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46 Top startups in Heidelberg for June 2026

We rank Getsafe, Aleph Alpha and Instaffo in Heidelberg along with 43 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #177 globally and #47 in Western Europe.

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Best Startups in Heidelberg for 2026

SB Score:522

Getsafe is a digital insurance company that creates a better insurance experience for everyone. Powered by its unique technological platform, Getsafe makes insurance simple, fair and accessible. As Getsafe replaces complexity and manual paperwork with smart bots and automation, customers can file claims or change their coverage in real time with just a few clicks.

Industry:
Fintech
Subindustry:
Insurance

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SB Score:515

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:484

Instaffo is a Heidelberg based HR technology company that has developed a reverse recruiting platform for a fulfilling employer-employee relationship to help people. Based on big data and artificial intelligence, Instaffo automatically connects workers and employers who are ideally matched. For this, not only the skills, but also the professional goals and wishes of candidates are considered. As a result, the proposed companies and jobs are the perfect match for the candidates and the candidates for the companies. In direct chat, both can quickly and directly clarify open questions and arrange interviews.

Industry:
Software & Data
Subindustry:
Data Analytics

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Talk’n’Job, a virtual voice job-application via mobile phone. By enabling candidates to apply for jobs using voice response on their mobile phones, Talk’n’Job effectively reduces barriers and provides a convenient and seamless job application experience. It is particularly beneficial for entry-level and high- volume roles, and for candidates without resumes or an online presence. Thanks to its multilingual capability, candidates who have not previously had the opportunity to apply to the job market can also apply. With an integration in most ATS it integrates fast and easy into the customers' internal processes (e.g. SuccessFactors, SmartRecruiters, Cornerstone) The integrated automated pre-qualification reduces the time-consuming first candidate screening to a maximum. BENEFIT - Generate more candidates, lower time-to-hire as well as cost per hire. - Lower process cost - Fast setup OTHERS - 1 mn EUR ARR in the 1st full year - 165 customers across 7 countries - Jan 2023: market entry in the USA (C-Corp; TalkandJob Inc.) supported by the German Accelerator program - 16 awards UNLEASH World 2023; 5 in the UK with the use case NHS: 73% total applications; 80% less cost/hire on jobboards) - References (extract) - REWE: 2nd largest retailer in D - DHL - EDEKA: largest retailer in D - NHS: 5th largest employer worldwide - B.Braun - Österreichische Post

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:348

AMERIA AG is the world leader for integrated gesture control in public spaces – helping manufacturers and retailers to sell more and to acquire personalized customer data with touchfree interaction that inspires customers. From retail to consumer goods manufacturers to public institutions, the areas of application for AMERIAs human-machine interfaces are practically limitless. With their all-in-one solution of software, hardware and consulting, AMERIA provides the link from offline to online and even into new worlds, like that of the metaverse, and sets the new standard for public interactions. AMERIAs deeptech approach has gained enormous importance for many companies due to current global developments and the acceleration of digitization.

Industry:
Ecommerce & Retail
Subindustry:
Retail

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SB Score:342

We are Backpackertrail and have built the largest backpacking community in DACH in the pandemic. We have built a two-sided marketplace for young travellers, where on the one hand our users can create personalised itineraries and book them at the current market price through our partners (Skyscanner, Booking.com, Hostelworld etc..). On the other hand, we enable travel content creators to publish their own itineraries with us, promote them to their followers and participate in the booking volume.

Industry:
Social & Leisure
Subindustry:
Travel

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SB Score:338

Heidelberg Pharma GmbH, a drug development company, provides pre-clinical drug discovery and development services for the development of anti-cancer and anti-inflammatory drugs to pharmaceutical and biotechnology industries. It offers services, such as explorative pharmacology, drug metabolism and pharmacokinetics analysis, and molecular biology in the fields of oncology or inflammatory/autoimmune diseases.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:331

Paretos is the leading AI-based decision intelligence platform to make effective, data-driven decisions across entire organizations, enabling business users to evaluate complex data, predict future scenarios and take optimal actions via a no-code UI and integrations with no prior data science knowledge needed. First success stories of implementing the 100% SaaS solution in E-Commerce, Logistics & Consulting (e.g. Accenture, SNOCKS, or one of the biggest parcel services in Europe) demonstrate the groundbreaking impact paretos delivers as a horizontal platform with a use-case focused approach covering: Recommendation Engines, Dynamic Pricing and Discounting, Ad Spend Optimization, Demand and Churn Prediction as well as Warehouse Optimization.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:329

Apogenix is a clinical stage biopharmaceutical company developing novel protein therapeutics for the treatment of cancer and inflammatory diseases. The compound´s mechanism of action is either based on the targeted modulation of the programmed cell death (a.k.a. apoptosis - ἁπόπτωσισ is used in Greek to describe the "falling off" of leaves from trees) or on the inhibition of tumour cell growth. The lead product candidate of the company, APG101, is currently in a controlled phase II proof of concept study with GBM patients (GBM: Glioblastoma multiforme).

