StartupBlink

34 Top startups in San José for July 2026

We rank Calix, HuliHealth and Decentral Games in San José along with 31 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. San José startup ecosystem ranks #388 globally and #1 in Costa Rica.

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Best Startups in San José for 2026

SB Score:588

Calix cloud and software platforms enable service providers of all types and sizes to innovate and transform. Our customers utilize the real-time data and insights from Calix platforms to simplify their business and deliver experiences that excite their subscribers. The resulting growth in subscriber acquisition, loyalty and revenue creates more value for their businesses and communities. This is the Calix mission; to enable communications service providers of all sizes to simplify, excite and grow.

Industry:
Software & Data
Subindustry:
Comtech

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SB Score:359

HuliHealth is an online medical appointments service in Costa Rica. It enables users to find doctors based on the location, treatment type, ailment, and more. HuliHealth also facilitates finding, selecting, and booking medical procedures and health services abroad. It was founded in March 2011 by Alejandro Vega.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:318

Decentral Games builds ICE Poker, the first metaverse-native, play-and-own poker game that give players economic freedom through self-custody and delegation of wearables.

Industry:
Fintech
Subindustry:
Blockchain

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SB Score:305

Rayo Credit offers small quick loans with a 45-day repayment period. With a user-friendly online platform, fast processing times, and customer rewards, Rayo Credit is the top choice for Emergency Cash loans.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:288

Tobipets is a one-stop shop that connects pet parents with pet brands, services, and veterinarians.

Industry:
Ecommerce & Retail
Subindustry:
Marketplaces

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SB Score:281

Speratum Biopharma Inc. is a U.S.-based biopharmaceutical company formally founded in 2021, with corporate headquarters in Dover, Delaware, and R&D operations in San José, Costa Rica and Houston, Texas. We are dedicated to transforming the treatment of aggressive and resistant cancers through the development of next-generation RNA-based therapeutics. While our scientific foundation began in 2014 with pioneering research led by Dr. Christian Marín-Müller, it was in 2021 that Speratum Biopharma transitioned from an academic and incubator-led initiative into a commercially focused company. This milestone marked our incorporation in the United States, the establishment of structured corporate governance, and the launch of our clinical and translational development strategy.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:278

Thalex is a cryptocurrency-native derivatives trading platform that specializes in options and futures. It combines unrivaled platform stability with a collaborative and innovative approach to enable traders to capitalize on the enormous opportunities presented by digital assets. Thalex was established in 2020 and is headquartered in Mahé, Seychelles.

Industry:
Fintech
Subindustry:
Blockchain

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8th

Huli
SB Score:268

Huli is a technology and information system for health care. They provide services that include health professionals, medical centers, and institutions. Huli improves people's lives by connecting the Latin American health ecosystem in an agile and secure manner.

Industry:
Healthtech
Subindustry:
Medtech

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SB Score:238

WECO Protocol is a next-generation Web3 ecosystem powered by AI agents for Real-World Assets. Through WECO Protocol, diverse real assets—ranging from entertainment IP and digital human celebrities, player and team cards for sports and esports to bio-pharmaceutical R&D pipelines and leisure industry real estate—are tokenized on our decentralized platform and integrated with AI agents. This holistic approach creates new revenue streams, fosters global community building, and democratizes ownership. Fans become “INVESUMER” stakeholders, actively contributing to direct investment to digital human celebrities and related IPs, content creation, marketing, and the economic success of these tokenized assets. Combining AI innovations with blockchain and advanced DeFi primitives, WECO Protocol ensures transparent governance, high liquidity, real-time automation, and frictionless user interactions. The project aspires to be a community-driven ecosystem for various verticals of RWA including entertainment, digital human, intellectual property, real estate, leisure, franchise, biomedical, and De-Fi with RWA token in order to stand out as a premier platform that merges fun, fulfillment, and profitability in a way that’s both inclusive and future-proof.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:203

Processim Labs develops college-level educational games. Simulations of real-world scenarios designed specifically for mobile devices that enable students to learn by doing, put their decision-making skills to practice, and exercise critical thinking in a fun, entertaining, and dynamic way.

Industry:
Edtech
Subindustry:
Edtech

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11th

Mensis
SB Score:193

Mensis is an innovative platform designed to harness internal expertise for personalized, one-on-one training sessions through intelligent connections. We focus on enhancing key processes such as onboarding, offboarding, reskilling, and upskilling, ensuring that your team remains agile and ahead of the curve. Our platform offers a constantly evolving library of skills and knowledge, covering essential topics such as employee experience, streamlined onboarding and offboarding processes, and impactful reskilling and upskilling initiatives. By leveraging the wealth of knowledge within your organization, Mensis helps unlock the full potential of your workforce, driving professional growth and organizational success. With Mensis, you can create a culture of continuous learning and development, ensuring that critical knowledge is captured, retained, and transferred efficiently. Our approach not only maximizes employee engagement and productivity but also empowers your team to achieve their professional goals. Investing in Mensis means investing in the future of corporate learning, where internal knowledge and intelligent connections transform the way your organization grows and thrives.

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (San José)

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Regional Rank (Central America)

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Total amount:34

SB Score:588

Calix cloud and software platforms enable service providers of all types and sizes to innovate and transform. Our customers utilize the real-time data and insights from Calix platforms to simplify their business and deliver experiences that excite their subscribers. The resulting growth in subscriber acquisition, loyalty and revenue creates more value for their businesses and communities. This is the Calix mission; to enable communications service providers of all sizes to simplify, excite and grow.

