72 Top startups in Charlottesville for April 2025

We rank Contraline, Yay Lunch and Poppy Flowers in Charlottesville along with 69 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Charlottesville startup ecosystem ranks #272 globally and #79 in United States.

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Best Startups in Charlottesville for 2025

SB Score:418

Contraline is revolutionizing contraception with the first long-lasting, reversible option for men. Their innovative product offers a convenient and effective solution for couples looking to share responsibility for family planning.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:409

Yay Lunch is a digital marketplace that revolutionizes K-12 dining by partnering with top local restaurants and chefs. It offers customizable, nutritious versions of beloved children's meals, delivering them directly to schools every day, ensuring that students enjoy delicious and healthy options at lunchtime.

Industry:
Edtech
Subindustry:
Education-Other

National Rank (United States)

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SB Score:404

Poppy Flowers offers a seamless online experience for purchasing full-service wedding florals. With a focus on quality and convenience, couples can effortlessly select and customize stunning floral arrangements to enhance their special day, all from the comfort of their homes.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

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SB Score:387

SafeGuard Cyber is a SaaS security platform providing cloud-native defense for critical cloud communication applications that organizations are increasingly reliant upon, such as Microsoft Teams, Slack, Zoom, Salesforce, and social media.  A blind-spot is growing for security operations as adoption of these tools increases, creating more risk and vulnerability to ransomware, business compromise, and confidential information leakage. Email security lacks the ability to both create visibility outside of email, and primarily defend against malicious files and links. CASB/SASE solutions are difficult to deploy and manage, and the control function is typically left “open” to prevent false positives from affecting business productivity SafeGuard Cyber's award-winning platform helps businesses gain the unprecedented visibility they need to detect and respond to internal and external risks hidden in the cloud communication ecosystem. Our platform’s agentless architecture creates a portable security layer wherever your workforce communicates, no matter the device or network. Manage day-to-day business communication risk extending beyond email and into enterprise collaboration applications. According to the Verizon DBIR, 92% of social engineering attacks achieve infiltration. Secure your business by protecting the human attack vector from advanced social engineering and targeted threats.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:384

Pearl certifies homes as healthy, safe, comfortable, energy, and water-efficient. Their third-party certification ensures quality and sustainability, giving homeowners peace of mind.

Industry:
Energy & Environment
Subindustry:
Clean Energy

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SB Score:363

Maternity Neighborhood offers digital tools to support woman-centered care, with a focus on empowering expectant mothers. Their mission-driven approach provides a portfolio of innovative solutions for a holistic maternity experience.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:355

Fermata Energy integrates electric vehicles with the power grid, optimizing energy flow. Join us as we revolutionize the way vehicles and electricity interact, creating a more sustainable future.

Industry:
Energy & Environment
Subindustry:
Energy

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8th

Hum
SB Score:349

The startup helps content-driven organizations streamline data integration and setup, aligning with their current technology stack. They assist associations, publishers, and B2B media companies in unifying and maximizing data efficiency.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:347

SceneThink connects event creators with local influencers to boost event attendance. Our platform streamlines the process, making it easy for creators to reach out to influencers who can help promote their events.

Industry:
Marketing & Sales
Subindustry:
Events

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SB Score:344

Brightspec offers analytical chemistry solutions through FT-MRR spectroscopy, a cutting-edge technology for precise chemical analysis.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:343

Rivus Pharmaceuticals is a biopharmaceutical company focused on enhancing cardio-metabolic health. Their mission is to improve overall well-being through innovative solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Total amount:72

Top 23 Healthtech Startups in Charlottesville for 2025

The top three Healthtech startups in Charlottesville have raised more than USD 325M. Charlottesville startup ecosystem ranks #107 globally for the Healthtech industry.
SB Score:418

Contraline is revolutionizing contraception with the first long-lasting, reversible option for men. Their innovative product offers a convenient and effective solution for couples looking to share responsibility for family planning.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:363

Maternity Neighborhood offers digital tools to support woman-centered care, with a focus on empowering expectant mothers. Their mission-driven approach provides a portfolio of innovative solutions for a holistic maternity experience.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

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SB Score:343

Rivus Pharmaceuticals is a biopharmaceutical company focused on enhancing cardio-metabolic health. Their mission is to improve overall well-being through innovative solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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Total amount:23

Top 22 Software & Data Startups in Charlottesville for 2025

The top three Software & Data startups in Charlottesville have raised more than USD 154M. Charlottesville startup ecosystem ranks #273 globally for the Software & Data industry.
SB Score:387

