33 Top startups in Des Moines for February 2025

We rank OpenLoop Health, Roboflow and Dwolla in Des Moines along with 30 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Des Moines startup ecosystem ranks #299 globally and #85 in United States.

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Best Startups in Des Moines for 2025

SB Score:601

OpenLoop is the infrastructure for digital healthcare. Its clients, healthcare companies, rely on its tech platform and systems to power healthcare delivery. To provide a comprehensive, turnkey solution, OpenLoop provides clinicians, labs, medications, regulatory and patient support, and other services through its platform.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:566

Roboflow accelerates computer vision model development for developers, increasing speed and accuracy. Create powerful models quickly and easily with this essential tool.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:509

Dwolla is a payment services provider powering innovations with sophisticated account-to-account payment solutions. Dwolla’s modern API simplifies the complex process of integrating with the various payment networks to create a single end-to-end solution–giving businesses the ability to program payments on the same day, next day or in real-time directly to bank accounts. With minimal development, start-ups to Fortune 500 companies can gain efficiency, flexibility and improved cash flow by working with Dwolla.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:372

This logistics startup revolutionizes supply chain networks by providing cutting-edge technologies designed to enhance efficiency and optimize operations. By streamlining processes and improving visibility, it empowers businesses to navigate the complexities of logistics with ease and precision.

Industry:
Transportation
Subindustry:
Transportation-Other

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SB Score:353

Hummingbirds connects brands with local influencers to collaborate on campaigns. Create a campaign, and influencers can apply. Streamlined, efficient, and tailored for success, Hummingbirds makes influencer marketing easy.

Industry:
Social & Leisure
Subindustry:
Digital Media

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SB Score:322

Pitchly is a platform that helps M&A professionals manage and utilize their intellectual property. With a cloud-based service, users can efficiently organize and access their content.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:318

Gross-Wen Technologies is a biotechnology company focused on enhancing water quality and wastewater treatment. By providing innovative, sustainable solutions, it enables municipalities and industrial clients to effectively and affordably manage water resources while addressing nitrogen challenges.

Industry:
Energy & Environment
Subindustry:
Energy & Environment-Other

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SB Score:313

Workgroups DaVinci is a comprehensive productivity tool tailored for modern marketing and creative teams. Streamline your workflow with this end-to-end solution designed to boost collaboration and efficiency.

Industry:
Fintech
Subindustry:
Fintech-Other

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SB Score:309

WINPRO specializes in creating high-quality blood protein supplements for dogs. Their products are designed to support overall canine health and are trusted by many pet owners.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:304

Introducing innovative insurance financial reporting software, streamlining data analysis and reporting for insurance companies. Enhance financial transparency and decision-making with user-friendly tools and real-time insights.

Industry:
Fintech
Subindustry:
Insurance

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SB Score:271

Goodstock & Co. connects passionate individuals with meaningful causes through thoughtfully crafted products. Founded by seasoned campaign professionals with over 60 years of combined political and advocacy experience, the company celebrates positive change and fosters community engagement.

Industry:
Social & Leisure
Subindustry:
Communities

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Total amount:33

Top 10 Software & Data Startups in Des Moines for 2025

The top three Software & Data startups in Des Moines have raised more than USD 111M. Des Moines startup ecosystem ranks #261 globally for the Software & Data industry.
SB Score:566

Roboflow accelerates computer vision model development for developers, increasing speed and accuracy. Create powerful models quickly and easily with this essential tool.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

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Regional Rank (North America)

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SB Score:322

Pitchly is a platform that helps M&A professionals manage and utilize their intellectual property. With a cloud-based service, users can efficiently organize and access their content.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:229

Emory Dry Ice provides cutting-edge Cold Jet blasting technology for rent, offering efficient and powerful equipment when needed.

