56 Top startups in Panama for April 2025

We rank Zaros Finance, BitDAO and Citadel.one in Panama along with 53 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Panama startup ecosystem ranks #84 globally and #3 in Central America.

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Best Startups in Panama for 2025

SB Score:427

Zaros is an innovative protocol designed to enhance liquidity and maximize staking rewards from Liquid Staking Tokens (LSTs). As a leading perpetual futures decentralized exchange on Ethereum, Zaros aims to establish itself as the go-to liquidity hub for on-chain derivatives.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (Panama City)

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Regional Rank (Central America)

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SB Score:362

BitDAO is a pioneering decentralized autonomous organization dedicated to creating a more equitable economic landscape for everyone. By accelerating the growth of the decentralized tokenized economy, it empowers individuals globally to participate in and benefit from innovative financial opportunities.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (Panama City)

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Regional Rank (Central America)

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SB Score:350

Virtex Apps, LLC has developed Virtex Arena, an innovative multiplayer augmented reality platform that enables sports teams to engage their fans in exciting new ways. Through immersive competitions, fans can interact and connect, enhancing their overall experience and fostering a vibrant community around their favorite teams.

Industry:
Software & Data
Subindustry:
Apps

City Rank (Arraijan)

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Regional Rank (Central America)

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4th

Hero
SB Score:348

Hero is a cost organization tool for Latam SMBs, eliminating the need for manual tracking. Launched in 2021 and headquartered in Panama City, Panama, Hero streamlines cost management for businesses in a user-friendly digital format.

Industry:
Edtech
Subindustry:
Education-Other

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Regional Rank (Central America)

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SB Score:324

Crypto Ramps enables users in Panama, Guatemala, Honduras, and Costa Rica to easily buy, hold, and sell cryptocurrencies, as well as send and receive remittances with minimal fees. This platform provides seamless access to crypto and DeFi services, making digital finance more accessible for local communities.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (Panama City)

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Regional Rank (Central America)

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SB Score:320

Eprezto.com is an online platform that provides comprehensive vehicle damage insurance to third parties, offering reliable protection against property damage, medical expenses, accidents, and more. With a secure interface, it ensures users can confidently safeguard their assets and navigate unforeseen incidents.

Industry:
Fintech
Subindustry:
Financial Services

City Rank (Panama City)

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Regional Rank (Central America)

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SB Score:316

PayCaddy enables Latam companies to launch financial products with an API based platform. Rather than building fintech from scratch, or dealing with a legacy bank, companies can use PayCaddy to open digital wallets with KYC checks, process online payments, and issue personalized debit and prepaid cards for customers or employees.

Industry:
Fintech
Subindustry:
Financial Services

City Rank (Panama City)

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Regional Rank (Central America)

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SB Score:313

HEAL Software is a groundbreaking preventive healing solution for IT operations, designed to identify and resolve issues before they arise. It surpasses traditional AI-assisted application performance management (APM) and monitoring tools, ensuring smooth and efficient IT environments while minimizing downtime and enhancing overall system reliability.

Industry:
Software & Data
Subindustry:
Software

City Rank (Arraijan)

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Regional Rank (Central America)

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SB Score:310

Venmetro is an innovative online lending platform in Panama that simplifies access to personal loans. By connecting borrowers with flexible financing options, it empowers individuals to achieve their financial goals with ease and convenience.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

City Rank (Panama City)

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Regional Rank (Central America)

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11th

Factor
SB Score:307

The CarTongyun intelligent maintenance platform offers precise insights through its extensive database, covering nearly 2 million vehicles. This innovative system empowers users to optimize vehicle maintenance, ensuring efficiency and reliability for all types of vehicles.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (Panama City)

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Regional Rank (Central America)

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Total amount:56

Top 23 Software & Data Startups in Panama for 2025

The top three Software & Data startups in Panama have raised more than USD 11M. Panama startup ecosystem ranks among the top 10 locations in the world for startups in Software & Data, holding the falseth position.
SB Score:350

Virtex Apps, LLC has developed Virtex Arena, an innovative multiplayer augmented reality platform that enables sports teams to engage their fans in exciting new ways. Through immersive competitions, fans can interact and connect, enhancing their overall experience and fostering a vibrant community around their favorite teams.

Industry:
Software & Data
Subindustry:
Apps

City Rank (Arraijan)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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SB Score:313

HEAL Software is a groundbreaking preventive healing solution for IT operations, designed to identify and resolve issues before they arise. It surpasses traditional AI-assisted application performance management (APM) and monitoring tools, ensuring smooth and efficient IT environments while minimizing downtime and enhancing overall system reliability.

