98 Top startups in Buffalo for April 2025

We rank Kangarootime, Synacor and CleanFiber in Buffalo along with 95 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Buffalo startup ecosystem ranks #201 globally and #57 in United States.

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Best Startups in Buffalo for 2025

SB Score:524

Kangarootime connects families with childcare providers through a user-friendly software platform. Find the perfect care for your little ones with ease.

Industry:
Social & Leisure
Subindustry:
Communities

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SB Score:443

Synacor's online content, portal and comprehensive front-end technology solutions enable MSOs, ISPs and telecommunications companies to bundle, promote and deliver narrowband and broadband premium content and services as part of existing Internet access products. Its solutions offer the combined strength of a flexible portal framework, a robust provisioning platform, a unified back-end and a network of in-demand standard and premium content enabling service providers to maintain critical contact with consumers as they shift from screen-to-screen while seeking increasingly personalized entertainment experiences.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:398

CleanFiber manufactures eco-friendly building insulation using recycled cardboard, providing sustainable construction solutions.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

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SB Score:395

Viridi Parente revolutionizes fuel and engine technology for modern times. Their innovative solutions are efficient, sustainable, and designed for the future.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:371

Azuna Fresh provides an all-natural, handcrafted gel infused with Australian tea tree oil, effectively releasing antimicrobial properties into the air. Utilizing the room's natural airflow, it enhances indoor environments, promoting a healthier atmosphere without harsh chemicals.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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SB Score:364

Revolutionize industries with Digital Twins SaaS for renewable energy, rail maintenance, automotive, and defense systems. Enhance operations and decision-making with cutting-edge technology.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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SB Score:358

Targetprocess 3 is an agile project management software that emphasizes information visualization and user freedom. Users have full control to view and modify all project details.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:349

Anysphere develops innovative AI tools and assistants designed to enhance human productivity and decision-making. By seamlessly integrating advanced technology into everyday tasks, Anysphere empowers users to work smarter, streamline processes, and unlock their full potential.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

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Regional Rank (North America)

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PostProcess Technologies offers cutting-edge software and patented machines for post-processing. Their innovative solutions streamline production processes for optimal results.

Industry:
Edtech
Subindustry:
Education-Other

National Rank (United States)

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SB Score:345

FLARE by 3AM is an innovative IPS solution using advanced sensors, communication tech, and software for top-notch security. Experience cutting-edge protection in one powerful system.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

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Regional Rank (North America)

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SB Score:338

Circuit Clinical was born from the experiences of a physician conducting clinical research in his busy private practice. From the core belief that patients prefer to learn about clinical research from healthcare providers they trust, came the vision for Circuit Clinical. Since 2015 we've built one of the largest Integrated Research Organizations [IRO] in the US. Our focus on physician and participant engagement gives us a distinct advantage with the identification of motivated participants through direct HIPAA/FDA-compliant Electronic Medical Record (EMR) review. Coupled with our technology products that enhance the participant and physician experience, Circuit Clinical provides our network of more than 1 million patients, our physicians, and our sponsor partners with a new path forward in clinical research.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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Regional Rank (North America)

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Total amount:98

Top 13 Ecommerce & Retail Startups in Buffalo for 2025

The top three Ecommerce & Retail startups in Buffalo have raised more than USD 27.4M. Buffalo startup ecosystem ranks #118 globally for the Ecommerce & Retail industry.
SB Score:371

Azuna Fresh provides an all-natural, handcrafted gel infused with Australian tea tree oil, effectively releasing antimicrobial properties into the air. Utilizing the room's natural airflow, it enhances indoor environments, promoting a healthier atmosphere without harsh chemicals.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:336

OnCore aims to revolutionize the golf ball industry with its patented hollow metal core ball, promising unprecedented straightness and accuracy. With a stagnant market in need of innovation, OnCore believes its product will appeal to golfers of all levels, offering a game-changing experience.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

0

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Regional Rank (North America)

0

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SB Score:299

Braidbabes is a mobile braiding service dedicated to creating stunning boho braids for events and bridal parties. With a focus on convenience and style, Braidbabes brings expert hairstylists directly to clients, ensuring they look their best on their special day.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:13

Top 31 Software & Data Startups in Buffalo for 2025

The top three Software & Data startups in Buffalo have raised more than USD 348M. Buffalo startup ecosystem ranks #248 globally for the Software & Data industry.
SB Score:443

Synacor's online content, portal and comprehensive front-end technology solutions enable MSOs, ISPs and telecommunications companies to bundle, promote and deliver narrowband and broadband premium content and services as part of existing Internet access products. Its solutions offer the combined strength of a flexible portal framework, a robust provisioning platform, a unified back-end and a network of in-demand standard and premium content enabling service providers to maintain critical contact with consumers as they shift from screen-to-screen while seeking increasingly personalized entertainment experiences.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:364

Revolutionize industries with Digital Twins SaaS for renewable energy, rail maintenance, automotive, and defense systems. Enhance operations and decision-making with cutting-edge technology.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:358

Targetprocess 3 is an agile project management software that emphasizes information visualization and user freedom. Users have full control to view and modify all project details.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:31

Top 17 Healthtech Startups in Buffalo for 2025

The top three Healthtech startups in Buffalo have raised more than USD 64M. Buffalo startup ecosystem ranks #177 globally for the Healthtech industry.
SB Score:320

A convenient online therapy platform tailored for college students, providing accessible counseling services anytime, anywhere. Join now to connect with licensed therapists and receive support for your mental health needs.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:311

MimiVax develops immunotherapeutic vaccines and targeted therapies to combat tumor growth and prevent recurrence, providing innovative solutions for cancer treatment.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Garwood Medical Devices is a developer of electronic medical devices intended to eliminate infection-causing bacteria on metallic implants without the need for follow-up surgeries, while also allowing patients to retain their implants, enabling medical practitioners to treat implant infections in a better and more effective manner.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:17

Most Funded Startups in Buffalo for 2025

The top three most funded startups in Buffalo have raised total funding of more than USD 461M. Anysphere has 0.06% more funding than CleanFiber.
SB Score:349

Anysphere develops innovative AI tools and assistants designed to enhance human productivity and decision-making. By seamlessly integrating advanced technology into everyday tasks, Anysphere empowers users to work smarter, streamline processes, and unlock their full potential.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:398

CleanFiber manufactures eco-friendly building insulation using recycled cardboard, providing sustainable construction solutions.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:395

Viridi Parente revolutionizes fuel and engine technology for modern times. Their innovative solutions are efficient, sustainable, and designed for the future.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:98

Top Hiring Startups in Buffalo by Employee Number

The top three hiring startups in Buffalo have an median employee size that is between [101-250]
SB Score:443

Synacor's online content, portal and comprehensive front-end technology solutions enable MSOs, ISPs and telecommunications companies to bundle, promote and deliver narrowband and broadband premium content and services as part of existing Internet access products. Its solutions offer the combined strength of a flexible portal framework, a robust provisioning platform, a unified back-end and a network of in-demand standard and premium content enabling service providers to maintain critical contact with consumers as they shift from screen-to-screen while seeking increasingly personalized entertainment experiences.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:358

Targetprocess 3 is an agile project management software that emphasizes information visualization and user freedom. Users have full control to view and modify all project details.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:395

Viridi Parente revolutionizes fuel and engine technology for modern times. Their innovative solutions are efficient, sustainable, and designed for the future.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:98

Explore the Startup Ecosystem of Buffalo

National Rank

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Regional Rank

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66th

6

Global Rank

(WorldWide)

201st

30

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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