64 Top startups in Saint Paul for April 2025

We rank Kindeva Drug Delivery, Track and Traive in Saint Paul along with 61 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Saint Paul is part of Minneapolis startup ecosystem which ranks #42 globally and #19 in North America.

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Best Startups in Saint Paul for 2025

SB Score:496

Kindeva Drug Delivery is a leading global contract development and manufacturing organization (CDMO) specializing in innovative drug delivery solutions. They partner with pharmaceutical companies to develop and manufacture advanced therapies, enhancing patient outcomes and streamlining the path from concept to market.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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SB Score:422

TRACK Hospitality Software is a premier omnichannel cloud communication platform designed specifically for the hospitality industry. It empowers hospitality companies to streamline their operations, enhance guest experiences, and improve communication across multiple channels, ultimately driving efficiency and satisfaction in their services.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:405

Traive is an AI-driven fintech platform revolutionizing the credit landscape, starting in agriculture. Utilizing advanced machine learning techniques like Language Learning Models (LLMs) and Generative Adversarial Networks (GANs), we provide dynamic and highly accurate credit risk assessments. Our innovative platform connects those in need of credit to a range of lenders, offering real-time, ML-powered risk assessment and ongoing portfolio monitoring. This empowers borrowers with fair and transparent credit evaluations, paving the way for affordable funding options to grow their businesses. For lenders in agriculture, Traive offers unparalleled insights into credit risk through the analysis of alternative farming data and individual farmer behavior. This enables access to a diversified and expanded portfolio of credit-worthy borrowers, optimizing risk and return metrics.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:390

Herself Health, co-founded by Kristen Helton and Juxtapose, offers cutting-edge primary care services to women aged 65+ on Medicare. Soon expanding to Medicare Advantage, the healthcare tech company aims to revolutionize elderly women's healthcare.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:355

Extempore offers a speaking practice app for assigning oral homework and assessments to students. Improve language skills with engaging and efficient assignments.

Industry:
Software & Data
Subindustry:
Apps

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Regional Rank (North America)

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SB Score:353

Nested Knowledge revolutionizes clinician access to meta-analytical research, streamlining information retrieval for improved decision-making.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:349

Torax Medical, Inc., a clinical stage medical device company, develops an implantable device for the treatment of gastroesophageal reflux disease. It provides treatments for digestive diseases, including acid reflux. The company was founded in 2002 and is based in Shoreview, Minnesota.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:343

A platform that connects people within a company, promoting growth and collaboration by matching skills with opportunities. It streamlines processes, enhances efficiency, and creates a more positive work environment for all.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:325

Aria CV is creating a device to enhance the lives of those with pulmonary hypertension. It aims to improve patient outcomes and quality of life.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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SB Score:319

Egg Medical provides EGGNEST, an innovative passive protection solution that significantly minimizes scatter radiation exposure for the entire cath lab team, all while maintaining seamless workflow. This cutting-edge device enhances safety without disrupting procedures, ensuring a healthier working environment for medical professionals.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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Total amount:64

Top 21 Software & Data Startups in Saint Paul for 2025

The top three Software & Data startups in Saint Paul have raised more than USD 135M. Saint Paul is part of Minneapolis startup ecosystem which ranks #46 globally for the Software & Data industry.
SB Score:422

TRACK Hospitality Software is a premier omnichannel cloud communication platform designed specifically for the hospitality industry. It empowers hospitality companies to streamline their operations, enhance guest experiences, and improve communication across multiple channels, ultimately driving efficiency and satisfaction in their services.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:405

Traive is an AI-driven fintech platform revolutionizing the credit landscape, starting in agriculture. Utilizing advanced machine learning techniques like Language Learning Models (LLMs) and Generative Adversarial Networks (GANs), we provide dynamic and highly accurate credit risk assessments. Our innovative platform connects those in need of credit to a range of lenders, offering real-time, ML-powered risk assessment and ongoing portfolio monitoring. This empowers borrowers with fair and transparent credit evaluations, paving the way for affordable funding options to grow their businesses. For lenders in agriculture, Traive offers unparalleled insights into credit risk through the analysis of alternative farming data and individual farmer behavior. This enables access to a diversified and expanded portfolio of credit-worthy borrowers, optimizing risk and return metrics.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:355

Extempore offers a speaking practice app for assigning oral homework and assessments to students. Improve language skills with engaging and efficient assignments.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:21

Top 23 Healthtech Startups in Saint Paul for 2025

The top three Healthtech startups in Saint Paul have raised more than USD 264M. Saint Paul is part of Minneapolis startup ecosystem which ranks #22 globally for the Healthtech industry.
SB Score:390

