StartupBlink

41 Top startups in Lancaster for June 2026

We rank Legacy Education, Simulations Plus and Immunomic Therapeutics in Lancaster along with 38 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Lancaster startup ecosystem ranks #483 globally and #133 in United States.

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Best Startups in Lancaster for 2026

SB Score:398

Legacy Education offers programs that focus on the allied healthcare industry along with an emphasis on veterinary and business. Legacy Education was founded in 2009 and currently owns and operates 3 nationally accredited academic institutions across 5 campuses in California.

Industry:
Edtech
Subindustry:
Education-Other

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SB Score:361

Simulations Plus is a developer of Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) and Physiologically-Based Pharmacokinetic (PBPK) modeling and simulation software for the pharmaceutical and biotechnology, generics, chemical, cosmetic, and food ingredient industries today. Our software allows pharmaceutical scientists to predict certain key potential endpoints and dynamics, in silico, thereby reducing research & development costs and helping clients make better projects decisions... sooner. Founded in 1996, Simulations Plus employs over 60 employees and is publicly-traded on the NASDAQ stock exchange (ticker symbol = SLP).Our headquarters are based in Lancaster, California, with our pharmacometrics consulting team located in Buffalo, New York. Trusted distributors handle sales and scientific support in Asian territories. 19 of the top 20 pharmaceutical companies, plus numerous mid- and small-sized companies and all major regulatory agencies, license our modeling & simulation technology.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:340

Immunomic Therapeutics is a development stage biotechnology company that develops lysosomal associated membrane protein-based vaccines for the treatment of allergy and other human health targets. The company was founded in 2005 and is based in Lancaster, Pennsylvania.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:325

In a part of the country where it’s more common to see an Amish buggy than an electric car, BeneFix, an insurTech start-up, is working to change how health insurance brokers manage small group benefits with their simple, speedy, and secure technology. BeneFix offers health insurance brokers a digital platform that delivers 100% accurate quotes 100 times faster. Based in Lancaster, Pa., BeneFix manages data from thousands of plans offered by major carriers in Pennsylvania and New Jersey, offering quotes in minutes from a simple-to-use online interface reminiscent of Zillow. Less than two years after founder Matt Ranauro first had the idea for the platform, the business had a brick-and-mortar office in Lancaster City, over 1,000 customers, and, most recently, became one of nine central Pennsylvania finalists competing for a $100,000 investment from AOL co-founder Steve Case’s “Rise of the Rest” initiative. The success is due, Ranauro believes, to three factors. First, his own passion for the product. Ranauro has co-founded several tech companies, most notably ILL Co., a company that has built apps for HBO and Nickelodeon, analytics platforms for KPMG and products for the Mayo Clinic. With each company, Ranauro needed to find health insurance for himself and his co-founders and employees. “It took about two months just to find out what was available, then get enrolled in those products.” He said. “Which seems crazy, right? In 2017?” The question became: how do we streamline this and make it a better experience for everyone? Ranauro’s previous experience is the second factor that contributes to the success and growth of BeneFix. The final is the Insurtech industry itself. With insurance, and health insurance particularly, still lagging behind other industries in terms of using and creating technologies that work, the Insurtech industry, a $4.5 trillion industry, has attracted the attention of venture capitalists and tech entrepreneurs alike. Lancaster (Ranauro’s hometown) may be Amish country, full of farms, buggies and country roads, but BeneFix is out to prove that it’s also fertile soil for creating a company that will revolutionize the health insurance industries’ outdated model.

Industry:
Fintech
Subindustry:
Insurance

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SB Score:316

Specializing in purchasing distressed properties in the Antelope Valley, we renovate and sell to first-time homebuyers. Our mission is to provide affordable housing options while revitalizing the community.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

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SB Score:292

Specializing in online marketing optimization, this startup drives profitable revenue growth for businesses. Their expert strategies and tactics help businesses achieve success in the digital landscape.

Industry:
Ecommerce & Retail
Subindustry:
Social Commerce

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SB Score:291

Boostpoint® platform provides Talent Acquisition teams with everything they need to capture qualified leads and build their brand presence on social media.

Industry:
Marketing & Sales
Subindustry:
Adtech

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SB Score:250

MAKE/FILMS specializes in producing identity films, TV commercials, training films, short films, documentaries, and more. MAKE/FILMS works with businesses and individuals to create inspiring content or an impactful commercial that resonates with audiences and delivers results.