Industry:
Healthtech
Subindustry:
Biotechnology

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11th

Exciva
SB Score:320

exciva is a Provider of targeted drug rescue program intended to involve pharmaceutical research and development based in Heidelberg, Germany. The company's program has been formulated for developing symptomatic and disease-modifying treatments, therapies, cures, prophylactics, supplements, formulations and methods of making and using such compositions, enabling the healthcare industry to access their program for rescuing and reusing approved drugs for new indications and new uses.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Heidelberg)

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Total amount:46

Top 13 Software & Data Startups in Heidelberg for 2026

The top three Software & Data startups in Heidelberg have raised more than USD 571M. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #123 globally for the Software & Data industry.
SB Score:515

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

City Rank (Heidelberg)

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Regional Rank (Western Europe)

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SB Score:484

Instaffo is a Heidelberg based HR technology company that has developed a reverse recruiting platform for a fulfilling employer-employee relationship to help people. Based on big data and artificial intelligence, Instaffo automatically connects workers and employers who are ideally matched. For this, not only the skills, but also the professional goals and wishes of candidates are considered. As a result, the proposed companies and jobs are the perfect match for the candidates and the candidates for the companies. In direct chat, both can quickly and directly clarify open questions and arrange interviews.

Industry:
Software & Data
Subindustry:
Data Analytics

City Rank (Heidelberg)

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Regional Rank (Western Europe)

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Talk’n’Job, a virtual voice job-application via mobile phone. By enabling candidates to apply for jobs using voice response on their mobile phones, Talk’n’Job effectively reduces barriers and provides a convenient and seamless job application experience. It is particularly beneficial for entry-level and high- volume roles, and for candidates without resumes or an online presence. Thanks to its multilingual capability, candidates who have not previously had the opportunity to apply to the job market can also apply. With an integration in most ATS it integrates fast and easy into the customers' internal processes (e.g. SuccessFactors, SmartRecruiters, Cornerstone) The integrated automated pre-qualification reduces the time-consuming first candidate screening to a maximum. BENEFIT - Generate more candidates, lower time-to-hire as well as cost per hire. - Lower process cost - Fast setup OTHERS - 1 mn EUR ARR in the 1st full year - 165 customers across 7 countries - Jan 2023: market entry in the USA (C-Corp; TalkandJob Inc.) supported by the German Accelerator program - 16 awards UNLEASH World 2023; 5 in the UK with the use case NHS: 73% total applications; 80% less cost/hire on jobboards) - References (extract) - REWE: 2nd largest retailer in D - DHL - EDEKA: largest retailer in D - NHS: 5th largest employer worldwide - B.Braun - Österreichische Post

Industry:
Software & Data
Subindustry:
Enterprise Technology

City Rank (Heidelberg)

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Regional Rank (Western Europe)

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Total amount:13

Top 2 Energy & Environment Startups in Heidelberg for 2026

The top three Energy & Environment startups in Heidelberg have raised more than USD 81.9K. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #151 globally for the Energy & Environment industry.
SB Score:148

Alpha Cleantec AG (ACT) was founded in the second half of 2016. The Company entered into the activity in the field of environmental technologies, with experts bringing in-depth relevant technological know-how. The team of high-qualified multi-year experienced scientists and technicians under the tactful guidance of the skilled management have reached solid and promising results in the research & development sector to be competitive and prominent with the company’s innovative solutions on a world-wide level. The basic philosophy of the ACT team is to design tailor-made and safe approaches for the cases to eliminate the impacts of the industrial activity with minimized economic input and maximum environmental-friendly output. Apart from the own R&D Division, ACT has a direct co-operational agreement with Casali Institute of Applied Chemistry in Jerusalem, Israel, which is a department within the Institute of Chemistry at the Hebrew University of Jerusalem. It conducts research and development in a wide range of topics of concern to the chemical, biotechnology and related industries. Despite the short existence period, the company has proven its technologies on a laboratory scale through independent test showing conversion rates of up to 97% and is now in the process of carrying out pilot tests to prove the scale-up capacity of its technologies. ACT is very proud to be engaged in the field of environmental technologies not just as a promising business opportunity, but also to solve one of the world's greatest problem, contamination from industrial activity, and to make the Earth healthy and green again for future generations.

