StartupBlink

34 Top startups in San José for September 2026

We rank Calix, HuliHealth and Decentral Games in San José along with 31 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. San José startup ecosystem ranks #388 globally and #1 in Costa Rica.

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Best Startups in San José for 2026

1st
Calix logo
CalixSB Score: 592

Calix cloud and software platforms enable service providers of all types and sizes to innovate and transform. Our customers utilize the real-time data and insights from Calix platforms to simplify their business and deliver experiences that excite their subscribers. The resulting growth in subscriber acquisition, loyalty and revenue creates more value for their businesses and communities. This is the Calix mission; to enable communications service providers of all sizes to simplify, excite and grow.

View Full Page
Website
www.calix.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$100M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
2nd
HuliHealth logo
HuliHealthSB Score: 363

HuliHealth is an online medical appointments service in Costa Rica. It enables users to find doctors based on the location, treatment type, ailment, and more. HuliHealth also facilitates finding, selecting, and booking medical procedures and health services abroad. It was founded in March 2011 by Alejandro Vega.

View Full Page
Website
hulihealth.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$2M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
3rd
Decentral Games logo
Decentral GamesSB Score: 321

Decentral Games builds ICE Poker, the first metaverse-native, play-and-own poker game that give players economic freedom through self-custody and delegation of wearables.

View Full Page
Website
decentral.games
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$6M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
4th
Rayo Credit logo
Rayo CreditSB Score: 318

Rayo Credit offers small quick loans with a 45-day repayment period. With a user-friendly online platform, fast processing times, and customer rewards, Rayo Credit is the top choice for Emergency Cash loans.

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Website
www.rayo.cr
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$3.4M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
5th
Tobipets logo
TobipetsSB Score: 292

Tobipets is a one-stop shop that connects pet parents with pet brands, services, and veterinarians.

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Website
tobipets.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$200K
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
6th
Speratum logo
SperatumSB Score: 282

Speratum Biopharma Inc. is a U.S.-based biopharmaceutical company formally founded in 2021, with corporate headquarters in Dover, Delaware, and R&D operations in San José, Costa Rica and Houston, Texas. We are dedicated to transforming the treatment of aggressive and resistant cancers through the development of next-generation RNA-based therapeutics. While our scientific foundation began in 2014 with pioneering research led by Dr. Christian Marín-Müller, it was in 2021 that Speratum Biopharma transitioned from an academic and incubator-led initiative into a commercially focused company. This milestone marked our incorporation in the United States, the establishment of structured corporate governance, and the launch of our clinical and translational development strategy.

View Full Page
Website
www.speratum.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$5.5M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
7th
Thalex logo
ThalexSB Score: 281

Thalex is a cryptocurrency-native derivatives trading platform that specializes in options and futures. It combines unrivaled platform stability with a collaborative and innovative approach to enable traders to capitalize on the enormous opportunities presented by digital assets. Thalex was established in 2020 and is headquartered in Mahé, Seychelles.

View Full Page
Website
www.thalex.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$7.6M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
8th
Huli logo
HuliSB Score: 271

Huli is a technology and information system for health care. They provide services that include health professionals, medical centers, and institutions. Huli improves people's lives by connecting the Latin American health ecosystem in an agile and secure manner.

View Full Page
Website
www.huli.io
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$9.3M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
9th
Processim Labs logo
Processim LabsSB Score: 205
EdtechEdtech

Processim Labs develops college-level educational games. Simulations of real-world scenarios designed specifically for mobile devices that enable students to learn by doing, put their decision-making skills to practice, and exercise critical thinking in a fun, entertaining, and dynamic way.

View Full Page
Website
www.processimlabs.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$230K
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
10th
Mensis logo
MensisSB Score: 194

Mensis is an innovative platform designed to harness internal expertise for personalized, one-on-one training sessions through intelligent connections. We focus on enhancing key processes such as onboarding, offboarding, reskilling, and upskilling, ensuring that your team remains agile and ahead of the curve. Our platform offers a constantly evolving library of skills and knowledge, covering essential topics such as employee experience, streamlined onboarding and offboarding processes, and impactful reskilling and upskilling initiatives. By leveraging the wealth of knowledge within your organization, Mensis helps unlock the full potential of your workforce, driving professional growth and organizational success. With Mensis, you can create a culture of continuous learning and development, ensuring that critical knowledge is captured, retained, and transferred efficiently. Our approach not only maximizes employee engagement and productivity but also empowers your team to achieve their professional goals. Investing in Mensis means investing in the future of corporate learning, where internal knowledge and intelligent connections transform the way your organization grows and thrives.