SafeGuard Cyber is a SaaS security platform providing cloud-native defense for critical cloud communication applications that organizations are increasingly reliant upon, such as Microsoft Teams, Slack, Zoom, Salesforce, and social media.  A blind-spot is growing for security operations as adoption of these tools increases, creating more risk and vulnerability to ransomware, business compromise, and confidential information leakage. Email security lacks the ability to both create visibility outside of email, and primarily defend against malicious files and links. CASB/SASE solutions are difficult to deploy and manage, and the control function is typically left “open” to prevent false positives from affecting business productivity SafeGuard Cyber's award-winning platform helps businesses gain the unprecedented visibility they need to detect and respond to internal and external risks hidden in the cloud communication ecosystem. Our platform’s agentless architecture creates a portable security layer wherever your workforce communicates, no matter the device or network. Manage day-to-day business communication risk extending beyond email and into enterprise collaboration applications. According to the Verizon DBIR, 92% of social engineering attacks achieve infiltration. Secure your business by protecting the human attack vector from advanced social engineering and targeted threats.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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2nd

Hum
SB Score:349

The startup helps content-driven organizations streamline data integration and setup, aligning with their current technology stack. They assist associations, publishers, and B2B media companies in unifying and maximizing data efficiency.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:344

Brightspec offers analytical chemistry solutions through FT-MRR spectroscopy, a cutting-edge technology for precise chemical analysis.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:22

Top 4 Energy & Environment Startups in Charlottesville for 2025

The top three Energy & Environment startups in Charlottesville have raised more than USD 112M. Charlottesville startup ecosystem ranks #107 globally for the Energy & Environment industry.
SB Score:384

Pearl certifies homes as healthy, safe, comfortable, energy, and water-efficient. Their third-party certification ensures quality and sustainability, giving homeowners peace of mind.

Industry:
Energy & Environment
Subindustry:
Clean Energy

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:355

Fermata Energy integrates electric vehicles with the power grid, optimizing energy flow. Join us as we revolutionize the way vehicles and electricity interact, creating a more sustainable future.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:341

Lumin is the pioneer and market leader for responsive load control, adding exceptional value to residential microgrids by balancing the needs of energy storage and multiple power sources.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:4

Most Funded Startups in Charlottesville for 2025

The top three most funded startups in Charlottesville have raised total funding of more than USD 357M. Rivus Pharmaceuticals has 0.46% more funding than HemoShear Therapeutics.
SB Score:343

Rivus Pharmaceuticals is a biopharmaceutical company focused on enhancing cardio-metabolic health. Their mission is to improve overall well-being through innovative solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:302

AgroSpheres develops novel technologies that aim to set a new standard for bio-based delivery of active ingredients. It uses a unique platform technology for crop protection solutions and other industrial applications. The company is an encapsulation and delivery technology that dramatically enhances the performance of a broad range of crop protection products including fungicides, insecticides, and herbicides. AgroSpheres was founded in 2016 and is based in Charlottesville, Virginia.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:72

Top Hiring Startups in Charlottesville by Employee Number

The top three hiring startups in Charlottesville have an median employee size that is between [101-250]
SB Score:409

Yay Lunch is a digital marketplace that revolutionizes K-12 dining by partnering with top local restaurants and chefs. It offers customizable, nutritious versions of beloved children's meals, delivering them directly to schools every day, ensuring that students enjoy delicious and healthy options at lunchtime.

Industry:
Edtech
Subindustry:
Education-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:341

Cosaic is a software developer that offers products such as the financial charting software and a smart desktop platform. The company offers ChartIQ, crowdsourced analytics, and financial visualization platform that allows clients to create responsive and interactive charting experiences for their end-users. It is focused on building HTML5 financial charting and data visualization tools for brokerages, individual traders, institutional trading desks, financial portals, and independent trading platforms. It maintains partnerships with Xignite, OpenFin, StockTwits, Estimize, Autochartist, and Thomson Reuters. Megan Read, Dan Schleifer, and Terry Thorsen incorporated the company in 2012 and is based in Charlottesville, Virginia.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

0

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Regional Rank (North America)

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SB Score:387

SafeGuard Cyber is a SaaS security platform providing cloud-native defense for critical cloud communication applications that organizations are increasingly reliant upon, such as Microsoft Teams, Slack, Zoom, Salesforce, and social media.  A blind-spot is growing for security operations as adoption of these tools increases, creating more risk and vulnerability to ransomware, business compromise, and confidential information leakage. Email security lacks the ability to both create visibility outside of email, and primarily defend against malicious files and links. CASB/SASE solutions are difficult to deploy and manage, and the control function is typically left “open” to prevent false positives from affecting business productivity SafeGuard Cyber's award-winning platform helps businesses gain the unprecedented visibility they need to detect and respond to internal and external risks hidden in the cloud communication ecosystem. Our platform’s agentless architecture creates a portable security layer wherever your workforce communicates, no matter the device or network. Manage day-to-day business communication risk extending beyond email and into enterprise collaboration applications. According to the Verizon DBIR, 92% of social engineering attacks achieve infiltration. Secure your business by protecting the human attack vector from advanced social engineering and targeted threats.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:341

Lumin is the pioneer and market leader for responsive load control, adding exceptional value to residential microgrids by balancing the needs of energy storage and multiple power sources.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:72

Explore the Startup Ecosystem of Charlottesville

National Rank

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Regional Rank

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91st

8

Global Rank

(WorldWide)

272nd

20

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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