102 Top startups in Charleston for January 2025

We rank Palmetto Clean Technology, Zebedee and PhishLabs in Charleston along with 99 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Charleston ranks #187 globally and #53 in United States.

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Best Startups in Charleston for 2025

Palmetto Clean Technology develops and manages clean energy solutions for homes, businesses, and energy providers. Specializing in renewable energy projects, Palmetto offers sustainable options for residential, commercial, and utility customers.

Industry:
Energy & Environment
Subindustry:
Clean Energy

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SB Score:563

Zebedee integrates Bitcoin and Lightning support into digital platforms, creating seamless and secure experiences. Unlock the power of cryptocurrency in your digital world with our cutting-edge software and infrastructure.

Industry:
Fintech
Subindustry:
Cryptocurrency

National Rank (United States)

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SB Score:461

PhishLabs offers cybercrime prevention services to reduce fraud losses and protect online channels. Their fixed subscription fee aligns with client goals to lower cybercrime incidents and manage customer security incidents more efficiently.

Industry:
Software & Data
Subindustry:
Cybersecurity

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SB Score:409

Founded in August 2019, Natalist is a company led by moms, doctors, and scientists with a mission to provide evidence-based, educational, and user-friendly products for the pregnancy journey. They aim to eliminate shame, misinformation, and outdated offerings in the industry.

Industry:
Healthtech
Subindustry:
Life Sciences

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SB Score:406

GigPro is a dynamic platform that connects job seekers with opportunities in the hospitality industry. It simplifies the hiring process, enabling employers to find qualified workers quickly and allowing individuals to discover flexible job options that suit their skills and schedules.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:403

Ceterus offers small business owners automated accounting services and detailed performance reports, simplifying financial management.

Industry:
Software & Data
Subindustry:
Apps

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SB Score:367

GreenGasUSA specializes in managing wastewater and producing green gas to lower carbon emissions. They assess biogas potential in waste streams, transport it post-anaerobic digestion, purify it, and inject it into designated points. Their services aim to reduce environmental impact and promote sustainable energy solutions.

Industry:
Energy & Environment
Subindustry:
Energy & Environment-Other

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SB Score:365

PunchListUSA is a pioneering online platform that digitizes home inspection data, enabling homeowners, brokers, and institutional investors to receive instant repair estimates and easily place service orders. This innovative approach streamlines the home maintenance process, making it more efficient and accessible for all involved.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

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SB Score:364

Empower your wellness and performance with MICROGELâ„¢. Experience nutrients you can absorb for better healthspan. Love the journey to a healthier you.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:355

DriveMatch connects commercial drivers with carrier operators through a job search platform. Find the perfect match for your driving career with ease.

Industry:
Software & Data
Subindustry:
Software

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Total amount:102

Top 31 Software & Data Startups in Charleston for 2025

The top three Software & Data startups in Charleston have raised more than USD 78.1M. Charleston ranks #170 globally for the Software & Data industry.
SB Score:461

PhishLabs offers cybercrime prevention services to reduce fraud losses and protect online channels. Their fixed subscription fee aligns with client goals to lower cybercrime incidents and manage customer security incidents more efficiently.

Industry:
Software & Data
Subindustry:
Cybersecurity

National Rank (United States)

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SB Score:406

GigPro is a dynamic platform that connects job seekers with opportunities in the hospitality industry. It simplifies the hiring process, enabling employers to find qualified workers quickly and allowing individuals to discover flexible job options that suit their skills and schedules.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:403

Ceterus offers small business owners automated accounting services and detailed performance reports, simplifying financial management.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

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Total amount:31

Top 4 Energy & Environment Startups in Charleston for 2025

The top three Energy & Environment startups in Charleston have raised more than USD 428M. Charleston ranks #52 globally for the Energy & Environment industry.

Palmetto Clean Technology develops and manages clean energy solutions for homes, businesses, and energy providers. Specializing in renewable energy projects, Palmetto offers sustainable options for residential, commercial, and utility customers.

