StartupBlink

46 Top startups in Des Moines for November 2026

We rank Roboflow, OpenLoop Health and Dwolla in Des Moines along with 43 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Des Moines startup ecosystem ranks #315 globally and #86 in United States.

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Best Startups in Des Moines for 2026

1st
Roboflow logo
RoboflowSB Score: 545

Roboflow's developer tools enable teams to build computer vision models faster and more accurately.We replace ad-hoc code with production infrastructure, enable versioned datasets to be used in any framework, eliminate common errors that reduce model performance.

View Full Page
Website
roboflow.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
$99.7M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
2nd
OpenLoop Health logo
OpenLoop HealthSB Score: 513

OpenLoop is the infrastructure for digital healthcare. Its clients, healthcare companies, rely on its tech platform and systems to power healthcare delivery. To provide a comprehensive, turnkey solution, OpenLoop provides clinicians, labs, medications, regulatory and patient support, and other services through its platform.

View Full Page
Website
openloophealth.com
Employee range
501 – 1,000
Web Traffic (Monthly)
—
Funding amount
$26.6M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
3rd
Dwolla logo
DwollaSB Score: 466

Dwolla is a payment services provider powering innovations with sophisticated account-to-account payment solutions. Dwolla’s modern API simplifies the complex process of integrating with the various payment networks to create a single end-to-end solution–giving businesses the ability to program payments on the same day, next day or in real-time directly to bank accounts. With minimal development, start-ups to Fortune 500 companies can gain efficiency, flexibility and improved cash flow by working with Dwolla.

View Full Page
Website
www.dwolla.com
Employee range
51 – 100
Web Traffic (Monthly)
—
Funding amount
$72.4M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
4th
WINPRO Pet logo
WINPRO PetSB Score: 342

WINPRO is the world's first and only line of blood protein supplements. WINPRO products use the power of clinically proven animal blood proteins to help prevent and combat the negative effects of stress-induced inflammation in dogs.

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Website
www.winpropet.com
Employee range
1 – 10
Web Traffic (Monthly)
—
Funding amount
$3.3M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
5th
Gain Compliance logo
Gain ComplianceSB Score: 321

We believe that financial reporting teams deserve modern software. Over the past two years, Gain has worked in close collaboration with insurers to identify and solve the challenges of both the Annual and Quarterly processes. We started from scratch, and the result is an innovative approach to an often-overlooked (and certainly under-appreciated) task. We offer both a Notes product which is compatible with other available filing software, as well as a full Annual Statement Software Package. Our software is 100% cloud-based and requires no installation, updates, or IT involvement.

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Website
gaincompliance.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
$2.6M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
6th
Pitchly logo
PitchlySB Score: 319

Pitchly provides a SaaS platform for non-technical users to create data-infused real-time PowerPoint and Word documents linked to internal business data wherever it may live. Typically, before Pitchly, this work takes place in disconnected and inefficient tools like Excel, Word, PowerPoint, Sharepoint, or IT-owned databases. The platform aggregates disparate information sources, making information easy to catalog, find, and produce compelling and relevant data-driven Word and PowerPoint documents. This generates a 93% reduction in time to create data-heavy documents with 100% error reduction; all in half the time it takes to locate information when compared to traditional approaches. Pitchly end-users can even create custom forms to populate data to those original sources to make certain their teams are using the most relevant and up-to-date data. It aggregates digital data sources, such as Excel, SQL, Salesforce, and more, into one normalized tabular view of the data to reference, search, filter, and then integrate into documents and presentations in real-time. The platform gives the ability to easily publish select information from your database(s) on a website, in various digital forms. The company was founded in 2014 and is headquartered in Des Moines, Iowa.

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Website
pitchly.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
$10.6M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
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8th
Gross-Wen Technologies logo

Gross-Wen Technologies is a biotechnology company focused on enhancing water quality and wastewater treatment. By providing innovative, sustainable solutions, it enables municipalities and industrial clients to effectively and affordably manage water resources while addressing nitrogen challenges.

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Website
algae.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
$14.1M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
9th
SourceEazy logo
SourceEazySB Score: 258
Ecommerce & RetailEcommerce & Retail-Other

SourceEazy.com revolutionizes the $110B legacy promotional product industry with its innovative, factory-direct B2B marketplace. By eliminating the middleman, our platform directly connects distributors with vetted manufacturers, dramatically streamlining the entire ordering process. SourceEazy goes beyond simplifying transactions. It transforms project management by providing real-time updates and a comprehensive timeline feature, ensuring unparalleled visibility into every stage of the production process. This level of transparency and efficiency not only saves time and reduces costs but also allows distributors to focus on what truly matters—growing their sales and nurturing client relationships. By redefining the supply chain, SourceEazy not only optimizes operations for distributors but also enhances the overall quality and timeliness of promotional product campaigns, making it a game-changer in the industry.

