StartupBlink

135 Top startups in Charleston for July 2026

We rank Zebedee, Palmetto Clean Technology and Blackbaud in Charleston along with 132 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Charleston startup ecosystem ranks #210 globally and #60 in United States.

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Best Startups in Charleston for 2026

1st
Zebedee logo
ZebedeeSB Score: 572

Zebedee integrates Bitcoin and Lightning support into digital platforms, creating seamless and secure experiences. Unlock the power of cryptocurrency in your digital world with our cutting-edge software and infrastructure.

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Website
zebedee.io
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
$86.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Palmetto Clean Technology logo

Palmetto is a leading clean tech company on a mission to accelerate the transition to a clean energy future. We believe consumers can have it all—lower energy bills, smarter homes, and a healthier planet—without compromise. Our award-winning technology platform empowers homeowners, businesses, and entrepreneurs to adopt renewable energy through simple, scalable, and innovative solutions. Operating at the intersection of B2B and D2C, we offer software, financial products, and services that drive measurable environmental impact and long-term value. From solar and energy storage to HVAC and smart home integrations, Palmetto delivers end-to-end solutions for whole-home electrification—putting clean energy within reach for everyone.

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Website
www.palmetto.com
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$415M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Blackbaud logo
BlackbaudSB Score: 428

Ubie is a developer of an AI symptom checker software that will provide its patients with individualized evaluation reports. One of Ubie's primary offerings is an AI-driven symptom checker. This tool provides users with a free, personalized report on possible symptoms' causes after completing a brief questionnaire. The system customizes its questions based on individual factors such as biological sex, age, medical history, and lifestyle choices.

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Website
www.blackbaud.co.uk
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$86.3M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
4th
PhishLabs logo
PhishLabsSB Score: 416

PhishLabs is the leading provider of 24/7 cybersecurity services that protect against threats that exploit people. The company is trusted by top organizations worldwide, including 4 of the 5 largest U.S. financial institutions. PhishLabs combines proprietary technology, intelligence, and human expertise to rapidly detect, analyze, and stop targeted cyberattacks before they impact organizations. Additionally, the company provides robust threat intelligence that strengthens existing cyber defenses and optimizes threat prevention. Leading organizations partner with PhishLabs to more effectively disrupt targeted cyberattacks, prevent data breaches, and reduce online fraud. Follow PhishLabs: Twitter | http://www.twitter.com/phishlabs LinkedIn | http://www.linkedin.com/organization/phishlabs Google+ | https://plus.google.com/+PhishlabsTeam/posts

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Website
www.phishlabs.com
Employee range
101 – 250
Web Traffic (Monthly)
Funding amount
$31.7M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
6th
AmplifiedAg logo
AmplifiedAgSB Score: 388

AmplifiedAg aims to provide global access to safe food. It is the parent company of Vertical Roots, Tiger Corner Farms, and Boxcar Central. All four companies work together to create a more powerful and efficient way of farming through state-of-the-art technologies. In doing this, they are engaging a new generation of farmers and providing them with sustainable jobs. It was founded in 2018 and is headquartered in Charleston, South Carolina.

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Website
www.amplifiedaginc.com
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
$40M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
7th
Healthycell logo
HealthycellSB Score: 382

Healthycell is based on the simple idea that nutrients need to be absorbed into the bloodstream and then into cells where they work to improve health. But most supplements use the same pill-form delivery technologies that were around in the 1930's, back when we were using rotary phones! Our nutrient delivery technologies have not kept pace with the innovation of other industries. Decades of lab work show that most pills (and even powders) have low absorption. These older delivery systems compress dehydrated, large, dense, insoluble particles that are 10x to 100x too big for absorption through the small intestine where the human body absorbs most nutrients. That's why we forced the evolution of nutrition supplements with MICROGEL™.

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Website
www.healthycell.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$6.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
8th
ShiftNOW logo
ShiftNOWSB Score: 378

shiftNOW is a gig economy platform that provides a flexible solution to the hospitality industry’s toughest problem - its temporary workforce. From one-time, recurring, or temp-to-hire work, shiftNOW enables hospitality businesses to control how they resource their business and provides top-tier talent with an easy way to make money on their own terms.

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Website
shiftnow.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$2.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
9th
Ceterus logo
CeterusSB Score: 377

Ceterus, a national accounting and intelligence technology company, empowers entrepreneurs to succeed by automating their bookkeeping and reporting. Through Edge, its proprietary, cloud-based technology, Ceterus delivers on-time, accurate bookkeeping, financial reporting, and peer benchmarks for all business performance metrics. Ceterus operates from its headquarters in Charleston, South Carolina, bringing together a team of talented accounting and technology professionals. For more information on the company and its offerings, visit www.ceterus.com.

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Website
www.ceterus.com
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
$33.6M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
10th
GoodUnited logo
GoodUnitedSB Score: 374

GoodUnited is a fundraising software that leverages the power of social media, offering a solution that simplifies lead generation, enhances supporter engagement, and maximizes fundraising revenue. Using GoodUnited’s data-driven tools, nonprofits can easily connect with a new generation of supporters, track mission impact across campaigns, and elevate social media fundraising outcomes - something that simply can’t be done with other solutions on the market today. 100s of the world's top nonprofits trust GoodUnited to help grow their mission on social networks - including Susan G. Komen, Stop Soldier Suicide, Make-A-Wish, the Michael J. Fox Foundation, and The Trevor Project.

