49 Top startups in La Jolla for April 2025

We rank Resilience, Salk Institute for Biological Studies and Aira in La Jolla along with 46 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. La Jolla is part of San Diego startup ecosystem which ranks #24 globally and #10 in North America.

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Best Startups in La Jolla for 2025

SB Score:610

Resilience offers comprehensive biopharmaceutical manufacturing and development solutions, committed to expanding access to complex medicines while safeguarding supply chains from disruptions. Founded in 2020 in La Jolla, California, the company is dedicated to enhancing the reliability and accessibility of critical biopharmaceuticals.

Industry:
Healthtech
Subindustry:
Biotechnology

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Salk Institute for Biological Studies conducts research on molecular biology and genetics, neurosciences, and plant biology. The research is conducted under the guidance of 59 faculty investigators and more than 850 scientific staff, including visiting scientists, postdoctoral fellows, and graduate students. The institute’s operates to identify therapies and treatments for a range of diseases such as cancer, AIDS, Alzheimer's disease, cardiovascular disorders, anomalies of the brain, and birth defects. Six key areas represent strategic research priorities: chemistry and proteomics, stem cell biology, cell biology, regulatory biology, metabolic research, and computational and theoretical biology. The Institute has trained more than 2,700 scientists, out of which five have won Nobel prizes. Salk is home to nine Howard Hughes Medical Investigators and 14 members of the National Academy of Sciences. NCI Cancer Center, Crick-Jacobs Center, Glenn Center for Aging Research, Helmsley Center for Genomic Medicine, Waitt Advanced Biophotonics Center, and Glenn Center for Aging Research are some of the research centers operated by Salk Institute for Biological Studies. The Salk Institute for Biological Studies was established in the 1960s by Jonas Salk and is based in California, United States.

Industry:
Healthtech
Subindustry:
Biotechnology

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3rd

Aira
SB Score:475

Called a Godsend by The New York Times, Aira is on a mission to make the world accessible anywhere, anytime. They provide on-remand, remote visual interpretation services for the blind and low vision community. Download the app, press a button and your phone's camera streams a live video to one our highly screened Visual Interpreters.

Industry:
Hardware & IoT
Subindustry:
Hardware

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SB Score:418

Good Face Project has created a groundbreaking AI-driven innovation hub for beauty and personal care, utilizing the world's largest proprietary cosmetic ingredients ontology. This science-backed platform empowers users to discover personalized product recommendations and enhance their understanding of cosmetic ingredients for more informed purchasing decisions.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:410

Fate Therapeutics is using the fundamental biological mechanisms that guide cell fate to develop stem cell therapeutics. The company has brought together the foremost scientists from the nation's research hotbeds (Boston, San Francisco, San Diego, and Seattle) who have demonstrated the potential to create and modulate stem cells to restore health. The backstory is that while others were working towards therapies based on transplanting stem cell-derived cells into patients, Randall Moon (HHMI and the University of Washington) and Alex Rives (Arch Venture Capitol) envisioned a different approach to develop regenerative therapies. The concept, based on data from hematopoietic progenitor cells, was that one could modulate the properties of stem cells in vivo using small molecules or biologics. They presented this idea to Arch Venture Capitol in Seattle, which launched the company, soon to be joined by other investors.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:398

Ambrx is a clinical stage biopharmaceutical company using an expanded genetic code technology platform to discover and develop Engineered Precision Biologics. These include next generation antibody drug conjugates (ADCs), bispecifics, targeted immuno-oncology therapies, novel cytokines to modulate the immune system, and long-acting therapeutic peptides for metabolic and cardiovascular disease. Ambrx is advancing a robust portfolio of clinical and preclinical programs designed to optimize efficacy, safety and ease of use, in multiple therapeutic areas, including its lead product candidate ARX788.

Industry:
Healthtech
Subindustry:
Biotechnology

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7th

XNow
SB Score:359

XNow is an innovative online platform that offers proprietary eligibility verification technologies, enabling users to easily determine their qualification for exclusive discounts on travel, hotels, car rentals, and event tickets, including major league sports, concerts, festivals, theme parks, and more.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:353

Enlaza Therapeutics, a biotech research startup based in La Jolla, CA, was established in 2020. Specializing in biotechnology, the company focuses on cutting-edge research and development.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:351

Genome Insight develops a comprehensive genome sequence analysis and interpretation platform. By delivering precise insights from full-length genomic data, it empowers clients to effectively leverage this information to enhance their operations and drive informed decision-making.

