StartupBlink

723 Top startups in Philadelphia for June 2026

We rank DuckDuckGo, Piano and Guru in Philadelphia along with 720 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Philadelphia startup ecosystem ranks #38 globally and #15 in United States.

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Top Unicorn Startups in Philadelphia for 2026

Four startups have achieved unicorn status by exceeding USD 1 billion in valuation. Collectively, the top three unicorns in Philadelphia have raised more than USD 21.2B.
SB Score:746

Gopuff is an on-demand delivery service for snacks and drinks. Users can order directly from their app for quick delivery to their doorstep. Get your favorite munchies and beverages delivered fast with Gopuff.

Industry:
Foodtech
Subindustry:
Online Food Ordering

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SB Score:716

Misfits Market offers affordable, high-quality food to combat food waste. They make it easier for people to access fresh produce while helping reduce waste.

Industry:
Foodtech
Subindustry:
Food and Beverage

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SB Score:614

Phenom is the AI solution to help candidates find ideal jobs, assist employers in discovering top talent, and enable managers to build teams efficiently.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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Total amount:4

Best Startups in Philadelphia for 2026

SB Score:845

At DuckDuckGo, we believe the best way to protect your personal information from hackers, scammers, and privacy-invasive companies is to stop it from being collected at all. That's why millions of people choose DuckDuckGo over Chrome and other browsers to search and browse online. Our built-in search engine is like Google but never tracks your searches. And our browsing protections, such as ad tracker blocking and cookie blocking, help stop other companies from collecting your data. Oh, and our browser is free — we make money from privacy-respecting search ads, not by exploiting your data. Take back control of your personal information with the browser designed for data protection, not data collection.

Industry:
Software & Data
Subindustry:
Software

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SB Score:639

Piano’s Digital Experience Platform empowers organizations to understand and influence customer behavior. By unifying customer data, analyzing behavior metrics, and creating personalized customer journeys, Piano helps brands launch campaigns and products faster, strengthen customer engagement, and drive personalization at scale from a single platform. Headquartered in Amsterdam with offices across the Americas, Europe, and Asia Pacific, Piano serves a global client base, including Air France, the BBC, CBS, IBM, Kirin Holdings, Jaguar Land Rover, Nielsen, The Wall Street Journal, and more.

Industry:
Software & Data
Subindustry:
SaaS

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3rd

Guru
SB Score:542

Guru is the AI Source of Truth for companies that want trusted knowledge everywhere work happens. Our platform connects everything teams know—across chats, docs, and apps—into one governed, permission-aware knowledge layer that delivers cited AI answers, chat, and research directly in the tools people use every day.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:528

TicketLeap, a solution of Leap Event Technology, takes self-service ticketing to a whole new level with their easy-to-use platform, full set of features, and lightning-fast setup. The solution provides branded event pages, built-in management tools, and flexible ticketing options so organizers can create awesome events in just minutes. That’s why haunted attractions, festivals, tours, theaters, and so many more choose TicketLeap.

Industry:
Marketing & Sales
Subindustry:
Events

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SB Score:513

cofenster offers a suite of Video AI assistants that automate video production. Our assistants produce videos fully autonomously and work alongside Communication, HR and Marketing teams, combining AI efficiency with human creativity. - Milo transforms long videos into viral short clips - Ella creates authentic user generated videos. - Theo transforms text into videos. We serve leading corporations like TUI, Rewe Group, Siemens, Beiersdorf, and Vorvwerk, as well as small and medium-sized businesses.

Industry:
Social & Leisure
Subindustry:
Gaming

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SB Score:507

Ophelia offers medication and support for quitting opioids. They are a diverse collection of hearts and minds - doctors, scientists, techies, and citizens - on a mission to offer the best of medicine without the baggage of rehab. They are driven by science, committed to privacy, and bound to the client's right to make their own choices. They believe in recommendations, not orders. It was founded in 2019 and is based in New York, New York.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:506

Honeygrow has aimed to bring people together over high quality, wholesome and simple foods, focusing on eating honestly and spending time doing what matters: from visiting local farm vendors to whipping up sauces and dressings in-house (no freezers). Honeygrow specializes in colorful stir-fries, smoothies, salads and honeybar treats featuring local and seasonal ingredients. Honeygrow = honest eating + growing local

Industry:
Social & Leisure
Subindustry:
Social & Leisure-Other

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SB Score:502

Magento is a modern cloud commerce platform with an open-source ecosystem. Flexible for B2C, B2B, and hybrid solutions, Magento extends beyond the shopping cart for every shoppable experience, including email, mobile, in-store, shipping, and marketplaces. Recognized as the leading commerce platform to the 2015 Internet Retailer Top 1000, B2B 300, and Europe 500 lists, Magento works hand-in-hand with the world’s biggest retailers, brands, and branded manufacturers across B2C and B2B industries.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:475

