StartupBlink

8 Top startups in Eagan for June 2026

We rank Sonex Health, Regenevida and Leafline Labs in Eagan along with 5 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Eagan is part of Minneapolis startup ecosystem which ranks #61 globally and #24 in North America.

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Best Startups in Eagan for 2026

SB Score:366

Sonex Health reduces invasiveness, improves safety, and lowers the cost of care through transformative ultrasound. “Refined simplicity” is the guiding principle behind Sonex Health. To drive efforts and innovations that result in elegant, effective solutions to some of the healthcare system’s most pressing needs. Mayo Clinic physicians Darryl Barnes, MD and Jay Smith, MD, and business operations expert Aaron Keenan founded Sonex Health in 2014. Sonex Health has developed the SX-One MicroKnife(R) with Meerkat Technology™ to treat carpal tunnel syndrome in a novel fashion, termed Micro-invasive Carpal Tunnel Release. This innovation allows a procedure that once took place in an operating room to be safely and effectively performed in a surgery center or office setting, resulting in rapid patient recovery, improved cosmesis, and reduced costs. The ultra-low-profile SX-One MicroKnife with Meerkat Technology is an innovative surgical device that enables physicians to perform Micro-invasive Carpal Tunnel Release surgery through a single micro-incision under ultrasound guidance, or with a traditional mini-open incision without ultrasound guidance. The SX-One MicroKnife utilizes a micro-incision that’s up to five times smaller than the incision made during traditional CTR surgery—an incision so small, it can be closed with a small adhesive bandage or strip instead of sutures or stitches. The result is a low-trauma surgical environment that has been associated with a more rapid recovery. Immobilization is unnecessary so patients can begin rehabilitation and get back to their jobs and lives.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:315

Recombinetics is a developer of gene editing technologies to improve human health through advanced disease models and regenerative medicine. Its gene-editing technologies manipulate deoxyribonucleic acid (DNA) samples to add and activate genes to solve problems and also offer gene repair and gene editing tools that enable biomedical research, livestock productivity, animal agriculture, and livestock vertical markets to modify animal genomes accurately and efficiently.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Eagan)

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SB Score:276

LeafLine Labs was founded by practicing physicians who see the unnecessary suffering patients endure every day. We are, first and foremost, caregivers who exist to give our patients the quality of life they deserve.

Industry:
Healthtech
Subindustry:
Cannabis

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SB Score:273

Before the ‘80s, if you had a low tire, you’d better hope you also had your own air compressor. In 1981, Dave Bobert changed all that. That year, working from his garage, Dave created the coin-operated tire inflator industry and launched Air Resource Vending, Inc. (ARV). By 1998, ARV had $20 million in sales and retail and distributor partnerships not just across the nation, but across the globe. Demand was clear, and competitors popped up, but ARV stayed on top, leading the industry in innovation and service. It seemed like a good time to step out of the business, and that’s what Dave did…for a while.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

City Rank (Eagan)

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SB Score:213

Vail Scientific develops medical devices designed to provide rapid diagnosis of diverse diseases. Its products measure two components in exhaled breath that includes nitric oxide and carbon dioxide. Also, its proprietary algorithm provides a predictive probability of sepsis risk for a given patient.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:160

Exogal develops high-definition digital audio applications providing products for high-end systems. The company's core products are Comet DAC, Ion PowerDAC, Comet Power Supply Upgrade, and Vortex Streaming Hubs. Exogal was founded by Jim Kinne, Larry Jacoby, Jeff Haagenstad, and Jan Larsen.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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SB Score:89

Version1 is a property esports organization. They host the events. Version1 employs full-time employees in content, communications, partnerships, business development, operations, and finance. They believe in the power of bringing together people from various backgrounds to create the best organization possible.

Industry:
Social & Leisure
Subindustry:
Gaming

City Rank (Eagan)

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SB Score:24

HouseRater LLC offers a comprehensive suite of energy rating software designed to streamline site inspections and enhance the accuracy of energy ratings. The platform includes web and mobile applications that facilitate the collection, analysis, and sharing of energy rating data among inspectors, energy modelers, quality assessors, builders, and utility staff. By optimizing the process of energy data management, HouseRater LLC supports the energy industry in achieving more efficient and sustainable building practices.

