556 Top startups in Portland for April 2025

We rank Vets First Choice, VetSource and CashStar in Portland along with 553 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Portland startup ecosystem ranks #59 globally and #21 in United States.

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Best Startups in Portland for 2025

SB Score:600

Vets First Choice offers veterinary practices an online pharmacy and convenient home delivery services for pet medications and supplies. Providing a seamless experience for pet owners to access their pet's healthcare needs with ease.

Industry:
Healthtech
Subindustry:
Pharmaceuticals

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SB Score:551

VetSource offers pet care medications and vaccinations for your furry companions. Simplifying the process of accessing essential healthcare for pets, VetSource ensures convenient and reliable services for pet owners.

Industry:
Healthtech
Subindustry:
Medtech

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SB Score:543

CashStar provides prepaid commerce solutions specializing in mobile payments, digital gifting, and branded currency. Merchants use their CashStar Commerce platform to enhance revenue, lower costs, and improve customer experiences across different channels. Additionally, the CashStar Exchange platform supports distribution and loyalty programs by facilitating the procurement and delivery of gift cards from various brands. CashStar’s clientele includes companies like Sephora, Starbucks, The Home Depot, Uber, and Walmart, along with distribution partners such as American Express Membership Rewards and United MileagePlusX.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:535

Become the ultimate neighborhood grocery store by providing the best shopping experience. Offering a wide range of high-quality products and exceptional customer service, our goal is to create a convenient and welcoming atmosphere for all customers.

Industry:
Ecommerce & Retail
Subindustry:
Retail

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SB Score:525

Customer.io empowers users to send targeted newsletters to specific customer segments using data from their website. Engage customers effectively by sending personalized messages based on their behavior, all through one easy-to-use platform.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:509

Puppet provides system administrators with a simplified platform that allows for consistent, transparent, and flexible systems management.

Industry:
Software & Data
Subindustry:
Software and Data-Other

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SB Score:506

Lumen Learning offers top-notch open courseware and assistance for schools. Elevate your educational experience with our resources and services.

Industry:
Edtech
Subindustry:
Edtech

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SB Score:504

Airship helps brands master mobile-first customer experiences to build lasting relationships and accelerate business growth. Since 2009, Airship has enabled thousands of the world’s leading brands to be at the forefront of the customer experience revolution with industry-first support for push notifications, in-app messages and mobile wallet boarding passes — all now the norm in elevating experiences everywhere. Today, the Airship Experience Platform provides an end-to-end solution for unifying experiences across apps, websites and all channels, including email, SMS, mobile wallet and more. Its no-code Experience Editor and Journeys AI solutions enable marketers and product managers to get work done in minutes instead of months, capturing more value across the entire customer lifecycle without ongoing developer support. With the Airship Experience Platform and App Store Optimization technology and expertise, brands now have a complete set of solutions to optimize the entire customer lifecycle – from the point of discovery to loyalty – driving greater value for everyone involved.

Industry:
Software & Data
Subindustry:
Apps

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SB Score:504

OpenSesame is a marketplace for buying and selling elearning courses, offering over 21,000 courses from 260 sellers. Users can purchase courses instantly with no subscriptions, using them online or in any learning system. It simplifies the $4.5B elearning content market with easy access and flexibility.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:499

Tripwire is a leading provider of advanced threat, security and compliance solutions that enable enterprises, service providers and government agencies to confidently detect, prevent and respond to cybersecurity threats. Tripwire solutions are based on high-fidelity asset visibility and deep endpoint intelligence combined with business-context and enable security automation through enterprise integration. Tripwire’s portfolio of enterprise-class security solutions includes configuration and policy management, file integrity monitoring, vulnerability management and log intelligence. Learn more at www.tripwire.com, get security news, trends and insights at http://www.tripwire.com/state-of-security/ or follow us on Twitter @TripwireInc.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Total amount:556

Top 165 Software & Data Startups in Portland for 2025

The top three Software & Data startups in Portland have raised more than USD 587M. Portland startup ecosystem ranks #58 globally for the Software & Data industry.
SB Score:525

Customer.io empowers users to send targeted newsletters to specific customer segments using data from their website. Engage customers effectively by sending personalized messages based on their behavior, all through one easy-to-use platform.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

0

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Regional Rank (North America)

0

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SB Score:509

Puppet provides system administrators with a simplified platform that allows for consistent, transparent, and flexible systems management.