Crossbeam is the first and largest Ecosystem-Led Growth platform, used by over 19,000 companies to attract, convert, and grow customer relationships using their partner ecosystems.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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10th

Ritten
SB Score:463

Ritten delivers a platform that helps clinicians and administrators provide personalized, data-informed care. The company's platform offers customized workflow configurations that help to deliver complex treatment consistently and compliantly, enabling clinicians and administrators to maintain a comprehensive patient record that tracks all aspects of a patient's care, including clinical notes, medications, and treatment plans, and deliver personalized, data-informed care.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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11th

Vybe
SB Score:461

vybe Urgent Service, provides care to both adults and children. Vybe is open every day of the week and provides a telemedicine service for customers who want to consult a doctor virtually. Appointments are not necessary for in-clinic visits, however they are provided for the comfort of the patient.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:724

SB Score:845

At DuckDuckGo, we believe the best way to protect your personal information from hackers, scammers, and privacy-invasive companies is to stop it from being collected at all. That's why millions of people choose DuckDuckGo over Chrome and other browsers to search and browse online. Our built-in search engine is like Google but never tracks your searches. And our browsing protections, such as ad tracker blocking and cookie blocking, help stop other companies from collecting your data. Oh, and our browser is free — we make money from privacy-respecting search ads, not by exploiting your data. Take back control of your personal information with the browser designed for data protection, not data collection.

Industry:
Software & Data
Subindustry:
Software

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SB Score:639

Piano’s Digital Experience Platform empowers organizations to understand and influence customer behavior. By unifying customer data, analyzing behavior metrics, and creating personalized customer journeys, Piano helps brands launch campaigns and products faster, strengthen customer engagement, and drive personalization at scale from a single platform. Headquartered in Amsterdam with offices across the Americas, Europe, and Asia Pacific, Piano serves a global client base, including Air France, the BBC, CBS, IBM, Kirin Holdings, Jaguar Land Rover, Nielsen, The Wall Street Journal, and more.

Industry:
Software & Data
Subindustry:
SaaS

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3rd

Guru
SB Score:542

Guru is the AI Source of Truth for companies that want trusted knowledge everywhere work happens. Our platform connects everything teams know—across chats, docs, and apps—into one governed, permission-aware knowledge layer that delivers cited AI answers, chat, and research directly in the tools people use every day.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:724

SB Score:845

At DuckDuckGo, we believe the best way to protect your personal information from hackers, scammers, and privacy-invasive companies is to stop it from being collected at all. That's why millions of people choose DuckDuckGo over Chrome and other browsers to search and browse online. Our built-in search engine is like Google but never tracks your searches. And our browsing protections, such as ad tracker blocking and cookie blocking, help stop other companies from collecting your data. Oh, and our browser is free — we make money from privacy-respecting search ads, not by exploiting your data. Take back control of your personal information with the browser designed for data protection, not data collection.

Industry:
Software & Data
Subindustry:
Software

City Rank (Philadelphia)

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SB Score:639

Piano’s Digital Experience Platform empowers organizations to understand and influence customer behavior. By unifying customer data, analyzing behavior metrics, and creating personalized customer journeys, Piano helps brands launch campaigns and products faster, strengthen customer engagement, and drive personalization at scale from a single platform. Headquartered in Amsterdam with offices across the Americas, Europe, and Asia Pacific, Piano serves a global client base, including Air France, the BBC, CBS, IBM, Kirin Holdings, Jaguar Land Rover, Nielsen, The Wall Street Journal, and more.

Industry:
Software & Data
Subindustry:
SaaS

City Rank (Philadelphia)

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3rd

Guru
SB Score:542

Guru is the AI Source of Truth for companies that want trusted knowledge everywhere work happens. Our platform connects everything teams know—across chats, docs, and apps—into one governed, permission-aware knowledge layer that delivers cited AI answers, chat, and research directly in the tools people use every day.

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (Philadelphia)

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Total amount:724

SB Score:845

At DuckDuckGo, we believe the best way to protect your personal information from hackers, scammers, and privacy-invasive companies is to stop it from being collected at all. That's why millions of people choose DuckDuckGo over Chrome and other browsers to search and browse online. Our built-in search engine is like Google but never tracks your searches. And our browsing protections, such as ad tracker blocking and cookie blocking, help stop other companies from collecting your data. Oh, and our browser is free — we make money from privacy-respecting search ads, not by exploiting your data. Take back control of your personal information with the browser designed for data protection, not data collection.

Industry:
Software & Data
Subindustry:
Software

City Rank (Philadelphia)

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SB Score:639

Piano’s Digital Experience Platform empowers organizations to understand and influence customer behavior. By unifying customer data, analyzing behavior metrics, and creating personalized customer journeys, Piano helps brands launch campaigns and products faster, strengthen customer engagement, and drive personalization at scale from a single platform. Headquartered in Amsterdam with offices across the Americas, Europe, and Asia Pacific, Piano serves a global client base, including Air France, the BBC, CBS, IBM, Kirin Holdings, Jaguar Land Rover, Nielsen, The Wall Street Journal, and more.

