StartupBlink

108 Top startups in San Carlos for June 2026

We rank Farmer's Business Network, WHILL and Vaxcyte in San Carlos along with 105 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. San Carlos is part of San Francisco Bay startup ecosystem which ranks #1 globally and #1 in North America.

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Top Unicorn Startups in San Carlos for 2026

Farmers Business Network is the only unicorn in San Carlos raising more than USD 4B. It is the undefined ranked unicorn in North America.

Total amount:1

Best Startups in San Carlos for 2026

SB Score:501

WHILL designs and creates personal mobility products for indoor and outdoor applications. WHILL is making transportation enjoyable and smart for everybody. It aims to change the perception of mobility devices such as wheelchairs and scooters through advanced technology and smart design. It was founded in 2013 and is headquartered in San Carlos, California.

Industry:
Hardware & IoT
Subindustry:
Hardware

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SB Score:467

Vaxcyte is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide. The Company’s cell-free protein synthesis platform, comprising the XpressCFTM platform, exclusively licensed from Sutro Biopharma, Inc., together with Vaxcyte’s proprietary know-how, enables the design and production of protein carriers and antigens, the critical building blocks of vaccines, in ways that the Company believes conventional vaccine technologies currently cannot. In addition to its pneumococcal conjugate vaccines in development, VAX-24 and VAX-XP, Vaxcyte is leveraging its proprietary platform to advance other novel vaccines, including a prophylactic vaccine to prevent Group A Strep infections (VAX-A1) and a therapeutic vaccine to treat periodontal disease (VAX-PG).

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:447

Noah Medical is a manufacturer of medical robotic devices used to diagnose and treat patients in a variety of settings. The company's devices perform early diagnoses and treatments in advanced clinical settings, allowing hospitals to treat patients earlier and save lives while leaving only minor scars.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:444

XP Health is a health tech startup introducing a new kind of vision benefit for employees leveraging machine learning. Founded in 2019 by Antonio Moraes and James Wong, XP Health is an AI-powered vision benefits platform for employees and their families to get frames from the world’s leading designers like Tom Ford, Ray-Ban, Armani, Gucci, Coach. Its proprietary deep learning model uses facial recognition technology that recommends the best frames based on facial dimensions with 98% accuracy. The company is working with companies like Chegg, Zenefits, and Sequoia Consulting Group.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:424

Born from the founders’ recognition that their diverse but complementary skills and experiences would enable them to successfully address challenges that others had not, the company set about solving a vexing problem: how to bring true proteomics to the world in a way that accelerates therapeutic development, dramatically improves medical diagnostics, and makes personalized and predictive medicine a reality. The extraordinary team at Nautilus represents a wide spectrum of disciplines and expertise, including protein chemists, chip designers, molecular biologists, data scientists, material scientists, biophysicists, optical engineers, microfluidics engineers, bioinformaticists, software engineers, and more. Nautilus is positioned to revolutionize proteomics, transform the way drugs are developed, and significantly improve the way human health is managed.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:421

Integrated Biosciences develops next-generation therapeutics for age-related diseases. Originating from labs at Harvard, MIT, and UCSB and with breakthrough publications in Nature and Science, Integrated Biosciences has demonstrated the first AI-driven discovery of anti-aging drug candidates, as well as the first novel structural class of antibiotics in 60 years.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:415

CelLink’s high-conductance circuits integrate busing, fusing, voltage monitoring, and temperature monitoring wiring systems into a single circuit. Our circuits provide much greater control over power and data transmission than traditional round wire – at 1/4th the weight and 1/10th the volume.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:411

Telo Trucks manufactures cleverly designed, compact electric vehicle trucks for city dwellers and weekend adventurers.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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SB Score:411

Galvanize Therapeutics is an energy-based medical device technology that provides therapeutic products and services to deliver healthcare solutions. The company aims to become the global leader in delivering medical technology innovations that drive biological processes to treat a range of diseases, starting with treating chronic bronchitis symptoms, cardiac arrhythmias, and solid tumors. It was formed by Apple Tree Partners in 2022.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:404

