32 Top startups in Annapolis for May 2025

We rank BlueLine Grid, Zentility and Link Labs in Annapolis along with 29 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Annapolis is part of Baltimore startup ecosystem which ranks #82 globally and #29 in North America.

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Best Startups in Annapolis for 2025

SB Score:387

Zentility offers a user-friendly energy automation platform for businesses to efficiently purchase and control energy costs. Streamline energy management with Zentility's seamless solution.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:357

Link Labs creates a range of modules that enable seamless and reliable connections between devices and individuals over long distances.

Industry:
Software & Data
Subindustry:
Software and Data-Other

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4th

XONA
SB Score:329

Xona offers a streamlined platform for secure and compliant user access in critical infrastructure. Their solution simplifies operations while ensuring data protection, making it an essential tool for businesses in need of reliable OT security.

Industry:
Software & Data
Subindustry:
Cybersecurity

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Everywhere Communications offers innovative dual-mode cellular and satellite communication solutions using cutting-edge technology. Stay connected anytime, anywhere with our patented technology.

Industry:
Software & Data
Subindustry:
Cybersecurity

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SB Score:302

Revista is the go-to source for medical real estate information, offering a comprehensive database of over 60K properties and valuable market insights for investors and professionals. With useful property details and industry reports, Revista is the affordable alternative for better healthcare real estate decisions.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:282

Zephyr™ is a global leader in real-time physiological and biomechanical monitoring, or “Physical Status Monitoring” (PSM) solutions for mHealth, Defense, First Responder, Training and Research markets. Founded in 2003, Zephyr Technology is a US based business, with headquarters in Annapolis, Maryland. Zephyr™ is a pioneer in the use of PSM in training and high stress operational environments. The company’s ongoing collaboration with fire departments, NASA Ames Research Centre, National Guard Civil Support Teams, and multiple US Special Forces contracts has been invaluable in the development and validation of Zephyr™’s technology, and its application in the most extreme operating environments. Zephyr™ strategic partners include Motorola, Department of Defense / Technical Support Working Group (TSWG), UCLA Medical School Stanford University Sports Medicine Dept, NASA Ames. Based in Annapolis, Maryland, Zephyr™ leverages a world class team of engineers, scientists, physiologists and business experts. Local universities and government labs augment Zephyr™’s internal development in specialized areas such as materials science, garment and textile design, sports science, medical monitoring and software / web applications. In addition to the US, Zephyr™ has distributors and representatives in key markets such as the UK, Germany and Singapore.

Industry:
Hardware & IoT
Subindustry:
Hardware

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SB Score:281

BlueLine Grid operates the nation’s premier, trusted collaboration network for law enforcement, first responders, security teams, and corporations. BlueLine Grid provides an encrypted suite of messaging, voice, location, conferencing, virtual command, and file-sharing tools dedicated to the needs of public and private security officials, connecting teams internally and with each other on any device. BlueLine Grid was founded in 2013 and is headquartered in Annapolis, Maryland.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:268

BreachBits is an AI-powered SaaS solution for cyber risk and penetration testing. It uses hacker techniques to monitor organizations, enabling faster decision-making.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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11th

SIXGEN
SB Score:266

SIXGEN delivers top-tier cybersecurity solutions, safeguarding critical assets and infrastructure against escalating global threats. Their expert team ensures robust protection, empowering organizations to operate securely in an increasingly dangerous digital landscape.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

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Total amount:32

Top 12 Software & Data Startups in Annapolis for 2025

The top three Software & Data startups in Annapolis have raised more than USD 59.2M. Annapolis is part of Baltimore startup ecosystem which ranks #70 globally for the Software & Data industry.
SB Score:387

Zentility offers a user-friendly energy automation platform for businesses to efficiently purchase and control energy costs. Streamline energy management with Zentility's seamless solution.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:357

Link Labs creates a range of modules that enable seamless and reliable connections between devices and individuals over long distances.