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Website
www.goodunited.io
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$3M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
11th
Best Buds Premium Hemp Products logo

Best Buds is a Premium Cannabis Company operating in the United States Federally compliant hemp industry. We have years of experience and combine our products with the education needed to use them effectively. We believe in providing an experience with our goods and building a brand people can trust.

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Website
bestbudsbff.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$791.2K
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:70

Most Funded Startups in Charleston for 2026

The top three most funded startups in Charleston have raised total funding of more than USD 588M. Palmetto Clean Technology has 3.80% more funding than Zebedee.
1st
Palmetto Clean Technology logo

Palmetto is a leading clean tech company on a mission to accelerate the transition to a clean energy future. We believe consumers can have it all—lower energy bills, smarter homes, and a healthier planet—without compromise. Our award-winning technology platform empowers homeowners, businesses, and entrepreneurs to adopt renewable energy through simple, scalable, and innovative solutions. Operating at the intersection of B2B and D2C, we offer software, financial products, and services that drive measurable environmental impact and long-term value. From solar and energy storage to HVAC and smart home integrations, Palmetto delivers end-to-end solutions for whole-home electrification—putting clean energy within reach for everyone.

View Full Page
Website
www.palmetto.com
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$415M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Zebedee logo
ZebedeeSB Score: 572

Zebedee integrates Bitcoin and Lightning support into digital platforms, creating seamless and secure experiences. Unlock the power of cryptocurrency in your digital world with our cutting-edge software and infrastructure.

View Full Page
Website
zebedee.io
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
$86.5M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Blackbaud logo
BlackbaudSB Score: 428

Ubie is a developer of an AI symptom checker software that will provide its patients with individualized evaluation reports. One of Ubie's primary offerings is an AI-driven symptom checker. This tool provides users with a free, personalized report on possible symptoms' causes after completing a brief questionnaire. The system customizes its questions based on individual factors such as biological sex, age, medical history, and lifestyle choices.

View Full Page
Website
www.blackbaud.co.uk
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$86.3M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:70

Top Hiring Startups in Charleston by Employee Number

The top three hiring startups in Charleston have an median employee size that is between [251-500]
1st
Oktana logo
OktanaSB Score: 192

Oktana is a custom software development agency of 300+ nearshore and onshore technologists who help companies innovate with Salesforce products, including Heroku and MuleSoft. We are developers and can build any app or integrate any system with Salesforce. Headquartered in Uruguay, our team has expanded into Bolivia, Colombia, Ecuador, Paraguay, Peru and the mountains of West Virginia. Our generous timezone overlap, English proficiency, SOC2 certification and continuous training offer you the ability to quickly, and safely, move forward with a team of Salesforce experts.

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Website
www.oktana.com
Employee range
501 – 1,000
Web Traffic (Monthly)
Funding amount
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
2nd
Palmetto Clean Technology logo

Palmetto is a leading clean tech company on a mission to accelerate the transition to a clean energy future. We believe consumers can have it all—lower energy bills, smarter homes, and a healthier planet—without compromise. Our award-winning technology platform empowers homeowners, businesses, and entrepreneurs to adopt renewable energy through simple, scalable, and innovative solutions. Operating at the intersection of B2B and D2C, we offer software, financial products, and services that drive measurable environmental impact and long-term value. From solar and energy storage to HVAC and smart home integrations, Palmetto delivers end-to-end solutions for whole-home electrification—putting clean energy within reach for everyone.

View Full Page
Website
www.palmetto.com
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$415M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
3rd
Blackbaud logo
BlackbaudSB Score: 428

Ubie is a developer of an AI symptom checker software that will provide its patients with individualized evaluation reports. One of Ubie's primary offerings is an AI-driven symptom checker. This tool provides users with a free, personalized report on possible symptoms' causes after completing a brief questionnaire. The system customizes its questions based on individual factors such as biological sex, age, medical history, and lifestyle choices.

View Full Page
Website
www.blackbaud.co.uk
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
$86.3M
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)
4th
AI Product Plaza logo
AI Product PlazaSB Score: 104

DENGENSHA TOA CO., LTD. is a machinery manufacturing company. They are manufacturing stationary spot welders, welding guns, projection welders, weld controls, automatic feeders, measuring equipment, seam welders, robot seam Welders, specialized welding machines, portable shear welders, fiber laser welding, welding transformers, and welding-related equipment.

View Full Page
Website
aiproductplaza.com
Employee range
251 – 500
Web Traffic (Monthly)
Funding amount
National Rank(United States)
Regional Rank(North America)
Global Rank(Worldwide)

Total amount:135

Explore More Top Startups

Explore the Startup Ecosystem of Charleston

National Rank

(United States)

60th

new

Regional Rank

(North America)

62nd

1

Global Rank

(WorldWide)

210th

27

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2026 National Rank CityGlobal RankTotal Score & National ShareAnnual Growth

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