12 Top startups in Brookline for January 2025

We rank Preply, XRHealth and ViRB in Brookline along with 9 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Brookline is part of Boston Area which ranks #5 globally and #4 in North America.

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Unicorns

Exits

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Accelerators

Top Unicorn Startups in Brookline for 2025

airSlate is the only unicorn in Brookline raising more than USD 1.25B. It is the undefined ranked unicorn in North America.
SB Score:604

Empowering teams to innovate, automate, and digitally transform business operations. Our solutions drive creativity and efficiency, revolutionizing the way organizations work.

Industry:
Software & Data
Subindustry:
Software

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Total amount:1

Best Startups in Brookline for 2025

SB Score:745

Preply connects learners with tutors globally for personalized language lessons online. Students can create custom learning plans and choose their own schedule for flexibility.

Industry:
Edtech
Subindustry:
Edtech

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SB Score:477

XRHealth offers a VR platform for remote treatment, revolutionizing telemedicine. Users can access virtual therapy sessions from the comfort of their own homes, making healthcare more accessible and convenient.

Industry:
Healthtech
Subindustry:
Health Care

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3rd

ViRB
SB Score:392

ViRB sources, trains, and deploys clinical research professionals for the life sciences industry using technology. Get started with ViRB to access a pool of skilled professionals ready to contribute to your projects.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:324

Panoptic is an innovative options trading protocol on the Ethereum blockchain, offering a seamless, oracle-free experience for instant-settlement. It empowers traders with perpetual options, enabling efficient and transparent transactions in the decentralized finance ecosystem.

Industry:
Fintech
Subindustry:
Blockchain

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SB Score:276

Layer Health addresses the challenge of healthcare information management by harnessing artificial intelligence to automate clinical, administrative, and research tasks that involve reviewing unstructured data. This innovative approach streamlines workflows and enhances decision-making in the healthcare sector.

Industry:
Healthtech
Subindustry:
Health Care

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6th

C14
SB Score:274

C14 offers a user-friendly payment widget for websites and dApps, compatible with various blockchain ecosystems. It simplifies transactions and enhances the online shopping experience with seamless integration.

Industry:
Fintech
Subindustry:
Blockchain

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SB Score:273

Edgewood Oncology is a clinical-stage biotechnology company dedicated to unlocking the potential of BTX-A51 for patients with genetically targeted solid tumors and hematologic malignancies. Their innovative approach aims to provide new treatment options and improve outcomes for those affected by these challenging conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:201

Revolutionizing building access, our smartphone video intercom system enhances tenant satisfaction in multi-tenant buildings. Streamlined control and ease of use boost retention for building managers, ensuring seamless access for all users.

Industry:
Hardware & IoT
Subindustry:
Internet of Everything

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SB Score:155

EatWell partners with health insurers to provide Food is Medicine meal kits designed to combat food insecurity and lower healthcare costs for diabetic patients. By prescribing nutritious meals, EatWell aims to enhance health outcomes and promote well-being within vulnerable populations.

Industry:
Foodtech
Subindustry:
Food and Beverage

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SB Score:49

Exaloop develops user-friendly computational tools with high-performance capabilities, specializing in bridging the gap between technology and life sciences. Their focus on bioinformatics ensures efficient and effective solutions for various industries.

Industry:
Edtech
Subindustry:
Education-Other

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Total amount:12

Top 4 Healthtech Startups in Brookline for 2025

The top three Healthtech startups in Brookline have raised more than USD 64.8M. Brookline is part of Boston Area which ranks #2 globally for the Healthtech industry.
SB Score:477

XRHealth offers a VR platform for remote treatment, revolutionizing telemedicine. Users can access virtual therapy sessions from the comfort of their own homes, making healthcare more accessible and convenient.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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SB Score:276

Layer Health addresses the challenge of healthcare information management by harnessing artificial intelligence to automate clinical, administrative, and research tasks that involve reviewing unstructured data. This innovative approach streamlines workflows and enhances decision-making in the healthcare sector.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:273

Edgewood Oncology is a clinical-stage biotechnology company dedicated to unlocking the potential of BTX-A51 for patients with genetically targeted solid tumors and hematologic malignancies. Their innovative approach aims to provide new treatment options and improve outcomes for those affected by these challenging conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Total amount:4

Top 1 Software & Data Startups in Brookline for 2025

The top three Software & Data startups in Brookline have raised more than USD 3M. Brookline is part of Boston Area which ranks #5 globally for the Software & Data industry.

1st

ViRB
SB Score:392

ViRB sources, trains, and deploys clinical research professionals for the life sciences industry using technology. Get started with ViRB to access a pool of skilled professionals ready to contribute to your projects.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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Total amount:1

Top 1 Ecommerce & Retail Startups in Brookline for 2025

Brookline is part of Boston Area which ranks #11 globally for the Ecommerce & Retail industry.
Unranked

Busy Beauty helps women reclaim time by offering efficient personal care solutions. The startup streamlines routines, providing products that simplify and speed up daily beauty tasks.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

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Total amount:1

Most Funded Startups in Brookline for 2025

The top three most funded startups in Brookline have raised total funding of more than USD 203M. Preply has 2.48% more funding than XRHealth.
SB Score:745

Preply connects learners with tutors globally for personalized language lessons online. Students can create custom learning plans and choose their own schedule for flexibility.

Industry:
Edtech
Subindustry:
Edtech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:477

XRHealth offers a VR platform for remote treatment, revolutionizing telemedicine. Users can access virtual therapy sessions from the comfort of their own homes, making healthcare more accessible and convenient.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:273

Edgewood Oncology is a clinical-stage biotechnology company dedicated to unlocking the potential of BTX-A51 for patients with genetically targeted solid tumors and hematologic malignancies. Their innovative approach aims to provide new treatment options and improve outcomes for those affected by these challenging conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:12

Top Hiring Startups in Brookline by Employee Number

The top three hiring startups in Brookline have an median employee size that is between [101-250]
SB Score:745

Preply connects learners with tutors globally for personalized language lessons online. Students can create custom learning plans and choose their own schedule for flexibility.

Industry:
Edtech
Subindustry:
Edtech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:477

XRHealth offers a VR platform for remote treatment, revolutionizing telemedicine. Users can access virtual therapy sessions from the comfort of their own homes, making healthcare more accessible and convenient.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

3rd

ViRB
SB Score:392

ViRB sources, trains, and deploys clinical research professionals for the life sciences industry using technology. Get started with ViRB to access a pool of skilled professionals ready to contribute to your projects.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:324

Panoptic is an innovative options trading protocol on the Ethereum blockchain, offering a seamless, oracle-free experience for instant-settlement. It empowers traders with perpetual options, enabling efficient and transparent transactions in the decentralized finance ecosystem.

Industry:
Fintech
Subindustry:
Blockchain

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:12

Explore the Startup Ecosystem of Brookline

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710.966
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251.377
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121.937
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109.679
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