Herself Health, co-founded by Kristen Helton and Juxtapose, offers cutting-edge primary care services to women aged 65+ on Medicare. Soon expanding to Medicare Advantage, the healthcare tech company aims to revolutionize elderly women's healthcare.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:349

Torax Medical, Inc., a clinical stage medical device company, develops an implantable device for the treatment of gastroesophageal reflux disease. It provides treatments for digestive diseases, including acid reflux. The company was founded in 2002 and is based in Shoreview, Minnesota.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:325

Aria CV is creating a device to enhance the lives of those with pulmonary hypertension. It aims to improve patient outcomes and quality of life.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:23

Top 3 Hardware & IoT Startups in Saint Paul for 2025

The top three Hardware & IoT startups in Saint Paul have raised more than USD 47M. Saint Paul is part of Minneapolis startup ecosystem which ranks #58 globally for the Hardware & IoT industry.
SB Score:496

Kindeva Drug Delivery is a leading global contract development and manufacturing organization (CDMO) specializing in innovative drug delivery solutions. They partner with pharmaceutical companies to develop and manufacture advanced therapies, enhancing patient outcomes and streamlining the path from concept to market.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:161

aspectLED is a Minneapolis-based company that creates and sells top-notch LED products.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:23

Kudu Laboratories, founded by Theron Kotze in May 2014, specializes in developing industrial networking solutions that connect designs to Ethernet-based industrial networks, empowering customers to enhance their connectivity and efficiency in industrial applications.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:3

Most Funded Startups in Saint Paul for 2025

The top three most funded startups in Saint Paul have raised total funding of more than USD 320M. Traive has 0.26% more funding than Aria CV.
SB Score:405

Traive is an AI-driven fintech platform revolutionizing the credit landscape, starting in agriculture. Utilizing advanced machine learning techniques like Language Learning Models (LLMs) and Generative Adversarial Networks (GANs), we provide dynamic and highly accurate credit risk assessments. Our innovative platform connects those in need of credit to a range of lenders, offering real-time, ML-powered risk assessment and ongoing portfolio monitoring. This empowers borrowers with fair and transparent credit evaluations, paving the way for affordable funding options to grow their businesses. For lenders in agriculture, Traive offers unparalleled insights into credit risk through the analysis of alternative farming data and individual farmer behavior. This enables access to a diversified and expanded portfolio of credit-worthy borrowers, optimizing risk and return metrics.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:325

Aria CV is creating a device to enhance the lives of those with pulmonary hypertension. It aims to improve patient outcomes and quality of life.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:349

Torax Medical, Inc., a clinical stage medical device company, develops an implantable device for the treatment of gastroesophageal reflux disease. It provides treatments for digestive diseases, including acid reflux. The company was founded in 2002 and is based in Shoreview, Minnesota.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:64

Top Hiring Startups in Saint Paul by Employee Number

The top three hiring startups in Saint Paul have an median employee size that is between [501-1000]
SB Score:496

Kindeva Drug Delivery is a leading global contract development and manufacturing organization (CDMO) specializing in innovative drug delivery solutions. They partner with pharmaceutical companies to develop and manufacture advanced therapies, enhancing patient outcomes and streamlining the path from concept to market.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:160

Cardiovascular Systems, Inc. (CSI) is devoted to developing and commercializing innovative solutions for treating peripheral and coronary vascular disease. Their primary focus is helping physicians conquer even the most difficult disease states, including calcium, given the complications. Cardiovascular Systems develop solutions for the treatment of peripheral and coronary artery disease, to help physicians conquer calcium, one of the largest challenges when treating PAD and CAD.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:349

Torax Medical, Inc., a clinical stage medical device company, develops an implantable device for the treatment of gastroesophageal reflux disease. It provides treatments for digestive diseases, including acid reflux. The company was founded in 2002 and is based in Shoreview, Minnesota.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:405

Traive is an AI-driven fintech platform revolutionizing the credit landscape, starting in agriculture. Utilizing advanced machine learning techniques like Language Learning Models (LLMs) and Generative Adversarial Networks (GANs), we provide dynamic and highly accurate credit risk assessments. Our innovative platform connects those in need of credit to a range of lenders, offering real-time, ML-powered risk assessment and ongoing portfolio monitoring. This empowers borrowers with fair and transparent credit evaluations, paving the way for affordable funding options to grow their businesses. For lenders in agriculture, Traive offers unparalleled insights into credit risk through the analysis of alternative farming data and individual farmer behavior. This enables access to a diversified and expanded portfolio of credit-worthy borrowers, optimizing risk and return metrics.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:64

Explore the Startup Ecosystem of Saint Paul

National Rank

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Regional Rank

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19th

1

Global Rank

(WorldWide)

42nd

5

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
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1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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