StartupBlink

7 Top startups in Rye for June 2026

We rank Serendipity Labs, Curemark and Kayezen in Rye along with 4 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Rye is part of New York startup ecosystem which ranks #2 globally and #2 in North America.

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Best Startups in Rye for 2026

SB Score:410

Serendipity Labs is an international coworking brand that offers flexible membership plans and event space for private functions. For those who can work from anywhere, no place works like Serendipity Labs Coworking. Experience the workplace as an upscale, lifestyle brand, featuring inspirational design, corporate standards, and unmatched hospitality. It provides a network of premium, members-only workplaces with high-performance facilities at corporate standards for connecting professionals with their greatest potential. Serendipity Labs accelerates innovation with a network of on-demand private and flexible workspaces. The company combines a state-of-the-art workplace design, technology, and security with the highest service level standards to deliver a consistent and peerless workplace experience.

Industry:
Marketing & Sales
Subindustry:
Events

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SB Score:326

Curemark is a biopharmaceutical company that focuses on the development of novel therapies to treat serious diseases for which there are limited treatment options for patients in need. Their pipeline includes two Phase III clinical-stage programs for Autism and ADHD as well as three preclinical programs directed at Parkinson’s Disease, Schizophrenia, and Addiction. All of their product candidates address severe neurologic diseases that are currently believed to be underserved by available approved therapies and represent large potential commercial market opportunities. They believe that their product candidates offer innovative therapeutic approaches and may have the potential to provide significant advantages relative to current therapies.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Rye)

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SB Score:229

Kayezen is dial-in resistance tube system designed to deliver single and multi-VECTOR exercises that create new challenges to help athletes and patients improve.

Industry:
Social & Leisure
Subindustry:
Arts

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SB Score:181

Vetano – Vetted. Talent. Now. Bad hires are expensive. They cost you money, time, and team morale. And yet most hiring is still a game of résumé roulette — buzzwords, inflated titles, and interviews that don’t reflect how someone will actually perform. Vetano is not another AI interview tool. We’re a secure hiring marketplace built to end the guesswork. Every professional on Vetano is ID-verified and proves their real-world skills on video — so you see ability before you waste time on résumés or inflated claims. With Vetano, employers make faster, smarter hiring decisions and find candidates who can actually do the job. We launched first in the haircare and restaurant industries, but our platform is designed for any profession where practical skill demonstration beats paper résumés and keyword filters. No more resume roulette. Prove it on video. Hire with confidence. Vetted. Talent. Now.

Industry:
Marketing & Sales
Subindustry:
Marketing & Sales-Other

City Rank (Rye)

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SB Score:166

Cipher Mining is an industrial-scale Bitcoin mining company dedicated to expanding and strengthening the Bitcoin network's critical infrastructure. Its goal is to be the leading Bitcoin mining company in the United States. Cipher Mining aims to leverage best-in-class technology, market-leading power purchase arrangements, and a seasoned, dedicated senior management team to become the market leader in Bitcoin mining.

Industry:
Fintech
Subindustry:
Cryptocurrency

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SB Score:114

After careers in direct business lending spanning SBA, asset-based and non-bank working capital, our mission is to educate business owners on industry best practices as well as the many paths to be avoided. A trusted business financing consultants with $150 Million+ in direct lending experience across SBA, asset-based and non-bank working capital, keeping our clients away from the noise and in front of exclusive business financing options catered to you. Our services include SBA loans, Business line of credit, Asset-based loans (receivables, invoice, equipment, etc.), Term loans, Short-term working capital, Business debt refinancing & consolidation, Growth strategy.

Industry:
Fintech
Subindustry:
Financial Services

City Rank (Rye)

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SB Score:76

The Forward Marketer provides marketing strategy, marketing automation, hubspot management, and optimization, search engine marketing, lead generation, search engine optimization, and email marketing.

Industry:
Marketing & Sales
Subindustry:
Sales

City Rank (Rye)

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Total amount:7

Top 2 Fintech Startups in Rye for 2026

Rye is part of New York startup ecosystem which ranks #2 globally for the Fintech industry.
SB Score:166

Cipher Mining is an industrial-scale Bitcoin mining company dedicated to expanding and strengthening the Bitcoin network's critical infrastructure. Its goal is to be the leading Bitcoin mining company in the United States. Cipher Mining aims to leverage best-in-class technology, market-leading power purchase arrangements, and a seasoned, dedicated senior management team to become the market leader in Bitcoin mining.

