75 Top startups in Lexington for May 2025

We rank Ginger Software, Fooji and Fractyl Health in Lexington along with 72 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Lexington startup ecosystem ranks #150 globally and #46 in United States.

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Best Startups in Lexington for 2025

SB Score:505

Fooji empowers major brands to easily run large-scale experiential marketing campaigns through on-demand delivery services.

Industry:
Transportation
Subindustry:
Logistics

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SB Score:494

Fractyl Health offers curative treatments for metabolic diseases. Their biotechnology solutions aim to improve patient outcomes by addressing the root causes of these conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:407

The commercial building industry faces challenges in achieving large-scale energy efficiency. Our meter data analytics platform addresses barriers like customer engagement, access to building information, and high costs, making it easier to meet efficiency goals and regulatory mandates across commercial portfolios.

Industry:
Energy & Environment
Subindustry:
Cleantech

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SB Score:406

OmniGuide pioneers minimally-invasive surgical tools for medical professionals. Their innovative devices enhance precision and efficiency in surgeries.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:400

Authentica provides content security software for protecting and controlling business information in companies. It offers enterprise rights management solutions to control, secure, and track information. The company's products provide secure delivery, and after-delivery protection for email, electronic documents, and Web content. Authentica, Inc. was founded in 1998 and is headquartered in Lexington, Massachusetts.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:393

Accent Therapeutics is a biopharmaceutical company focused on developing cutting-edge therapies to target RNA-modifying proteins involved in cancer.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:351

Founded in August 2004, QD Vision is a nanotechnology product company delivering a new generation of display and lighting solutions to major industries where color, power, and design matter. The company is harnessing the unique light-emitting properties of quantum dots to deliver a new generation of display solutions that provide unmatched color, power efficiency, and cost savings QD Vision's technology platform sets new standards for color purity, brightness, power consumption, and design flexibility. Backed by a patent portfolio secured by the founders' research at MIT and continued developments at QD Vision, the company is targeting applications such as consumer electronics products, flat-panel displays, electronic signage, solid-state lighting, and national security.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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SB Score:349

GelSight offers optical measurement equipment for imaging surface structures at the micron level, along with software for generating 3D images. Their affordable systems use commodity optics and are compatible with both bench-top and handheld devices, making high-resolution imaging accessible for all.

Industry:
Software & Data
Subindustry:
Software and Data-Other

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SB Score:348

VulnCheck is a Cyber Threat Intelligence platform that delivers real-time exploit and vulnerability insights directly into the essential tools and systems organizations use. By integrating this intelligence, VulnCheck empowers teams to stay ahead of cyber adversaries and enhance their security posture effectively.

Industry:
Software & Data
Subindustry:
Cybersecurity

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SB Score:336

LWD operates as a cohesive team and family, united by common CORE VALUES. Their startup fosters teamwork and a sense of belonging, driving their success in delivering innovative solutions.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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Total amount:75

Top 25 Healthtech Startups in Lexington for 2025

The top three Healthtech startups in Lexington have raised more than USD 935M. Lexington startup ecosystem ranks #128 globally for the Healthtech industry.
SB Score:494

Fractyl Health offers curative treatments for metabolic diseases. Their biotechnology solutions aim to improve patient outcomes by addressing the root causes of these conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:406

OmniGuide pioneers minimally-invasive surgical tools for medical professionals. Their innovative devices enhance precision and efficiency in surgeries.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:393

Accent Therapeutics is a biopharmaceutical company focused on developing cutting-edge therapies to target RNA-modifying proteins involved in cancer.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Lexington)

0

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Regional Rank (North America)

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Total amount:25

Top 23 Software & Data Startups in Lexington for 2025

The top three Software & Data startups in Lexington have raised more than USD 76.3M. Lexington startup ecosystem ranks #273 globally for the Software & Data industry.
SB Score:400

Authentica provides content security software for protecting and controlling business information in companies. It offers enterprise rights management solutions to control, secure, and track information. The company's products provide secure delivery, and after-delivery protection for email, electronic documents, and Web content. Authentica, Inc. was founded in 1998 and is headquartered in Lexington, Massachusetts.

