20 Top startups in Framingham for April 2025

We rank Punchbowl, Re:Build and Variantyx in Framingham along with 17 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Framingham is part of Boston Area startup ecosystem which ranks #5 globally and #4 in North America.

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Top Unicorn Startups in Framingham for 2025

Alzheon is the only unicorn in Framingham raising more than USD 1.31B. It is the undefined ranked unicorn in North America.
SB Score:378

Alzheon's ALZ-801 is the leading oral treatment being tested for Alzheimer's disease, offering potential disease-modifying benefits. It is the only product in late-stage trials, providing hope for those affected by this devastating condition.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:1

Best Startups in Framingham for 2025

SB Score:539

Punchbowl is a web-based software platform that offers party planning services, customized digital invitations, and greeting cards. The platform guides a host through all of the steps of planning a party and solves common problems along the way. Its party planning features include customizable digital invitations, potluck organization, gift registries, local vendor search, RSVP management, party supplies, photo and video sharing, and much more. Punchbowl has made setting a date much easier through the help of an algorithm that recommends the best date for its clients’ party. Invitees are sent a ""Date Decider"" email through its platform, allowing them to select the best date from a set of dates supplied by the host. Punchbowl also allows clients to set up message boards and integrate Google Maps’ to display the location. After the party’s over, Punchbowl lets clients create an after-party message board where attendees can share comments, photos, and videos.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:476

Re:Build is an innovative industrial manufacturing company that seamlessly combines advanced technologies with traditional manufacturing processes, enhancing efficiency and quality. By leveraging cutting-edge solutions, Re:Build transforms the manufacturing landscape, driving productivity and enabling businesses to thrive in a competitive market.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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SB Score:427

Based on clinical whole genome sequencing (WGS) and using a single patient sample, Variantyx's Genomic Unity® test identifies and reports all major variant types including small sequence changes, structural variants, mitochondrial variants and short tandem repeat expansions. This comprehensive test test eliminates the need for traditional step-wise, reiterative genetic testing.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:386

Beamable helps game developers enhance their games with social, commerce, and content management tools. With Beamable, developers can easily add features to engage players and monetize their games effectively.

Industry:
Social & Leisure
Subindustry:
Communities

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SB Score:380

Trilio is a leader in cloud-native data protection for Kubernetes, OpenStack and Red Hat Virtualization environments. Our TrilioVault technology is trusted by cloud infrastructure operators and developers for backup and recovery, migration and application mobility. Customers in telecom, defense, automotive and financial services leverage TrilioVault to recover from disasters, migrate workloads, move workloads to new infrastructure and migrate to new software distributions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:327

Raven360 offers a sales readiness platform that provides sales teams with current content, training, and coaching to enhance their performance.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:318

Correlsense provides powerful software that identifies issues with app performance, preventing downtime and disruptions for businesses. Their enterprise solution detects and resolves problems quickly, ensuring smooth operation and optimal user experience.

Industry:
Software & Data
Subindustry:
Apps

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SB Score:316

DetraPel is a cleantech advanced materials company that specializes in synthesizing and manufacturing PFAS-Free Protective Coatings.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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SB Score:289

Vizium is an e-marketing and customer relationship consulting firm that helps businesses enhance their online presence and customer engagement.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:276

Prelert provides incident management tools that automatically isolate the causality of application interruptions in real-time. Its solutions include a business service management solution that isolates application behavior abnormality root-causality in real-time, and Incident Cause Analysis software that employs pattern detection algorithms, used in DNA sequencing the human genome, to analyze terabytes of information technology incident data. The company was founded in 2009 and headquartered in Framingham, Massachusetts.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

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Regional Rank (North America)

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Total amount:20

Top 6 Healthtech Startups in Framingham for 2025

The top three Healthtech startups in Framingham have raised more than USD 234M. Framingham is part of Boston Area startup ecosystem which ranks #2 globally for the Healthtech industry.
SB Score:427

Based on clinical whole genome sequencing (WGS) and using a single patient sample, Variantyx's Genomic Unity® test identifies and reports all major variant types including small sequence changes, structural variants, mitochondrial variants and short tandem repeat expansions. This comprehensive test test eliminates the need for traditional step-wise, reiterative genetic testing.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:269