Industry:
Social & Leisure
Subindustry:
Entertainment

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SB Score:247

MedStatix offers a white-labeled, cloud-based specialty-specific patient experience survey platform. The company's vision is to strengthen the patient-provider relationship in order to promote higher engagement, increased understanding, better outcomes, and lower costs. Their unique approach involves specialty-specific surveys and a partnership with industry-leading physicians and advisors that ensures they are asking the right questions, providing the right analytics, and offering actionable insights. Their cloud-based, mobile-optimized surveys deliver simplicity and convenience, resulting in response rates of more than 40% and completion rates of more than 97%, which are unprecedented within the industry. Patients are given a voice through their familiar star rating system, while real-time data allows providers to actively manage their reputation by identifying both risks and opportunities for improvement.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:235

CarthroniX develops small-molecule-based therapies for cartilage diseases, including arthritis. They are able to preserve, repair, and regenerate cartilage in joints and simultaneously suppress inflammation.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Lancaster)

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Total amount:41

Top 8 Marketing & Sales Startups in Lancaster for 2026

The top three Marketing & Sales startups in Lancaster have raised more than USD 700K. Lancaster startup ecosystem ranks #331 globally for the Marketing & Sales industry.
SB Score:291

Boostpoint® platform provides Talent Acquisition teams with everything they need to capture qualified leads and build their brand presence on social media.

Industry:
Marketing & Sales
Subindustry:
Adtech

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SB Score:89

Icing Digital is a marketer and project manager, and they are doing brands as well as dynamic local businesses and their services, web development, mobile apps, hosting, and digital marketing.

Industry:
Marketing & Sales
Subindustry:
Digital Marketing

City Rank (Lancaster)

0

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Steinman Communications is an innovative, multi-channel communications company that delivers high-quality news, information and entertainment to diverse audiences while providing significant value to our marketing and advertising partners.

Industry:
Marketing & Sales
Subindustry:
Marketing & Sales-Other

City Rank (Lancaster)

0

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Total amount:8

Top 13 Software & Data Startups in Lancaster for 2026

The top three Software & Data startups in Lancaster have raised more than USD 2.46M. Lancaster startup ecosystem ranks #480 globally for the Software & Data industry.
SB Score:247

MedStatix offers a white-labeled, cloud-based specialty-specific patient experience survey platform. The company's vision is to strengthen the patient-provider relationship in order to promote higher engagement, increased understanding, better outcomes, and lower costs. Their unique approach involves specialty-specific surveys and a partnership with industry-leading physicians and advisors that ensures they are asking the right questions, providing the right analytics, and offering actionable insights. Their cloud-based, mobile-optimized surveys deliver simplicity and convenience, resulting in response rates of more than 40% and completion rates of more than 97%, which are unprecedented within the industry. Patients are given a voice through their familiar star rating system, while real-time data allows providers to actively manage their reputation by identifying both risks and opportunities for improvement.

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (Lancaster)

0

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SB Score:192

Intulse offers flexible and feature-rich VOIP business phone solutions for growing businesses. Their expert team helps organizations maximize unified communications tools on a reliable network that evolves with their needs.

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (Lancaster)

0

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Total amount:13

Top 5 Fintech Startups in Lancaster for 2026

The top three Fintech startups in Lancaster have raised more than USD 10.1M. Lancaster startup ecosystem is currently unranked globally for the Fintech industry.
SB Score:325

In a part of the country where it’s more common to see an Amish buggy than an electric car, BeneFix, an insurTech start-up, is working to change how health insurance brokers manage small group benefits with their simple, speedy, and secure technology. BeneFix offers health insurance brokers a digital platform that delivers 100% accurate quotes 100 times faster. Based in Lancaster, Pa., BeneFix manages data from thousands of plans offered by major carriers in Pennsylvania and New Jersey, offering quotes in minutes from a simple-to-use online interface reminiscent of Zillow. Less than two years after founder Matt Ranauro first had the idea for the platform, the business had a brick-and-mortar office in Lancaster City, over 1,000 customers, and, most recently, became one of nine central Pennsylvania finalists competing for a $100,000 investment from AOL co-founder Steve Case’s “Rise of the Rest” initiative. The success is due, Ranauro believes, to three factors. First, his own passion for the product. Ranauro has co-founded several tech companies, most notably ILL Co., a company that has built apps for HBO and Nickelodeon, analytics platforms for KPMG and products for the Mayo Clinic. With each company, Ranauro needed to find health insurance for himself and his co-founders and employees. “It took about two months just to find out what was available, then get enrolled in those products.” He said. “Which seems crazy, right? In 2017?” The question became: how do we streamline this and make it a better experience for everyone? Ranauro’s previous experience is the second factor that contributes to the success and growth of BeneFix. The final is the Insurtech industry itself. With insurance, and health insurance particularly, still lagging behind other industries in terms of using and creating technologies that work, the Insurtech industry, a $4.5 trillion industry, has attracted the attention of venture capitalists and tech entrepreneurs alike. Lancaster (Ranauro’s hometown) may be Amish country, full of farms, buggies and country roads, but BeneFix is out to prove that it’s also fertile soil for creating a company that will revolutionize the health insurance industries’ outdated model.

Industry:
Fintech
Subindustry:
Insurance

City Rank (Lancaster)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:59

The social enterprise provides agricultural training, micro loans, leadership development, market sourcing, and fair pricing to empower the poor in East Africa.

