239 Top startups in Indianapolis for February 2025

We rank Anagin, Jobvite and Community Health Network in Indianapolis along with 236 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Indianapolis startup ecosystem ranks #110 globally and #38 in United States.

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Best Startups in Indianapolis for 2025

SB Score:684

Anagin is creating innovative treatments for neuropsychiatric conditions, targeting root causes with minimal side effects. Their goal is to revolutionize therapy options for these disorders.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:671

Jobvite offers comprehensive talent acquisition solutions to streamline recruiting processes, improve hiring outcomes, and reduce costs. Their software and services enhance recruitment quality, efficiency, and affordability for businesses of all sizes.

Industry:
Software & Data
Subindustry:
Data Analytics

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Community Health Network is a nonprofit health system that facilitates specialty and acute care hospitals, surgery centers, home care services, and behavioral and employer health services. Its health services focus on breast and cancer care, diet and nutrition, digestive health, fertility and home care, genetic testing and counselling, medical imaging, mental and behavioral health, neuroscience, and more. Community Health Network offers an online platform that enables its customers to find information and book the services of doctors, and pay bills. It also provides its customers with financial assistance. Community Health Network was founded in 1956 and is based in Indianapolis, Indiana.

Industry:
Social & Leisure
Subindustry:
Communities

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OneCause Fundraising Solutions empowers nonprofits to maximize donations and expand their donor base. With our innovative platform, organizations can easily raise funds and connect with more supporters to further their mission.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:499

Empowering successful in-person, virtual, and hybrid events. A versatile solution for all event formats, ensuring seamless execution and maximum impact.

Industry:
Marketing & Sales
Subindustry:
Events

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SB Score:497

BrüMate is the go-to brand for top-quality outdoor drinkware and coolers, perfect for any adventure. Their innovative products ensure your drinks stay cold and refreshing wherever you go, making BrüMate a must-have for outdoor enthusiasts.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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SB Score:496

Bloomerang empowers nonprofits to connect with and retain their supporters through a user-friendly donor database solution. By incorporating the latest fundraising strategies and technology, Bloomerang helps organizations boost revenue and decrease donor turnover, all while providing valuable insights for successful fundraising efforts.

Industry:
Software & Data
Subindustry:
Software and Data-Other

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SB Score:468

Sharpen is a cloud contact center platform that prioritizes agents and offers voice and software solutions. It provides an omnichannel experience for seamless customer interactions.

Industry:
Software & Data
Subindustry:
Cloud

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SB Score:461

PactSafe simplifies contract acceptance for fast-paced businesses by preparing, finding, and securing contract acceptances.

Industry:
Software & Data
Subindustry:
Software

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SB Score:448

Market Wagon transforms local food production by empowering farmers to sell directly to consumers through an online marketplace. Its platform streamlines e-commerce, inventory management, customer engagement, and last-mile logistics, allowing farmers to focus on what they do best: farming.

Industry:
Foodtech
Subindustry:
Agtech

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SB Score:443

Greenlight Guru is the ultimate quality management software for medical device companies. Streamline processes, ensure compliance, and accelerate time to market with a platform tailored to your unique needs.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:239

Top 91 Software & Data Startups in Indianapolis for 2025

The top three Software & Data startups in Indianapolis have raised more than USD 161M. Indianapolis startup ecosystem ranks #103 globally for the Software & Data industry.
SB Score:671

Jobvite offers comprehensive talent acquisition solutions to streamline recruiting processes, improve hiring outcomes, and reduce costs. Their software and services enhance recruitment quality, efficiency, and affordability for businesses of all sizes.

Industry:
Software & Data
Subindustry:
Data Analytics

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OneCause Fundraising Solutions empowers nonprofits to maximize donations and expand their donor base. With our innovative platform, organizations can easily raise funds and connect with more supporters to further their mission.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:496

Bloomerang empowers nonprofits to connect with and retain their supporters through a user-friendly donor database solution. By incorporating the latest fundraising strategies and technology, Bloomerang helps organizations boost revenue and decrease donor turnover, all while providing valuable insights for successful fundraising efforts.

Industry:
Software & Data
Subindustry:
Software and Data-Other

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Total amount:91

Top 10 Hardware & IoT Startups in Indianapolis for 2025

The top three Hardware & IoT startups in Indianapolis have raised more than USD 19.7M. Indianapolis startup ecosystem ranks #68 globally for the Hardware & IoT industry.
SB Score:349

Elate streamlines business operations by integrating internal technologies and data to drive successful outcomes.