View Full Page
Website
mensismentor.com/business
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$62K
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
11th
Unicoderns logo
UnicodernsSB Score: 147

Unicoderns is a software company that has experience coding and designing MVPs for startups in USA. And we want to bring all that cutting edge tech to Latam shortening technological barriers, encouraging entrepreneurship, sharing knowledge, and promoting constructive information sourcing.

View Full Page
Website
unicoderns.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$50K
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)

Total amount:20

Most Funded Startups in San José for 2026

The top three most funded startups in San José have raised total funding of more than USD 117M. Calix has 9.72% more funding than Huli.
1st
Calix logo
CalixSB Score: 592

Calix cloud and software platforms enable service providers of all types and sizes to innovate and transform. Our customers utilize the real-time data and insights from Calix platforms to simplify their business and deliver experiences that excite their subscribers. The resulting growth in subscriber acquisition, loyalty and revenue creates more value for their businesses and communities. This is the Calix mission; to enable communications service providers of all sizes to simplify, excite and grow.

View Full Page
Website
www.calix.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$100M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
2nd
Huli logo
HuliSB Score: 271

Huli is a technology and information system for health care. They provide services that include health professionals, medical centers, and institutions. Huli improves people's lives by connecting the Latin American health ecosystem in an agile and secure manner.

View Full Page
Website
www.huli.io
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$9.3M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
3rd
Thalex logo
ThalexSB Score: 281

Thalex is a cryptocurrency-native derivatives trading platform that specializes in options and futures. It combines unrivaled platform stability with a collaborative and innovative approach to enable traders to capitalize on the enormous opportunities presented by digital assets. Thalex was established in 2020 and is headquartered in Mahé, Seychelles.

View Full Page
Website
www.thalex.com
Employee range
1 – 10
Web Traffic (Monthly)
Funding amount
$7.6M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)

Total amount:20

Top Hiring Startups in San José by Employee Number

The top three hiring startups in San José have an median employee size that is between [51-100]
1st
Calix logo
CalixSB Score: 592

Calix cloud and software platforms enable service providers of all types and sizes to innovate and transform. Our customers utilize the real-time data and insights from Calix platforms to simplify their business and deliver experiences that excite their subscribers. The resulting growth in subscriber acquisition, loyalty and revenue creates more value for their businesses and communities. This is the Calix mission; to enable communications service providers of all sizes to simplify, excite and grow.

View Full Page
Website
www.calix.com
Employee range
1,001 – 5,000
Web Traffic (Monthly)
Funding amount
$100M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
2nd
ZENIT logo
ZENITSB Score: 106

Zenit empowers people to excel in the crypto market by providing access to advanced trading strategies and technologies for all.

View Full Page
Website
zenit.world
Employee range
51 – 100
Web Traffic (Monthly)
Funding amount
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
3rd
HuliHealth logo
HuliHealthSB Score: 363

HuliHealth is an online medical appointments service in Costa Rica. It enables users to find doctors based on the location, treatment type, ailment, and more. HuliHealth also facilitates finding, selecting, and booking medical procedures and health services abroad. It was founded in March 2011 by Alejandro Vega.

View Full Page
Website
hulihealth.com
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$2M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)
4th
Decentral Games logo
Decentral GamesSB Score: 321

Decentral Games builds ICE Poker, the first metaverse-native, play-and-own poker game that give players economic freedom through self-custody and delegation of wearables.

View Full Page
Website
decentral.games
Employee range
11 – 50
Web Traffic (Monthly)
Funding amount
$6M
National Rank(Costa Rica)
Regional Rank(Central America)
Global Rank(Worldwide)

Total amount:34

Explore More Top Startups

Explore the Startup Ecosystem of San José

National Rank

(Costa Rica)

1st

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Regional Rank

(Central America)

6th

1

Global Rank

(WorldWide)

388th

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Top Cities for Startups in Costa Rica - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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