41 Top startups in Heidelberg for July 2025

We rank Getsafe, Aleph Alpha and Instaffo in Heidelberg along with 38 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #169 globally and #46 in Western Europe.

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Best Startups in Heidelberg for 2025

SB Score:524

Getsafe is a modern insurance company designed for mobile users. Offering seamless digital solutions, Getsafe is perfect for today's tech-savvy individuals.

Industry:
Fintech
Subindustry:
Insurance

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SB Score:518

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

City Rank (Heidelberg)

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SB Score:485

Instaffo revolutionizes recruiting with a fully automated platform for companies and ambitious professionals. Discover top talent and exciting career opportunities effortlessly.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:384

Heidelberg Pharma GmbH, a drug development company, provides pre-clinical drug discovery and development services for the development of anti-cancer and anti-inflammatory drugs to pharmaceutical and biotechnology industries. It offers services, such as explorative pharmacology, drug metabolism and pharmacokinetics analysis, and molecular biology in the fields of oncology or inflammatory/autoimmune diseases.

Industry:
Healthtech
Subindustry:
Biotechnology

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Talk’n’Job is an innovative app for blue-collar workers and young professionals, providing a modern alternative to traditional job applications. Connect with employers in production, service, and logistics with ease.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:357

Apogenix creates innovative protein therapies for cancer and inflammatory conditions. Their biopharmaceutical products aim to revolutionize treatment options in these areas.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:338

Luxendo specializes in the manufacturing and sales of cutting-edge Single Plane Illumination Microscopes (SPIM), originally developed at EMBL by Lars Hufnagel and his team. These advanced microscopes enable researchers to achieve unparalleled imaging quality, enhancing their ability to explore biological processes with precision and clarity.

Industry:
Healthtech
Subindustry:
Life Sciences

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SB Score:328

Paretos is a leading AI-driven decision intelligence platform that empowers organizations to make data-driven choices. With its no-code interface and seamless integrations, it enables business users to analyze complex data, forecast future scenarios, and execute optimal actions without requiring prior data science expertise.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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10th

Lora
SB Score:322

Lora specializes in aesthetic dental treatments, offering routine checkups, cleanings, implantology, orthodontics, and teeth whitening. With services like invisible tooth correction and veneers, Lora ensures a radiant smile. Convenient online booking is available for all treatments, making dental care accessible and hassle-free.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:307

Quality Match is a premier knowledge annotation provider that delivers exceptional annotation services. By utilizing advanced techniques and skilled professionals, it enhances data quality, ensuring accurate and reliable insights for businesses seeking to optimize their machine learning and artificial intelligence projects.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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Total amount:41

Top 13 Software & Data Startups in Heidelberg for 2025

The top three Software & Data startups in Heidelberg have raised more than USD 764M. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #100 globally for the Software & Data industry.
SB Score:518

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

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SB Score:485

Instaffo revolutionizes recruiting with a fully automated platform for companies and ambitious professionals. Discover top talent and exciting career opportunities effortlessly.

Industry:
Software & Data
Subindustry:
Data Analytics

City Rank (Heidelberg)

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Regional Rank (Western Europe)

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Talk’n’Job is an innovative app for blue-collar workers and young professionals, providing a modern alternative to traditional job applications. Connect with employers in production, service, and logistics with ease.

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (Heidelberg)

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Regional Rank (Western Europe)

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Total amount:13

Top 15 Healthtech Startups in Heidelberg for 2025

The top three Healthtech startups in Heidelberg have raised more than USD 131M. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #180 globally for the Healthtech industry.
SB Score:384

Heidelberg Pharma GmbH, a drug development company, provides pre-clinical drug discovery and development services for the development of anti-cancer and anti-inflammatory drugs to pharmaceutical and biotechnology industries. It offers services, such as explorative pharmacology, drug metabolism and pharmacokinetics analysis, and molecular biology in the fields of oncology or inflammatory/autoimmune diseases.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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SB Score:357

Apogenix creates innovative protein therapies for cancer and inflammatory conditions. Their biopharmaceutical products aim to revolutionize treatment options in these areas.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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SB Score:338

Luxendo specializes in the manufacturing and sales of cutting-edge Single Plane Illumination Microscopes (SPIM), originally developed at EMBL by Lars Hufnagel and his team. These advanced microscopes enable researchers to achieve unparalleled imaging quality, enhancing their ability to explore biological processes with precision and clarity.

Industry:
Healthtech
Subindustry:
Life Sciences

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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Total amount:15

Top 1 Hardware & IoT Startups in Heidelberg for 2025

Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #242 globally for the Hardware & IoT industry.
SB Score:99

HD Vision Systems creates LumiScan products for advanced light field automation and quality inspection, providing affordable high-performance solutions that bridge the gap between costly 3D scanners and customer needs.

Industry:
Hardware & IoT
Subindustry:
3D Printing

City Rank (Heidelberg)

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Regional Rank (Western Europe)

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Total amount:1

Most Funded Startups in Heidelberg for 2025

The top three most funded startups in Heidelberg have raised total funding of more than USD 892M. Aleph Alpha has 5.18% more funding than Getsafe.
SB Score:518

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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SB Score:524

Getsafe is a modern insurance company designed for mobile users. Offering seamless digital solutions, Getsafe is perfect for today's tech-savvy individuals.

Industry:
Fintech
Subindustry:
Insurance

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

Browse
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SB Score:357

Apogenix creates innovative protein therapies for cancer and inflammatory conditions. Their biopharmaceutical products aim to revolutionize treatment options in these areas.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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Total amount:41

Top Hiring Startups in Heidelberg by Employee Number

The top three hiring startups in Heidelberg have an median employee size that is between [251-500]
SB Score:338

Luxendo specializes in the manufacturing and sales of cutting-edge Single Plane Illumination Microscopes (SPIM), originally developed at EMBL by Lars Hufnagel and his team. These advanced microscopes enable researchers to achieve unparalleled imaging quality, enhancing their ability to explore biological processes with precision and clarity.

Industry:
Healthtech
Subindustry:
Life Sciences

City Rank (Heidelberg)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:524

Getsafe is a modern insurance company designed for mobile users. Offering seamless digital solutions, Getsafe is perfect for today's tech-savvy individuals.

Industry:
Fintech
Subindustry:
Insurance

City Rank (Heidelberg)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:518

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

City Rank (Heidelberg)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:485

Instaffo revolutionizes recruiting with a fully automated platform for companies and ambitious professionals. Discover top talent and exciting career opportunities effortlessly.

Industry:
Software & Data
Subindustry:
Data Analytics

City Rank (Heidelberg)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:41

Explore the Startup Ecosystem of Heidelberg

National Rank

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Regional Rank

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38th

2

Global Rank

(WorldWide)

152nd

4

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Top Cities for Startups in Germany - Ranked by StartupBlink

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