57 Top startups in New Haven for March 2025

We rank Vytyl Health Management, Quantum Circuits and Valisure in New Haven along with 54 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. New Haven startup ecosystem ranks #103 globally and #36 in United States.

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Best Startups in New Haven for 2025

Vytyl Health Management provides exceptional mental health care for adolescents and transitional-age youth, emphasizing the importance of connection in the healing process. By fostering supportive relationships, Vytyl helps young individuals navigate their mental health challenges and achieve lasting wellness.

Industry:
Healthtech
Subindustry:
Health-Other

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SB Score:406

QCI is creating the world's first quantum computers using superconducting technology. Their goal is to make quantum computing accessible and practical for all, revolutionizing the way we solve complex problems.

Industry:
Hardware & IoT
Subindustry:
Hardware

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SB Score:395

Valisure is a digital pharmacy that ensures medication quality by chemically validating each batch for consistency.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:369

Verb Energy creates tasty and nutritious energy snacks for daily consumption. The Verb Caffeinated Energy Bar is our top product, providing a delicious boost of energy whenever needed.

Industry:
Foodtech
Subindustry:
Food and Beverage

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SB Score:365

Wellinks revolutionizes respiratory care with innovative hardware technology, putting patients at the center.

Industry:
Healthtech
Subindustry:
Fitness

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SB Score:343

ReNetX Bio's technology platform aims to restore function in patients with spinal cord injuries, stroke, and glaucoma. It offers hope for those seeking recovery from debilitating conditions through innovative solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:335

Simcha Therapeutics is a biopharmaceutical company developing engineered cytokine immunotherapy for cancer. The company uses directed evolution to engineer novel cytokines designed to unlock the precision and power of the immune system. Simcha’s lead program, ST-067, is a designer IL-18 cytokine that has shown potent antitumor effects in animal models, both as a monotherapy and when combined with anti-PD-1 checkpoint inhibitors, as described in Nature in June 2020. It was founded in 2018 and is headquartered in New Haven, Connecticut, USA.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:325

Oerth Bio is a developer of targeted protein degraders for agricultural applications. The company leverages Arvinas' novel PROTAC protein degrader technology to develop new human therapeutics for patients with cardiovascular, oncological, and gynecological diseases.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:317

AtlasXomics revolutionizes biotechnology by advancing spatial multi-omics for cancer, brain health, and aging. Their innovative approach accelerates research in these critical fields, offering groundbreaking solutions for a healthier future.

Industry:
Healthtech
Subindustry:
Biotechnology

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10th

Kleo
SB Score:314

Kleo is creating two types of small molecules to target cancer, infectious diseases, and various other conditions. Their innovative treatments offer hope for a wide range of medical challenges.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:312

PatientWisdom, Inc. developed a SaaS digital health platform that transforms the experience and delivery of care by listening to the people involved, individually and at scale. The offers three powerful solutions: PatientWisdom makes it easy to understand what matters to patients ahead of clinical encounters so providers can do better without taking longer, ProviderWisdom obtains real-world insights from clinicians and staff to create more responsive ecosystems that enhance engagement, address burnout and streamline care, CommunityWisdom produces a deep view of the community to give health organizations clear lines-of-sight for developing or partnering with programs people will use. The Tech Tribune named PatientWisdom, Inc. one of the Best Tech Startups in 2018 and 2019, and PatientWisdom was named “Most-Patient Centered” and an Audience Favorite at the Health Tech StandOut! Competition during the 2018 Connected Health Conference.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Total amount:57

Top 23 Healthtech Startups in New Haven for 2025

The top three Healthtech startups in New Haven have raised more than USD 164M. New Haven startup ecosystem ranks #32 globally for the Healthtech industry.

Vytyl Health Management provides exceptional mental health care for adolescents and transitional-age youth, emphasizing the importance of connection in the healing process. By fostering supportive relationships, Vytyl helps young individuals navigate their mental health challenges and achieve lasting wellness.

Industry:
Healthtech
Subindustry:
Health-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:395

Valisure is a digital pharmacy that ensures medication quality by chemically validating each batch for consistency.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:365

Wellinks revolutionizes respiratory care with innovative hardware technology, putting patients at the center.

Industry:
Healthtech
Subindustry:
Fitness

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:23

Top 13 Software & Data Startups in New Haven for 2025

The top three Software & Data startups in New Haven have raised more than USD 21.2M. New Haven startup ecosystem ranks #178 globally for the Software & Data industry.