Industry:
Energy & Environment
Subindustry:
Energy & Environment-Other

City Rank (Heidelberg)

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SB Score:55

Daulto is revolutionizing the heating industry through a fresh approach to its processes. Embracing a technology-driven perspective, coupled with industrialized, standardized installation methods and a strong emphasis on software, Daulto has innovatively transformed the installation of heat pumps for homeowners into an assembly line-like process. This innovative approach not only makes the installation process more streamlined but also increases efficiency, thereby making sustainable heating solutions more accessible and dependable for a wider audience.

Industry:
Energy & Environment
Subindustry:
Energy

City Rank (Heidelberg)

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Regional Rank (Western Europe)

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Total amount:2

Top 3 Social & Leisure Startups in Heidelberg for 2026

The top three Social & Leisure startups in Heidelberg have raised more than USD 1.91M. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #161 globally for the Social & Leisure industry.
SB Score:342

We are Backpackertrail and have built the largest backpacking community in DACH in the pandemic. We have built a two-sided marketplace for young travellers, where on the one hand our users can create personalised itineraries and book them at the current market price through our partners (Skyscanner, Booking.com, Hostelworld etc..). On the other hand, we enable travel content creators to publish their own itineraries with us, promote them to their followers and participate in the booking volume.

Industry:
Social & Leisure
Subindustry:
Travel

City Rank (Heidelberg)

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SB Score:214

GameFlavor bridges the gap between the virtual and physical worlds by imbuing the gaming experience with a genuine flavor. Their goal is to mimic the versatility of video games by experimenting with various ingredients and providing a plethora of opportunities for licensed beverages.

Industry:
Social & Leisure
Subindustry:
Gaming

City Rank (Heidelberg)

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Total amount:3

Most Funded Startups in Heidelberg for 2026

The top three most funded startups in Heidelberg have raised total funding of more than USD 719M. Aleph Alpha has 3.60% more funding than Getsafe.
SB Score:515

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

City Rank (Heidelberg)

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Regional Rank (Western Europe)

0

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SB Score:522

Getsafe is a digital insurance company that creates a better insurance experience for everyone. Powered by its unique technological platform, Getsafe makes insurance simple, fair and accessible. As Getsafe replaces complexity and manual paperwork with smart bots and automation, customers can file claims or change their coverage in real time with just a few clicks.

Industry:
Fintech
Subindustry:
Insurance

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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SB Score:320

exciva is a Provider of targeted drug rescue program intended to involve pharmaceutical research and development based in Heidelberg, Germany. The company's program has been formulated for developing symptomatic and disease-modifying treatments, therapies, cures, prophylactics, supplements, formulations and methods of making and using such compositions, enabling the healthcare industry to access their program for rescuing and reusing approved drugs for new indications and new uses.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

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Total amount:46

Top Hiring Startups in Heidelberg by Employee Number

The top three hiring startups in Heidelberg have an median employee size that is between [101-250]
SB Score:522

Getsafe is a digital insurance company that creates a better insurance experience for everyone. Powered by its unique technological platform, Getsafe makes insurance simple, fair and accessible. As Getsafe replaces complexity and manual paperwork with smart bots and automation, customers can file claims or change their coverage in real time with just a few clicks.

Industry:
Fintech
Subindustry:
Insurance

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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SB Score:515

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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SB Score:338

Heidelberg Pharma GmbH, a drug development company, provides pre-clinical drug discovery and development services for the development of anti-cancer and anti-inflammatory drugs to pharmaceutical and biotechnology industries. It offers services, such as explorative pharmacology, drug metabolism and pharmacokinetics analysis, and molecular biology in the fields of oncology or inflammatory/autoimmune diseases.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

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SB Score:484

Instaffo is a Heidelberg based HR technology company that has developed a reverse recruiting platform for a fulfilling employer-employee relationship to help people. Based on big data and artificial intelligence, Instaffo automatically connects workers and employers who are ideally matched. For this, not only the skills, but also the professional goals and wishes of candidates are considered. As a result, the proposed companies and jobs are the perfect match for the candidates and the candidates for the companies. In direct chat, both can quickly and directly clarify open questions and arrange interviews.

Industry:
Software & Data
Subindustry:
Data Analytics

City Rank (Heidelberg)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

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Total amount:46

Explore the Startup Ecosystem of Heidelberg

National Rank

(Germany)

new

Regional Rank

(Western Europe)

47th

11

Global Rank

(WorldWide)

177th

29

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Top Cities for Startups in Germany - Ranked by StartupBlink

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2026 National Rank CityGlobal RankTotal ScoreAnnual GrowthQuantity ScoreQuality ScoreBusiness Score
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