Industry:
Software & Data
Subindustry:
Data Analytics

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Total amount:10

Top 2 Ecommerce & Retail Startups in Des Moines for 2025

Des Moines startup ecosystem ranks #264 globally for the Ecommerce & Retail industry.
SB Score:154

Salt Solutions is an Iowa-based startup that offers an innovative online platform designed to streamline learning for chartered financial analysts. By providing essential digital tools and resources, it empowers investment professionals to enhance their studying experience and achieve their career goals more effectively.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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SB Score:80

Assistagram offers a range of services including digital marketing, social media management, influencer partnerships, web and graphic design, paid advertising, and public relations. Their expertise helps startups and businesses grow their online presence and reach new audiences effectively.

Industry:
Ecommerce & Retail
Subindustry:
Social Commerce

National Rank (United States)

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Total amount:2

Top 2 Marketing & Sales Startups in Des Moines for 2025

The top three Marketing & Sales startups in Des Moines have raised more than USD 1.12M. Des Moines startup ecosystem ranks #178 globally for the Marketing & Sales industry.
SB Score:56

Franzenburg specializes in providing centrifuge solutions including parts, bearings, kits, rebuilds, repairs, gearboxes, control panels, sales, and service. Streamlined and reliable, Franzenburg is your one-stop shop for all your centrifuge needs.

Industry:
Marketing & Sales
Subindustry:
Marketing & Sales-Other

National Rank (United States)

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Total amount:2

Most Funded Startups in Des Moines for 2025

The top three most funded startups in Des Moines have raised total funding of more than USD 199M. Roboflow has 0.38% more funding than Dwolla.
SB Score:566

Roboflow accelerates computer vision model development for developers, increasing speed and accuracy. Create powerful models quickly and easily with this essential tool.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:509

Dwolla is a payment services provider powering innovations with sophisticated account-to-account payment solutions. Dwolla’s modern API simplifies the complex process of integrating with the various payment networks to create a single end-to-end solution–giving businesses the ability to program payments on the same day, next day or in real-time directly to bank accounts. With minimal development, start-ups to Fortune 500 companies can gain efficiency, flexibility and improved cash flow by working with Dwolla.

Industry:
Fintech
Subindustry:
Financial Services

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:601

OpenLoop is the infrastructure for digital healthcare. Its clients, healthcare companies, rely on its tech platform and systems to power healthcare delivery. To provide a comprehensive, turnkey solution, OpenLoop provides clinicians, labs, medications, regulatory and patient support, and other services through its platform.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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View full page

Total amount:33

Top Hiring Startups in Des Moines by Employee Number

The top three hiring startups in Des Moines have an median employee size that is between [51-100]
SB Score:601

OpenLoop is the infrastructure for digital healthcare. Its clients, healthcare companies, rely on its tech platform and systems to power healthcare delivery. To provide a comprehensive, turnkey solution, OpenLoop provides clinicians, labs, medications, regulatory and patient support, and other services through its platform.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:509

Dwolla is a payment services provider powering innovations with sophisticated account-to-account payment solutions. Dwolla’s modern API simplifies the complex process of integrating with the various payment networks to create a single end-to-end solution–giving businesses the ability to program payments on the same day, next day or in real-time directly to bank accounts. With minimal development, start-ups to Fortune 500 companies can gain efficiency, flexibility and improved cash flow by working with Dwolla.

Industry:
Fintech
Subindustry:
Financial Services

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:566

Roboflow accelerates computer vision model development for developers, increasing speed and accuracy. Create powerful models quickly and easily with this essential tool.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:372

This logistics startup revolutionizes supply chain networks by providing cutting-edge technologies designed to enhance efficiency and optimize operations. By streamlining processes and improving visibility, it empowers businesses to navigate the complexities of logistics with ease and precision.

Industry:
Transportation
Subindustry:
Transportation-Other

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:33

Explore the Startup Ecosystem of Des Moines

National Rank

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Regional Rank

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99th

7

Global Rank

(WorldWide)

299th

21

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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Quantity Score
Quality ScoreBusiness Score
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710.966
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2nd
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251.377
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3rd
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4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
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