Trinity Mobile Networks enhances mobile data speed and network capacity with innovative wireless mesh networking technology. Their goal is to offer fast and affordable connectivity for users, improving overall network performance.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

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SB Score:282

RxAll is a cutting-edge platform using Deep Learning and Hyperspectral IoT technology to authenticate and track the quality of drugs worldwide in real-time.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

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SB Score:281

Frontier Nutrition develops, manufacture, and markets packaged food products. Their products and strategies are based on research in pediatric nutrition and behavioral marketing. Their recipes are localized for traditional diets and optimized for taste, nutrition, and price. Frontier Nutrition, Inc. was founded in 2017 by Eddie Bearnot and Tanveer Ali and is based in New Haven, Connecticut, United States.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:13

Top 4 Hardware & IoT Startups in New Haven for 2025

The top three Hardware & IoT startups in New Haven have raised more than USD 83.3M. New Haven startup ecosystem ranks #165 globally for the Hardware & IoT industry.
SB Score:406

QCI is creating the world's first quantum computers using superconducting technology. Their goal is to make quantum computing accessible and practical for all, revolutionizing the way we solve complex problems.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

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Regional Rank (North America)

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SB Score:279

NextVein harnesses augmented reality technology to deliver affordable vein-finding solutions, enhancing the efficiency and accuracy of vascular access. With its innovative approach, NextVein empowers healthcare professionals to easily locate veins, improving patient care and streamlining procedures.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

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Regional Rank (North America)

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SB Score:242

CubicAcres is a vertical farming company dedicated to delivering fresh, nutrient-dense produce sustainably. By utilizing hyper-local farming techniques and advanced technology, it cultivates crops without pesticides or fungicides, ensuring a healthy food source for communities while promoting environmental stewardship.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:4

Most Funded Startups in New Haven for 2025

The top three most funded startups in New Haven have raised total funding of more than USD 198M. Quantum Circuits has 0.20% more funding than Simcha Therapeutics.
SB Score:406

QCI is creating the world's first quantum computers using superconducting technology. Their goal is to make quantum computing accessible and practical for all, revolutionizing the way we solve complex problems.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:335

Simcha Therapeutics is a biopharmaceutical company developing engineered cytokine immunotherapy for cancer. The company uses directed evolution to engineer novel cytokines designed to unlock the precision and power of the immune system. Simcha’s lead program, ST-067, is a designer IL-18 cytokine that has shown potent antitumor effects in animal models, both as a monotherapy and when combined with anti-PD-1 checkpoint inhibitors, as described in Nature in June 2020. It was founded in 2018 and is headquartered in New Haven, Connecticut, USA.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:325

Oerth Bio is a developer of targeted protein degraders for agricultural applications. The company leverages Arvinas' novel PROTAC protein degrader technology to develop new human therapeutics for patients with cardiovascular, oncological, and gynecological diseases.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:57

Top Hiring Startups in New Haven by Employee Number

The top three hiring startups in New Haven have an median employee size that is between [101-250]

Vytyl Health Management provides exceptional mental health care for adolescents and transitional-age youth, emphasizing the importance of connection in the healing process. By fostering supportive relationships, Vytyl helps young individuals navigate their mental health challenges and achieve lasting wellness.

Industry:
Healthtech
Subindustry:
Health-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:264

VEOCI is the ultimate Emergency and Crisis Management software, providing a virtual command center for communication, coordination, and situational awareness. Plan ahead, launch coordinated responses, and manage incident communications from anywhere, ensuring a quick recovery from any situation. Be better prepared with VEOCI.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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SB Score:189

Spot on Networks provides wireless broadband access to residential, hotel, and commercial users nationwide. With a $35mm investment in technology and infrastructure, they offer high-quality and cost-effective Internet services to enhance connectivity for their subscribers.

Industry:
Hardware & IoT
Subindustry:
Hardware & IoT-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:406

QCI is creating the world's first quantum computers using superconducting technology. Their goal is to make quantum computing accessible and practical for all, revolutionizing the way we solve complex problems.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:57

Explore the Startup Ecosystem of New Haven

National Rank

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Regional Rank

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41st

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Global Rank

(WorldWide)

103rd

3

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Top Cities for Startups in United States - Ranked by StartupBlink

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Quantity Score
Quality ScoreBusiness Score
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710.966
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251.377
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121.937
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109.679
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