Industry:
Software & Data
Subindustry:
Software and Data-Other

National Rank (United States)

0

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Regional Rank (North America)

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SB Score:504

Airship helps brands master mobile-first customer experiences to build lasting relationships and accelerate business growth. Since 2009, Airship has enabled thousands of the world’s leading brands to be at the forefront of the customer experience revolution with industry-first support for push notifications, in-app messages and mobile wallet boarding passes — all now the norm in elevating experiences everywhere. Today, the Airship Experience Platform provides an end-to-end solution for unifying experiences across apps, websites and all channels, including email, SMS, mobile wallet and more. Its no-code Experience Editor and Journeys AI solutions enable marketers and product managers to get work done in minutes instead of months, capturing more value across the entire customer lifecycle without ongoing developer support. With the Airship Experience Platform and App Store Optimization technology and expertise, brands now have a complete set of solutions to optimize the entire customer lifecycle – from the point of discovery to loyalty – driving greater value for everyone involved.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

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Regional Rank (North America)

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Total amount:165

Top 79 Ecommerce & Retail Startups in Portland for 2025

The top three Ecommerce & Retail startups in Portland have raised more than USD 105M. Portland startup ecosystem ranks #53 globally for the Ecommerce & Retail industry.
SB Score:535

Become the ultimate neighborhood grocery store by providing the best shopping experience. Offering a wide range of high-quality products and exceptional customer service, our goal is to create a convenient and welcoming atmosphere for all customers.

Industry:
Ecommerce & Retail
Subindustry:
Retail

National Rank (United States)

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SB Score:494

CrowdStreet disrupts the $20 billion commercial real estate financing market by connecting accredited investors with exclusive opportunities. Investors gain access to high-quality, income-producing properties, while property owners secure capital for acquisitions and renovations. Think AngelList for real estate investments.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

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SB Score:480

TrovaTrip is a platform where creators, entrepreneurs, and businesses can monetize their audience by organizing and selling group trips, livestreams, and digital products. It simplifies the process of planning and selling experiences, making it easy for hosts to generate income from their offerings.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

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Regional Rank (North America)

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Total amount:79

Top 49 Healthtech Startups in Portland for 2025

The top three Healthtech startups in Portland have raised more than USD 227M. Portland startup ecosystem ranks #64 globally for the Healthtech industry.
SB Score:600

Vets First Choice offers veterinary practices an online pharmacy and convenient home delivery services for pet medications and supplies. Providing a seamless experience for pet owners to access their pet's healthcare needs with ease.

Industry:
Healthtech
Subindustry:
Pharmaceuticals

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:551

VetSource offers pet care medications and vaccinations for your furry companions. Simplifying the process of accessing essential healthcare for pets, VetSource ensures convenient and reliable services for pet owners.

Industry:
Healthtech
Subindustry:
Medtech

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:441

Brave Care provides convenient urgent childcare services through its healthcare clinics. Offering quick and efficient care for children, Brave Care aims to ease the burden on parents seeking immediate medical attention for their little ones.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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Total amount:49

Most Funded Startups in Portland for 2025

The top three most funded startups in Portland have raised total funding of more than USD 593M. Torq has 0.89% more funding than Eclypsium.

1st

Torq
SB Score:458

Torq empowers security and ops teams with a user-friendly no-code automation platform. Streamline processes and enhance efficiency without the need for coding skills. Boost productivity and stay ahead of potential threats with Torq's intuitive solution.

Industry:
Software & Data
Subindustry:
Cybersecurity

National Rank (United States)

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Regional Rank (North America)

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SB Score:426

Eclypsium is the industry’s first enterprise firmware protection platform. Firmware in servers, laptops, and networking equipment is the unguarded attack surface of the enterprise. Once compromised, this blind spot allows attackers to subvert traditional security controls, persist undetected indefinitely, or even disable devices completely.

Industry:
Software & Data
Subindustry:
Cybersecurity

National Rank (United States)

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Total amount:556

Top Hiring Startups in Portland by Employee Number

The top three hiring startups in Portland have an median employee size that is between [5001-10000]
SB Score:441

This platform allows designers to collaborate in real-time on spatial designs in VR and AR. With cloud-based technology, users can create and share immersive projects seamlessly.

Industry:
Software & Data
Subindustry:
VR/AR

National Rank (United States)

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Regional Rank (North America)

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SB Score:600

Vets First Choice offers veterinary practices an online pharmacy and convenient home delivery services for pet medications and supplies. Providing a seamless experience for pet owners to access their pet's healthcare needs with ease.

Industry:
Healthtech
Subindustry:
Pharmaceuticals

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:535

Become the ultimate neighborhood grocery store by providing the best shopping experience. Offering a wide range of high-quality products and exceptional customer service, our goal is to create a convenient and welcoming atmosphere for all customers.

Industry:
Ecommerce & Retail
Subindustry:
Retail

National Rank (United States)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:425

Woodard & Curran is a national firm that provides engineering, science, and operations services to both public and private clients. They specialize in helping their clients with a wide range of projects, from water treatment to environmental remediation.

Industry:
Energy & Environment
Subindustry:
Energy & Environment-Other

National Rank (United States)

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Total amount:556

Explore the Startup Ecosystem of Portland

National Rank

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Regional Rank

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24th

2

Global Rank

(WorldWide)

59th

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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