vital resources to thrive.

National Rank (United States)

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Regional Rank (North America)

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Total amount:14

Top 4 Hardware & IoT Startups in San Luis Obispo for 2025

The top three Hardware & IoT startups in San Luis Obispo have raised more than USD 60.9M. San Luis Obispo startup ecosystem ranks #189 globally for the Hardware & IoT industry.
SB Score:411

Flume is dedicated to conserving water and safeguarding homes by providing homeowners and communities with real-time water usage data. Founded in 2016 and based in San Luis Obispo, California, Flume empowers users to monitor their water consumption, helping to eliminate waste and promote sustainable practices.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

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Regional Rank (North America)

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SB Score:250

A comprehensive PV soiling monitoring solution for solar array stakeholders. Monitor and optimize system performance with ease.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:4

Top 5 Healthtech Startups in San Luis Obispo for 2025

The top three Healthtech startups in San Luis Obispo have raised more than USD 45.6M. San Luis Obispo startup ecosystem ranks #290 globally for the Healthtech industry.
SB Score:296

Rx Redefined empowers physicians to provide specialized medical products to patients through a seamless logistics platform. Founded in 2018 by Brandon Boots and Erik Smith, the Oakland-based company offers innovative healthcare solutions.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:288

Novocuff is a medical device company dedicated to enhancing pregnancy outcomes and minimizing preterm deliveries associated with preterm premature rupture of membranes (PPROM) and cervical shortening. Their innovative solutions aim to support expectant mothers and improve maternal and infant health.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:5

Most Funded Startups in San Luis Obispo for 2025

The top three most funded startups in San Luis Obispo have raised total funding of more than USD 86.8M. WhiteFox Defense Technologies has 0.44% more funding than Novocuff.
SB Score:377

Automated direct mail and gifting that integrates into sales and marketing workflows

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:288

Novocuff is a medical device company dedicated to enhancing pregnancy outcomes and minimizing preterm deliveries associated with preterm premature rupture of membranes (PPROM) and cervical shortening. Their innovative solutions aim to support expectant mothers and improve maternal and infant health.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:40

Top Hiring Startups in San Luis Obispo by Employee Number

The top three hiring startups in San Luis Obispo have an median employee size that is between [51-100]
SB Score:296

Rx Redefined empowers physicians to provide specialized medical products to patients through a seamless logistics platform. Founded in 2018 by Brandon Boots and Erik Smith, the Oakland-based company offers innovative healthcare solutions.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:411

Flume is dedicated to conserving water and safeguarding homes by providing homeowners and communities with real-time water usage data. Founded in 2016 and based in San Luis Obispo, California, Flume empowers users to monitor their water consumption, helping to eliminate waste and promote sustainable practices.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:40

Explore the Startup Ecosystem of San Luis Obispo

National Rank

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Regional Rank

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142nd

7

Global Rank

(WorldWide)

431st

38

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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