Industry:
Software & Data
Subindustry:
Software and Data-Other

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Total amount:12

Top 5 Healthtech Startups in Annapolis for 2025

The top three Healthtech startups in Annapolis have raised more than USD 6.54M. Annapolis is part of Baltimore startup ecosystem which ranks #48 globally for the Healthtech industry.
SB Score:302

Revista is the go-to source for medical real estate information, offering a comprehensive database of over 60K properties and valuable market insights for investors and professionals. With useful property details and industry reports, Revista is the affordable alternative for better healthcare real estate decisions.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Annapolis)

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SB Score:236

WhisperSom develops personalized neurostimulation devices to prevent and treat sleep apnea. Founded in 2014 in Annapolis, Maryland, the company aims to improve sleep quality with innovative biomedical solutions.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Annapolis)

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SB Score:224

Kikimora.io streamlines the vulnerability management process by making it centralized, transparent, and easy to navigate. It empowers companies to prioritize vulnerability remediation and effectively tackle security issues in a timely manner, ensuring a more robust defense against potential threats.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Annapolis)

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Total amount:5

Top 4 Ecommerce & Retail Startups in Annapolis for 2025

The top three Ecommerce & Retail startups in Annapolis have raised more than USD 2.04M. Annapolis is part of Baltimore startup ecosystem which ranks #93 globally for the Ecommerce & Retail industry.
SB Score:266

SIXGEN delivers top-tier cybersecurity solutions, safeguarding critical assets and infrastructure against escalating global threats. Their expert team ensures robust protection, empowering organizations to operate securely in an increasingly dangerous digital landscape.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

City Rank (Annapolis)

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SB Score:230

Trivalent revolutionizes data protection by rendering data useless to hackers. Their advanced technology transforms data properties for maximum security, giving users peace of mind.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

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SB Score:83

Aid Through Trade, a founding member of the Fair Trade Federation, is reenergized with new leadership and a growing team of artisans in Nepal. With a focus on innovative designs and ethical practices, they aim to lead the fair trade fashion industry.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

City Rank (Annapolis)

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Total amount:4

Most Funded Startups in Annapolis for 2025

The top three most funded startups in Annapolis have raised total funding of more than USD 154M. AeroVanti has 3.03% more funding than XONA.

2nd

XONA
SB Score:329

Xona offers a streamlined platform for secure and compliant user access in critical infrastructure. Their solution simplifies operations while ensuring data protection, making it an essential tool for businesses in need of reliable OT security.

Industry:
Software & Data
Subindustry:
Cybersecurity

City Rank (Annapolis)

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Regional Rank (North America)

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SB Score:357

Link Labs creates a range of modules that enable seamless and reliable connections between devices and individuals over long distances.

Industry:
Software & Data
Subindustry:
Software and Data-Other

City Rank (Annapolis)

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Regional Rank (North America)

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Total amount:32

Top Hiring Startups in Annapolis by Employee Number

The top three hiring startups in Annapolis have an median employee size that is between [101-250]
SB Score:266

SIXGEN delivers top-tier cybersecurity solutions, safeguarding critical assets and infrastructure against escalating global threats. Their expert team ensures robust protection, empowering organizations to operate securely in an increasingly dangerous digital landscape.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

City Rank (Annapolis)

0

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Regional Rank (North America)

0

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SB Score:387

Zentility offers a user-friendly energy automation platform for businesses to efficiently purchase and control energy costs. Streamline energy management with Zentility's seamless solution.

Industry:
Software & Data
Subindustry:
Data Analytics

City Rank (Annapolis)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:357

Link Labs creates a range of modules that enable seamless and reliable connections between devices and individuals over long distances.

Industry:
Software & Data
Subindustry:
Software and Data-Other

City Rank (Annapolis)

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Total amount:32

Explore the Startup Ecosystem of Annapolis

National Rank

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Regional Rank

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32nd

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Global Rank

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82nd

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2025 National Rank CityGlobal RankTotal Score

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Quality ScoreBusiness Score
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315.515
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139.115
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128.476
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