Industry:
Fintech
Subindustry:
Cryptocurrency

City Rank (Rye)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:114

After careers in direct business lending spanning SBA, asset-based and non-bank working capital, our mission is to educate business owners on industry best practices as well as the many paths to be avoided. A trusted business financing consultants with $150 Million+ in direct lending experience across SBA, asset-based and non-bank working capital, keeping our clients away from the noise and in front of exclusive business financing options catered to you. Our services include SBA loans, Business line of credit, Asset-based loans (receivables, invoice, equipment, etc.), Term loans, Short-term working capital, Business debt refinancing & consolidation, Growth strategy.

Industry:
Fintech
Subindustry:
Financial Services

City Rank (Rye)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:2

Most Funded Startups in Rye for 2026

The top three most funded startups in Rye have raised total funding of more than USD 78.9M. Curemark has 3.36% more funding than Serendipity Labs.
SB Score:326

Curemark is a biopharmaceutical company that focuses on the development of novel therapies to treat serious diseases for which there are limited treatment options for patients in need. Their pipeline includes two Phase III clinical-stage programs for Autism and ADHD as well as three preclinical programs directed at Parkinson’s Disease, Schizophrenia, and Addiction. All of their product candidates address severe neurologic diseases that are currently believed to be underserved by available approved therapies and represent large potential commercial market opportunities. They believe that their product candidates offer innovative therapeutic approaches and may have the potential to provide significant advantages relative to current therapies.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Rye)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:410

Serendipity Labs is an international coworking brand that offers flexible membership plans and event space for private functions. For those who can work from anywhere, no place works like Serendipity Labs Coworking. Experience the workplace as an upscale, lifestyle brand, featuring inspirational design, corporate standards, and unmatched hospitality. It provides a network of premium, members-only workplaces with high-performance facilities at corporate standards for connecting professionals with their greatest potential. Serendipity Labs accelerates innovation with a network of on-demand private and flexible workspaces. The company combines a state-of-the-art workplace design, technology, and security with the highest service level standards to deliver a consistent and peerless workplace experience.

Industry:
Marketing & Sales
Subindustry:
Events

City Rank (Rye)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:229

Kayezen is dial-in resistance tube system designed to deliver single and multi-VECTOR exercises that create new challenges to help athletes and patients improve.

Industry:
Social & Leisure
Subindustry:
Arts

City Rank (Rye)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:7

Top Hiring Startups in Rye by Employee Number

The top three hiring startups in Rye have an median employee size that is between [11-50]
SB Score:410

Serendipity Labs is an international coworking brand that offers flexible membership plans and event space for private functions. For those who can work from anywhere, no place works like Serendipity Labs Coworking. Experience the workplace as an upscale, lifestyle brand, featuring inspirational design, corporate standards, and unmatched hospitality. It provides a network of premium, members-only workplaces with high-performance facilities at corporate standards for connecting professionals with their greatest potential. Serendipity Labs accelerates innovation with a network of on-demand private and flexible workspaces. The company combines a state-of-the-art workplace design, technology, and security with the highest service level standards to deliver a consistent and peerless workplace experience.

Industry:
Marketing & Sales
Subindustry:
Events

City Rank (Rye)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:326

Curemark is a biopharmaceutical company that focuses on the development of novel therapies to treat serious diseases for which there are limited treatment options for patients in need. Their pipeline includes two Phase III clinical-stage programs for Autism and ADHD as well as three preclinical programs directed at Parkinson’s Disease, Schizophrenia, and Addiction. All of their product candidates address severe neurologic diseases that are currently believed to be underserved by available approved therapies and represent large potential commercial market opportunities. They believe that their product candidates offer innovative therapeutic approaches and may have the potential to provide significant advantages relative to current therapies.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Rye)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:166

Cipher Mining is an industrial-scale Bitcoin mining company dedicated to expanding and strengthening the Bitcoin network's critical infrastructure. Its goal is to be the leading Bitcoin mining company in the United States. Cipher Mining aims to leverage best-in-class technology, market-leading power purchase arrangements, and a seasoned, dedicated senior management team to become the market leader in Bitcoin mining.

Industry:
Fintech
Subindustry:
Cryptocurrency

City Rank (Rye)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:229

Kayezen is dial-in resistance tube system designed to deliver single and multi-VECTOR exercises that create new challenges to help athletes and patients improve.

Industry:
Social & Leisure
Subindustry:
Arts

City Rank (Rye)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:7

Explore the Startup Ecosystem of Rye

National Rank

(United States)

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Regional Rank

(North America)

2nd

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Global Rank

(WorldWide)

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal ScoreAnnual Growth

Access subscores for 1000 cities and 100 countries

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Quality ScoreBusiness Score
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152.371
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127.119
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