Ziplines Education, an industry-leading education company, partners with universities to deliver industry-focused certificate courses that prepare professionals for today’s digital-first workforce so individuals can confidently pursue the career they’ve always wanted. The award-winning industry innovator launched in 2017 as GreenFig and relaunched as Ziplines Education in early 2024. Today, dozens of leading U.S. colleges and universities trust Ziplines Education as their continuing education partner, including the University of Virginia School of Continuing and Professional Studies, Texas Tech University, and the University of North Carolina at Charlotte. To learn more about the company, visit ziplines.com and follow them on @ZiplinesEducation on Linkedin, Facebook, Instagram, and YouTube, and on @ZiplinesEdu on Twitter.

Industry:
Edtech
Subindustry:
Education-Other

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Total amount:108

Top 30 Software & Data Startups in San Carlos for 2026

The top three Software & Data startups in San Carlos have raised more than USD 311M. San Carlos is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Software & Data industry.
SB Score:444

XP Health is a health tech startup introducing a new kind of vision benefit for employees leveraging machine learning. Founded in 2019 by Antonio Moraes and James Wong, XP Health is an AI-powered vision benefits platform for employees and their families to get frames from the world’s leading designers like Tom Ford, Ray-Ban, Armani, Gucci, Coach. Its proprietary deep learning model uses facial recognition technology that recommends the best frames based on facial dimensions with 98% accuracy. The company is working with companies like Chegg, Zenefits, and Sequoia Consulting Group.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:382

Simular develops software that uses AI agents to operate digital interfaces through natural language instructions. The platform interprets user commands to handle actions across desktop and browser environments, allowing repetitive tasks such as information gathering, form interaction, and navigation to run through automated sequences. Simular offers on-device agents along with cloud-based execution options that support remote operation and integration with existing workflows. Its open-source foundation provides transparency into how automations run, giving organizations a way to monitor, adjust, and embed autonomous computer agents into daily processes. This approach helps teams streamline digital work while maintaining clear insight into each automated step.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:376

Clear Labs offers next-generation sequencing and data analytics for infectious disease surveillance and food safety testing. The company's platforms, Clear Dx™ and Clear Safety™, enable rapid identification of pathogens and support public health initiatives. The company focuses on delivering actionable insights to enhance safety and operational efficiency in various sectors.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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Total amount:30

Top 42 Healthtech Startups in San Carlos for 2026

The top three Healthtech startups in San Carlos have raised more than USD 677M. San Carlos is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Healthtech industry.
SB Score:467

Vaxcyte is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide. The Company’s cell-free protein synthesis platform, comprising the XpressCFTM platform, exclusively licensed from Sutro Biopharma, Inc., together with Vaxcyte’s proprietary know-how, enables the design and production of protein carriers and antigens, the critical building blocks of vaccines, in ways that the Company believes conventional vaccine technologies currently cannot. In addition to its pneumococcal conjugate vaccines in development, VAX-24 and VAX-XP, Vaxcyte is leveraging its proprietary platform to advance other novel vaccines, including a prophylactic vaccine to prevent Group A Strep infections (VAX-A1) and a therapeutic vaccine to treat periodontal disease (VAX-PG).

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (San Carlos)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:447

Noah Medical is a manufacturer of medical robotic devices used to diagnose and treat patients in a variety of settings. The company's devices perform early diagnoses and treatments in advanced clinical settings, allowing hospitals to treat patients earlier and save lives while leaving only minor scars.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (San Carlos)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:424

Born from the founders’ recognition that their diverse but complementary skills and experiences would enable them to successfully address challenges that others had not, the company set about solving a vexing problem: how to bring true proteomics to the world in a way that accelerates therapeutic development, dramatically improves medical diagnostics, and makes personalized and predictive medicine a reality. The extraordinary team at Nautilus represents a wide spectrum of disciplines and expertise, including protein chemists, chip designers, molecular biologists, data scientists, material scientists, biophysicists, optical engineers, microfluidics engineers, bioinformaticists, software engineers, and more. Nautilus is positioned to revolutionize proteomics, transform the way drugs are developed, and significantly improve the way human health is managed.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (San Carlos)