Industry:
Software & Data
Subindustry:
Software

City Rank (Eagan)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:8

Top 4 Healthtech Startups in Eagan for 2026

The top three Healthtech startups in Eagan have raised more than USD 159M. Eagan is part of Minneapolis startup ecosystem which ranks #40 globally for the Healthtech industry.
SB Score:366

Sonex Health reduces invasiveness, improves safety, and lowers the cost of care through transformative ultrasound. “Refined simplicity” is the guiding principle behind Sonex Health. To drive efforts and innovations that result in elegant, effective solutions to some of the healthcare system’s most pressing needs. Mayo Clinic physicians Darryl Barnes, MD and Jay Smith, MD, and business operations expert Aaron Keenan founded Sonex Health in 2014. Sonex Health has developed the SX-One MicroKnife(R) with Meerkat Technology™ to treat carpal tunnel syndrome in a novel fashion, termed Micro-invasive Carpal Tunnel Release. This innovation allows a procedure that once took place in an operating room to be safely and effectively performed in a surgery center or office setting, resulting in rapid patient recovery, improved cosmesis, and reduced costs. The ultra-low-profile SX-One MicroKnife with Meerkat Technology is an innovative surgical device that enables physicians to perform Micro-invasive Carpal Tunnel Release surgery through a single micro-incision under ultrasound guidance, or with a traditional mini-open incision without ultrasound guidance. The SX-One MicroKnife utilizes a micro-incision that’s up to five times smaller than the incision made during traditional CTR surgery—an incision so small, it can be closed with a small adhesive bandage or strip instead of sutures or stitches. The result is a low-trauma surgical environment that has been associated with a more rapid recovery. Immobilization is unnecessary so patients can begin rehabilitation and get back to their jobs and lives.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Eagan)

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Regional Rank (North America)

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Global Rank (WorldWide)

0

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SB Score:315

Recombinetics is a developer of gene editing technologies to improve human health through advanced disease models and regenerative medicine. Its gene-editing technologies manipulate deoxyribonucleic acid (DNA) samples to add and activate genes to solve problems and also offer gene repair and gene editing tools that enable biomedical research, livestock productivity, animal agriculture, and livestock vertical markets to modify animal genomes accurately and efficiently.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Eagan)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:276

LeafLine Labs was founded by practicing physicians who see the unnecessary suffering patients endure every day. We are, first and foremost, caregivers who exist to give our patients the quality of life they deserve.

Industry:
Healthtech
Subindustry:
Cannabis

City Rank (Eagan)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:4

Most Funded Startups in Eagan for 2026

The top three most funded startups in Eagan have raised total funding of more than USD 159M. Sonex Health has 0.36% more funding than Regenevida.
SB Score:366

Sonex Health reduces invasiveness, improves safety, and lowers the cost of care through transformative ultrasound. “Refined simplicity” is the guiding principle behind Sonex Health. To drive efforts and innovations that result in elegant, effective solutions to some of the healthcare system’s most pressing needs. Mayo Clinic physicians Darryl Barnes, MD and Jay Smith, MD, and business operations expert Aaron Keenan founded Sonex Health in 2014. Sonex Health has developed the SX-One MicroKnife(R) with Meerkat Technology™ to treat carpal tunnel syndrome in a novel fashion, termed Micro-invasive Carpal Tunnel Release. This innovation allows a procedure that once took place in an operating room to be safely and effectively performed in a surgery center or office setting, resulting in rapid patient recovery, improved cosmesis, and reduced costs. The ultra-low-profile SX-One MicroKnife with Meerkat Technology is an innovative surgical device that enables physicians to perform Micro-invasive Carpal Tunnel Release surgery through a single micro-incision under ultrasound guidance, or with a traditional mini-open incision without ultrasound guidance. The SX-One MicroKnife utilizes a micro-incision that’s up to five times smaller than the incision made during traditional CTR surgery—an incision so small, it can be closed with a small adhesive bandage or strip instead of sutures or stitches. The result is a low-trauma surgical environment that has been associated with a more rapid recovery. Immobilization is unnecessary so patients can begin rehabilitation and get back to their jobs and lives.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Eagan)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:315