Kephera Diagnostics tackles global infectious diseases with innovative solutions. Their startup aims to improve public health by providing advanced diagnostic tools.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Total amount:6

Top 5 Software & Data Startups in Framingham for 2025

The top three Software & Data startups in Framingham have raised more than USD 96.4M. Framingham is part of Boston Area startup ecosystem which ranks #5 globally for the Software & Data industry.
SB Score:539

Punchbowl is a web-based software platform that offers party planning services, customized digital invitations, and greeting cards. The platform guides a host through all of the steps of planning a party and solves common problems along the way. Its party planning features include customizable digital invitations, potluck organization, gift registries, local vendor search, RSVP management, party supplies, photo and video sharing, and much more. Punchbowl has made setting a date much easier through the help of an algorithm that recommends the best date for its clients’ party. Invitees are sent a ""Date Decider"" email through its platform, allowing them to select the best date from a set of dates supplied by the host. Punchbowl also allows clients to set up message boards and integrate Google Maps’ to display the location. After the party’s over, Punchbowl lets clients create an after-party message board where attendees can share comments, photos, and videos.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:380

Trilio is a leader in cloud-native data protection for Kubernetes, OpenStack and Red Hat Virtualization environments. Our TrilioVault technology is trusted by cloud infrastructure operators and developers for backup and recovery, migration and application mobility. Customers in telecom, defense, automotive and financial services leverage TrilioVault to recover from disasters, migrate workloads, move workloads to new infrastructure and migrate to new software distributions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:327

Raven360 offers a sales readiness platform that provides sales teams with current content, training, and coaching to enhance their performance.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:5

Most Funded Startups in Framingham for 2025

The top three most funded startups in Framingham have raised total funding of more than USD 516M. Re:Build has 0.08% more funding than Variantyx.
SB Score:476

Re:Build is an innovative industrial manufacturing company that seamlessly combines advanced technologies with traditional manufacturing processes, enhancing efficiency and quality. By leveraging cutting-edge solutions, Re:Build transforms the manufacturing landscape, driving productivity and enabling businesses to thrive in a competitive market.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:427

Based on clinical whole genome sequencing (WGS) and using a single patient sample, Variantyx's Genomic Unity® test identifies and reports all major variant types including small sequence changes, structural variants, mitochondrial variants and short tandem repeat expansions. This comprehensive test test eliminates the need for traditional step-wise, reiterative genetic testing.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:386

Beamable helps game developers enhance their games with social, commerce, and content management tools. With Beamable, developers can easily add features to engage players and monetize their games effectively.

Industry:
Social & Leisure
Subindustry:
Communities

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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Total amount:20

Top Hiring Startups in Framingham by Employee Number

The top three hiring startups in Framingham have an median employee size that is between [251-500]
SB Score:476

Re:Build is an innovative industrial manufacturing company that seamlessly combines advanced technologies with traditional manufacturing processes, enhancing efficiency and quality. By leveraging cutting-edge solutions, Re:Build transforms the manufacturing landscape, driving productivity and enabling businesses to thrive in a competitive market.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:252

BERG LLC supplies pharmaceutical and biotechnology products to medical professionals. Specializing in innovative solutions, they offer cutting-edge treatments for various health conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

Browse
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SB Score:427

Based on clinical whole genome sequencing (WGS) and using a single patient sample, Variantyx's Genomic Unity® test identifies and reports all major variant types including small sequence changes, structural variants, mitochondrial variants and short tandem repeat expansions. This comprehensive test test eliminates the need for traditional step-wise, reiterative genetic testing.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:318

Correlsense provides powerful software that identifies issues with app performance, preventing downtime and disruptions for businesses. Their enterprise solution detects and resolves problems quickly, ensuring smooth operation and optimal user experience.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:20

Explore the Startup Ecosystem of Framingham

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal RankTotal Score

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Quantity Score
Quality ScoreBusiness Score
1st
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1st
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710.966
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2nd
0
2nd
0
251.377
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3rd
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4th
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121.937
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4th
0
5th
0
109.679
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00.00
00.00
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