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:42

Top 5 Fintech Startups in San Carlos for 2026

The top three Fintech startups in San Carlos have raised more than USD 6.33M. San Carlos is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Fintech industry.
SB Score:262

CapConnect+ is a fintech company that designs and develops cloud-based digital platforms for communication and transactions among corporate issuers, investors, and their banking partners. The company's platform facilitates corporate bond issuance for issuers and assists dealers and investors, promoting simplicity and transparency in the fixed-income markets while digitizing the investment process.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:185

Hustle Fund is a seed fund that invests in early-stage startups operating in software, business-to-business, fintech, and digital health sectors.

Industry:
Fintech
Subindustry:
Investment

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SB Score:78

Fintech. Flow is a platform upgrading the consumer payment experience and eliminating paper to enable fully-digital purchase journeys

Industry:
Fintech
Subindustry:
Financial Services

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Total amount:5

Most Funded Startups in San Carlos for 2026

The top three most funded startups in San Carlos have raised total funding of more than USD 1.55B. Farmer's Business Network has 2.26% more funding than Cellink.
SB Score:415

CelLink’s high-conductance circuits integrate busing, fusing, voltage monitoring, and temperature monitoring wiring systems into a single circuit. Our circuits provide much greater control over power and data transmission than traditional round wire – at 1/4th the weight and 1/10th the volume.

Industry:
Energy & Environment
Subindustry:
Energy

City Rank (San Carlos)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:467

Vaxcyte is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide. The Company’s cell-free protein synthesis platform, comprising the XpressCFTM platform, exclusively licensed from Sutro Biopharma, Inc., together with Vaxcyte’s proprietary know-how, enables the design and production of protein carriers and antigens, the critical building blocks of vaccines, in ways that the Company believes conventional vaccine technologies currently cannot. In addition to its pneumococcal conjugate vaccines in development, VAX-24 and VAX-XP, Vaxcyte is leveraging its proprietary platform to advance other novel vaccines, including a prophylactic vaccine to prevent Group A Strep infections (VAX-A1) and a therapeutic vaccine to treat periodontal disease (VAX-PG).

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (San Carlos)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:108

Top Hiring Startups in San Carlos by Employee Number

The top three hiring startups in San Carlos have an median employee size that is between [501-1000]
SB Score:339

Teradata is the connected multi-cloud data platform for enterprise analytics company. Our enterprise analytics solve business challenges from start to scale. Only Teradata gives you the flexibility to handle the massive and mixed data workloads of the future, today. Teradata offers analytic data platforms, applications, and services for data warehousing and analytic technologies. The company was founded in January 1979 and is globally headquartered in San Diego, California.

Industry:
Software & Data
Subindustry:
Data Analytics

City Rank (San Carlos)

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SB Score:501

WHILL designs and creates personal mobility products for indoor and outdoor applications. WHILL is making transportation enjoyable and smart for everybody. It aims to change the perception of mobility devices such as wheelchairs and scooters through advanced technology and smart design. It was founded in 2013 and is headquartered in San Carlos, California.

Industry:
Hardware & IoT
Subindustry:
Hardware

City Rank (San Carlos)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:467

Vaxcyte is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide. The Company’s cell-free protein synthesis platform, comprising the XpressCFTM platform, exclusively licensed from Sutro Biopharma, Inc., together with Vaxcyte’s proprietary know-how, enables the design and production of protein carriers and antigens, the critical building blocks of vaccines, in ways that the Company believes conventional vaccine technologies currently cannot. In addition to its pneumococcal conjugate vaccines in development, VAX-24 and VAX-XP, Vaxcyte is leveraging its proprietary platform to advance other novel vaccines, including a prophylactic vaccine to prevent Group A Strep infections (VAX-A1) and a therapeutic vaccine to treat periodontal disease (VAX-PG).

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (San Carlos)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:108

Explore the Startup Ecosystem of San Carlos

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Regional Rank

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Global Rank

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal ScoreAnnual Growth

Access subscores for 1000 cities and 100 countries

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