Industry:
Hardware & IoT
Subindustry:
Hardware

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SB Score:312

West Fork Whiskey crafts, sells, and distributes exceptional whiskey. Experience the art of distillation with our small-batch, handcrafted spirits, perfect for whiskey enthusiasts and connoisseurs alike.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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SB Score:283

Amplio enables you to reclaim control of your supply chain by making sourcing more cost-effective.

Industry:
Hardware & IoT
Subindustry:
Hardware

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Total amount:10

Top 30 Healthtech Startups in Indianapolis for 2025

The top three Healthtech startups in Indianapolis have raised more than USD 122M. Indianapolis startup ecosystem ranks #112 globally for the Healthtech industry.
SB Score:684

Anagin is creating innovative treatments for neuropsychiatric conditions, targeting root causes with minimal side effects. Their goal is to revolutionize therapy options for these disorders.

Industry:
Healthtech
Subindustry:
Biotechnology

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2nd

hc1
SB Score:408

HC1 empowers health systems, laboratories, and physicians with real-time lab stewardship and precision prescribing. Streamline processes and improve patient care with cutting-edge technology.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:371

Prevounce is a team of experts creating wellness solutions for healthcare providers. Their dedicated professionals in legal, healthcare, and software fields develop innovative tools to support organizations in delivering better care.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:30

Most Funded Startups in Indianapolis for 2025

The top three most funded startups in Indianapolis have raised total funding of more than USD 329M. Sanctuary Wealth has 1.13% more funding than Cityscape Residential.
SB Score:441

Sanctuary Wealth empowers elite advisors with an innovative platform designed for entrepreneurial-minded professionals. It enables them to build and manage their practices with advanced tools, fostering growth and success in a competitive landscape.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:368

Cityscape Residential is a real estate development and construction company specializing in creating vibrant multifamily communities. They offer full-service solutions to bring high-quality living spaces to life.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

National Rank (United States)

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3rd

Zylo
SB Score:439

As the leader in SaaS Management, Zylo empowers companies to discover, optimize and govern their SaaS applications while elevating the employee experience. Organizations large and small trust Zylo’s enterprise-proven technology and unparalleled SaaS Management expertise to optimize more than 30 million SaaS licenses and $7 billion in SaaS spend. Zylo’s patent-pending, AI-powered Discovery Engine provides continual, frictionless monitoring of SaaS spend, licenses, and usage to create the industry’s most trusted SaaS system of record. Fueled by more data than any other provider, Zylo delivers actionable insights that allow you to take action quickly to optimize growing SaaS portfolios. For more information, visit zylo.com.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:239

Top Hiring Startups in Indianapolis by Employee Number

The top three hiring startups in Indianapolis have an median employee size that is between [1001-5000]

Community Health Network is a nonprofit health system that facilitates specialty and acute care hospitals, surgery centers, home care services, and behavioral and employer health services. Its health services focus on breast and cancer care, diet and nutrition, digestive health, fertility and home care, genetic testing and counselling, medical imaging, mental and behavioral health, neuroscience, and more. Community Health Network offers an online platform that enables its customers to find information and book the services of doctors, and pay bills. It also provides its customers with financial assistance. Community Health Network was founded in 1956 and is based in Indianapolis, Indiana.

Industry:
Social & Leisure
Subindustry:
Communities

National Rank (United States)

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Regional Rank (North America)

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SB Score:684

Anagin is creating innovative treatments for neuropsychiatric conditions, targeting root causes with minimal side effects. Their goal is to revolutionize therapy options for these disorders.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:671

Jobvite offers comprehensive talent acquisition solutions to streamline recruiting processes, improve hiring outcomes, and reduce costs. Their software and services enhance recruitment quality, efficiency, and affordability for businesses of all sizes.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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Assured Health is a short-term inpatient psychiatric hospital dedicated to addressing the mental health needs of older adults. With a focus on compassionate care and tailored treatment, it provides a safe environment for recovery and support, ensuring that each patient receives the attention they deserve.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:239

Explore the Startup Ecosystem of Indianapolis

National Rank

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Regional Rank

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44th

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Global Rank

(WorldWide)

110th

2

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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Quantity Score
Quality ScoreBusiness Score
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710.966
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251.377
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121.937
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109.679
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