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (Lexington)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:349

GelSight offers optical measurement equipment for imaging surface structures at the micron level, along with software for generating 3D images. Their affordable systems use commodity optics and are compatible with both bench-top and handheld devices, making high-resolution imaging accessible for all.

Industry:
Software & Data
Subindustry:
Software and Data-Other

City Rank (Lexington)

0

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Regional Rank (North America)

0

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0

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SB Score:348

VulnCheck is a Cyber Threat Intelligence platform that delivers real-time exploit and vulnerability insights directly into the essential tools and systems organizations use. By integrating this intelligence, VulnCheck empowers teams to stay ahead of cyber adversaries and enhance their security posture effectively.

Industry:
Software & Data
Subindustry:
Cybersecurity

City Rank (Lexington)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:23

Top 4 Ecommerce & Retail Startups in Lexington for 2025

The top three Ecommerce & Retail startups in Lexington have raised more than USD 23.3M. Lexington startup ecosystem ranks #146 globally for the Ecommerce & Retail industry.
SB Score:336

LWD operates as a cohesive team and family, united by common CORE VALUES. Their startup fosters teamwork and a sense of belonging, driving their success in delivering innovative solutions.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

City Rank (Lexington)

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SB Score:208

Sword Performance creates hydration products that combat dehydration and fatigue, providing a solution to keep users energized and refreshed.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

City Rank (Lexington)

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SB Score:70

Scante bridges IoT products and consumer durables, helping companies leverage data for sales, support, and promotions. Monetize IoT data, deepen customer interactions, and maximize revenue. Platform is hardware agnostic, driving parts sales and marketing.

Industry:
Ecommerce & Retail
Subindustry:
Mobile Commerce

City Rank (Lexington)

0

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Regional Rank (North America)

0

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Total amount:4

Most Funded Startups in Lexington for 2025

The top three most funded startups in Lexington have raised total funding of more than USD 962M. Fractyl Health has 2.52% more funding than Accent Therapeutics.
SB Score:494

Fractyl Health offers curative treatments for metabolic diseases. Their biotechnology solutions aim to improve patient outcomes by addressing the root causes of these conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Lexington)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:393

Accent Therapeutics is a biopharmaceutical company focused on developing cutting-edge therapies to target RNA-modifying proteins involved in cancer.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Lexington)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:351

Founded in August 2004, QD Vision is a nanotechnology product company delivering a new generation of display and lighting solutions to major industries where color, power, and design matter. The company is harnessing the unique light-emitting properties of quantum dots to deliver a new generation of display solutions that provide unmatched color, power efficiency, and cost savings QD Vision's technology platform sets new standards for color purity, brightness, power consumption, and design flexibility. Backed by a patent portfolio secured by the founders' research at MIT and continued developments at QD Vision, the company is targeting applications such as consumer electronics products, flat-panel displays, electronic signage, solid-state lighting, and national security.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

City Rank (Lexington)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:75

Top Hiring Startups in Lexington by Employee Number

The top three hiring startups in Lexington have an median employee size that is between [251-500]
SB Score:244

Helpware is an outsourcing company that creates tailored teams for customer support, back office, and medical concierge services, as well as data annotation, labeling, entry, and content moderation for modern businesses.

Industry:
Fintech
Subindustry:
Accounting

City Rank (Lexington)

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SB Score:406

OmniGuide pioneers minimally-invasive surgical tools for medical professionals. Their innovative devices enhance precision and efficiency in surgeries.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Lexington)

0

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Regional Rank (North America)

0

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0

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SB Score:336

LWD operates as a cohesive team and family, united by common CORE VALUES. Their startup fosters teamwork and a sense of belonging, driving their success in delivering innovative solutions.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

City Rank (Lexington)

0

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Regional Rank (North America)

0

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SB Score:101

Deerwalk empowers you with the population health management management, healthcare analytics and reporting solutions

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Lexington)

0

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Total amount:75

Explore the Startup Ecosystem of Lexington

National Rank

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Regional Rank

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54th

3

Global Rank

(WorldWide)

150th

23

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2025 National Rank CityGlobal RankTotal Score

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Quantity Score
Quality ScoreBusiness Score
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852.643
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315.515
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0
4th
0
139.115
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0
6th
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1
128.476
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