Industry:
Software & Data
Subindustry:
Software

City Rank (Arraijan)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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Total amount:23

Top 22 Fintech Startups in Panama for 2025

The top three Fintech startups in Panama have raised more than USD 483M. Panama startup ecosystem ranks among the top 10 locations in the world for startups in Fintech, holding the falseth position.
SB Score:427

Zaros is an innovative protocol designed to enhance liquidity and maximize staking rewards from Liquid Staking Tokens (LSTs). As a leading perpetual futures decentralized exchange on Ethereum, Zaros aims to establish itself as the go-to liquidity hub for on-chain derivatives.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (Panama City)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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SB Score:362

BitDAO is a pioneering decentralized autonomous organization dedicated to creating a more equitable economic landscape for everyone. By accelerating the growth of the decentralized tokenized economy, it empowers individuals globally to participate in and benefit from innovative financial opportunities.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (Panama City)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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SB Score:324

Crypto Ramps enables users in Panama, Guatemala, Honduras, and Costa Rica to easily buy, hold, and sell cryptocurrencies, as well as send and receive remittances with minimal fees. This platform provides seamless access to crypto and DeFi services, making digital finance more accessible for local communities.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (Panama City)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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Total amount:22

Top 4 Ecommerce & Retail Startups in Panama for 2025

The top three Ecommerce & Retail startups in Panama have raised more than USD 750K. Panama startup ecosystem ranks among the top 10 locations in the world for startups in Ecommerce & Retail, holding the falseth position.
SB Score:310

Venmetro is an innovative online lending platform in Panama that simplifies access to personal loans. By connecting borrowers with flexible financing options, it empowers individuals to achieve their financial goals with ease and convenience.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

City Rank (Panama City)

0

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Regional Rank (Central America)

0

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SB Score:85

Trusted Node is building a validator network for proof-of-stake and next-generation blockchains, enabling professional oversight of the network. It offers stakeholders the opportunity to earn yields while actively participating in decision-making regarding the network's node infrastructure.

Industry:
Ecommerce & Retail
Subindustry:
Marketplaces

City Rank (Panama City)

0

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Regional Rank (Central America)

0

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SB Score:53

TG DAO 3.0 serves as the launchpad for the TG Ecosystem, enabling investment in both traditional and crypto startups. Investors are not just contributors; they become co-owners, actively participating in the decision-making processes that shape the launchpad's operations.

Industry:
Ecommerce & Retail
Subindustry:
Marketplaces

City Rank (Panama City)

0

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Regional Rank (Central America)

0

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Total amount:4

Most Funded Startups in Panama for 2025

The top three most funded startups in Panama have raised total funding of more than USD 505M. BitDAO has 14.33% more funding than Ignite Tournaments.
SB Score:362

BitDAO is a pioneering decentralized autonomous organization dedicated to creating a more equitable economic landscape for everyone. By accelerating the growth of the decentralized tokenized economy, it empowers individuals globally to participate in and benefit from innovative financial opportunities.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (Panama City)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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SB Score:307

The CarTongyun intelligent maintenance platform offers precise insights through its extensive database, covering nearly 2 million vehicles. This innovative system empowers users to optimize vehicle maintenance, ensuring efficiency and reliability for all types of vehicles.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (Panama City)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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Total amount:56

Top Hiring Startups in Panama by Employee Number

The top three hiring startups in Panama have an median employee size that is between [101-250]
SB Score:265

NordLayer, from Nord Security, is a cutting-edge network access security solution for businesses. It offers adaptive protection and is backed by a trusted cybersecurity brand, making it an essential tool for modern companies looking to safeguard their networks.

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (Panama City)

0

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Regional Rank (Central America)

0

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SB Score:253

NordLocker is an easy-to-use file encryption tool. It lets you store and share your data securely. With a simple drag-and-drop function, NordLocker secures your files with powerful end-to-end encryption. So put your mind at ease – encryption is on us.

Industry:
Software & Data
Subindustry:
Cybersecurity

City Rank (Panama City)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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SB Score:313

HEAL Software is a groundbreaking preventive healing solution for IT operations, designed to identify and resolve issues before they arise. It surpasses traditional AI-assisted application performance management (APM) and monitoring tools, ensuring smooth and efficient IT environments while minimizing downtime and enhancing overall system reliability.

Industry:
Software & Data
Subindustry:
Software

City Rank (Arraijan)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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Total amount:56

Explore the Startup Ecosystem of Panama

Population

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4.5 Million

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Regional Rank

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3rd

0

Global Rank

(WorldWide)

84th

2

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Top Cities for Startups in Panama - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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