Industry:
Energy & Environment
Subindustry:
Clean Energy

National Rank (United States)

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Regional Rank (North America)

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SB Score:367

GreenGasUSA specializes in managing wastewater and producing green gas to lower carbon emissions. They assess biogas potential in waste streams, transport it post-anaerobic digestion, purify it, and inject it into designated points. Their services aim to reduce environmental impact and promote sustainable energy solutions.

Industry:
Energy & Environment
Subindustry:
Energy & Environment-Other

National Rank (United States)

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SB Score:332

Nacelle specializes in gas conditioning technologies and services tailored to the dynamic needs of the Energy and Biogas industries. By leveraging their expertise, Nacelle continuously enhances the value delivered to customers, ensuring effective solutions that adapt to industry challenges.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

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Total amount:4

Top 13 Ecommerce & Retail Startups in Charleston for 2025

The top three Ecommerce & Retail startups in Charleston have raised more than USD 56.7M. Charleston ranks #185 globally for the Ecommerce & Retail industry.
SB Score:365

PunchListUSA is a pioneering online platform that digitizes home inspection data, enabling homeowners, brokers, and institutional investors to receive instant repair estimates and easily place service orders. This innovative approach streamlines the home maintenance process, making it more efficient and accessible for all involved.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

National Rank (United States)

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SB Score:320

Marolina Outdoor offers extensive outdoor expertise across all categories, bringing valuable industry knowledge to the table.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

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3rd

Biom
SB Score:294

Biom is an innovative manufacturer of eco-friendly wipes designed to combat plastic waste while promoting recycling. Their wipes are crafted from natural ingredients, ensuring safety and sanitation at an affordable price, allowing customers to make environmentally conscious choices without compromising on quality.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

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Total amount:13

Most Funded Startups in Charleston for 2025

The top three most funded startups in Charleston have raised total funding of more than USD 510M. Palmetto Clean Technology has 7.53% more funding than PunchListUSA.

Palmetto Clean Technology develops and manages clean energy solutions for homes, businesses, and energy providers. Specializing in renewable energy projects, Palmetto offers sustainable options for residential, commercial, and utility customers.

Industry:
Energy & Environment
Subindustry:
Clean Energy

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:365

PunchListUSA is a pioneering online platform that digitizes home inspection data, enabling homeowners, brokers, and institutional investors to receive instant repair estimates and easily place service orders. This innovative approach streamlines the home maintenance process, making it more efficient and accessible for all involved.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:563

Zebedee integrates Bitcoin and Lightning support into digital platforms, creating seamless and secure experiences. Unlock the power of cryptocurrency in your digital world with our cutting-edge software and infrastructure.

Industry:
Fintech
Subindustry:
Cryptocurrency

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:102

Top Hiring Startups in Charleston by Employee Number

The top three hiring startups in Charleston have an median employee size that is between [501-1000]
SB Score:219

Blackbaud offers software and services tailored for non-profits, empowering them to foster connections and achieve their goals effectively.

Industry:
Software & Data
Subindustry:
Cloud

National Rank (United States)

0

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Regional Rank (North America)

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Palmetto Clean Technology develops and manages clean energy solutions for homes, businesses, and energy providers. Specializing in renewable energy projects, Palmetto offers sustainable options for residential, commercial, and utility customers.

Industry:
Energy & Environment
Subindustry:
Clean Energy

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:461

PhishLabs offers cybercrime prevention services to reduce fraud losses and protect online channels. Their fixed subscription fee aligns with client goals to lower cybercrime incidents and manage customer security incidents more efficiently.

Industry:
Software & Data
Subindustry:
Cybersecurity

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:365

PunchListUSA is a pioneering online platform that digitizes home inspection data, enabling homeowners, brokers, and institutional investors to receive instant repair estimates and easily place service orders. This innovative approach streamlines the home maintenance process, making it more efficient and accessible for all involved.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:102

Explore the Startup Ecosystem of Charleston

National Rank

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53rd

1

Regional Rank

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62nd

1

Global Rank

(WorldWide)

187th

4

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Quantity Score
Quality ScoreBusiness Score
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710.966
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251.377
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3rd
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121.937
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109.679
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