StartupBlink

41 Top startups in Lancaster for July 2026

We rank Legacy Education, Simulations Plus and Immunomic Therapeutics in Lancaster along with 38 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Lancaster startup ecosystem ranks #483 globally and #133 in United States.

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Best Startups in Lancaster for 2026

1st
Legacy Education logo
Legacy EducationSB Score: 398

Legacy Education offers programs that focus on the allied healthcare industry along with an emphasis on veterinary and business. Legacy Education was founded in 2009 and currently owns and operates 3 nationally accredited academic institutions across 5 campuses in California.

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Website
www.legacyed.com
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$1.4M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Simulations Plus logo
Simulations PlusSB Score: 361

Simulations Plus is a developer of Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) and Physiologically-Based Pharmacokinetic (PBPK) modeling and simulation software for the pharmaceutical and biotechnology, generics, chemical, cosmetic, and food ingredient industries today. Our software allows pharmaceutical scientists to predict certain key potential endpoints and dynamics, in silico, thereby reducing research & development costs and helping clients make better projects decisions... sooner. Founded in 1996, Simulations Plus employs over 60 employees and is publicly-traded on the NASDAQ stock exchange (ticker symbol = SLP).Our headquarters are based in Lancaster, California, with our pharmacometrics consulting team located in Buffalo, New York. Trusted distributors handle sales and scientific support in Asian territories. 19 of the top 20 pharmaceutical companies, plus numerous mid- and small-sized companies and all major regulatory agencies, license our modeling & simulation technology.

View Full Page
Website
www.simulations-plus.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$1.7M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Immunomic Therapeutics logo

Immunomic Therapeutics is a development stage biotechnology company that develops lysosomal associated membrane protein-based vaccines for the treatment of allergy and other human health targets. The company was founded in 2005 and is based in Lancaster, Pennsylvania.

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Website
www.immunomix.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$84.9M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
4th
BeneFix logo
BeneFixSB Score: 325

In a part of the country where it’s more common to see an Amish buggy than an electric car, BeneFix, an insurTech start-up, is working to change how health insurance brokers manage small group benefits with their simple, speedy, and secure technology. BeneFix offers health insurance brokers a digital platform that delivers 100% accurate quotes 100 times faster. Based in Lancaster, Pa., BeneFix manages data from thousands of plans offered by major carriers in Pennsylvania and New Jersey, offering quotes in minutes from a simple-to-use online interface reminiscent of Zillow. Less than two years after founder Matt Ranauro first had the idea for the platform, the business had a brick-and-mortar office in Lancaster City, over 1,000 customers, and, most recently, became one of nine central Pennsylvania finalists competing for a $100,000 investment from AOL co-founder Steve Case’s “Rise of the Rest” initiative. The success is due, Ranauro believes, to three factors. First, his own passion for the product. Ranauro has co-founded several tech companies, most notably ILL Co., a company that has built apps for HBO and Nickelodeon, analytics platforms for KPMG and products for the Mayo Clinic. With each company, Ranauro needed to find health insurance for himself and his co-founders and employees. “It took about two months just to find out what was available, then get enrolled in those products.” He said. “Which seems crazy, right? In 2017?” The question became: how do we streamline this and make it a better experience for everyone? Ranauro’s previous experience is the second factor that contributes to the success and growth of BeneFix. The final is the Insurtech industry itself. With insurance, and health insurance particularly, still lagging behind other industries in terms of using and creating technologies that work, the Insurtech industry, a $4.5 trillion industry, has attracted the attention of venture capitalists and tech entrepreneurs alike. Lancaster (Ranauro’s hometown) may be Amish country, full of farms, buggies and country roads, but BeneFix is out to prove that it’s also fertile soil for creating a company that will revolutionize the health insurance industries’ outdated model.

View Full Page
Website
benefix.us
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$9.6M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
5th
Improve & Grow logo
Improve & GrowSB Score: 292

Specializing in online marketing optimization, this startup drives profitable revenue growth for businesses. Their expert strategies and tactics help businesses achieve success in the digital landscape.

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Website
improveandgrow.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$7.4M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
6th
Boostpoint logo
BoostpointSB Score: 291

Boostpoint® platform provides Talent Acquisition teams with everything they need to capture qualified leads and build their brand presence on social media.

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Website
www.boostpoint.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$700K
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
8th
MAKE/FILMS logo
MAKE/FILMSSB Score: 250

MAKE/FILMS specializes in producing identity films, TV commercials, training films, short films, documentaries, and more. MAKE/FILMS works with businesses and individuals to create inspiring content or an impactful commercial that resonates with audiences and delivers results.

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Website
makefilms.cc
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$2.8M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
9th
MedStatix logo
MedStatixSB Score: 247

MedStatix offers a white-labeled, cloud-based specialty-specific patient experience survey platform. The company's vision is to strengthen the patient-provider relationship in order to promote higher engagement, increased understanding, better outcomes, and lower costs. Their unique approach involves specialty-specific surveys and a partnership with industry-leading physicians and advisors that ensures they are asking the right questions, providing the right analytics, and offering actionable insights. Their cloud-based, mobile-optimized surveys deliver simplicity and convenience, resulting in response rates of more than 40% and completion rates of more than 97%, which are unprecedented within the industry. Patients are given a voice through their familiar star rating system, while real-time data allows providers to actively manage their reputation by identifying both risks and opportunities for improvement.