Industry:
Healthtech
Subindustry:
Biotechnology

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10th

Tr1x
SB Score:347

Tr1x specializes in developing innovative cellular therapies aimed at effectively treating autoimmune disorders. By harnessing the power of cellular technology, Tr1x strives to provide groundbreaking solutions that improve patient outcomes and enhance quality of life for those affected by these challenging conditions.

Industry:
Ecommerce & Retail
Subindustry:
Retail

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SB Score:318

Celladon Corporation, a biotechnology company, develops and manufactures molecular therapies for the treatment of heart failure. Its products include SERCA2a, an enzyme that regulates calcium cycling and contractility in heart muscle cells, and MYDICAR, an enzyme replacement therapy for heart failure. Celladon was founded in 2000 and is based in La Jolla, California.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Total amount:49

Top 17 Healthtech Startups in La Jolla for 2025

The top three Healthtech startups in La Jolla have raised more than USD 2.45B. La Jolla is part of San Diego startup ecosystem which ranks #5 globally for the Healthtech industry.
SB Score:610

Resilience offers comprehensive biopharmaceutical manufacturing and development solutions, committed to expanding access to complex medicines while safeguarding supply chains from disruptions. Founded in 2020 in La Jolla, California, the company is dedicated to enhancing the reliability and accessibility of critical biopharmaceuticals.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Salk Institute for Biological Studies conducts research on molecular biology and genetics, neurosciences, and plant biology. The research is conducted under the guidance of 59 faculty investigators and more than 850 scientific staff, including visiting scientists, postdoctoral fellows, and graduate students. The institute’s operates to identify therapies and treatments for a range of diseases such as cancer, AIDS, Alzheimer's disease, cardiovascular disorders, anomalies of the brain, and birth defects. Six key areas represent strategic research priorities: chemistry and proteomics, stem cell biology, cell biology, regulatory biology, metabolic research, and computational and theoretical biology. The Institute has trained more than 2,700 scientists, out of which five have won Nobel prizes. Salk is home to nine Howard Hughes Medical Investigators and 14 members of the National Academy of Sciences. NCI Cancer Center, Crick-Jacobs Center, Glenn Center for Aging Research, Helmsley Center for Genomic Medicine, Waitt Advanced Biophotonics Center, and Glenn Center for Aging Research are some of the research centers operated by Salk Institute for Biological Studies. The Salk Institute for Biological Studies was established in the 1960s by Jonas Salk and is based in California, United States.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:410

Fate Therapeutics is using the fundamental biological mechanisms that guide cell fate to develop stem cell therapeutics. The company has brought together the foremost scientists from the nation's research hotbeds (Boston, San Francisco, San Diego, and Seattle) who have demonstrated the potential to create and modulate stem cells to restore health. The backstory is that while others were working towards therapies based on transplanting stem cell-derived cells into patients, Randall Moon (HHMI and the University of Washington) and Alex Rives (Arch Venture Capitol) envisioned a different approach to develop regenerative therapies. The concept, based on data from hematopoietic progenitor cells, was that one could modulate the properties of stem cells in vivo using small molecules or biologics. They presented this idea to Arch Venture Capitol in Seattle, which launched the company, soon to be joined by other investors.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:17

Top 13 Software & Data Startups in La Jolla for 2025

The top three Software & Data startups in La Jolla have raised more than USD 50M. La Jolla is part of San Diego startup ecosystem which ranks #20 globally for the Software & Data industry.
SB Score:418

Good Face Project has created a groundbreaking AI-driven innovation hub for beauty and personal care, utilizing the world's largest proprietary cosmetic ingredients ontology. This science-backed platform empowers users to discover personalized product recommendations and enhance their understanding of cosmetic ingredients for more informed purchasing decisions.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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2nd

XNow
SB Score:359

XNow is an innovative online platform that offers proprietary eligibility verification technologies, enabling users to easily determine their qualification for exclusive discounts on travel, hotels, car rentals, and event tickets, including major league sports, concerts, festivals, theme parks, and more.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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SB Score:290

Genomic Life empowers policyholders and employees globally by providing innovative genomic products through trusted employee benefit brokers. By advancing genomic medicine and proactive health, it aims to make transformative healthcare accessible to everyone, revolutionizing the way individuals approach their health and wellness.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Total amount:13

Top 1 Marketing & Sales Startups in La Jolla for 2025

The top three Marketing & Sales startups in La Jolla have raised more than USD 366K. La Jolla is part of San Diego startup ecosystem which ranks #12 globally for the Marketing & Sales industry.
SB Score:215

Novelty Media's owned-and-operated properties celebrate and engage with the vibrant world of internet culture, showcasing the best of online trends and communities. Through innovative content and interactive experiences, they actively participate in shaping and honoring the digital landscape.