Industry:
Software & Data
Subindustry:
SaaS

City Rank (Philadelphia)

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3rd

Guru
SB Score:542

Guru is the AI Source of Truth for companies that want trusted knowledge everywhere work happens. Our platform connects everything teams know—across chats, docs, and apps—into one governed, permission-aware knowledge layer that delivers cited AI answers, chat, and research directly in the tools people use every day.

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (Philadelphia)

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Total amount:724

Most Funded Startups in Philadelphia for 2026

The top three most funded startups in Philadelphia have raised total funding of more than USD 889M. Century Therapeutics has 0.62% more funding than Imvax.
SB Score:428

Century Therapeutics builds an allogeneic iPSC-derived cell therapy platform that integrates gene editing, protein engineering, technical development, and manufacturing capabilities to generate allogeneic, iPSC-derived NK and T cell therapies for both hematological and solid tumor malignancies with significant unmet medical needs.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:366

Imvax is a biotechnology company focused on the development of novel patient-specific vaccines and immunotherapy strategies for the treatment of malignant gliomas and other cancers with unmet medical needs. Its product, IGV-001, is an autologous tumor cell vaccine that delivers a multi-pronged response against tumor cells by leveraging the patient’s immune system as a defense mechanism. The company was incorporated in 2015 by David W. Andrews, Craig Hooper, Arthur W. Howe, and Peter B. Corr in Philadelphia, Pennsylvania.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:390

Passage Bio is a fully integrated gene therapy company with a mission to develop a portfolio of five life-transforming AAV-delivered therapeutics for the treatment of rare monogenic central nervous system diseases. The company is based in Philadelphia, PA and has a research, collaboration and license agreement with the University of Pennsylvania and its Gene Therapy Program (GTP) as well as the Orphan Disease Center (ODC). Pursuant to the research collaboration, GTP conducts IND-enabling preclinical work, and Passage Bio is responsible for clinical development, regulatory, manufacturing and commercialization of all product candidates. The ODC is responsible for natural history studies, KOL engagement, and patient advocacy outreach.

Industry:
Healthtech
Subindustry:
Biotechnology

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Total amount:724

Top Hiring Startups in Philadelphia by Employee Number

The top three hiring startups in Philadelphia have an median employee size that is between [1001-5000]
SB Score:381

Qlik simplifies the way people use data by making it a natural part of how they make decisions. We help people to do more than just report findings; we help them to change their worlds, in ways both small and large, through understanding and sharing data more naturally and effectively to create value. Our mission, “Simplifying decisions for everyone, everywhere,” is about harnessing the real potential of data – big and small - and unleashing its power to change the world.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:200

Comoto is America's Powersports aftermarket retailer serving motorcycle enthusiasts everywhere through Cycle Gear, J&P Cycles, and RevZilla.com.With 150 stores nationwide and over 90 years of combined experience, we have hundreds of experts on-hand to fuel your passion for motorcycling. We deliver products, dedicated expertise, engaging media, and passionate customer support through best-in-class eCommerce and retail experiences.

Industry:
Transportation
Subindustry:
Automotive

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SB Score:639

Piano’s Digital Experience Platform empowers organizations to understand and influence customer behavior. By unifying customer data, analyzing behavior metrics, and creating personalized customer journeys, Piano helps brands launch campaigns and products faster, strengthen customer engagement, and drive personalization at scale from a single platform. Headquartered in Amsterdam with offices across the Americas, Europe, and Asia Pacific, Piano serves a global client base, including Air France, the BBC, CBS, IBM, Kirin Holdings, Jaguar Land Rover, Nielsen, The Wall Street Journal, and more.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:502

Magento is a modern cloud commerce platform with an open-source ecosystem. Flexible for B2C, B2B, and hybrid solutions, Magento extends beyond the shopping cart for every shoppable experience, including email, mobile, in-store, shipping, and marketplaces. Recognized as the leading commerce platform to the 2015 Internet Retailer Top 1000, B2B 300, and Europe 500 lists, Magento works hand-in-hand with the world’s biggest retailers, brands, and branded manufacturers across B2C and B2B industries.

Industry:
Software & Data
Subindustry:
SaaS

City Rank (Philadelphia)

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Total amount:723

Explore the Startup Ecosystem of Philadelphia

National Rank

(United States)

15th

new

Regional Rank

(North America)

16th

1

Global Rank

(WorldWide)

38th

5

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal ScoreAnnual Growth

Access subscores for 1000 cities and 100 countries

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Quality ScoreBusiness Score
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