Recombinetics is a developer of gene editing technologies to improve human health through advanced disease models and regenerative medicine. Its gene-editing technologies manipulate deoxyribonucleic acid (DNA) samples to add and activate genes to solve problems and also offer gene repair and gene editing tools that enable biomedical research, livestock productivity, animal agriculture, and livestock vertical markets to modify animal genomes accurately and efficiently.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Eagan)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

Browse
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SB Score:276

LeafLine Labs was founded by practicing physicians who see the unnecessary suffering patients endure every day. We are, first and foremost, caregivers who exist to give our patients the quality of life they deserve.

Industry:
Healthtech
Subindustry:
Cannabis

City Rank (Eagan)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:8

Top Hiring Startups in Eagan by Employee Number

The top three hiring startups in Eagan have an median employee size that is between [11-50]
SB Score:366

Sonex Health reduces invasiveness, improves safety, and lowers the cost of care through transformative ultrasound. “Refined simplicity” is the guiding principle behind Sonex Health. To drive efforts and innovations that result in elegant, effective solutions to some of the healthcare system’s most pressing needs. Mayo Clinic physicians Darryl Barnes, MD and Jay Smith, MD, and business operations expert Aaron Keenan founded Sonex Health in 2014. Sonex Health has developed the SX-One MicroKnife(R) with Meerkat Technology™ to treat carpal tunnel syndrome in a novel fashion, termed Micro-invasive Carpal Tunnel Release. This innovation allows a procedure that once took place in an operating room to be safely and effectively performed in a surgery center or office setting, resulting in rapid patient recovery, improved cosmesis, and reduced costs. The ultra-low-profile SX-One MicroKnife with Meerkat Technology is an innovative surgical device that enables physicians to perform Micro-invasive Carpal Tunnel Release surgery through a single micro-incision under ultrasound guidance, or with a traditional mini-open incision without ultrasound guidance. The SX-One MicroKnife utilizes a micro-incision that’s up to five times smaller than the incision made during traditional CTR surgery—an incision so small, it can be closed with a small adhesive bandage or strip instead of sutures or stitches. The result is a low-trauma surgical environment that has been associated with a more rapid recovery. Immobilization is unnecessary so patients can begin rehabilitation and get back to their jobs and lives.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Eagan)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:315

Recombinetics is a developer of gene editing technologies to improve human health through advanced disease models and regenerative medicine. Its gene-editing technologies manipulate deoxyribonucleic acid (DNA) samples to add and activate genes to solve problems and also offer gene repair and gene editing tools that enable biomedical research, livestock productivity, animal agriculture, and livestock vertical markets to modify animal genomes accurately and efficiently.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Eagan)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:276

LeafLine Labs was founded by practicing physicians who see the unnecessary suffering patients endure every day. We are, first and foremost, caregivers who exist to give our patients the quality of life they deserve.

Industry:
Healthtech
Subindustry:
Cannabis

City Rank (Eagan)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:273

Before the ‘80s, if you had a low tire, you’d better hope you also had your own air compressor. In 1981, Dave Bobert changed all that. That year, working from his garage, Dave created the coin-operated tire inflator industry and launched Air Resource Vending, Inc. (ARV). By 1998, ARV had $20 million in sales and retail and distributor partnerships not just across the nation, but across the globe. Demand was clear, and competitors popped up, but ARV stayed on top, leading the industry in innovation and service. It seemed like a good time to step out of the business, and that’s what Dave did…for a while.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

City Rank (Eagan)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:8

Explore the Startup Ecosystem of Eagan

National Rank

(United States)

new

Regional Rank

(North America)

24th

4

Global Rank

(WorldWide)

61st

14

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal ScoreAnnual Growth

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Quantity Score
Quality ScoreBusiness Score
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352.159
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152.371
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127.119
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