View Full Page
Website
www.medstatix.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$2.2M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
10th
CarthroniX logo
CarthroniXSB Score: 235

CarthroniX develops small-molecule-based therapies for cartilage diseases, including arthritis. They are able to preserve, repair, and regenerate cartilage in joints and simultaneously suppress inflammation.

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Website
www.carthronix.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$2.3M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:22

Most Funded Startups in Lancaster for 2026

The top three most funded startups in Lancaster have raised total funding of more than USD 145M. Immunomic Therapeutics has 0.70% more funding than CLM Homes.
1st
Immunomic Therapeutics logo

Immunomic Therapeutics is a development stage biotechnology company that develops lysosomal associated membrane protein-based vaccines for the treatment of allergy and other human health targets. The company was founded in 2005 and is based in Lancaster, Pennsylvania.

View Full Page
Website
www.immunomix.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$84.9M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
BeneFix logo
BeneFixSB Score: 325

In a part of the country where it’s more common to see an Amish buggy than an electric car, BeneFix, an insurTech start-up, is working to change how health insurance brokers manage small group benefits with their simple, speedy, and secure technology. BeneFix offers health insurance brokers a digital platform that delivers 100% accurate quotes 100 times faster. Based in Lancaster, Pa., BeneFix manages data from thousands of plans offered by major carriers in Pennsylvania and New Jersey, offering quotes in minutes from a simple-to-use online interface reminiscent of Zillow. Less than two years after founder Matt Ranauro first had the idea for the platform, the business had a brick-and-mortar office in Lancaster City, over 1,000 customers, and, most recently, became one of nine central Pennsylvania finalists competing for a $100,000 investment from AOL co-founder Steve Case’s “Rise of the Rest” initiative. The success is due, Ranauro believes, to three factors. First, his own passion for the product. Ranauro has co-founded several tech companies, most notably ILL Co., a company that has built apps for HBO and Nickelodeon, analytics platforms for KPMG and products for the Mayo Clinic. With each company, Ranauro needed to find health insurance for himself and his co-founders and employees. “It took about two months just to find out what was available, then get enrolled in those products.” He said. “Which seems crazy, right? In 2017?” The question became: how do we streamline this and make it a better experience for everyone? Ranauro’s previous experience is the second factor that contributes to the success and growth of BeneFix. The final is the Insurtech industry itself. With insurance, and health insurance particularly, still lagging behind other industries in terms of using and creating technologies that work, the Insurtech industry, a $4.5 trillion industry, has attracted the attention of venture capitalists and tech entrepreneurs alike. Lancaster (Ranauro’s hometown) may be Amish country, full of farms, buggies and country roads, but BeneFix is out to prove that it’s also fertile soil for creating a company that will revolutionize the health insurance industries’ outdated model.

View Full Page
Website
benefix.us
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$9.6M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Improve & Grow logo
Improve & GrowSB Score: 292

Specializing in online marketing optimization, this startup drives profitable revenue growth for businesses. Their expert strategies and tactics help businesses achieve success in the digital landscape.

View Full Page
Website
improveandgrow.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$7.4M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:22

Top Hiring Startups in Lancaster by Employee Number

The top three hiring startups in Lancaster have an median employee size that is between [101-250]
1st
Legacy Education logo
Legacy EducationSB Score: 398

Legacy Education offers programs that focus on the allied healthcare industry along with an emphasis on veterinary and business. Legacy Education was founded in 2009 and currently owns and operates 3 nationally accredited academic institutions across 5 campuses in California.

View Full Page
Website
www.legacyed.com
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$1.4M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Simulations Plus logo
Simulations PlusSB Score: 361

Simulations Plus is a developer of Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) and Physiologically-Based Pharmacokinetic (PBPK) modeling and simulation software for the pharmaceutical and biotechnology, generics, chemical, cosmetic, and food ingredient industries today. Our software allows pharmaceutical scientists to predict certain key potential endpoints and dynamics, in silico, thereby reducing research & development costs and helping clients make better projects decisions... sooner. Founded in 1996, Simulations Plus employs over 60 employees and is publicly-traded on the NASDAQ stock exchange (ticker symbol = SLP).Our headquarters are based in Lancaster, California, with our pharmacometrics consulting team located in Buffalo, New York. Trusted distributors handle sales and scientific support in Asian territories. 19 of the top 20 pharmaceutical companies, plus numerous mid- and small-sized companies and all major regulatory agencies, license our modeling & simulation technology.

View Full Page
Website
www.simulations-plus.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$1.7M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
CLM Homes logo
CLM HomesSB Score: 316

Specializing in purchasing distressed properties in the Antelope Valley, we renovate and sell to first-time homebuyers. Our mission is to provide affordable housing options while revitalizing the community.

View Full Page
Website
www.CLMHomes.com
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
$50M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
4th
LATRO logo
LATROSB Score: 123

LATRO provides data-centric solutions for the telecommunications industry, focusing on ensuring the financial health of mobile network operators (MNOs) and service providers. The company offers services such as revenue assurance, fraud management, and network security. LATRO's team consists of seasoned technical and business experts who help clients solve complex business problems and drive growth with confidence.

View Full Page
Website
latro.com
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:41

Explore More Top Startups

Explore the Startup Ecosystem of Lancaster

National Rank

(United States)

133rd

new

Regional Rank

(North America)

136th

4

Global Rank

(WorldWide)

483rd

99

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal Score & National ShareAnnual Growth

Access subscores for 1000 cities and 100 countries

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152.3715.7%
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127.1194.8%
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