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Website
sourceeazy.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
$600K
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
10th
Toggle, Inc. logo
Toggle, Inc.SB Score: 250

Innovator in the logistics industry supplying the latest technologies to enhance and optimize supply chain networks. for shippers and companies needing efficient freight support, Toggle is eradicating confusing pricing models, excessive costs, unclear shipping delays, and in some cases unfair pricing. For drivers and carriers, Toggle is addressing long-known industry challenges that result in payment delays, poorly planned routes, and difficult scheduling. The platform's focus on logistics efficiency means more time actually driving, simultaneously decreasing overall time away from home

View Full Page
Website
www.drivetoggle.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
$1.6M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
11th
Certintell logo
CertintellSB Score: 234

Certintell is a care management company that enables safety-net providers to make a lasting impact on the health of underserved patients through telehealth. The company provides an online healthcare platform that helps patients to text, send images, voice, and video collaboration to improve patient's diagnoses and treatments. It gives consumers direct access to their choice of U.S. board-certified clinicians for acute care, behavioral health, and nutrition counseling. Certintell was established in 2014 and is headquartered in Des Moines, Iowa, United States.

View Full Page
Website
certintell.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
$650K
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—

Total amount:20

Most Funded Startups in Des Moines for 2026

The top three most funded startups in Des Moines have raised total funding of more than USD 199M. Roboflow has 0.38% more funding than Dwolla.
1st
Roboflow logo
RoboflowSB Score: 545

Roboflow's developer tools enable teams to build computer vision models faster and more accurately.We replace ad-hoc code with production infrastructure, enable versioned datasets to be used in any framework, eliminate common errors that reduce model performance.

View Full Page
Website
roboflow.com
Employee range
11 – 50
Web Traffic (Monthly)
—
Funding amount
$99.7M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
2nd
Dwolla logo
DwollaSB Score: 466

Dwolla is a payment services provider powering innovations with sophisticated account-to-account payment solutions. Dwolla’s modern API simplifies the complex process of integrating with the various payment networks to create a single end-to-end solution–giving businesses the ability to program payments on the same day, next day or in real-time directly to bank accounts. With minimal development, start-ups to Fortune 500 companies can gain efficiency, flexibility and improved cash flow by working with Dwolla.

View Full Page
Website
www.dwolla.com
Employee range
51 – 100
Web Traffic (Monthly)
—
Funding amount
$72.4M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
3rd
OpenLoop Health logo
OpenLoop HealthSB Score: 513

OpenLoop is the infrastructure for digital healthcare. Its clients, healthcare companies, rely on its tech platform and systems to power healthcare delivery. To provide a comprehensive, turnkey solution, OpenLoop provides clinicians, labs, medications, regulatory and patient support, and other services through its platform.

View Full Page
Website
openloophealth.com
Employee range
501 – 1,000
Web Traffic (Monthly)
—
Funding amount
$26.6M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—

Total amount:20

Top Hiring Startups in Des Moines by Employee Number

The top three hiring startups in Des Moines have an median employee size that is between [101-250]
1st
OpenLoop Health logo
OpenLoop HealthSB Score: 513

OpenLoop is the infrastructure for digital healthcare. Its clients, healthcare companies, rely on its tech platform and systems to power healthcare delivery. To provide a comprehensive, turnkey solution, OpenLoop provides clinicians, labs, medications, regulatory and patient support, and other services through its platform.

View Full Page
Website
openloophealth.com
Employee range
501 – 1,000
Web Traffic (Monthly)
—
Funding amount
$26.6M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
3rd
Denim logo
DenimSB Score: 288

Butterfly Learnings strives to offer behavioural and developmental support in a compassionate, thoughtful, and respectful way.

View Full Page
Website
denimlabs.com
Employee range
101 – 250
Web Traffic (Monthly)
—
Funding amount
$5.3M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—
4th
Dwolla logo
DwollaSB Score: 466

Dwolla is a payment services provider powering innovations with sophisticated account-to-account payment solutions. Dwolla’s modern API simplifies the complex process of integrating with the various payment networks to create a single end-to-end solution–giving businesses the ability to program payments on the same day, next day or in real-time directly to bank accounts. With minimal development, start-ups to Fortune 500 companies can gain efficiency, flexibility and improved cash flow by working with Dwolla.

View Full Page
Website
www.dwolla.com
Employee range
51 – 100
Web Traffic (Monthly)
—
Funding amount
$72.4M
National Rank(United States)
—
Regional Rank(North America)
—
Global Rank(Worldwide)
—

Total amount:46

Explore More Top Startups

Explore the Startup Ecosystem of Des Moines

National Rank

(United States)

86th

new

Regional Rank

(North America)

99th

7

Global Rank

(WorldWide)

315th

37

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal Score & National ShareAnnual Growth

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