Industry:
Software & Data
Subindustry:
Comtech

City Rank (San José)

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Regional Rank (Central America)

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SB Score:359

HuliHealth is an online medical appointments service in Costa Rica. It enables users to find doctors based on the location, treatment type, ailment, and more. HuliHealth also facilitates finding, selecting, and booking medical procedures and health services abroad. It was founded in March 2011 by Alejandro Vega.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (San José)

0

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Regional Rank (Central America)

0

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SB Score:318

Decentral Games builds ICE Poker, the first metaverse-native, play-and-own poker game that give players economic freedom through self-custody and delegation of wearables.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (San José)

0

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Regional Rank (Central America)

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Total amount:34

SB Score:588

Calix cloud and software platforms enable service providers of all types and sizes to innovate and transform. Our customers utilize the real-time data and insights from Calix platforms to simplify their business and deliver experiences that excite their subscribers. The resulting growth in subscriber acquisition, loyalty and revenue creates more value for their businesses and communities. This is the Calix mission; to enable communications service providers of all sizes to simplify, excite and grow.

Industry:
Software & Data
Subindustry:
Comtech

City Rank (San José)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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SB Score:359

HuliHealth is an online medical appointments service in Costa Rica. It enables users to find doctors based on the location, treatment type, ailment, and more. HuliHealth also facilitates finding, selecting, and booking medical procedures and health services abroad. It was founded in March 2011 by Alejandro Vega.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (San José)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

Browse
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SB Score:318

Decentral Games builds ICE Poker, the first metaverse-native, play-and-own poker game that give players economic freedom through self-custody and delegation of wearables.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (San José)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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Total amount:34

SB Score:588

Calix cloud and software platforms enable service providers of all types and sizes to innovate and transform. Our customers utilize the real-time data and insights from Calix platforms to simplify their business and deliver experiences that excite their subscribers. The resulting growth in subscriber acquisition, loyalty and revenue creates more value for their businesses and communities. This is the Calix mission; to enable communications service providers of all sizes to simplify, excite and grow.

Industry:
Software & Data
Subindustry:
Comtech

City Rank (San José)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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SB Score:359

HuliHealth is an online medical appointments service in Costa Rica. It enables users to find doctors based on the location, treatment type, ailment, and more. HuliHealth also facilitates finding, selecting, and booking medical procedures and health services abroad. It was founded in March 2011 by Alejandro Vega.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (San José)

0

View

Regional Rank (Central America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:318

Decentral Games builds ICE Poker, the first metaverse-native, play-and-own poker game that give players economic freedom through self-custody and delegation of wearables.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (San José)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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Total amount:34

Most Funded Startups in San José for 2026

The top three most funded startups in San José have raised total funding of more than USD 117M. Calix has 9.72% more funding than Huli.
SB Score:588

Calix cloud and software platforms enable service providers of all types and sizes to innovate and transform. Our customers utilize the real-time data and insights from Calix platforms to simplify their business and deliver experiences that excite their subscribers. The resulting growth in subscriber acquisition, loyalty and revenue creates more value for their businesses and communities. This is the Calix mission; to enable communications service providers of all sizes to simplify, excite and grow.

Industry:
Software & Data
Subindustry:
Comtech

City Rank (San José)

0

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Regional Rank (Central America)

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Global Rank (WorldWide)

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2nd

Huli
SB Score:268

Huli is a technology and information system for health care. They provide services that include health professionals, medical centers, and institutions. Huli improves people's lives by connecting the Latin American health ecosystem in an agile and secure manner.

Industry:
Healthtech
Subindustry:
Medtech

City Rank (San José)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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SB Score:278

Thalex is a cryptocurrency-native derivatives trading platform that specializes in options and futures. It combines unrivaled platform stability with a collaborative and innovative approach to enable traders to capitalize on the enormous opportunities presented by digital assets. Thalex was established in 2020 and is headquartered in Mahé, Seychelles.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (San José)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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Total amount:34

Top Hiring Startups in San José by Employee Number

The top three hiring startups in San José have an median employee size that is between [51-100]
SB Score:588

Calix cloud and software platforms enable service providers of all types and sizes to innovate and transform. Our customers utilize the real-time data and insights from Calix platforms to simplify their business and deliver experiences that excite their subscribers. The resulting growth in subscriber acquisition, loyalty and revenue creates more value for their businesses and communities. This is the Calix mission; to enable communications service providers of all sizes to simplify, excite and grow.

Industry:
Software & Data
Subindustry:
Comtech

City Rank (San José)

0

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Regional Rank (Central America)

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SB Score:105

Zenit empowers people to excel in the crypto market by providing access to advanced trading strategies and technologies for all.

Industry:
Ecommerce & Retail
Subindustry:
Marketplaces

City Rank (San José)

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Regional Rank (Central America)

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SB Score:359

HuliHealth is an online medical appointments service in Costa Rica. It enables users to find doctors based on the location, treatment type, ailment, and more. HuliHealth also facilitates finding, selecting, and booking medical procedures and health services abroad. It was founded in March 2011 by Alejandro Vega.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (San José)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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SB Score:318

Decentral Games builds ICE Poker, the first metaverse-native, play-and-own poker game that give players economic freedom through self-custody and delegation of wearables.

Industry:
Fintech
Subindustry:
Blockchain

City Rank (San José)

0

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Regional Rank (Central America)

0

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Global Rank (WorldWide)

0

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Total amount:34

Explore the Startup Ecosystem of San José

National Rank

(Costa Rica)

1st

new

Regional Rank

(Central America)

6th

1

Global Rank

(WorldWide)

388th

5

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Top Cities for Startups in Costa Rica - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
2026 National Rank CityGlobal RankTotal ScoreAnnual GrowthQuantity ScoreQuality ScoreBusiness Score
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