102 Top startups in Charleston for April 2025

We rank Zebedee, Palmetto Clean Technology and Gigpro in Charleston along with 99 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Charleston startup ecosystem ranks #187 globally and #53 in United States.

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Best Startups in Charleston for 2025

SB Score:574

Zebedee integrates Bitcoin and Lightning support into digital platforms, creating seamless and secure experiences. Unlock the power of cryptocurrency in your digital world with our cutting-edge software and infrastructure.

Industry:
Fintech
Subindustry:
Cryptocurrency

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Palmetto Clean Technology develops and manages clean energy solutions for homes, businesses, and energy providers. Specializing in renewable energy projects, Palmetto offers sustainable options for residential, commercial, and utility customers.

Industry:
Energy & Environment
Subindustry:
Clean Energy

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SB Score:451

GigPro is a dynamic platform that connects job seekers with opportunities in the hospitality industry. It simplifies the hiring process, enabling employers to find qualified workers quickly and allowing individuals to discover flexible job options that suit their skills and schedules.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:414

Founded in August 2019, Natalist is a company led by moms, doctors, and scientists with a mission to provide evidence-based, educational, and user-friendly products for the pregnancy journey. They aim to eliminate shame, misinformation, and outdated offerings in the industry.

Industry:
Healthtech
Subindustry:
Life Sciences

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SB Score:386

PhishLabs offers cybercrime prevention services to reduce fraud losses and protect online channels. Their fixed subscription fee aligns with client goals to lower cybercrime incidents and manage customer security incidents more efficiently.

Industry:
Software & Data
Subindustry:
Cybersecurity

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SB Score:382

PunchListUSA is the first online real estate platform digitizing national home inspection data to create instant repair estimates and online service orders for homeowners, brokers, and institutional investors. The platform is powered by proprietary technology and property data to deliver home repair, renovation and lifecycle services at scale through innovative products, process automation and direct integration with industry partners. Exclusive inspection data access will power end-to-end home lifecycle services and product offerings to homeowners through the PunchListUSA marketplace in its next phase of growth.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

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SB Score:374

Empower your wellness and performance with MICROGELâ„¢. Experience nutrients you can absorb for better healthspan. Love the journey to a healthier you.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:344

Over the past decade, the team has successfully built and scaled content channels in highly competitive sectors like insurance, personal loans, and B2B SaaS. They are now developing a powerful toolset designed to help content teams accelerate growth and enhance organic search traffic.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:342

GoodUnited enables non-profits to maximize their fundraising efforts on Facebook by leveraging its full potential.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:340

Questis empowers employees with a holistic financial solution designed to alleviate financial stress and enhance overall well-being. By benefiting individuals, employers, and advisors, Questis serves as a valuable asset for companies aiming to improve their workforce's financial wellness and foster a thriving work environment.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Total amount:102

Top 31 Software & Data Startups in Charleston for 2025

The top three Software & Data startups in Charleston have raised more than USD 86.6M. Charleston startup ecosystem ranks #170 globally for the Software & Data industry.
SB Score:451

GigPro is a dynamic platform that connects job seekers with opportunities in the hospitality industry. It simplifies the hiring process, enabling employers to find qualified workers quickly and allowing individuals to discover flexible job options that suit their skills and schedules.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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SB Score:386

PhishLabs offers cybercrime prevention services to reduce fraud losses and protect online channels. Their fixed subscription fee aligns with client goals to lower cybercrime incidents and manage customer security incidents more efficiently.

Industry:
Software & Data
Subindustry:
Cybersecurity

National Rank (United States)

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Regional Rank (North America)

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SB Score:344

Over the past decade, the team has successfully built and scaled content channels in highly competitive sectors like insurance, personal loans, and B2B SaaS. They are now developing a powerful toolset designed to help content teams accelerate growth and enhance organic search traffic.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:31

Top 4 Energy & Environment Startups in Charleston for 2025

The top three Energy & Environment startups in Charleston have raised more than USD 428M. Charleston startup ecosystem ranks #52 globally for the Energy & Environment industry.

Palmetto Clean Technology develops and manages clean energy solutions for homes, businesses, and energy providers. Specializing in renewable energy projects, Palmetto offers sustainable options for residential, commercial, and utility customers.