Industry:
Fintech
Subindustry:
Financial Services

City Rank (Lancaster)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:5

Most Funded Startups in Lancaster for 2026

The top three most funded startups in Lancaster have raised total funding of more than USD 145M. Immunomic Therapeutics has 0.70% more funding than CLM Homes.
SB Score:340

Immunomic Therapeutics is a development stage biotechnology company that develops lysosomal associated membrane protein-based vaccines for the treatment of allergy and other human health targets. The company was founded in 2005 and is based in Lancaster, Pennsylvania.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Lancaster)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:316

Specializing in purchasing distressed properties in the Antelope Valley, we renovate and sell to first-time homebuyers. Our mission is to provide affordable housing options while revitalizing the community.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

City Rank (Lancaster)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:325

In a part of the country where it’s more common to see an Amish buggy than an electric car, BeneFix, an insurTech start-up, is working to change how health insurance brokers manage small group benefits with their simple, speedy, and secure technology. BeneFix offers health insurance brokers a digital platform that delivers 100% accurate quotes 100 times faster. Based in Lancaster, Pa., BeneFix manages data from thousands of plans offered by major carriers in Pennsylvania and New Jersey, offering quotes in minutes from a simple-to-use online interface reminiscent of Zillow. Less than two years after founder Matt Ranauro first had the idea for the platform, the business had a brick-and-mortar office in Lancaster City, over 1,000 customers, and, most recently, became one of nine central Pennsylvania finalists competing for a $100,000 investment from AOL co-founder Steve Case’s “Rise of the Rest” initiative. The success is due, Ranauro believes, to three factors. First, his own passion for the product. Ranauro has co-founded several tech companies, most notably ILL Co., a company that has built apps for HBO and Nickelodeon, analytics platforms for KPMG and products for the Mayo Clinic. With each company, Ranauro needed to find health insurance for himself and his co-founders and employees. “It took about two months just to find out what was available, then get enrolled in those products.” He said. “Which seems crazy, right? In 2017?” The question became: how do we streamline this and make it a better experience for everyone? Ranauro’s previous experience is the second factor that contributes to the success and growth of BeneFix. The final is the Insurtech industry itself. With insurance, and health insurance particularly, still lagging behind other industries in terms of using and creating technologies that work, the Insurtech industry, a $4.5 trillion industry, has attracted the attention of venture capitalists and tech entrepreneurs alike. Lancaster (Ranauro’s hometown) may be Amish country, full of farms, buggies and country roads, but BeneFix is out to prove that it’s also fertile soil for creating a company that will revolutionize the health insurance industries’ outdated model.

Industry:
Fintech
Subindustry:
Insurance

City Rank (Lancaster)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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View full page

Total amount:41

Top Hiring Startups in Lancaster by Employee Number

The top three hiring startups in Lancaster have an median employee size that is between [101-250]
SB Score:398

Legacy Education offers programs that focus on the allied healthcare industry along with an emphasis on veterinary and business. Legacy Education was founded in 2009 and currently owns and operates 3 nationally accredited academic institutions across 5 campuses in California.

Industry:
Edtech
Subindustry:
Education-Other

City Rank (Lancaster)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:361

Simulations Plus is a developer of Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) and Physiologically-Based Pharmacokinetic (PBPK) modeling and simulation software for the pharmaceutical and biotechnology, generics, chemical, cosmetic, and food ingredient industries today. Our software allows pharmaceutical scientists to predict certain key potential endpoints and dynamics, in silico, thereby reducing research & development costs and helping clients make better projects decisions... sooner. Founded in 1996, Simulations Plus employs over 60 employees and is publicly-traded on the NASDAQ stock exchange (ticker symbol = SLP).Our headquarters are based in Lancaster, California, with our pharmacometrics consulting team located in Buffalo, New York. Trusted distributors handle sales and scientific support in Asian territories. 19 of the top 20 pharmaceutical companies, plus numerous mid- and small-sized companies and all major regulatory agencies, license our modeling & simulation technology.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Lancaster)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:316

Specializing in purchasing distressed properties in the Antelope Valley, we renovate and sell to first-time homebuyers. Our mission is to provide affordable housing options while revitalizing the community.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

City Rank (Lancaster)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:123

LATRO provides data-centric solutions for the telecommunications industry, focusing on ensuring the financial health of mobile network operators (MNOs) and service providers. The company offers services such as revenue assurance, fraud management, and network security. LATRO's team consists of seasoned technical and business experts who help clients solve complex business problems and drive growth with confidence.

Industry:
Hardware & IoT
Subindustry:
Hardware

City Rank (Lancaster)

0

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Regional Rank (North America)

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Total amount:41

Explore the Startup Ecosystem of Lancaster

National Rank

(United States)

133rd

new

Regional Rank

(North America)

136th

4

Global Rank

(WorldWide)

483rd

99

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal ScoreAnnual Growth

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Quantity Score
Quality ScoreBusiness Score
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1st
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935.325
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2nd
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352.159
0.0%
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0
4th
0
152.371
0.0%
00.00
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00.00
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0
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1
127.119
0.0%
00.00
00.00
00.00
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