14 Top startups in Kalamazoo for May 2025

We rank Vestaron, Cirius Therapeutics and Inovelli in Kalamazoo along with 11 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Kalamazoo startup ecosystem ranks #570 globally and #149 in United States.

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Best Startups in Kalamazoo for 2025

SB Score:380

Vestaron is leading a peptide-based revolution in crop protection. We are committed to providing growers with novel, effective peptide-based biopesticides that address proven targets. Our peptides overcome existing resistance issues while offering a desired safety profile for workers, beneficials and the environment. Vestaron has earned global recognition for its work, including the inaugural 2015 Bernard Blum Award for novel biocontrol solutions, the prestigious Green Chemistry Challenge Award from the U.S. Environmental Protection Agency and the American Chemical Society Green Chemistry Institute in 2020 and Best New Biologic Product in the 2021 Crop Science Awards.

Industry:
Foodtech
Subindustry:
Agtech

City Rank (Kalamazoo)

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SB Score:335

Cirius Therapeutics develops insulin sensitizers to treat non-alcoholic steatohepatitis, a liver disease. Their clinical-stage products aim to improve liver health and combat the effects of the condition.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Kalamazoo)

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SB Score:309

CALIGENIA revitalizes degraded soils by converting organic waste into BACTERCHAR, an innovative evolution of traditional biochar. This transformative product enhances soil productivity, promoting healthier ecosystems and sustainable agriculture for a greener future.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

City Rank (Kalamazoo)

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Metabolic Solutions Development creates groundbreaking therapies for type two diabetes using a unique pharmacological approach. Their innovative treatments aim to revolutionize diabetes management by targeting underlying metabolic processes.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:236

Naitive Traits enhances corn genetics for increased yield, drought resistance, and temperature tolerance. Their startup focuses on developing traits that make corn more resilient and productive in challenging environmental conditions.

Industry:
Foodtech
Subindustry:
Agtech

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SB Score:223

Epredia offers innovative solutions that are revolutionizing the anatomical pathology industry. Their wide range of products is transforming how professionals work, making processes more efficient and accurate.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:208

RealBio Technology develops cutting-edge biorealistic cell and tissue culture technology for life science research. Their innovative solutions provide a realistic environment for studying cells and tissues, advancing research in the field.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Kalamazoo)

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SB Score:190

Cocoa™ revolutionizes farming by producing sustainable fertilizer from organic waste, increasing crop yields, saving farmers money, and reducing pollution. With $1.5M in funding from top investors, Cocoa aims to disrupt the $22Bn US fertilizer market with its Midwest compost facility and plans for expansion.

Industry:
Energy & Environment
Subindustry:
Cleantech

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SB Score:32

Smart Planet Software delivers cost-effective technology solutions for businesses of all sizes. By leveraging modern design principles and cutting-edge mobile and web technologies, it empowers organizations to enhance their operations and achieve their goals efficiently.

Industry:
Marketing & Sales
Subindustry:
Marketing & Sales-Other

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10th

Adlore
SB Score:29

This innovative device is designed to effectively treat challenging lower extremity wounds, including diabetic foot ulcers, neuropathic conditions, venous stasis leg wounds, and arterial ulcers. It enhances healing and improves patient outcomes, addressing the critical needs of those suffering from these difficult-to-treat conditions.

Industry:
Healthtech
Subindustry:
Health Care

City Rank (Kalamazoo)

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SB Score:23

NixCode offers no-code app development services. The company uses software that functions like a human brain and the high-tech ability of a robot to create mobile apps that work effectively without using any code. The apps created by Nixcode are user-friendly, reasonably priced, and simple to create.

Industry:
Software & Data
Subindustry:
Apps

City Rank (Kalamazoo)

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Total amount:14

Top 8 Healthtech Startups in Kalamazoo for 2025

The top three Healthtech startups in Kalamazoo have raised more than USD 104M. Kalamazoo startup ecosystem ranks #286 globally for the Healthtech industry.
SB Score:335

Cirius Therapeutics develops insulin sensitizers to treat non-alcoholic steatohepatitis, a liver disease. Their clinical-stage products aim to improve liver health and combat the effects of the condition.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Kalamazoo)

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Regional Rank (North America)

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Metabolic Solutions Development creates groundbreaking therapies for type two diabetes using a unique pharmacological approach. Their innovative treatments aim to revolutionize diabetes management by targeting underlying metabolic processes.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Kalamazoo)

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SB Score:223

Epredia offers innovative solutions that are revolutionizing the anatomical pathology industry. Their wide range of products is transforming how professionals work, making processes more efficient and accurate.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Kalamazoo)

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Regional Rank (North America)

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Total amount:8

Top 2 Foodtech Startups in Kalamazoo for 2025

The top three Foodtech startups in Kalamazoo have raised more than USD 266M. Kalamazoo startup ecosystem ranks among the top 10 locations in the world for startups in Foodtech, holding the falseth position.
SB Score:380

Vestaron is leading a peptide-based revolution in crop protection. We are committed to providing growers with novel, effective peptide-based biopesticides that address proven targets. Our peptides overcome existing resistance issues while offering a desired safety profile for workers, beneficials and the environment. Vestaron has earned global recognition for its work, including the inaugural 2015 Bernard Blum Award for novel biocontrol solutions, the prestigious Green Chemistry Challenge Award from the U.S. Environmental Protection Agency and the American Chemical Society Green Chemistry Institute in 2020 and Best New Biologic Product in the 2021 Crop Science Awards.