Industry:
Energy & Environment
Subindustry:
Clean Energy

National Rank (United States)

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SB Score:324

GreenGasUSA specializes in managing wastewater and producing green gas to lower carbon emissions. They assess biogas potential in waste streams, transport it post-anaerobic digestion, purify it, and inject it into designated points. Their services aim to reduce environmental impact and promote sustainable energy solutions.

Industry:
Energy & Environment
Subindustry:
Energy & Environment-Other

National Rank (United States)

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SB Score:297

Nacelle specializes in gas conditioning technologies and services tailored to the dynamic needs of the Energy and Biogas industries. By leveraging their expertise, Nacelle continuously enhances the value delivered to customers, ensuring effective solutions that adapt to industry challenges.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

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Total amount:4

Top 13 Ecommerce & Retail Startups in Charleston for 2025

The top three Ecommerce & Retail startups in Charleston have raised more than USD 71.5M. Charleston startup ecosystem ranks #185 globally for the Ecommerce & Retail industry.
SB Score:382

PunchListUSA is the first online real estate platform digitizing national home inspection data to create instant repair estimates and online service orders for homeowners, brokers, and institutional investors. The platform is powered by proprietary technology and property data to deliver home repair, renovation and lifecycle services at scale through innovative products, process automation and direct integration with industry partners. Exclusive inspection data access will power end-to-end home lifecycle services and product offerings to homeowners through the PunchListUSA marketplace in its next phase of growth.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

National Rank (United States)

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Regional Rank (North America)

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SB Score:328

Marolina Outdoor offers extensive outdoor expertise across all categories, bringing valuable industry knowledge to the table.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

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Regional Rank (North America)

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3rd

Biom
SB Score:281

Biom is an innovative manufacturer of eco-friendly wipes designed to combat plastic waste while promoting recycling. Their wipes are crafted from natural ingredients, ensuring safety and sanitation at an affordable price, allowing customers to make environmentally conscious choices without compromising on quality.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

0

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Regional Rank (North America)

0

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Total amount:13

Most Funded Startups in Charleston for 2025

The top three most funded startups in Charleston have raised total funding of more than USD 588M. Palmetto Clean Technology has 3.46% more funding than Zebedee.

Palmetto Clean Technology develops and manages clean energy solutions for homes, businesses, and energy providers. Specializing in renewable energy projects, Palmetto offers sustainable options for residential, commercial, and utility customers.

Industry:
Energy & Environment
Subindustry:
Clean Energy

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:574

Zebedee integrates Bitcoin and Lightning support into digital platforms, creating seamless and secure experiences. Unlock the power of cryptocurrency in your digital world with our cutting-edge software and infrastructure.

Industry:
Fintech
Subindustry:
Cryptocurrency

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:102

Top Hiring Startups in Charleston by Employee Number

The top three hiring startups in Charleston have an median employee size that is between [101-250]

Palmetto Clean Technology develops and manages clean energy solutions for homes, businesses, and energy providers. Specializing in renewable energy projects, Palmetto offers sustainable options for residential, commercial, and utility customers.

Industry:
Energy & Environment
Subindustry:
Clean Energy

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:386

PhishLabs offers cybercrime prevention services to reduce fraud losses and protect online channels. Their fixed subscription fee aligns with client goals to lower cybercrime incidents and manage customer security incidents more efficiently.

Industry:
Software & Data
Subindustry:
Cybersecurity

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:382

PunchListUSA is the first online real estate platform digitizing national home inspection data to create instant repair estimates and online service orders for homeowners, brokers, and institutional investors. The platform is powered by proprietary technology and property data to deliver home repair, renovation and lifecycle services at scale through innovative products, process automation and direct integration with industry partners. Exclusive inspection data access will power end-to-end home lifecycle services and product offerings to homeowners through the PunchListUSA marketplace in its next phase of growth.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:259

CareTeam provides top-quality primary care services to employees of businesses, ensuring comprehensive healthcare support.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

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Total amount:102

Explore the Startup Ecosystem of Charleston

National Rank

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Regional Rank

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62nd

1

Global Rank

(WorldWide)

187th

4

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
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1
37.971
00.00
00.00
00.00
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0
24th
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2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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