Industry:
Marketing & Sales
Subindustry:
Adtech

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:1

Most Funded Startups in La Jolla for 2025

The top three most funded startups in La Jolla have raised total funding of more than USD 2.45B. Resilience has 11.86% more funding than Enlaza Therapeutics.
SB Score:610

Resilience offers comprehensive biopharmaceutical manufacturing and development solutions, committed to expanding access to complex medicines while safeguarding supply chains from disruptions. Founded in 2020 in La Jolla, California, the company is dedicated to enhancing the reliability and accessibility of critical biopharmaceuticals.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:353

Enlaza Therapeutics, a biotech research startup based in La Jolla, CA, was established in 2020. Specializing in biotechnology, the company focuses on cutting-edge research and development.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Salk Institute for Biological Studies conducts research on molecular biology and genetics, neurosciences, and plant biology. The research is conducted under the guidance of 59 faculty investigators and more than 850 scientific staff, including visiting scientists, postdoctoral fellows, and graduate students. The institute’s operates to identify therapies and treatments for a range of diseases such as cancer, AIDS, Alzheimer's disease, cardiovascular disorders, anomalies of the brain, and birth defects. Six key areas represent strategic research priorities: chemistry and proteomics, stem cell biology, cell biology, regulatory biology, metabolic research, and computational and theoretical biology. The Institute has trained more than 2,700 scientists, out of which five have won Nobel prizes. Salk is home to nine Howard Hughes Medical Investigators and 14 members of the National Academy of Sciences. NCI Cancer Center, Crick-Jacobs Center, Glenn Center for Aging Research, Helmsley Center for Genomic Medicine, Waitt Advanced Biophotonics Center, and Glenn Center for Aging Research are some of the research centers operated by Salk Institute for Biological Studies. The Salk Institute for Biological Studies was established in the 1960s by Jonas Salk and is based in California, United States.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:49

Top Hiring Startups in La Jolla by Employee Number

The top three hiring startups in La Jolla have an median employee size that is between [501-1000]
SB Score:610

Resilience offers comprehensive biopharmaceutical manufacturing and development solutions, committed to expanding access to complex medicines while safeguarding supply chains from disruptions. Founded in 2020 in La Jolla, California, the company is dedicated to enhancing the reliability and accessibility of critical biopharmaceuticals.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

Browse
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Salk Institute for Biological Studies conducts research on molecular biology and genetics, neurosciences, and plant biology. The research is conducted under the guidance of 59 faculty investigators and more than 850 scientific staff, including visiting scientists, postdoctoral fellows, and graduate students. The institute’s operates to identify therapies and treatments for a range of diseases such as cancer, AIDS, Alzheimer's disease, cardiovascular disorders, anomalies of the brain, and birth defects. Six key areas represent strategic research priorities: chemistry and proteomics, stem cell biology, cell biology, regulatory biology, metabolic research, and computational and theoretical biology. The Institute has trained more than 2,700 scientists, out of which five have won Nobel prizes. Salk is home to nine Howard Hughes Medical Investigators and 14 members of the National Academy of Sciences. NCI Cancer Center, Crick-Jacobs Center, Glenn Center for Aging Research, Helmsley Center for Genomic Medicine, Waitt Advanced Biophotonics Center, and Glenn Center for Aging Research are some of the research centers operated by Salk Institute for Biological Studies. The Salk Institute for Biological Studies was established in the 1960s by Jonas Salk and is based in California, United States.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:410

Fate Therapeutics is using the fundamental biological mechanisms that guide cell fate to develop stem cell therapeutics. The company has brought together the foremost scientists from the nation's research hotbeds (Boston, San Francisco, San Diego, and Seattle) who have demonstrated the potential to create and modulate stem cells to restore health. The backstory is that while others were working towards therapies based on transplanting stem cell-derived cells into patients, Randall Moon (HHMI and the University of Washington) and Alex Rives (Arch Venture Capitol) envisioned a different approach to develop regenerative therapies. The concept, based on data from hematopoietic progenitor cells, was that one could modulate the properties of stem cells in vivo using small molecules or biologics. They presented this idea to Arch Venture Capitol in Seattle, which launched the company, soon to be joined by other investors.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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SB Score:117

Genesis Digital offers Karta, an online business platform with marketing and sales tools to help businesses grow. Founded in 2013 and headquartered in La Jolla, California, they provide SaaS eCommerce solutions to a growing market of innovators.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:49

Explore the Startup Ecosystem of La Jolla

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10th

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Global Rank

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24th

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Top Cities for Startups in United States - Ranked by StartupBlink

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710.966
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251.377
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121.937
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109.679
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