Industry:
Foodtech
Subindustry:
Agtech

City Rank (Kalamazoo)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:236

Naitive Traits enhances corn genetics for increased yield, drought resistance, and temperature tolerance. Their startup focuses on developing traits that make corn more resilient and productive in challenging environmental conditions.

Industry:
Foodtech
Subindustry:
Agtech

City Rank (Kalamazoo)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:2

Top 1 undefined Startups in Kalamazoo for 2025

Kalamazoo startup ecosystem ranks among the top 10 locations in the world for startups in undefined, holding the falseth position.
SB Score:23

NixCode offers no-code app development services. The company uses software that functions like a human brain and the high-tech ability of a robot to create mobile apps that work effectively without using any code. The apps created by Nixcode are user-friendly, reasonably priced, and simple to create.

Industry:
Software & Data
Subindustry:
Apps

City Rank (Kalamazoo)

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Regional Rank (North America)

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Total amount:1

Most Funded Startups in Kalamazoo for 2025

The top three most funded startups in Kalamazoo have raised total funding of more than USD 367M. Vestaron has 3.95% more funding than Metabolic Solutions Development.
SB Score:380

Vestaron is leading a peptide-based revolution in crop protection. We are committed to providing growers with novel, effective peptide-based biopesticides that address proven targets. Our peptides overcome existing resistance issues while offering a desired safety profile for workers, beneficials and the environment. Vestaron has earned global recognition for its work, including the inaugural 2015 Bernard Blum Award for novel biocontrol solutions, the prestigious Green Chemistry Challenge Award from the U.S. Environmental Protection Agency and the American Chemical Society Green Chemistry Institute in 2020 and Best New Biologic Product in the 2021 Crop Science Awards.

Industry:
Foodtech
Subindustry:
Agtech

City Rank (Kalamazoo)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Metabolic Solutions Development creates groundbreaking therapies for type two diabetes using a unique pharmacological approach. Their innovative treatments aim to revolutionize diabetes management by targeting underlying metabolic processes.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Kalamazoo)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:335

Cirius Therapeutics develops insulin sensitizers to treat non-alcoholic steatohepatitis, a liver disease. Their clinical-stage products aim to improve liver health and combat the effects of the condition.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Kalamazoo)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:14

Top Hiring Startups in Kalamazoo by Employee Number

The top three hiring startups in Kalamazoo have an median employee size that is between [11-50]
SB Score:223

Epredia offers innovative solutions that are revolutionizing the anatomical pathology industry. Their wide range of products is transforming how professionals work, making processes more efficient and accurate.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Kalamazoo)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:380

Vestaron is leading a peptide-based revolution in crop protection. We are committed to providing growers with novel, effective peptide-based biopesticides that address proven targets. Our peptides overcome existing resistance issues while offering a desired safety profile for workers, beneficials and the environment. Vestaron has earned global recognition for its work, including the inaugural 2015 Bernard Blum Award for novel biocontrol solutions, the prestigious Green Chemistry Challenge Award from the U.S. Environmental Protection Agency and the American Chemical Society Green Chemistry Institute in 2020 and Best New Biologic Product in the 2021 Crop Science Awards.

Industry:
Foodtech
Subindustry:
Agtech

City Rank (Kalamazoo)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:335

Cirius Therapeutics develops insulin sensitizers to treat non-alcoholic steatohepatitis, a liver disease. Their clinical-stage products aim to improve liver health and combat the effects of the condition.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Kalamazoo)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Metabolic Solutions Development creates groundbreaking therapies for type two diabetes using a unique pharmacological approach. Their innovative treatments aim to revolutionize diabetes management by targeting underlying metabolic processes.

Industry:
Healthtech
Subindustry:
Biotechnology

City Rank (Kalamazoo)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:14

Explore the Startup Ecosystem of Kalamazoo

National Rank

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Regional Rank

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159th

3

Global Rank

(WorldWide)

479th

18

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2025 National Rank CityGlobal RankTotal Score

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Quantity Score
Quality ScoreBusiness Score
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1st
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852.643
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2nd
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315.515
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3rd
0
4th
0
139.115
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4th
0
6th
-
1
128.476
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00.00
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